The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Tissue-specific selection for different mtDNA genotypes in heteroplasmic mice
Abstract
Mammalian mitochondrial DNA (mtDNA) is a highly polymorphic, high-copy-number genome that is maternally inherited. New mutations in mtDNA segregate rapidly in the female germline due to a genetic bottleneck in early oogenesis and as a result most individuals are homoplasmic for a single species of mtDNA. Sequence variants thus accumulate along maternal lineages without genetic recombination. Most of the extant variation in mtDNA in mammalian populations has been assumed to be neutral with respect to selection; however, comparisons of the ratio of replacement to silent nucleotide substitutions between species suggest that the evolution of mammalian mtDNA is not strictly neutral. To test directly whether polymorphic mtDNAs behave as neutral variants, we examined the segregation of two different mtDNA genotypes in the tissues of heteroplasmic mice. We find evidence for random genetic drift in some tissues, but in others strong, tissue-specific and age-related, directional selection for different mtDNA genotypes in the same animal. These surprising data suggest that the coding sequence of mtDNA may represent a compromise between the competing demands of different tissues and point to the existence of unknown, tissue-specific nuclear genes important in the interaction between the nuclear and mitochondrial genomes.
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“The first heteroplasmic mice were generated by cytoplasmic fusion of two normal mouse strains carrying distinct haplotypes [74,169].”
From Mitochondrial DNA mutations and human disease (2010) · cites this paper as [169]
In the citing paper
“Whilst there is concern whether the mutation load detected in the prenatal sample would accurately reflect the heteroplasmy levels in other foetal tissues, present evidence suggests that this should not be a problem [169,249].”
From Mitochondrial DNA mutations and human disease (2010) · cites this paper as [169]
Citations
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Research works printed but not linked: 2
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Kadam, P. S., Yang, Z., Lu, Y., Zhu, H., Atiyas, Y., Shah, N., Fisher, S., Nordgren, E., Kim, J., Issadore, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26755261
Kadam, P. S., Yang, Z., Lu, Y., Zhu, H., Atiyas, Y., Shah, N., Fisher, S., Nordgren, E., Kim, J., Issadore, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26755258
Kadam, P. S., Yang, Z., Lu, Y., Zhu, H., Atiyas, Y., Shah, N., Fisher, S., Nordgren, E., Kim, J., Issadore, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26755186
Kadam, P. S., Yang, Z., Lu, Y., Zhu, H., Atiyas, Y., Shah, N., Fisher, S., Nordgren, E., Kim, J., Issadore, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26755252
Kadam, P. S., Yang, Z., Lu, Y., Zhu, H., Atiyas, Y., Shah, N., Fisher, S., Nordgren, E., Kim, J., Issadore, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26755234
Kadam, P. S., Yang, Z., Lu, Y., Zhu, H., Atiyas, Y., Shah, N., Fisher, S., Nordgren, E., Kim, J., Issadore, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26755297
Kadam, P. S., Yang, Z., Lu, Y., Zhu, H., Atiyas, Y., Shah, N., Fisher, S., Nordgren, E., Kim, J., Issadore, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26755264
Kadam, P. S., Yang, Z., Lu, Y., Zhu, H., Atiyas, Y., Shah, N., Fisher, S., Nordgren, E., Kim, J., Issadore, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26755288
Kadam, P. S., Yang, Z., Lu, Y., Zhu, H., Atiyas, Y., Shah, N., Fisher, S., Nordgren, E., Kim, J., Issadore, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26755246
Kadam, P. S., Yang, Z., Lu, Y., Zhu, H., Atiyas, Y., Shah, N., Fisher, S., Nordgren, E., Kim, J., Issadore, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26755189
Kadam, P. S., Yang, Z., Lu, Y., Zhu, H., Atiyas, Y., Shah, N., Fisher, S., Nordgren, E., Kim, J., Issadore, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26755231
Kadam, P. S., Yang, Z., Lu, Y., Zhu, H., Atiyas, Y., Shah, N., Fisher, S., Nordgren, E., Kim, J., Issadore, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26755276
Kadam, P. S., Yang, Z., Lu, Y., Zhu, H., Atiyas, Y., Shah, N., Fisher, S., Nordgren, E., Kim, J., Issadore, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26755192
Kadam, P. S., Yang, Z., Lu, Y., Zhu, H., Atiyas, Y., Shah, N., Fisher, S., Nordgren, E., Kim, J., Issadore, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26755195
Kadam, P. S., Yang, Z., Lu, Y., Zhu, H., Atiyas, Y., Shah, N., Fisher, S., Nordgren, E., Kim, J., Issadore, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26755213
Kadam, P. S., Yang, Z., Lu, Y., Zhu, H., Atiyas, Y., Shah, N., Fisher, S., Nordgren, E., Kim, J., Issadore, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26755255
Mechanisms of Intracellular Selection of Mitochondrial DNA
Muravyov, G., & Кнорре, Д. А. (2025) · Biochemistry (Moscow) · doi:10.1134/s0006297925603296
Etude de la ségrégation de l'ADN mitochondrial au cours du développement embryofoetal humain
Steffann, J. (2006) · OpenGrey (Institut de l'Information Scientifique et Technique)
Metadata
- Authors
- Jenuth, J. P., Peterson, A. C., & Shoubridge, E. A.
- Affiliations
- Montreal Neurological Institute and Hospital (CA)
- McGill University (CA)
- Corresponding author
- Shoubridge, Eric A.
- Venue
- Nature Genetics
- Published
- 1997-05
- Volume
- 16
- Issue
- 1
- Pages
- 93-95
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2080844913
- Cited by
- 415
- References
- 21
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 35 · 2023: 12 · 2022: 8 · 2021: 13 · 2020: 11 · 2019: 12 · 2018: 11 · 2017: 7 · 2016: 8 · 2015: 22 · 2014: 17 · 2013: 11 · 2012: 12
- FWCI
- 10.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Genetics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
- Keywords
- mitochondrial DNA, heteroplasmy, genetic drift, mtDNA polymorphisms, neutral evolution, nuclear-mitochondrial interactions, nuclear genes
- MeSH terms
- Age Factors, Animals, Animals, Newborn, Blastocyst, Blood Physiological Phenomena, Colon, DNA, Mitochondrial, Female, Kidney, Liver, Male, Mice, Inbred C57BL, Mice, Inbred NZB, Mice, Inbred Strains, Mice, Transgenic, Models, Genetic, Organ Specificity, Selection, Genetic, Spleen, Stem Cells, Genetic Variation, Mice
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