The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors

Kawaguchi, Yoshiya, Cooper, Bonnie, Gannon, Maureen, Ray, Michael, MacDonald, Raymond J., Wright, Christopher V.E.·2002·Nature Genetics
DOI 10.1038/ng959

Cited by (916)

Items 801–900 of 916

  1. SOX9 as One of the Central Units of Regulation Axis of Pancreas Embryogenesis and Cancer Progression
    S. Bulanenkova, E. Snezhkov, S. B. Akopov · 2019 · Molecular Genetics Microbiology and Virology
  2. Congenital and Inherited Anomalies of the Pancreas
    M. Zenker, M. Lerch · 2018 · Wiley eBooks
  3. PTF1a Activity in Enriched Posterior Foregut Endoderm, but Not Definitive Endoderm, Leads to Enhanced Pancreatic Differentiation in an In Vitro Mouse ESC-Based Model
    Gopika G. Nair, J. Odorico · 2016 · Stem Cells International
  4. Adult stem cells and other cancer residents. Part I
    E. Sverdlov, V. Pleshkan, I. Alekseenko, T. Vinogradova, E. Kopantsev, D. Didych · 2015 · Molecular Genetics Microbiology and Virology
  5. Inhibition of progression of PanIN through antagonizing EGFR
    Xiao-Jun He, Hui Zhang, Mei Xiao, Ya-Lin Kong, Wen-Bing Li, Hong-Yi Zhang · 2015 · Tumor Biology
  6. RETRACTED ARTICLE: Augmented TGFβ receptor signaling induces apoptosis of pancreatic carcinoma cells
    Cheng-Gang Li, Zhi-Ming Zhao, Zhi-Peng Zhou, Rong Liu · 2015 · Tumor Biology · Retracted
  7. RETRACTED ARTICLE: Sports-induced blood sugar utilization prevents development of pancreatic ductal adenocarcinoma
    Jin-Kui Lu, Xiao-Jian Yin, Jiazhen Jiang · 2015 · Tumor Biology · Retracted
  8. Induction of mouse pancreatic ductal differentiation, an in vitro assay
    J. Rhodes, Angela Criscimanna, F. Esni · 2012 · In Vitro Cellular & Developmental Biology - Animal
  9. New frontiers in pancreatic cancer research.
    G. Khan, M. P. di Magliano, D. Simeone · 2010 · Surgical Oncology Clinics of North America
  10. Insulin-expressing engineered cell lines and primary cells: surrogate β cells from liver, gut, and other sources
    R. Wideman, Yukihiro Fujita, T. Kieffer · 2007 · Current Opinion in Organ Transplantation
  11. PDX-1 and MafA in β-cell differentiation and dysfunction
    H. Kaneto, T. Miyatsuka, D. Kawamori, T. Shiraiwa, Y. Fujitani, T. Matsuoka · 2006 · Expert Review of Endocrinology & Metabolism
  12. Transgenic Tagging Defining Pancreatic Pedigrees
    P. Merino · 2004
  13. 6 – The Pancreas
    A. Hörnblad, Christoffer Nord, Saba Parween, J. Ahnfelt-Rønne, U. Ahlgren · 2016 · Elsevier eBooks
  14. Pancreas Development and Regeneration
    Kimberly G. Riley, MAUREEN A. GANNON · 2014 · Elsevier eBooks
  15. Pancreatic Regeneration in the Face of Diabetes
    Zeeshan Ahmad · 2012 · Humana Press eBooks
  16. Chapter 1A – Embryologic development of the liver, biliary tract, and pancreas
    Y. El-Gohary, G. Gittes · 2012 · Elsevier eBooks
  17. Bioartificial Pancreas: An Update
    A. Prokop, J. Davidson · 2005
  18. Macrophage-induced ferritin expression protects pancreatic cancer cells from ferroptosis.
    Eric C. Cheung, Meng-Han Wu, Wen-Chih Cheng, Jack Coomes, K. Blyth, Karen H. Vousden · 2026 · Cell Reports
  19. KMT2D depletion promotes KRAS-induced pancreatic carcinogenesis independent of TP53
    Ezequiel J Tolosa, G. L. Raja Arul, Ashley N. Sigafoos, Victoria Ferrero, David R. Pease, Luciana L. Almada, Renzo E Vera, Nicole M. Pena Ruiz, Tara L. Hogenson, Kayla C. LaRue-Nolan et al. · 2026 · Journal of Biological Chemistry
  20. Myc inhibition triggers GM-CSF-driven regression of pancreatic tumours
    Tania Campos, Roderik M. Kortlever, Nicole M. Sodir, Michael D. Buck, Julie Stockis, Jonathan Parker, CM Lam, Juan Rodrigo Patiño-Mercau, Alessandra Perfetto, Abigail R. Edwards et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  21. Loss of Brg1 and Pten in Pancreatic Ductal Cells Forms Intraductal Tubulopapillary Neoplasm via the YAP/TAZ Pathway
    Kei Iimori, A. Fukuda, M. Nagao, S. Matsuyama, Munehiro Ikeda, Yoko Masui, Shinnosuke Nakayama, Naoki Aoyama, Kenta Mizukoshi, Munenori Kawai et al. · 2025 · Cellular and Molecular Gastroenterology and Hepatology
  22. Molecular dynamics driving phenotypic divergence among KRAS mutants in pancreatic tumorigenesis
    A. Grimont, David Falvo, W. Sisso, P. Zumbo, Christopher W. Chan, F. Santos, Grace Pan, M. Cleveland, T. Yaron, Alexa Osterhoudt et al. · 2025 · bioRxiv
  23. HMG Box-containing Protein 1 (HBP1) Protects Against Pancreatic Injury in Acute Pancreatitis but Promotes Neoplastic Progression
    Seung-Won Lee, Taelor Ekstrom, Elise C. Manalo, Shangyuan Ye, Mark Berry, D. Grygoryev, Malwina Szczepaniak, Jin-Ho Lee, C. O. Marmolejo, Syber Haverlack et al. · 2025 · bioRxiv
  24. Approaches to Study Tumor Metabolism in Mice
    Yetiş Gültekin, Matthew G. Vander Heiden, Evan C. Lien · 2023 · Cold Spring Harbor Perspectives in Medicine
  25. Loss of CAPS2/Cadps2 leads to exocrine pancreatic cell injury and intracellular accumulation of secretory granules in mice
    Y. Sato, Miho Tsuyusaki, H. Takahashi-Iwanaga, R. Fujisawa, A. Masamune, Shin Hamada, Ryotaro Matsumoto, Yu Tanaka, Y. Kakuta, Y. Yamaguchi-Kabata et al. · 2022 · Frontiers in Molecular Biosciences
  26. Ptf1a Promoter-driven Cre Expression During Spermatogenesis Causes Germline Recombination
    Jia-Le Wang, Oliver H. Wang, Yan Bi, Ying Wang, H. Crawford, B. Ji · 2022 · Pancreas
  27. A pancreas specific Ptf1a-driven Cre mouse line causes paternally transmitted germline recombination.
    Derya Kabacaoglu, D. Ruess, K. Görgülü, K. Steiger, M. Lesina, H. Algül · 2021 · Gastroenterology
  28. Development of the Pancreas
    C. Fenech · 2017
  29. Unraveling the Myth of Foxa2 in Endocrine Formation of the Pancreatic Lineages
    S. Willmann · 2017
  30. Compensatory Response by Late Embryonic Tubular Epithelium to the Reduction in Pancreatic Progenitors
    W. Nishimura, A. Kapoor, I. El Khattabi, Wan-Zhu Jin, K. Yasuda, S. Bonner-Weir, Arun J. Sharma · 2015 · PLoS ONE
  31. Identification of MicroRNAs Regulating Ptf1a Expression in Mouse Pancreas Development*: Identification of MicroRNAs Regulating Ptf1a Expression in Mouse Pancreas Development*
    Yang An, Yankun Yang, Fei Gao, Kuan-Peng Zhu, T. Mu, Chun-Bo Teng · 2010
  32. Development and Life Cycle of a β‐Cell
    P. Serup, Jens H. Nielsen · 2003
  33. Embryonic development of the endocrine pancreas
    Spencer R. Andrei, MAUREEN A. GANNON · 2019 · Elsevier eBooks
  34. Human pancreatic progenitors
    Mirza Muhammad Fahd Qadir, Giacomo Lanzoni, Camillo Ricordi, Juan Domínguez‐Bendala · 2019 · Elsevier eBooks
  35. 91 – Development of the Exocrine Pancreas
    L. Sussel · 2017
  36. Comparative Analysis of Islet Development
    A. Poudel, Omid Savari, Zehra Tekin, M. Hara · 2016 · Stem cell biology and regenerative medicine
  37. Adult stem cells and other cancer residents. Part II
    E. Sverdlov, V. Pleshkan, I. Alekseenko, T. Vinogradova, E. Kopantsev, D. Didych · 2015 · Molecular Genetics Microbiology and Virology
  38. Mouse Models of Receptor Tyrosine Kinases
    Martin Holcmann, Nicole Amberg, Barbara Drobits, Elisabeth Glitzner, Karin Komposch, Jonathan Robson, Fabio Savarese, Sriram Srivatsa, Gabriel Stulnig, Maria Chiara Sibilia · 2014 · Springer eBooks
  39. Normal Pancreatic Development
    K. D. Henley, M. Gannon · 2014 · Elsevier eBooks
  40. Mouse Models of Pancreatic Ductal Adenocarcinoma
    Filip Bednar, M. P. di Magliano · 2013 · Springer eBooks
  41. Mouse Models of Pancreatic Cancer
    Katherine T. Ostapoff, Michael T. Dellinger, Niranjan Awasthi, Rolf A. Brekken, Roderich Egbert Schwarz · 2013 · Springer eBooks
  42. Genetically Engineered Mouse Models of Pancreatic Ductal Adenocarcinoma
    Aram F. Hezel, Nabeel M. Bardeesy · 2010 · Humana Press eBooks
  43. Pancreatic Plasticity and Reprogramming: Novel Directions Towards Disease Therapy
    Spencer G. Willet, C. Wright · 2011 · Humana Press eBooks
  44. Pancreas and Islet Development
    G. Gittes, K. Prasadan, S. Tulachan · 2010 · Humana Press eBooks
  45. The Genetic Basis of Diabetes
    Hui‐Qi Qu, Constantin Polychronakos · 2009 · Humana Press eBooks
  46. Regulation der Entwicklung des Pankreas
    L. st-Onge, Martins Wagner · 2006 · Springer eBooks
  47. Pancreatic Differentiation of Pluripotent Stem Cells
    N. Lumelsky · 2003 · Humana Press eBooks
  48. METTL10 trimethylation of eEF1A at K318 enhances protein synthesis and tumorigenesis.
    Lauren Buie, Simone Hausmann, Juhyung Park, Sabeen Ikram, Tourkian Chasan, Xiao-Jie Yang, Natasha M. Flores, Pawel K. Mazur, O. Gozani · 2026 · Journal of Biological Chemistry
  49. Frequency-dependent cerebellar circuits independently gate social vocalizations and movement
    Cheryl Brandenburg, S. Srivastava, Alejandro G. Rey Hipolito, Tao Lin, Benjamin R. Arenkiel, Roy V. Sillitoe · 2026 · iScience
  50. The making of cells and organs in xenogeneic animal bioreactor
    Yun-Han Tang, Ye Feng, Zhu Chen, Sai-Juan Chen, Lin Cheng · 2026 · Signal Transduction and Targeted Therapy
  51. Transcriptomic regulation of pancreatic acinar cell homeostasis and plasticity
    Xin Zhang, Christopher Luo, K. Coughlin, Feng-Qian Li, K. Takemaru, Le-Dong Wan · 2026 · Biochemical Society Transactions
  52. Understanding development and cellular plasticity in the pancreas in health and disease
    Alejo Torres-Cano, Francesca M. Spagnoli · 2026 · Nature Reviews Gastroenterology & Hepatology
  53. Translating the blueprint of cell fate: eIF5A-mediated translation regulates cellular identity in the pancreas
    Danielle L. Overton, C. B. Villaca, Dorian J. Dale, Caleb D. Rutan, M. Robertson, Craig T. Connors, E. Anderson-Baucum, Teresa L. Mastracci · 2026 · Molecular Metabolism
  54. Functional genomics analysis of developing zebrafish and human endoderm reveals highly conserved cis-regulatory modules acting during vertebrate organogenesis
    Daniela M. Riley, Randa Elsayed, Mark Walsh, Simaran Johal, Ying Lin, Harry Walton, Till Bretschneider, Sascha Ott, Andrew C. Nelson · 2026 · Genome Research
  55. Comparative β-cell development: insights from Rodents, humans and induced pluripotent stem cell models
    Radwan Darwish, Yasmine Alcibahy, Manjula Nandakumar, Alexandra E. Butler, Abu Saleh Md Moin · 2025 · Stem Cell Research & Therapy
  56. Reframing gastric lymph nodes as a parapancreatic lymph chain: an embryology-driven rationale for omento-bursectomy and omentum-preserving gastrectomy to facilitate safe infrapyloric lymph node dissection
    Takaya Tokuhara, E. Nakata, Isao Kawai, H. Kitaguchi · 2025 · World Journal of Surgical Oncology
  57. Wilms Tumor 1–Expressing Stromal Cells Promote Pancreatic Cancer Progression
    Allison C. Bischoff, Kristee L. Brown, E. Lasse-Opsahl, Hannah R. Watkoske, Carlos E. Espinoza, J. Okoye, A. Olivei, Leah M Green, Ridesh Rai, Stephanie The et al. · 2025 · Cancer Research
  58. Functional genomics analysis of developing zebrafish and human endoderm reveals highly conserved cis-regulatory modules controlling vertebrate organogenesis
    Daniela M. Figiel, Randa Elsayed, Mark Walsh, Simaran Johal, Ying Lin, Till Bretschneider, S. Ott, Andrew C. Nelson · 2025 · bioRxiv
  59. Production et sécrétion de l’insuline par la cellule bêta pancréatique
    G. Guillemain, A. Liboz, B. Blondeau · 2024 · EMC - Endocrinologie - Nutrition
  60. Specific Temporal Requirement of Prox1 Activity During Pancreatic Acinar Cell Development
    A. Martínez-Ramírez, T. Borders, Leena Paul, M. Schipma, Xin-Kun Wang, F. Korobova, Christopher V. Wright, B. Sosa-Pineda · 2022 · Gastro Hep Advances
  61. Genes and Cell Type Specification in Cerebellar Development
    Matt Larouche, Dan Goldowitz · 2012 · Springer eBooks
  62. Exocrine Pancreatic Insufficiency
    A. Krasaelap, S. Werlin, P. Goday · 2021 · Textbook of Pediatric Gastroenterology, Hepatology and Nutrition
  63. The Prolyl Isomerase PIN1 Plays a Critical Role in Fibroblast Differentiation States to Support Pancreatic Cancer
    Ellen M. Langer, Amy S Farrell, Brittany L. Allen-Petersen, Colin J. Daniel, K. Kresse, I. English, Vidhi M Shah, Kevin A. MacPherson, Xiaoyan Wang, C. Pelz et al. · 2021 · SSRN Electronic Journal
  64. An in vivo KRAS allelic series reveals distinct phenotypes of common oncogenic variants
    M. Zafra, Direna Alonso-Curbelo, Sukanya Goswami, Emma M. Schatoff, Teng Han, J. E. Wilkinson, Lukas E. Dow · 2019 · bioRxiv
  65. Presynaptic inhibition of cutaneous afferents prevents self-generated itch
    Augusto Escalante, Rüdiger Klein · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  66. Mesenchymal Igf2 is a major paracrine regulator of pancreatic growth and function
    Constanze M. Hammerle, I. Sandovici, G. Brierley, Nicola M. Smith, W. Zimmer, I. Zvetkova, H. Prosser, Y. Sekita, B. Lam, Marcella K. Ma et al. · 2019 · bioRxiv
  67. HNF1A recruits UTX to activate a differentiation program that suppresses pancreatic cancer
    M. Kalisz, Edgar Bernardo, Anthony Beucher, M. Maestro, Natalia Del Pozo, Irene Millán, L. Haeberle, M. Schlensog, S. Safi, W. Knoefel et al. · 2019 · bioRxiv
  68. SOX9 как одно из центральных звеньев оси регуляции эмбрионального развития и прогрессии рака поджелудочной железы
    С. C. Буланенкова, Е. В. Снежков, Сергій Акопов · 2019 · Molecular Genetics Microbiology and Virology (Russian)
  69. Ontogeny of the Human Pancreas
    A. E. Proshchina, Yuliya S. Krivova, Larisa E. Gurevich, Valeriy M. Barabanov, Dmitry Otlyga, Iya А. Voronkova, Sergey V. Saveliev · 2019 · IntechOpen eBooks
  70. The role of transcription factor GATA6 in the development of the human pancreas
    C. Y. Chia · 2018
  71. Expression ectopique du gène homéotique Cdx2 dans les pathologies du système digestif
    Asmaa Naïr · 2018 · theses.fr (ABES)
  72. An Essential Role for Argonaute 2 in EGFR-KRAS Signaling in Pancreatic Cancer Development
    Sunita Shankar, Jean C. Tien, Ronald F. Siebenaler, Seema Chugh, Vijaya L. Dommeti, Sylvia Zelenka-Wang, Jessica Waninger, Kristin Juckette, A. Xu, Xiao-Ming Wang et al. · 2017 · bioRxiv
  73. Etude du rôle de facteurs génétiques et épigénétiques dans l'homéostasie et la fonction des cellules pancréatiques
    Evans Quilichini · 2017
  74. Pancreatic somatostatin expressing-cells : an untapped source for β-cell regeneration ?
    Noémie Druelle · 2016
  75. Forcing alpha-cell-mediated beta-cell regeneration
    Nouha Ben-Othman · 2015 · theses.fr (ABES)
  76. Development and Differentiation of the Gastrointestinal System
    Ben Z. Stanger, Daniel K. Podolsky · 2015 · Wiley eBooks
  77. Mechanisms of transcriptional regulation in the maintenance of β cell function
    Aarthi V. Maganti · 2015 · IUScholarWorks (Indiana University)
  78. Prolactin as an Adjunct to Anti-CD3 Type I Diabetes Therapy
    Colin M. Hyslop · 2014 · Libraries and Cultural Resources (University of Calgary)
  79. Evaluating cerebellar functions using optogenetic transgenic mice
    J. Welsh, J. Turecek, E. Turner · 2013 · Biomedical optics
  80. Regulation of pancreatic and intestinal endocrine cell differentiation and function : roles of Pak3 and Rfx6
    Julie Piccand · 2012
  81. Genome Wide Transcriptional Analysis of Gene Expression Signatures and Pathways on Neoplastic Pancreatic Cancer
    Kusum Paul · 2012
  82. Characterization of the role of RITA and KDM5A as RBP-Jkappa interacting proteins involved in the transcriptional control of Notch target genes, and characterization of the role of patched1 conditional deletion in mouse exocrine pancreas development
    Cristóbal Alvarado Livacic · 2012
  83. Differentiation of mouse embryonic stem cells into insulin-secreting cells in vitro
    Jing Sui, Fang-Xu Jiang, Bingbo Shi · 2011
  84. Isolating endoderm and understanding developmental signals: defining sequential steps of embryonic stem cell differentiation to β cells
    Robert K. Vincent, J. Odorico · 2007 · Current Opinion in Organ Transplantation
  85. Entrails, heart, brain, limbs, and lymphatics- a recipe for success?
    D. Stainier, O. Pourquié · 2003 · Developmental Cell
  86. Developmental biology: Becoming competent
    M. Skipper · 2002 · Nature reviews genetics
  87. Differentiation of Stem Cells into Pancreatic Lineage: In vitro Cell Culture, in vivo Transplantation in Animal Models
    Reham M. Balahmar · 2021 · Stem cell biology and regenerative medicine
  88. Pancreatic Development
    J. Eisses, S. Husain · 2021 · Pediatric Gastrointestinal and Liver Disease
  89. Cell Biology and Translational Medicine, Volume 8: Stem Cells in Regenerative Medicine
    K. Turksen · 2020 · Advances in Experimental Medicine and Biology
  90. Organe des Hormonsystems und ihre Entstehung
    Bernhard Kleine, Winfried G. Rossmanith · 2020 · Springer eBooks
  91. Long noncoding RNAs are critical regulators of pancreatic islet development and function
    Ruth A. Singer · 2018
  92. Protocols in genetic mice models of pancreatic cancer
    Batool Al-Qambar, M. Chaker, M. Kamgar, Anteneh A. Tesfaye, Kay Uwe-Wagner, A. Azmi · 2019 · Animal Models in Cancer Drug Discovery
  93. Pancreas Embryology, Anatomy, and Physiology
    Joseph C Fusco, Y. El-Gohary, G. Gittes · 2018 · Springer eBooks
  94. Induction of Oct3/4 during direct reprogramming of dental pulp cells
    T. Nozaki, K. Ohura · 2017
  95. Directed Cell Differentiation by Inductive Signals in Salivary Gland Regeneration: Lessons Learned from Pancreas and Liver Regeneration
    Yun-Jong Park, Seunghee Cha · 2017 · Springer eBooks
  96. Metastatic Pancreatic Cancer
    P. Martinelli, E. Lonardo · 2017 · Elsevier eBooks
  97. Molecular Probes for Pancreatic Cancer Imaging
    Lei Wang · 2016
  98. The roles of SOX4 and MED15 in the development and maintenance of pancreatic β-cells
    Eric E. Xu · 2016
  99. Chapter 30 – Development of the Endocrine Pancreas
    M. Hebrok, M. German · 2016 · Elsevier eBooks
  100. Principles of Anatomy
    H. Shinohara, S. Hasegawa, S. Tsunoda, H. Hosogi, Y. Sakai · 2016