The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
The effects of human population structure on large genetic association studies
Abstract
Large-scale association studies hold substantial promise for unraveling the genetic basis of common human diseases. A well-known problem with such studies is the presence of undetected population structure, which can lead to both false positive results and failures to detect genuine associations. Here we examine approximately 15,000 genome-wide single-nucleotide polymorphisms typed in three population groups to assess the consequences of population structure on the coming generation of association studies. The consequences of population structure on association outcomes increase markedly with sample size. For the size of study needed to detect typical genetic effects in common diseases, even the modest levels of population structure within population groups cannot safely be ignored. We also examine one method for correcting for population structure (Genomic Control). Although it often performs well, it may not correct for structure if too few loci are used and may overcorrect in other settings, leading to substantial loss of power. The results of our analysis can guide the design of large-scale association studies.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“To avoid the influence of undesired population structures that can mimic the signal of associations and lead to false positives or missed real effects (Marchini et al., 2004), we estimated the population structure of 239 sweet potato genotypes using the model-based approach as implemented in STRUCTURE.”
From Development and identification of SSR markers associated with starch properties and β-carotene content in the storage root of sweet potato (Ipomoea batatas L.) (2016) · cites this paper as Marchini et al., 2004
In the citing paper
“To avoid the influence of undesired population structures that can mimic the signal of associations and lead to false positives or missed real effects (Marchini et al., 2004), we estimated the population structure of 239 sweet potato genotypes using the model-based approach as implemented in STRUCTURE.”
From Development and identification of SSR markers associated with starch properties and β-carotene content in the storage root of sweet potato (Ipomoea batatas L.) (2016) · cites this paper as Marchini et al., 2004
Citations
Cites
Inference of Population Structure Using Multilocus Genotype Data
Pritchard, J. K., Stephens, M., & Donnelly, P. (2000) · Genetics · doi:10.1093/genetics/155.2.945 · Cited by 33,871
Self-citationStatistical significance for genomewide studies
Storey, J. D., & Tibshirani, R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1530509100 · Cited by 9,692
The International HapMap Project
†The International HapMap Consortium, Genotyping centres: Baylor College of Medicine and ParAllele BioScience, Gibbs, R. A., Belmont, J. W., Hardenbol, P., Willis, T. D., Yu, F., Chinese HapMap Consortium, Yang, H., Ch'ang, L.-Y., et al. (2003) · Nature · doi:10.1038/nature02168 · Cited by 6,057
Self-citationThe Future of Genetic Studies of Complex Human Diseases
Risch, N., & Merikangas, K. (1996) · Science · doi:10.1126/science.273.5281.1516 · Cited by 5,355
The History and Geography of Human Genes
Cavalli-Sforza, L. L., Menozzi, P., & Piazza, A. (2018) · Princeton University Press eBooks · doi:10.2307/j.ctv301gjp · Cited by 3,175
Genomic Control for Association Studies
Devlin, B., & Roeder, K. (1999) · Biometrics · doi:10.1111/j.0006-341x.1999.00997.x · Cited by 3,162
Association mapping in structured populations.
Pritchard, J. K., Stephens, M., Rosenberg, N., & Donnelly, P. (2000) · American Journal of Human Genetics · doi:10.1086/302959 · Cited by 2,066
Self-citationSearching for genetic determinants in the new millennium
Risch, N. J. (2000) · Nature · doi:10.1038/35015718 · Cited by 1,839
Use of Unlinked Genetic Markers to Detect Population Stratification in Association Studies
Pritchard, J. K., & Rosenberg, N. A. (1999) · The American Journal of Human Genetics · doi:10.1086/302449 · Cited by 1,198
From Genotypes to Genes: Doubling the Sample Size
Sasieni, P. D. (1997) · Biometrics · doi:10.2307/2533494 · Cited by 897
Flagged first, then by citations
Cited by
Sorted by citations
Items 401–500 of 876
A Bayesian non-parametric mixed-effects model of microbial growth curves
Tonner, P. D., Darnell, C. L., Bushell, F. M. L., Lund, P. A., Schmid, A., & Schmidler, S. C. (2020) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1008366 · Cited by 24
Systematic meta-analyses and field synopsis of genetic association studies in colorectal adenomas
Montazeri, Z., Τheodoratou, E., Nyiraneza, C., Timofeeva, M. N., Chen, W., Svinti, V., Sivakumaran, S., Gresham, G. K., Cubitt, L., Carvajal‐Carmona, L. G., et al. (2015) · International Journal of Epidemiology · doi:10.1093/ije/dyv185 · Cited by 24
Yang, Y., Remmers, E. F., Ogunwole, C. B., Kastner, D. L., Gregersen, P. K., & Li, W. (2007) · Computational Biology and Chemistry · doi:10.1016/j.compbiolchem.2010.12.006 · Cited by 21
Gorroochurn, P., Hodge, S. E., Heiman, G. A., & Greenberg, D. A. (2007) · Human Heredity · doi:10.1159/000102988 · Cited by 24
Rigor and reproducibility in genetic research on eating disorders
Hübel, C., Leppä, V., Breen, G. D., & Bulik, C. M. (2018) · International Journal of Eating Disorders · doi:10.1002/eat.22896 · Cited by 24
Racial disparities in risk factors for thrombosis
Itakura, H. (2005) · Current Opinion in Hematology · doi:10.1097/01.moh.0000167746.26145.53 · Cited by 24
Subarachnoid hemorrhage: tests of association with apolipoprotein E and elastin genes
Kaushal, R. D., Woo, D., Pal, P., Haverbusch, M. A., Xi, H., Moomaw, C. J., Sekar, P., D, B. M. K. M., Kleindorfer, D., Flaherty, M. L., et al. (2007) · BMC Medical Genetics · doi:10.1186/1471-2350-8-49 · Cited by 23
Planning and Executing a Genome Wide Association Study (GWAS)
Sale, M. M., Mychaleckyj, J. C., & Chen, W. (2009) · Methods in molecular biology · doi:10.1007/978-1-60327-378-7_25 · Cited by 23
Correcting for relatedness in Bayesian models for genomic data association analysis
Pikkuhookana, P., & Sillanpää, M. J. (2009) · Heredity · doi:10.1038/hdy.2009.56 · Cited by 22
Ramírez‐Valiente, J. A., Lorenzo, Z., Soto, Á., Valladares, F., Gil, L., & Aranda, I. (2010) · Evolutionary Ecology · doi:10.1007/s10682-010-9365-6 · Cited by 22
- Applications of Autosomal SNPs and Indels in Forensic Analysis
Phillips, C. (2013) · CRC Press eBooks · doi:10.1201/b15361-17 · Cited by 23
Evaluation of the Precision of Ancestry Inferences in South American Admixed Populations
Pereira, V., Santangelo, R., Børsting, C., Tvedebrink, T., Almeida, A. P. F., de Carvalho, E. F., Morling, N., & Gusmão, L. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.00966 · Cited by 22
Impact of the AHI1 Gene on the Vulnerability to Schizophrenia: A Case-Control Association Study
Rivero, O., Reif, A., Sanjuán, J., Moltó, M. D., Kittel‐Schneider, S., Nájera, C., Töpner, T., & Lesch, K. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012254 · Cited by 23
Inferring the demographic history of European Ficedula flycatcher populations
Backström, N., Sætre, G., & Ellegren, H. (2013) · BMC Evolutionary Biology · doi:10.1186/1471-2148-13-2 · Cited by 27
Oxytocin receptor gene (OXTR) in relation to loneliness in adolescence
van Roekel, E., Verhagen, M., Engels, R. C. M. E., Goossens, L., & Scholte, R. H. J. (2013) · Psychiatric Genetics · doi:10.1097/ypg.0b013e328363f631 · Cited by 24
Effects of population structure on genetic association studies
Xu, H., & Shete, S. S. (2005) · BMC Genetics · doi:10.1186/1471-2156-6-s1-s109 · Cited by 24
Physiogenomic Analysis of Localized fMRI Brain Activity in Schizophrenia
Windemuth, A., Calhoun, V. D., Pearlson, G. D., Kocherla, M., Jagannathan, K., & Ruaño, G. (2008) · Annals of Biomedical Engineering · doi:10.1007/s10439-008-9475-2 · Cited by 22
Bromley, C. M., Close, S. L., Cohen, N., Favis, R., Fijal, B. A., Gheyas, F., Liu, W., López-Correa, C., Prokop, A., Singer, J. B., et al. (2008) · The Pharmacogenomics Journal · doi:10.1038/tpj.2008.11 · Cited by 22
Issues with Polymorphism Analysis in Sepsis
Sutherland, A. M., & Russell, J. A. (2005) · Clinical Infectious Diseases · doi:10.1086/431989 · Cited by 22
Genome-wide association studies of brain structure and function in the UK BiobankPreprint
Elliott, L. T., Sharp, K., Alfaro‐Almagro, F., Shi, S., Miller, K. L., Douaud, G., Marchini, J., & Smith, S. M. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/178806 · Cited by 23
Self-citationMimno, D., Blei, D. M., & Engelhardt, B. E. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1412301112 · Cited by 22
Genome-Wide Analysis of Blood Pressure Variability and Ischemic Stroke
Yadav, S., Cotlarciuc, I., Munroe, P. B., Khan, M. S., Nalls, M. A., Bevan, S., Cheng, Y.-C., Chen, W., Malik, R., McCarthy, N. S., et al. (2013) · Stroke · doi:10.1161/strokeaha.113.002186 · Cited by 21
Peloso, G. M., & Lunetta, K. L. (2011) · BMC Genetics · doi:10.1186/1471-2156-12-64 · Cited by 21
Genome-wide association studies of cancer: principles and potential utility.
Stadler, Z. K., Gallagher, D. J., Thom, P., & Offit, K. (2010) · PubMed · Cited by 21
Regional surnames and genetic structure in Great Britain
Kandt, J., Cheshire, J. A., & Longley, P. (2016) · Transactions of the Institute of British Geographers · doi:10.1111/tran.12131 · Cited by 21
Genetic Component of Type 2 Diabetes in a Mexican Population
Sanchez-Pozos, K. A., & Menjívar, M. (2016) · Archives of Medical Research · doi:10.1016/j.arcmed.2016.12.007 · Cited by 22
Confounding in Genetic Association Studies and Its Solutions
Hu, D., & Ziv, E. (2008) · Methods in molecular biology · doi:10.1007/978-1-59745-205-2_3 · Cited by 21
Case-Control Association Studies in Mixed Populations: Correcting Using Genomic Control
Shmulewitz, D., Zhang, J., & Greenberg, D. A. (2004) · Human Heredity · doi:10.1159/000083541 · Cited by 21
Rashid, M. A. R., Zhao, Y., Azeem, F., Zhao, Y., Ahmed, H. G. M., Atif, R. M., Pan, Y., Zhu, X., Liang, Y., Zhang, H., et al. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.960007 · Cited by 34
Global Individual Ancestry Using Principal Components for Family Data
de Andrade, M., Ray, D., Pereira, A. C., & Soler, J. M. P. (2015) · Human Heredity · doi:10.1159/000381908 · Cited by 20
Imaging genetics — towards discovery neuroscience
Ge, T., Schumann, G., & Feng, J. (2013) · Quantitative Biology · doi:10.1007/s40484-013-0023-1 · Cited by 21
Esposito, U., Das, R., Syed, S., Pirooznia, M., & Elhaik, E. (2018) · Genes · doi:10.3390/genes9120625 · Cited by 19
Yu, G., Olsen, K. M., & Schaal, B. A. (2010) · New Phytologist · doi:10.1111/j.1469-8137.2010.03495.x · Cited by 20
Systems biology and heart failure: concepts, methods, and potential research applications
Adams, K. F. (2009) · Heart Failure Reviews · doi:10.1007/s10741-009-9138-x · Cited by 20
Power considerations for λ inflation factor in meta-analyses of genome-wide association studies
Georgiopoulos, G. A., & Εvangelou, Ε. (2016) · Genetics Research · doi:10.1017/s0016672316000069 · Cited by 18
Lack of Effects of the Genetic Polymorphisms of Interleukin-10 in Clinical Outcomes of COVID-19
Avendaño-Félix, M. M., Ochoa‐Ramírez, L. A., Ramos‐Payán, R., Aguilar‐Medina, M., Ayala-Ham, A. D. R., Rendón‐Aguilar, H., Lizárraga-Verdugo, E. R., Peraza‐Garay, F. D. J., Ríos‐Tostado, J. J., & Velarde‐Félix, J. S. (2021) · Viral Immunology · doi:10.1089/vim.2021.0022 · Cited by 20
Sample matching by inferred agonal stress in gene expression analyses of the brain
Li, J. Z., Meng, F., Tsavaler, L., Evans, S. J., Choudary, P. V., Tomita, H., Vawter, M. P., Walsh, D. M. A., Shokoohi, V., Chung, T. R., et al. (2007) · BMC Genomics · doi:10.1186/1471-2164-8-336 · Cited by 19
Covariate adjustment in family‐based association studies
Whittemore, A. S., Halpern, J., & Ahsan, H. (2004) · Genetic Epidemiology · doi:10.1002/gepi.20055 · Cited by 19
Identifying susceptibility genes for immunological disorders: patterns, power, and proof
Plenge, R. M., & Rioux, J. D. (2006) · Immunological Reviews · doi:10.1111/j.0105-2896.2006.00372.x · Cited by 19
Lõhmussaar, E. (2006) · DSpace repository (University of Tartu) · Cited by 19
Cluster ensemble based on Random Forests for genetic data
Al-Husain, L., & Hafez, A. M. (2017) · BioData Mining · doi:10.1186/s13040-017-0156-2 · Cited by 18
Mixed‐effects Logistic Approach for Association Following Linkage Scan for Complex Disorders
Xu, H., & Shete, S. S. (2006) · Annals of Human Genetics · doi:10.1111/j.1469-1809.2006.00321.x · Cited by 18
Bio-Repository of DNA in stroke (BRAINS): A study protocol
Yadav, S., Schanz, R., Maheshwari, A., Khan, M. S., Slark, J., de Silva, R., Bentley, P., Froguel, P., Kooner, J. S., Shrivastav, P., et al. (2011) · BMC Medical Genetics · doi:10.1186/1471-2350-12-34 · Cited by 18
Pemberton, T. J., Verdu, P., Becker, N. S., Willer, C. J., Hewlett, B. S., Le Bomin, S., Froment, A., Rosenberg, N. A., & Heyer, E. (2018) · Human Genetics · doi:10.1007/s00439-018-1902-3 · Cited by 18
Efficient approaches for large-scale GWAS with genotype uncertainty
Jørsboe, E., & Albrechtsen, A. (2021) · G3 Genes Genomes Genetics · doi:10.1093/g3journal/jkab385 · Cited by 18
Indoor and outdoor air pollution and lung cancer in New Hampshire and Vermont
Sloan, C., Andrew, A. S., Gruber, J. F., Mwenda, K. M., Moore, J. H., Onega, T., Karagas, M. R., Shi, X., & Duell, E. J. (2012) · Toxicological & Environmental Chemistry Reviews · doi:10.1080/02772248.2012.659930 · Cited by 18
Masca, N. G. D., Burton, P. R., & Sheehan, N. A. (2011) · International Journal of Epidemiology · doi:10.1093/ije/dyr149 · Cited by 19
New Interventions for Malaria: Mining the Human and Parasite Genomes
Ntoumi, F., Kwiatkowski, D. P., Diakité, M., Mutabingwa, T. K., & Duffy, P. E. (2007) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2007.77.270 · Cited by 18
Efficient Utilization of Rare Variants for Detection of Disease-Related Genomic Regions
Zhang, L., Pei, Y., Li, J., Papasian, C. J., & Deng, H. (2010) · PLoS ONE · doi:10.1371/journal.pone.0014288 · Cited by 19
Khan, A., Tian, L., Zhang, C., Yuan, K., & Xu, S. (2016) · Scientific Reports · doi:10.1038/srep18755 · Cited by 17
Abegaz, F., Lishout, F. V., John, J. M., Chiachoompu, K., Bhardwaj, A., Duroux, D., Gusareva, E. S., Wei, Z., Hakonarson, H. H., & Steen, K. V. (2021) · BioData Mining · doi:10.1186/s13040-021-00247-w · Cited by 17
Dasgupta, M. G., Bari, M. P. A., Shanmugavel, S., Dharanishanthi, V., Muthupandi, M., Kumar, N., Chauhan, S., Kalaivanan, J., Mohan, H., Krutovsky, K. V., et al. (2021) · Genomics · doi:10.1016/j.ygeno.2021.11.013 · Cited by 18
A Genetics Primer for Social Health Research
Way, B. M., & Gurbaxani, B. M. (2008) · Social and Personality Psychology Compass · doi:10.1111/j.1751-9004.2008.00084.x · Cited by 17
Genome-wide genetic heterogeneity discovery with categorical covariates
Llinares-López, F., Meng-Papaxanthos, L., Bodenham, D. A., Roqueiro, D., COPDGene Investigators, & Borgwardt, K. M. (2017) · Bioinformatics · doi:10.1093/bioinformatics/btx071 · Cited by 17
Liu, C., Parveen, R. S., Revolinski, S. R., Garland-Campbell, K. A., Pumphrey, M., & Steber, C. M. (2021) · Seed Science Research · doi:10.1017/s0960258521000064 · Cited by 17
Zhao, H., Rebbeck, T. R., & Mitra, N. (2009) · Genetic Epidemiology · doi:10.1002/gepi.20419 · Cited by 17
The genetics of cardiovascular disease
Delles, C., McBride, M., Padmanabhan, S., & Dominiczak, A. F. (2008) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2008.07.010 · Cited by 16
Resources for Genetic Variation Studies
Serre, D., & Hudson, T. J. (2006) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.7.080505.115806 · Cited by 17
Ecogeographic genetic epidemiology
Sloan, C., Duell, E. J., Shi, X., Irwin, R. E., Andrew, A. S., Williams, S. M., & Moore, J. H. (2008) · Genetic Epidemiology · doi:10.1002/gepi.20386 · Cited by 17
Norton, E. M., Schultz, N. E., Geor, R. J., McFarlane, D., Mickelson, J. R., & McCue, M. E. (2019) · Genes · doi:10.3390/genes10110893 · Cited by 16
A Novel Method to Detect Gene-Gene Interactions in Structured Populations: MDR-SP
Niu, A., Zhang, S., & Sha, Q. (2011) · Annals of Human Genetics · doi:10.1111/j.1469-1809.2011.00681.x · Cited by 17
Velázquez‐Cruz, R., Jiménez-Ortega, R. F., Parra-Torres, A. Y., Castillejos-López, M. D. J., Patiño, N., Quiterio, M., Villarreal-Molina, M. T., & Salmerón, J. (2014) · BMC Musculoskeletal Disorders · doi:10.1186/1471-2474-15-400 · Cited by 16
Teyssèdre, S., Elsen, J.-M., & Ricard, A. (2012) · Genetics Selection Evolution · doi:10.1186/1297-9686-44-32 · Cited by 17
Aldrich, M. C., Selvin, S., Hansen, H. M., Barcellos, L. F., Wrensch, M., Sison, J. D., Quesenberry, C. P., Kittles, R. A., Silva, G. O., Buffler, P. A., et al. (2008) · American Journal of Epidemiology · doi:10.1093/aje/kwn224 · Cited by 16
Sillanpää, M. J., & Bhattacharjee, M. (2006) · Genetics · doi:10.1534/genetics.106.061275 · Cited by 16
Rethinking the Epigenetic Framework to Unravel the Molecular Pathology of Schizophrenia
Cariaga-Martínez, A. E., & Alelú‐Paz, R. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040790 · Cited by 15
Association statistics under the PPL framework
Huang, Y., & Vieland, V. J. (2010) · Genetic Epidemiology · doi:10.1002/gepi.20537 · Cited by 15
Sánchez-Leyva, M., Sánchez‐Zazueta, J. G., Osuna‐Ramos, J. F., Rendón‐Aguilar, H., Félix-Espinoza, R., Becerra‐Loaiza, D. S., Sánchez-García, D. C., Romero-Quintana, J. G., Castillo-Ureta, H., Velarde-Rodríguez, I., et al. (2017) · Viral Immunology · doi:10.1089/vim.2017.0029 · Cited by 15
Vlachos, C., & Kofler, R. (2019) · Molecular Biology and Evolution · doi:10.1093/molbev/msz183 · Cited by 15
Wang, C., Ma, Q., Xie, X., Zhang, X., Yang, D., Su, J., Ma, X., & Lin, H. (2021) · Industrial Crops and Products · doi:10.1016/j.indcrop.2021.114458 · Cited by 20
Castillejo, A., Mata‐Balaguer, T., Guarinós, C., Castillejo, M. I., Martínez-Cantó, A., Barberá, V. M., Montenegro, P. C., Ochoa, E., Lázaro, R., Guillén‐Ponce, C., et al. (2009) · BMC Cancer · doi:10.1186/1471-2407-9-406 · Cited by 15
Genetic Approaches to Coronary Heart Disease
Cohen, J. C. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.06.046 · Cited by 16
A variant in the gene FUT9 is associated with susceptibility to placental malaria infection
Sikora, M., Ferrer-Admetlla, A., Laayouni, H., Menéndez, C., Mayor, A. G., Bardají, A., Sigaúque, B., Mandomando, I., Alonso, P. L., Bertranpetit, J., et al. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp240 · Cited by 15
Foo, H., Thalamuthu, A., Jiang, J., Koch, F. C., Mather, K. A., Wen, W. X., & Sachdev, P. S. (2021) · Scientific Reports · doi:10.1038/s41598-021-94182-9 · Cited by 15
Variations in the uncoupling protein-3 gene are associated with specific obesity phenotypes
van Abeelen, A. F. M., de Krom, M., Hendriks, J., Grobbee, D. E., Adan, R. A. H., & van der Schouw, Y. T. (2008) · European Journal of Endocrinology · doi:10.1530/eje-07-0834 · Cited by 15
Genotyping, sequencing and analysis of 140,000 adults from the Mexico City Prospective StudyPreprint
Ziyatdinov, A., Torres, J., Alegre-Díaz, J., Backman, J., Mbatchou, J. S., Turner, M., Gaynor, S. M., Joseph, T., Zou, Y., Liu, D., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.06.26.495014 · Cited by 15
Self-citationRobnik, J., Bayer, A. E., Charisi, M., Haiman, Z., Lin, A., & Seljak, U. (2024) · Monthly Notices of the Royal Astronomical Society · doi:10.1093/mnras/stae2220 · Cited by 14
Huerta‐Chagoya, A., Moreno-Macías, H., Fernández-López, J. C., Ordóñez-Sánchez, M. L., Rodríguez-Guillén, R., Contreras, A. V., Hidalgo‐Miranda, A., Alfaro-Ruíz, L. A., Salazar-Fernandez, E., Moreno‐Estrada, A., et al. (2019) · BMC Genetics · doi:10.1186/s12863-018-0707-7 · Cited by 14
Ko, S., Chu, B. B., Peterson, D., Okenwa, C., Papp, J. C., Alexander, D. H., Sobel, E. M., Zhou, H., & Lange, K. L. (2023) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2022.12.008 · Cited by 13
Faster model-based estimation of ancestry proportions
Santander, C. G., Refoyo-Martínez, A., & Meisner, J. (2024) · Peer Community Journal · doi:10.24072/pcjournal.503 · Cited by 15
Qu, C., Hasan, M., Lu, K., Liu, L., Zhang, K., Fu, F., Wang, M., Liu, S., Bu, H., Wang, R., et al. (2014) · Canadian Journal of Plant Science · doi:10.4141/cjps2013-411 · Cited by 14
Lohoff, F. W., Bloch, P. J., Weller, A. E., Nall, A. H., Doyle, G. A. R., Buono, R. J., Ferraro, T. N., Kampman, K. M., Pettinati, H. M., Dackis, C. A., et al. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.05.073 · Cited by 13
Methods for Detecting and Correcting for Population Stratification
Edwards, T. L., & Gao, X. (2012) · Current Protocols in Human Genetics · doi:10.1002/0471142905.hg0122s73 · Cited by 15
Hajiloo, M., Sapkota, Y., Mackey, J. R., Robson, P. J., Greiner, R., & Damaraju, S. (2013) · BMC Bioinformatics · doi:10.1186/1471-2105-14-61 · Cited by 14
Gentzbittel, L., Ben, C., Mazurier, M., Shin, M., Lorenz, T., Rickauer, M., Marjoram, P., Nuzhdin, S. V., & Tatarinova, T. V. (2019) · Genome biology · doi:10.1186/s13059-019-1697-0 · Cited by 15
Mulle, J. G., Fallin, M. D., Lasseter, V. K., McGrath, J. A., Wolyniec, P. S., & Pulver, A. E. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001916 · Cited by 14
Andrew, T., & MacGregor, A. J. (2004) · Current Osteoporosis Reports · doi:10.1007/s11914-004-0015-1 · Cited by 14
Krutovsky, K. V. (2006) · Russian Journal of Genetics · doi:10.1134/s1022795406100024 · Cited by 14
Genomics applied to the study of adaptation in pine species
Guevara, M. Á., Soto, Á., Collada, C., Plomion, C., Savolainen, O., Neale, D. B., González‐Martínez, S. C., & Cervera, M. (2005) · Forest Systems · doi:10.5424/srf/2005143-00918 · Cited by 14
Novelli, G., Borgiani, P., Mango, R., Lauro, R., & Romeo, F. (2007) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2006.12.006 · Cited by 14
Combined linkage disequilibrium and linkage mapping: Bayesian multilocus approach
Pikkuhookana, P., & Sillanpää, M. J. (2014) · Heredity · doi:10.1038/hdy.2013.111 · Cited by 13
Pembleton, L. W., Wang, J., Cogan, N. O. I., Pryce, J. E., Ye, G., Bandaranayake, C., Hand, M. L., Baillie, R. C., Drayton, M. C., Lawless, K. A., et al. (2013) · Australian Journal of Agricultural Research · doi:10.1071/cp12392 · Cited by 14
Xu, C. D., Warsh, J. J., Wang, K. S., Mao, C. X., & Kennedy, J. L. (2012) · Psychiatric Genetics · doi:10.1097/ypg.0b013e32835d700d · Cited by 13
Genetic Analysis in Cardiovascular Disease
Ho, E. C., Bhindi, R., Ashley, E. A., & Figtree, G. A. (2011) · Cardiology in Review · doi:10.1097/crd.0b013e318207ffac · Cited by 13
Kytövuori, L., Seppänen, A., Martikainen, M. H., Moilanen, J. S., Kamppari, S., Särkioja, T., Remes, A. M., Räsänen, P. K., Rönnemaa, T., & Majamaa, K. (2013) · Journal of Human Genetics · doi:10.1038/jhg.2013.29 · Cited by 13
Sha’ari, H. M., Haerian, B. S., Baum, L., Saruwatari, J., Tan, H. J., Rafia, M. H., Raymond, A. A., Kwan, P., Ishitsu, T., Nakagawa, K., et al. (2014) · Pharmacogenomics · doi:10.2217/pgs.13.239 · Cited by 13
Sullivan, P. F., Montgomery, G. W., Hottenga, J., Wray, N. R., Boomsma, D. I., & Martin, N. G. (2006) · Twin Research and Human Genetics · doi:10.1375/183242706778025026 · Cited by 13
Inferring Population Structure and Admixture Proportions in Low Depth NGS DataPreprint
Meisner, J., & Albrechtsen, A. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/302463 · Cited by 13
Non-parametric Survival Analysis of EPG5 Gene with Age at Onset of Alzheimer’s Disease
Wang, K.-S., Liu, X., Xie, C., Liu, Y., & Xu, C. (2016) · Journal of Molecular Neuroscience · doi:10.1007/s12031-016-0821-9 · Cited by 12
European admixture on the Micronesian island of Kosrae: lessons from complete genetic information
Bonnen, P. E., Lowe, J. K., Altshuler, D., Breslow, J. L., Stoffel, M., Friedman, J. M., & Pe’er, I. (2009) · European Journal of Human Genetics · doi:10.1038/ejhg.2009.180 · Cited by 12
Metadata
- Authors
- Marchini, J., Cardon, L. R., Phillips, M. S., & Donnelly, P.
- Affiliations
- University of Oxford (GB)
- Centre for Human Genetics (GB)
- McGill Genome Centre (CA)
- Corresponding author
- Donnelly, Peter
- Venue
- Nature Genetics
- Published
- 2004-03-28
- Volume
- 36
- Issue
- 5
- Pages
- 512-517
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W1986265706
- Cited by
- 869
- References
- 31
- Citations by year
- 2026: 11 · 2025: 13 · 2024: 14 · 2023: 19 · 2022: 29 · 2021: 34 · 2020: 16 · 2019: 30 · 2018: 38 · 2017: 35 · 2016: 33 · 2015: 39 · 2014: 28 · 2013: 46 · 2012: 48
- FWCI
- 31.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Genetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
- Keywords
- population structure, genetic association studies, single nucleotide polymorphisms, genomic control, false positives, statistical power, common diseases
- MeSH terms
- Genetic Markers, Genetics, Population, Humans, Models, Genetic, Genetic Variation, Linkage Disequilibrium, Quantitative Trait, Heritable, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review