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Hints of hidden heritability in GWAS

Gibson, Greg·2010·Nature Genetics

DOI 10.1038/ng0710-558

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Abstract

Although susceptibility loci identified through genome-wide association studies (GWAS) typically explain only a small proportion of the heritability, a classical quantitative genetic analysis now argues that considering together all common SNPs can explain a large proportion of the heritability of these complex traits. A related study provides recommendations for the sample sizes needed in future GWAS to identify additional susceptibility loci.

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Authors: Gibson, G.
Affiliations: Georgia Institute of Technology (US)
Corresponding author: Gibson, Greg
ORCID: Gibson, Greg
Venue: Nature Genetics
Publisher: Springer Science and Business Media LLC
Published: 2010-07
Volume: 42
Issue: 7
Pages: 558-560
ISSN: 1061-4036 (ISSN-L)
1546-1718
DOI: 10.1038/ng0710-558
OpenAlex: W1987620105
Cited by: 281
References: 10
Citations by year: 2026: 7 · 2025: 2 · 2024: 5 · 2023: 6 · 2022: 12 · 2021: 10 · 2020: 19 · 2019: 13 · 2018: 16 · 2017: 15 · 2016: 23 · 2015: 28 · 2014: 20 · 2013: 34 · 2012: 41
FWCI: 18.87
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Genetics (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
Keywords: heritability, genome-wide association study, complex traits, genetic susceptibility loci, sample size, quantitative genetics, missing heritability
MeSH terms: Body Height, Breast Neoplasms, Crohn Disease, Female, Gene Frequency, Genotype, Humans, Male, Prostatic Neoplasms, Colorectal Neoplasms, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Genome-Wide Association Study

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