The DOI matches its Crossref record; 162 of the 162 references it cites were found in a registry or an index.
ORAI1 and STIM1 deficiency in human and mice: roles of store‐operated Ca2+ entry in the immune system and beyond
Open accessAbstract
Summary: Store‐operated Ca 2+ entry (SOCE) is a mechanism used by many cells types including lymphocytes and other immune cells to increase intracellular Ca 2+ concentrations to initiate signal transduction. Activation of immunoreceptors such as the T‐cell receptor, B‐cell receptor, or Fc receptors results in the release of Ca 2+ ions from endoplasmic reticulum (ER) Ca 2+ stores and subsequent activation of plasma membrane Ca 2+ channels such as the well‐characterized Ca 2+ release‐activated Ca 2+ (CRAC) channel. Two genes have been identified that are essential for SOCE: ORAI1 as the pore‐forming subunit of the CRAC channel in the plasma membrane and stromal interaction molecule‐1 (STIM1) sensing the ER Ca 2+ concentration and activating ORAI1‐CRAC channels. Intense efforts in the past several years have focused on understanding the molecular mechanism of SOCE and the role it plays for cell functions in vitro and in vivo. A number of transgenic mouse models have been generated to investigate the role of ORAI1 and STIM1 in immunity. In addition, mutations in ORAI1 and STIM1 identified in immunodeficient patients provide valuable insight into the role of both genes and SOCE. This review focuses on the role of ORAI1 and STIM1 in vivo, discussing the phenotypes of ORAI1‐ and STIM1‐deficient human patients and mice.
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Cites
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Self-citationSTIM Is a Ca2+ Sensor Essential for Ca2+-Store-Depletion-Triggered Ca2+ Influx
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Self-citationCRACM1 Is a Plasma Membrane Protein Essential for Store-Operated Ca 2+ Entry
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Cited by
Molecular Basis of Calcium Signaling in Lymphocytes: STIM and ORAI
Hogan, P. G., Lewis, R. S., & Rao, A. (2010) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132550 · Cited by 760
Ionic immune suppression within the tumour microenvironment limits T cell effector function
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Ion channels and transporters in lymphocyte function and immunity
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Self-citationStore-operated CRAC channels: function in health and disease
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Metadata
- Authors
- Feske, S.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2009-09
- Volume
- 231
- Issue
- 1
- Pages
- 189-209
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- OpenAlex
- W2166547308
- Cited by
- 299
- References
- 162
- FWCI
- 2.12
- Type
- journal article
- Language
- en
- Open access
- green
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