The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance

Villagra, Alejandro, Cheng, Fengdong, Wang, Hong-Wei, Suarez, Ildelfonso, Glozak, Michelle, Maurin, Michelle, Nguyen, Danny, Wright, Kenneth L, Atadja, Peter W, Bhalla, Kapil, Pinilla-Ibarz, Javier, Seto, Edward, Sotomayor, Eduardo M·2009·Nature Immunology
DOI 10.1038/ni.1673

Cited by (460)

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    Wenbin Wang · 2016 · ORCA Online Research @Cardiff (Cardiff University)
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    Camilla Susannah Laura Tuttle · 2013
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    Sagar Trivedi, Geeta N. Lodhi, C.A. Doifode, Harsha I. Raut · 2017 · Journal of Advance Research in Pharmacy & Biological Science
  23. The Role of HDAC6 and HDAC11 in Shaping Anti-Tumor Responses – Insights into Epigenetic Regulation of Tumor and T-Cell Immunobiology
    Karrune V. Woan · 2012 · University of Florida Digital Collections (University of Florida)
  24. DNA Methylation and Histone Modifications in Autoimmunity
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    Myong-Guk Ri, Cholho Kang · 2019 · Indian Journal of Allergy Asthma and Immunology
  26. Modulation of neuronal mitochondrial dynamics, autophagy and huntingtin proteostasis by HDAC inhibitors: Insights for Huntington's disease
    Pedro Gonçalo Guedes Dias · 2015 · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)
  27. Targeting histone modifications in cancer immunotherapy
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  28. Immunoregulation by HCV-generated Myeloid Suppressor Cells
    Celeste G. Yergin · 2016
  29. Anti Leishmanial Activities of Some Antidepressant Drugs And Antifungal Drugs
    Sagar Trivedi, Geeta N. Lodhi, C.A. Doifode, Harsha I. Raut · 2017 · Journal of Advance Research in Business Management and Accounting
  30. Data from HDAC11 Regulates Glycolysis through the LKB1/AMPK Signaling Pathway to Maintain Hepatocellular Carcinoma Stemness
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  31. Research Progress of HDACs Family in Breast Cancer
    豪芳 苑 · 2023 · Advances in Clinical Medicine
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  33. The Histone Acetylation-Related Gene Signature for Prediction of Prognosis and Immunotherapy Efficacy in Stomach Adenocarcinoma and Verification in vitro
    Chen Dai, Rishun Su, Zhenzhen Zhao, Yangyang Guo, Songcheng Yin, Jingyao Zhou, Yulong He, Changhua Zhang · 2024 · Research Square
  34. Identification of Critical Molecular Pathways Induced by HDAC11 Overexpression in Cardiac Mesenchymal Stem Cells
    Chongyu Zhang, Neal L. Weintraub, Yaoliang Tang · 2025 · Biomolecules
  35. Pharmacoepigenetics of histone deacetylase inhibitors in cancer
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  37. Identification and roles in inflammatory processes of the histone deacetylase family genes in the jawless vertebrate lamprey (Lethenteron camtschaticum)
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  38. HDAC11 promotes renal fibrosis by induing partial epithelial-mesenchymal transition and G2/M phase arrest in renal epithelial cells
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  39. HDAC11 Deacetylates BRAF to Regulate Kinase Activity and Cell Proliferation
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  40. Additional file 1 of Tackling tumor microenvironment through epigenetic tools to improve cancer immunotherapy
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  41. HDAC11 interacts with the NuRD (MTA3) complex to transcriptionally suppress TGFβ1 expression and inhibit hepatocellular carcinoma metastasis
    Yang Yang, Jiaoli Wang, Qingqing Wu, Yishan Wang, Hui Meng, Lulu Zeng, Tian Autumn Qiu, Haixia Zhao, Qin Hu, Qiaoyou Weng et al. · 2026 · Clinical Epigenetics
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  43. HDAC11 Regulates RNA Splicing via De-Fatty Acylation of SF3B2
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  44. A histone deacetylase CgHDAC11 regulates CgIL17 expression in the immune response of Pacific oyster (Crassostrea gigas)
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  45. Characterization and functional insights of histone deacetylases in bivalves: implications for temperature and immune response in Chlamys nobilis
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  46. HDAC11 as a potential therapeutic target for Alzheimer’s disease
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  47. Structure-guided identification of histone deacetylase 11 inhibitors for targeted chemotherapy through long-timescale molecular dynamics simulation
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  48. Elevenostat Is an HDAC6/Class I-Biased Multi-HDAC Inhibitor Rather than an HDAC11-Selective Chemical Probe
    Miroslava Vošahlíková, Zsófia Kutil, Julia Kudlacova, Barbora Havlínová, Marat Meleshin, Zora Nováková, Ivan Šnajdr, Mike Schutkowski, Cyril Bařinka · 2026 · ACS Chemical Biology
  49. Development of a Potent and Isoform-Selective HDAC11 Inhibitor with Anti-Tumor Efficacy against Non-Small Cell Lung Cancer
    Xinyu Yang, Xin Li, Rui Huang, Yanting Zhou, Hai Li, Pan Yao, Yue Hu, Yuhang Liu, Changning Wang, Ping Bai · 2026 · Journal of Medicinal Chemistry
  50. Discovery of a highly selective HDAC11 inhibitor that restrains hepatocellular carcinoma through metabolic and apoptotic reprogramming
    Weichen Wang, Xinyu Yang, Yun Yang, Yanting Zhou, Pan Yao, Ziyi Shu, Tiantian Li, Mingming Gao, Changning Wang, Ping Bai · 2026 · European Journal of Medicinal Chemistry
  51. BindingDB Entry 50040711: Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth.
    BindingDB · 2013 · UC San Diego
  52. BindingDB Entry 50003811: Biological function and small molecule inhibitors of histone deacetylase 11.
    BindingDB · 2026 · UC San Diego
  53. BindingDB Entry 50023577: HDAC11 Inhibition as a Potential Therapeutic Strategy for AML: Target Identification, Lead Discovery, Antitumor Potency, and Mechanism Investigation.
    BindingDB · 2026 · UC San Diego
  54. BindingDB Entry 50005962: Mutagenesis studies of the 14 Å internal cavity of histone deacetylase 1: insights toward the acetate-escape hypothesis and selective inhibitor design.
    BindingDB · 2020 · UC San Diego
  55. BindingDB Entry 50001250: Discovery of novel N-hydroxy-2-arylisoindoline-4-carboxamides as potent and selective inhibitors of HDAC11.
    BindingDB · 2020 · UC San Diego
  56. BindingDB Entry 50031396: Synthesis and biological evaluation of triazol-4-ylphenyl-bearing histone deacetylase inhibitors as anticancer agents.
    BindingDB · 2010 · UC San Diego
  57. BindingDB Entry 7705: Histone deacetylase 7 promotes Toll-like receptor 4-dependent proinflammatory gene expression in macrophages.
    BindingDB · 2017 · UC San Diego
  58. BindingDB Entry 50020538: Development and Pharmacochemical Characterization Discover a Novel Brain-Permeable HDAC11-Selective Inhibitor with Therapeutic Potential by Regulating Neuroinflammation in Mice.
    BindingDB · 2024 · UC San Diego
  59. Epigenetic messengers: extracellular vesicles at the interface of cancer communication
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