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Highly effective SNP-based association mapping and management of recessive defects in livestock
Open accessAbstract
The widespread use of elite sires by means of artificial insemination in livestock breeding leads to the frequent emergence of recessive genetic defects, which cause significant economic and animal welfare concerns. Here we show that the availability of genome-wide, high-density SNP panels, combined with the typical structure of livestock populations, markedly accelerates the positional identification of genes and mutations that cause inherited defects. We report the fine-scale mapping of five recessive disorders in cattle and the molecular basis for three of these: congenital muscular dystony (CMD) types 1 and 2 in Belgian Blue cattle and ichthyosis fetalis in Italian Chianina cattle. Identification of these causative mutations has an immediate translation into breeding practice, allowing marker assisted selection against the defects through avoidance of at-risk matings.
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Citations
Cited by
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Georges, M., Charlier, C., & Hayes, B. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-018-0082-2 · Cited by 384
Self-citationGlycine transporters and synaptic function
Zafra, F., & Giménez, C. (2008) · IUBMB Life · doi:10.1002/iub.128 · Cited by 73
Overview on the Role of Advance Genomics in Conservation Biology of Endangered Species
Khan, S., Nabi, G., Ullah, M. W., Yousaf, M., Manan, S., Siddique, R., & Hou, H. (2016) · International Journal of Genomics · doi:10.1155/2016/3460416 · Cited by 63
Metadata
- Authors
- Charlier, C., Coppieters, W., Rollin, F., Desmecht, D., Agerholm, J. S., Cambisano, N., Carta, E., Dardano, S., Dive, M., Fasquelle, C., Frennet, J.-C., Hanset, R., Hubin, X., Jorgensen, C., Karim, L., Kent, M., Harvey, K., Pearce, B. R., Simon, P., Tama, N., Nie, H., Vandeputte, S., Lien, S., Longeri, M., Fredholm, M., Harvey, R. J., & Georges, M.
- Venue
- Nature Genetics
- Published
- 2008-03-16
- Volume
- 40
- Issue
- 4
- Pages
- 449-454
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2043107286
- Cited by
- 329
- References
- 0
- FWCI
- 13.36
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Highly effective SNP-based association mapping and management of recessive defects in livestock. https://app.cochat.ai/papers/10.1038/ng.96
- The paper
- Charlier, C., Coppieters, W., Rollin, F., Desmecht, D., Agerholm, J. S., Cambisano, N., Carta, E., Dardano, S., Dive, M., Fasquelle, C., Frennet, J.-C., Hanset, R., Hubin, X., Jorgensen, C., Karim, L., Kent, M., Harvey, K., Pearce, B. R., Simon, P., . . . Georges, M. (2008). Highly effective SNP-based association mapping and management of recessive defects in livestock. Nature Genetics. https://doi.org/10.1038/ng.96
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