The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Hints of hidden heritability in GWAS
Abstract
Although susceptibility loci identified through genome-wide association studies (GWAS) typically explain only a small proportion of the heritability, a classical quantitative genetic analysis now argues that considering together all common SNPs can explain a large proportion of the heritability of these complex traits. A related study provides recommendations for the sample sizes needed in future GWAS to identify additional susceptibility loci.
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“Here it simply signifies the idea that the heritability is not so much missing, as hidden beneath the significance thresholds used to define risk alleles with high confidence15.”
From Rare and common variants: twenty arguments (2012) · cites this paper as [15]
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Cites
Finding the missing heritability of complex diseases
Manolio, T. A., Collins, F. S., Cox, N. J., Goldstein, D. B., Hindorff, L. A., Hunter, D. J., McCarthy, M. I., Ramos, E. M., Cardon, L. R., Chakravarti, A., et al. (2009) · Nature · doi:10.1038/nature08494 · Cited by 8,336
Self-citationCommon polygenic variation contributes to risk of schizophrenia and bipolar disorder
The International Schizophrenia Consortium (2009) · Nature · doi:10.1038/nature08185 · Cited by 4,821
Common SNPs explain a large proportion of the heritability for human height
Yang, J., Benyamin, B., McEvoy, B. P., Gordon, S., Henders, A. K., Nyholt, D. R., Madden, P. A., Heath, A. C., Martin, N. G., Montgomery, G. W., et al. (2010) · Nature Genetics · doi:10.1038/ng.608 · Cited by 4,446
XV.—The Correlation between Relatives on the Supposition of Mendelian Inheritance.
Fisher, R. A. (1919) · Transactions of the Royal Society of Edinburgh · doi:10.1017/s0080456800012163 · Cited by 4,387
Missing heritability and strategies for finding the underlying causes of complex disease
Eichler, E. E., Flint, J., Gibson, G. C., Kong, A., Leal, S. M., Moore, J. H., & Nadeau, J. H. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2809 · Cited by 1,728
Self-citationThe investigation of linkage between a quantitative trait and a marker locus
Haseman, J. K., & Elston, R. C. (1972) · Behavior Genetics · doi:10.1007/bf01066731 · Cited by 1,367
Park, J.-H., Wacholder, S., Gail, M. H., Peters, U., Jacobs, K. B., Chanock, S. J., & Chatterjee, N. (2010) · Nature Genetics · doi:10.1038/ng.610 · Cited by 678
The genetic interpretation of area under the ROC curve in genomic profiling
Wray, N. R., Yang, J., Goddard, M. E., & Visscher, P. M. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000864 · Cited by 334
Evans, D. M., Visscher, P. M., & Wray, N. R. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp295 · Cited by 297
Reaching new heights: insights into the genetics of human stature
Weedon, M. N., & Frayling, T. M. (2008) · Trends in Genetics · doi:10.1016/j.tig.2008.09.006 · Cited by 147
Cited by
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GCTA: a tool for genome-wide complex trait analysis
Yang, J., Lee, S. H., Goddard, M. E., & Visscher, P. M. (2011) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.11.011 · Cited by 8,279
Rare and common variants: twenty arguments
Gibson, G. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3118 · Cited by 1,278
Self-citationChronic obstructive pulmonary disease
Christenson, S. A., Smith, B. M., Bafadhel, M., & Putcha, N. (2022) · The Lancet · doi:10.1016/s0140-6736(22)00470-6 · Cited by 1,292
The genetics of asthma and allergic disease: a 21st century perspective
Ober, C., & Yao, T. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01029.x · Cited by 698
Progress and promise of genome-wide association studies for human complex trait genetics
Stranger, B. E., Stahl, E. A., & Raj, T. (2011) · Genetics · doi:10.1534/genetics.110.120907 · Cited by 567
Metadata
- Authors
- Gibson, G.
- Affiliations
- Georgia Institute of Technology (US)
- Corresponding author
- Gibson, Greg
- ORCID
- Gibson, Greg
- Venue
- Nature Genetics
- Published
- 2010-07
- Volume
- 42
- Issue
- 7
- Pages
- 558-560
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W1987620105
- Cited by
- 281
- References
- 10
- Citations by year
- 2026: 7 · 2025: 2 · 2024: 5 · 2023: 6 · 2022: 12 · 2021: 10 · 2020: 19 · 2019: 13 · 2018: 16 · 2017: 15 · 2016: 23 · 2015: 28 · 2014: 20 · 2013: 34 · 2012: 41
- FWCI
- 18.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Genetics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Keywords
- heritability, genome-wide association study, complex traits, genetic susceptibility loci, sample size, quantitative genetics, missing heritability
- MeSH terms
- Body Height, Breast Neoplasms, Crohn Disease, Female, Gene Frequency, Genotype, Humans, Male, Prostatic Neoplasms, Colorectal Neoplasms, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Genome-Wide Association Study
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