Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 432

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Delineation of a Fat tumor suppressor pathway

Cho, Eunjoo, Feng, Yongqiang, Rauskolb, Cordelia, Maitra, Sushmita, Fehon, Rick, Irvine, Kenneth D·2006·Nature Genetics
DOI 10.1038/ng1887
Open this paper in CoChat — free account

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1038/ng1887

Cites

1 of 1 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 1 references

Research works printed but not linked: 48

  1. Watson, K.L., Justice, R.W. & Bryant, P.J. Drosophila in cancer research: the first fifty tumor suppressor genes. J. Cell Sci. Suppl. 18, 19–33 (1994). · DOI
  2. Cho, E. & Irvine, K.D. Action of fat, four-jointed, dachsous and dachs in distal-to-proximal wing signaling. Development 131, 4489–4500 (2004). · DOI · Paper page
  3. Clark, H.F. et al. Dachsous encodes a member of the cadherin superfamily that controls imaginal disc morphogenesis in Drosophila. Genes Dev. 9, 1530–1542 (1995). · DOI · Paper page
  4. Ma, D., Yang, C.H., McNeill, H., Simon, M.A. & Axelrod, J.D. Fidelity in planar cell polarity signalling. Nature 421, 543–547 (2003). · DOI · Paper page
  5. Mahoney, P.A. et al. The fat tumor suppressor gene in Drosophila encodes a novel member of the cadherin gene superfamily. Cell 67, 853–868 (1991). · DOI · Paper page
  6. Matakatsu, H. & Blair, S.S. Interactions between Fat and Dachsous and the regulation of planar cell polarity in the Drosophila wing. Development 131, 3785–3794 (2004). · DOI · Paper page
  7. Simon, M.A. Planar cell polarity in the Drosophila eye is directed by graded Four-jointed and Dachsous expression. Development 131, 6175–6184 (2004). · DOI
  8. Strutt, H., Mundy, J., Hofstra, K. & Strutt, D. Cleavage and secretion is not required for Four-jointed function in Drosophila patterning. Development 131, 881–890 (2004). · DOI
  9. Strutt, H. & Strutt, D. Nonautonomous planar polarity patterning in Drosophila: dishevelled-independent functions of frizzled. Dev. Cell 3, 851–863 (2002). · DOI · Paper page
  10. Yang, C., Axelrod, J.D. & Simon, M.A. Regulation of frizzled by Fat-like cadherins during planar polarity signaling in the Drosophila compound eye. Cell 108, 675–688 (2002). · DOI · Paper page
  11. Casal, J., Struhl, G. & Lawrence, P. Developmental compartments and planar polarity in Drosophila. Curr. Biol. 12, 1189–1198 (2002). · DOI
  12. Bryant, P.J., Huettner, B., Held, L.I. Jr, Ryerse, J. & Szidonya, J. Mutations at the fat locus interfere with cell proliferation control and epithelial morphogenesis in Drosophila. Dev. Biol. 129, 541–554 (1988). · DOI · Paper page
  13. Fanto, M. et al. The tumor-suppressor and cell adhesion molecule Fat controls planar polarity via physical interactions with Atrophin, a transcriptional co-repressor. Development 130, 763–774 (2003). · DOI
  14. Mao, Y. et al. Dachs, an unconventional myosin that functions downstream of Fat to regulate growth, affinity and gene expression in Drosophila. Development 133, 2539–2551 (2006). · DOI · Paper page
  15. McClatchey, A.I. & Giovannini, M. Membrane organization and tumorigenesis–the NF2 tumor suppressor, Merlin. Genes Dev. 19, 2265–2277 (2005). · DOI · Paper page
  16. McClatchey, A.I. et al. Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors. Genes Dev. 12, 1121–1133 (1998). · DOI · Paper page
  17. Edgar, B.A. From cell structure to transcription: hippo forges a new path. Cell 124, 267–273 (2006). · DOI · Paper page
  18. Harvey, K.F., Pfleger, C.M. & Hariharan, I.K. The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis. Cell 114, 457–467 (2003). · DOI · Paper page
  19. Jia, J., Zhang, W., Wang, B., Trinko, R. & Jiang, J. The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis. Genes Dev. 17, 2514–2519 (2003). · DOI · Paper page
  20. Kango-Singh, M. et al. Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila. Development 129, 5719–5730 (2002). · DOI · Paper page
  21. Lai, Z.C. et al. Control of cell proliferation and apoptosis by mob as tumor suppressor, mats. Cell 120, 675–685 (2005). · DOI · Paper page
  22. Pantalacci, S., Tapon, N. & Leopold, P. The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila. Nat. Cell Biol. 5, 921–927 (2003). · DOI · Paper page
  23. Tapon, N. et al. salvador promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines. Cell 110, 467–478 (2002). · DOI · Paper page
  24. Udan, R.S., Kango-Singh, M., Nolo, R., Tao, C. & Halder, G. Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway. Nat. Cell Biol. 5, 914–920 (2003). · DOI · Paper page
  25. Wu, S., Huang, J., Dong, J. & Pan, D. hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts. Cell 114, 445–456 (2003). · DOI · Paper page
  26. Xu, T., Wang, W., Zhang, S., Stewart, R.A. & Yu, W. Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase. Development 121, 1053–1063 (1995). · DOI · Paper page
  27. Edwards, K.M. & Munger, K. Make WARTS, not cancer!. Oncogene 23, 5263–5265 (2004). · DOI
  28. Tao, W. et al. Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity. Nat. Genet. 21, 177–181 (1999). · DOI · Paper page
  29. Zilian, O. et al. double-time is identical to discs overgrown, which is required for cell survival, proliferation and growth arrest in Drosophila imaginal discs. Development 126, 5409–5420 (1999). · DOI
  30. Jia, J. et al. Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing. Dev. Cell 9, 819–830 (2005). · DOI
  31. Kloss, B. et al. The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Iepsilon. Cell 94, 97–107 (1998). · DOI · Paper page
  32. Price, M.A. & Kalderon, D. Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by glycogen synthase kinase 3 and casein kinase 1. Cell 108, 823–835 (2002). · DOI · Paper page
  33. Klein, T.J., Jenny, A., Djiane, A. & Mlodzik, M. CKIvarepsilon/discs overgrown promotes both Wnt-Fz/beta-catenin and Fz/PCP signaling in Drosophila. Curr. Biol. 16, 1337–1343 (2006). · DOI
  34. Boedigheimer, M. & Laughon, A. Expanded: a gene involved in the control of cell proliferation in imaginal discs. Development 118, 1291–1301 (1993). · DOI
  35. McCartney, B.M. & Fehon, R.G. Distinct cellular and subcellular patterns of expression imply distinct functions for the Drosophila homologues of moesin and the neurofibromatosis 2 tumor suppressor, merlin. J. Cell Biol. 133, 843–852 (1996). · DOI
  36. McCartney, B.M., Kulikauskas, R.M., LaJeunesse, D.R. & Fehon, R.G. The neurofibromatosis-2 homologue, Merlin, and the tumor suppressor expanded function together in Drosophila to regulate cell proliferation and differentiation. Development 127, 1315–1324 (2000). · DOI · Paper page
  37. Hamaratoglu, F. et al. The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis. Nat. Cell Biol. 8, 27–36 (2006). · DOI · Paper page
  38. Maitra, S., Kulikauskas, R.M., Gavilan, H. & Fehon, R.G. The tumor suppressors Merlin and expanded function cooperatively to modulate receptor endocytosis and signaling. Curr. Biol. 16, 702–709 (2006). · DOI · Paper page
  39. Zeidler, M.P., Perrimon, N. & Strutt, D.I. Multiple roles for four-jointed in planar polarity and limb patterning. Dev. Biol. 228, 181–196 (2000). · DOI
  40. Buckles, G.R., Rauskolb, C., Villano, J.L. & Katz, F.N. four-jointed interacts with dachs, abelson and enabled and feeds back onto the Notch pathway to affect growth and segmentation in the Drosophila leg. Development 128, 3533–3542 (2001). · DOI
  41. Blaumueller, C.M. & Mlodzik, M. The Drosophila tumor suppressor expanded regulates growth, apoptosis, and patterning during development. Mech. Dev. 92, 251–262 (2000). · DOI
  42. Huang, J., Wu, S., Barrera, J., Matthews, K. & Pan, D. The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP. Cell 122, 421–434 (2005). · DOI · Paper page
  43. Matakatsu, H. & Blair, S.S. Separating the adhesive and signaling functions of the Fat and Dachsous protocadherins. Development 133, 2315–2324 (2006). · DOI · Paper page
  44. Jaiswal, M., Agrawal, N. & Sinha, P. Fat and Wingless signaling oppositely regulate epithelial cell-cell adhesion and distal wing development in Drosophila. Development 133, 925–935 (2006) · DOI
  45. Garoia, F. et al. The tumor suppressor gene fat modulates the EGFR-mediated proliferation control in the imaginal tissues of Drosophila melanogaster. Mech. Dev. 122, 175–187 (2005). · DOI
  46. Zender, L. et al. Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Cell 125, 1253–1267 (2006). · DOI · Paper page
  47. Lee, T. & Luo, L. Mosaic analysis with a repressible cell marker (MARCM) for Drosophila neural development. Trends Neurosci. 24, 251–254 (2001). · DOI · Paper page
  48. Rauskolb, C. & Irvine, K.D. Notch-mediated segmentation and growth control of the Drosophila leg. Dev. Biol. 210, 339–350 (1999). · DOI · Paper page

Cited by

See all 432

Metadata

Authors
Cho, E., Feng, Y., Rauskolb, C., Maitra, S., Fehon, R., & Irvine, K. D.
Venue
Nature Genetics
Publisher
Springer Science and Business Media LLC
Published
2006-09-17
Volume
38
Issue
10
Pages
1142-1150
ISSN
  • 1061-4036 (ISSN-L)
  • 1546-1718
DOI
10.1038/ng1887
OpenAlex
W2056182849
Cited by
432
References
1
FWCI
10.73
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Delineation of a Fat tumor suppressor pathway. https://app.cochat.ai/papers/10.1038/ng1887
The paper
Cho, E., Feng, Y., Rauskolb, C., Maitra, S., Fehon, R., & Irvine, K. D. (2006). Delineation of a Fat tumor suppressor pathway. Nature Genetics. https://doi.org/10.1038/ng1887

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.