Random genetic drift in the female germline explains the rapid segregation of mammalian mitochondrial DNA

Rapid evolution of animal mitochondrial DNA

Brown, W. M., George, M., & Wilson, A. C. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.4.1967 · Cited by 3,439 · see citing works

Mitochondrial DNA sequences of primates: tempo and mode of evolution

Brown, W. M., Prager, E. M., Wang, A., & Wilson, A. C. (1982) · Journal of Molecular Evolution · doi:10.1007/bf01734101 · Cited by 1,554 · see citing works

Replication of animal mitochondrial DNA

Clayton, D. A. (1982) · Cell · doi:10.1016/0092-8674(82)90049-6 · Cited by 1,236 · see citing works

A quantitative and cytological study of germ cells in human ovaries

Baker, T. G. (1963) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1963.0055 · Cited by 1,094 · see citing works

Primordial germ cells in the mouse embryo during gastrulation

Ginsburg, M., Snow, M. H. L., & McLaren, A. (1990) · Development · doi:10.1242/dev.110.2.521 · Cited by 1,016 · see citing works

AN APPROACH TO POPULATION AND EVOLUTIONARY GENETIC THEORY FOR GENES IN MITOCHONDRIA AND CHLOROPLASTS, AND SOME RESULTS

Birky, C. W., Maruyama, T., & Fuerst, P. A. (1983) · Genetics · doi:10.1093/genetics/103.3.513 · Cited by 727 · see citing works

Nuclear Transplantation in the Mouse Embryo by Microsurgery and Cell Fusion

McGrath, J. M., & Solter, D. (1983) · Science · doi:10.1126/science.6857250 · Cited by 591 · see citing works

Proliferation and migration of primordial germ cells during compensatory growth in mouse embryos

Tam, P., & Mh, S. (1981) · Development · doi:10.1242/dev.64.1.133 · Cited by 553 · see citing works

The Number of Mitochondrial Deoxyribonucleic Acid Genomes in Mouse L and Human HeLa Cells

Bogenhagen, D. F., & Clayton, D. A. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42063-2 · Cited by 526 · see citing works

MELAS mutation in mtDNA binding site for transcription termination factor causes defects in protein synthesis and in respiration but no change in levels of upstream and downstream mature transcripts.

Chomyn, A., Martinuzzi, A., Yoneda, M., Daga, A., Hurko, O., Johns, D. R., Lai, S. T., Nonaka, I., Angelini, C. I., & Attardi, G. M. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.10.4221 · Cited by 491 · see citing works

Amounts of mitochondrial DNA and abundance of some mitochondrial gene transcripts in early mouse embryos

Pikó, L., & Taylor, K. D. (1987) · Developmental Biology · doi:10.1016/0012-1606(87)90395-2 · Cited by 448 · see citing works

Leber hereditary optic neuropathy: identification of the same mitochondrial ND1 mutation in six pedigrees.

Howell, N., Bindoff, L. A., McCullough, D. A., Kubacka, I., Poulton, J., Mackey, D. A., Taylor, L., & Turnbull, D. M. (1991) · PubMed · Cited by 400 · see citing works

Mitochondrial DNA polymorphism in a maternal lineage of Holstein cows.

Hauswirth, W. W., & Laipis, P. J. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.15.4686 · Cited by 377 · see citing works

Distribution and threshold expression of the tRNA(Lys) mutation in skeletal muscle of patients with myoclonic epilepsy and ragged-red fibers (MERRF).

Boulet, L., Karpati, G., & Shoubridge, E. A. (1992) · Europe PMC (PubMed Central) · Cited by 331 · see citing works

Maternally transmitted histocompatibility antigen of mice: A hydrophobic peptide of a mitochondrially encoded protein

Loveland, B. E. (1990) · Cell · doi:10.1016/0092-8674(90)90345-f · Cited by 320 · see citing works

Allelic genealogy and human evolution.

Takahata, N. (1993) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a039995 · Cited by 287 · see citing works

Nucleotide sequence evidence for rapid genotypic shifts in the bovine mitochondrial DNA D-loop

Olivo, P. D., de Walle, M. J. V., Laipis, P. J., & Hauswirth, W. W. (1983) · Nature · doi:10.1038/306400a0 · Cited by 250 · see citing works

Rapid segregation of heteroplasmic bovine mitodiondria

Ashley, M. V., Laipis, P. J., & Hauswirth, W. W. (1989) · Nucleic Acids Research · doi:10.1093/nar/17.18.7325 · Cited by 228 · see citing works

Mitochondrial DNA in mortal and immortal human cells. Genome number, integrity, and methylation.

Reis, R. J. S., & Goldstein, S. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44633-3 · Cited by 203 · see citing works

Replacement of bovine mitochondrial DNA by a sequence variant within one generation.

Koehler, C. M., Lindberg, G. L., Brown, D. R., et al. (1991) · Genetics · doi:10.1093/genetics/129.1.247 · Cited by 177 · see citing works

A rapid procedure for visualising the inner cell mass and trophectoderm nuclei of mouse blastocysts in situ using polynucleotide‐specific fluorochromes

Handyside, A. H., & Hunter, S. (1984) · Journal of Experimental Zoology · doi:10.1002/jez.1402310317 · Cited by 176 · see citing works

Mitochondrial DNA mutations in diseases of energy metabolism

Wallace, D. C. (1994) · Journal of Bioenergetics and Biomembranes · doi:10.1007/bf00763096 · Cited by 173 · see citing works

Segregation and manifestations of the mtDNA tRNA(Lys) A-->G(8344) mutation of myoclonus epilepsy and ragged-red fibers (MERRF) syndrome.

Larsson, N., Tulinius, M., Holme, E., Oldfors, A., Andersen, O., Wahlström, J., & Aasly, J. O. (1992) · Europe PMC (PubMed Central) · Cited by 163 · see citing works

Mitochondrial DNA

Nass, M. M. K. (1969) · Journal of Molecular Biology · doi:10.1016/0022-2836(69)90240-x · Cited by 160 · see citing works

Genetics of mitochondria in Drosophila: mtDNA inheritance in heteroplasmic strains of D. mauritiana

Solignac, M., Génermont, J., Monnerot, M., et al. (1984) · Molecular and General Genetics MGG · doi:10.1007/bf00330961 · Cited by 131 · see citing works

Mitochondrial gene segregation in mammals: is the bottleneck always narrow?

Howell, N., Halvorson, S. J., Kubacka, I., McCullough, D. A., Bindoff, L. A., & Turnbull, D. M. (1992) · Human Genetics · doi:10.1007/bf00210753 · Cited by 131 · see citing works

Biochemical studies of growing mouse oocytes: Preparation of oocytes and analysis of glucose-6-phosphate dehydrogenase and lactate dehydrogenase activities

Mangia, F., & Epstein, C. J. (1975) · Developmental Biology · doi:10.1016/0012-1606(75)90061-5 · Cited by 126 · see citing works

Heterogeneous mitochondrial DNA D-loop sequences in bovine tissue

Hauswirth, W. W., de Walle, M. J. V., Olivo, P. D., & Laipis, P. J. (1984) · Cell · doi:10.1016/0092-8674(84)90434-3 · Cited by 123 · see citing works

Relaxed and Stringent Genomes: Why Cytoplasmic Genes Don't Obey Mendel's Laws

Birky, C. W. (1994) · Journal of Heredity · doi:10.1093/oxfordjournals.jhered.a111480 · Cited by 123 · see citing works

Unequal partitioning of bovine mitochondrial genotypes among siblings.

Laipis, P. J., de Walle, M. J. V., & Hauswirth, W. W. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.21.8107 · Cited by 109 · see citing works

A T → C mutation at nt 8993 of mitochondrial DNA in a child with Leigh syndrome

Santorelli, F. M., Shanske, S., Jain, K., Tick, D. B., Schon, E. A., & DiMauro, S. (1994) · Neurology · doi:10.1212/wnl.44.5.972 · Cited by 89 · see citing works

A heteroplasmic LHON family: tissue distribution and transmission of the 11778 mutation.

Howell, N., Xu, M., Halvorson, S. J., Bodis-Wollner, I. G., & Sherman, J. (1994) · PubMed Central · Cited by 73 · see citing works

Pathogenetic aspects of the A8344G mutation of mitochondrial DNA associated with MERRF syndrome and multiple symmetric lipomas

Larsson, N., Tulinius, M., Holme, E., & Oldfors, A. (1995) · Muscle & Nerve · doi:10.1002/mus.880181421 · Cited by 66 · see citing works

Analysis of DNA sequence variation in single cells

Li, H., CUI, X., & Arnheim, N. (1991) · Methods · doi:10.1016/s1046-2023(05)80125-2 · Cited by 59 · see citing works

Longitudinal study of a heteroplasmic 3460 Leber hereditary optic neuropathy family by multiplexed primer-extension analysis and nucleotide sequencing.

Ghosh, S. S., Fahy, E., Bodis-Wollner, I. G., Sherman, J., & Howell, N. (1996) · PubMed Central · Cited by 54 · see citing works

Mitochondrial DNA mutation and heteroplasmy in type I Leber hereditary optic neuropathy

Zhu, D., Economou-Petersen, E., Antonarakis, S. E., & Maumenee, I. H. (1992) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320420208 · Cited by 37 · see citing works

Comparative Studies of Normal and Neoplastic Ovarian Germ Cells

Gondos, B. (1987) · International Journal of Gynecological Pathology · doi:10.1097/00004347-198706000-00003 · Cited by 24 · see citing works

A quantitative analysis of mitochondria during fetal mouse oogenesis

Nogawa, T., Sung, W. K., JAGIELLO, G. M., et al. (1988) · Journal of Morphology · doi:10.1002/jmor.1051950208 · Cited by 18 · see citing works

Mitochondrial diseases in man and mouse

Wallace, D. C. (1999) · Science · doi:10.1126/science.283.5407.1482 · Cited by 3,060 · see citing works

Mitochondrial DNA mutations and human disease

Tuppen, H. A. L., Blakely, E. L., Turnbull, D. M., & Taylor, R. W. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2009.09.005 · Cited by 676 · see citing works

A mouse model of mitochondrial disease reveals germline selection against severe mtDNA mutations

Fan, W., Waymire, K. G., Narula, N., Li, P., Rocher, C., Coskun, P. E., Vannan, M. A., Narula, J., MacGregor, G. R., & Wallace, D. C. (2008) · Science · doi:10.1126/science.1147786 · Cited by 466 · see citing works

Tissue-specific selection for different mtDNA genotypes in heteroplasmic mice

Jenuth, J. P., Peterson, A. C., & Shoubridge, E. A. (1997) · Nature Genetics · doi:10.1038/ng0597-93 · Cited by 415 · see citing works

Mitochondrial disorders: prevalence, myths and advances

Thorburn, D. R. (2004) · Journal of Inherited Metabolic Disease · doi:10.1023/b:boli.0000031098.41409.55 · Cited by 258 · see citing works

Random genetic drift determines the level of mutant mtDNA in human primary oocytes

Brown, D. T., Samuels, D. C., Michael, E. M., Turnbull, D. M., & Chinnery, P. F. (2001) · The American Journal of Human Genetics · doi:10.1086/318190 · Cited by 196 · see citing works

Functional organization of mammalian mitochondrial DNA in nucleoids: history, recent developments, and future challenges

Spelbrink, J. N. (2010) · IUBMB Life · doi:10.1002/iub.282 · Cited by 171 · see citing works

Nuclear genetic control of mitochondrial DNA segregation

Battersby, B. J., Loredo-Osti, J. C., & Shoubridge, E. A. (2003) · Nature Genetics · doi:10.1038/ng1073 · Cited by 144 · see citing works

Inhibition of mitochondrial fission favours mutant over wild-type mitochondrial DNA

Malena, A., Loro, E., Di Re, M., Holt, I. J., & Vergani, L. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp281 · Cited by 107 · see citing works

Exercise and training in mitochondrial myopathies

TAIVASSALO, T., & HALLER, R. G. (2005) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000177446.97671.2a · Cited by 106 · see citing works

DNA repair of UV photoproducts and mutagenesis in human mitochondrial DNA

Pascucci, B., Versteegh, A., van Hoffen, A., van Zeeland, A. A., Mullenders, L. H. F., & Dogliotti, E. (1997) · Journal of Molecular Biology · doi:10.1006/jmbi.1997.1268 · Cited by 82 · see citing works

Mitochondrial myopathies

Larsson, N. ‐., & Oldfors, A. (2001) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2001.00842.x · Cited by 65 · see citing works

Over-expression of Tfam improves the mitochondrial disease phenotypes in a mouse model system

Nishiyama, S., Shitara, H., Nakada, K., Ono, T., Sato, A., Suzuki, H., Ogawa, T., Masaki, H., Hayashi, J.-I., & Yonekawa, H. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.08.143 · Cited by 46 · see citing works

Mitochondrial DNA segregation in hematopoietic lineages does not depend on MHC presentation of mitochondrially encoded peptides

Battersby, B. J., Redpath, M. E., & Shoubridge, E. A. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi293 · Cited by 32 · see citing works

Diagnosis of Mitochondrial Disease: Assessment of Mitochondrial DNA Heteroplasmy in Blood

Taylor, R. W., Taylor, G. A., Morris, C. M., et al. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9553 · Cited by 43 · see citing works

Heteroplasmic mutation of mitochondrial DNA D-loop and 4977-bp deletion in human cancer cells during mitochondrial DNA depletion

Lee, H., Hsu, L., Yin, P., Lee, L.-M., & Chi, C. (2006) · Mitochondrion · doi:10.1016/j.mito.2006.11.016 · Cited by 29 · see citing works

Depletion of mitochondrial DNA in leucocytes harbouring the 3243A→G mtDNA mutation

Pyle, A., Taylor, R. W., Durham, S. E., Deschauer, M., Schaefer, A. M., Samuels, D. C., & Chinnery, P. F. (2006) · Journal of Medical Genetics · doi:10.1136/jmg.2006.043109 · Cited by 68 · see citing works

Live Birth Derived From Oocyte Spindle Transfer to Prevent Mitochondrial Disease

Zhang, J., Liu, H., Luo, S., et al. (2017) · Obstetrical & Gynecological Survey · doi:10.1097/01.ogx.0000524508.40309.08 · Cited by 26 · see citing works

The Detection and Partial Localisation of Heteroplasmic Mutations in the Mitochondrial Genome of Patients with Diabetic Retinopathy

Malik, A. N., Rosa, H. S., de Menezes, E. C. S., Tamang, P., Hamid, Z., Naik, A., Parsade, C. K., & Sivaprasad, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20246259 · Cited by 3 · see citing works