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The calcium-activated nonselective cation channel TRPM4 is essential for the migration but not the maturation of dendritic cells
Open accessAbstract
Dendritic cell (DC) maturation and migration are events critical for the initiation of immune responses. After encountering pathogens, DCs upregulate the expression of costimulatory molecules and subsequently migrate to secondary lymphoid organs. Calcium (Ca2+) entry governs the functions of many hematopoietic cell types, but the role of Ca2+ entry in DC biology remains unclear. Here we report that the Ca2+-activated nonselective cation channel TRPM4 was expressed in and controlled the Ca2+ homeostasis of mouse DCs. The absence of TRPM4, which elicited Ca2+ overload, did not influence DC maturation but did considerably impair chemokine-dependent DC migration. Our results establish TRPM4-regulated Ca2+ homeostasis as crucial for DC mobility but not maturation and emphasize that DC maturation and migration are independently regulated.
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Cites
Calcium signalling in lymphocyte activation and disease
Feske, S. (2007) · Nature Reviews Immunology · doi:10.1038/nri2152 · Cited by 1,043
de Gorter, D. J. J., Beuling, E. A., Kersseboom, R., Middendorp, S., van Gils, J. M., Hendriks, R. W., Pals, S. T., & Spaargaren, M. (2007) · Immunity · doi:10.1016/j.immuni.2006.11.012 · Cited by 285
Cited by
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Schwab, A., Fabian, A., Hanley, P. J., & Stock, C. (2012) · Physiological Reviews · doi:10.1152/physrev.00018.2011 · Cited by 420
Transient Receptor Potential Channels in the Vasculature
Earley, S., & Brayden, J. E. (2015) · Physiological Reviews · doi:10.1152/physrev.00026.2014 · Cited by 420
Feske, S. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00818.x · Cited by 299
Dendritic cell physiology and function in the eye
Forrester, J. V., Xu, H., Kuffová, L., Dick, A. D., & McMenamin, P. G. (2010) · Immunological Reviews · doi:10.1111/j.0105-2896.2009.00873.x · Cited by 195
Metadata
- Authors
- Barbet, G., Demion, M., Moura, I. C., Serafini, N., Léger, T., Vrtovsnik, F., Monteiro, R. C., Guinamard, R., Kinet, J.-P., & Launay, P.
- Venue
- Nature Immunology
- Published
- 2008-08-31
- Volume
- 9
- Issue
- 10
- Pages
- 1148-1156
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W1968006149
- Cited by
- 228
- References
- 2
- FWCI
- 4.41
- Type
- journal article
- Language
- en
- Open access
- green
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- Barbet, G., Demion, M., Moura, I. C., Serafini, N., Léger, T., Vrtovsnik, F., Monteiro, R. C., Guinamard, R., Kinet, J.-P., & Launay, P. (2008). The calcium-activated nonselective cation channel TRPM4 is essential for the migration but not the maturation of dendritic cells. Nature Immunology. https://doi.org/10.1038/ni.1648
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