Cited by 296Immune Response and InflammationNF-κB Signaling PathwaysGene Regulatory Network Analysis

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Function of C/EBPδ in a regulatory circuit that discriminates between transient and persistent TLR4-induced signals

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Litvak, Vladimir, Ramsey, Stephen A, Rust, Alistair G, Zak, Daniel E, Kennedy, Kathleen A, Lampano, Aaron E, Nykter, Matti, Shmulevich, Ilya, Aderem, Alan·2009·Nature Immunology

DOI 10.1038/ni.1721PMC PMC2780024

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Abstract

The innate immune system is like a double-edged sword: it is absolutely required for host defense against infection, but when uncontrolled, it can trigger a plethora of inflammatory diseases. Here we use systems-biology approaches to predict and confirm the existence of a gene-regulatory network involving dynamic interaction among the transcription factors NF-kappaB, C/EBPdelta and ATF3 that controls inflammatory responses. We mathematically modeled transcriptional regulation of the genes encoding interleukin 6 and C/EBPdelta and experimentally confirmed the prediction that the combination of an initiator (NF-kappaB), an amplifier (C/EBPdelta) and an attenuator (ATF3) forms a regulatory circuit that discriminates between transient and persistent Toll-like receptor 4-induced signals. Our results suggest a mechanism that enables the innate immune system to detect the duration of infection and to respond appropriately.

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The Elements of Statistical Learning
Hastie, T., Friedman, J., & Tibshirani, R. (2001) · Springer Series in Statistics · doi:10.1007/978-0-387-21606-5 · Cited by 24,162
Bioconductor: open software development for computational biology and bioinformatics
Gentleman, R. C., Carey, V. J., Bates, D. M., Bolstad, B., Dettling, M., Dudoit, S., Ellis, B., Gautier, L., Ge, Y., Gentry, J., et al. (2004) · Genome biology · doi:10.1186/gb-2004-5-10-r80 · Cited by 12,082
Pathogen Recognition and Innate Immunity
Akira, S., Uematsu, S., & Takeuchi, O. (2006) · Cell · doi:10.1016/j.cell.2006.02.015 · Cited by 11,976
Exploration, normalization, and summaries of high density oligonucleotide array probe level data
Irizarry, R. A. (2003) · Biostatistics · doi:10.1093/biostatistics/4.2.249 · Cited by 10,603
Innate immune recognition
Janeway, C. A., & Medzhitov, R. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.083001.084359 · Cited by 8,394
Alternative activation of macrophages
Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189
Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases
Barnes, P. J., & Karin, M. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704103361506 · Cited by 4,622
Toll-like receptors and innate immunity
Medzhitov, R. (2001) · Nature Reviews Immunology · doi:10.1038/35100529 · Cited by 4,308
NF-κB regulation in the immune system
Li, Q., & Verma, I. M. (2002) · Nature Reviews Immunology · doi:10.1038/nri910 · Cited by 4,007
Network motifs: theory and experimental approaches
Alon, U. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2102 · Cited by 3,279

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Loke, J. C. T., Chin, P. S., Keane, P., Pickin, A., Assi, S. A., Ptasinska, A., Imperato, M. R., Cockerill, P. N., & Bonifer, C. (2018) · Blood Advances · doi:10.1182/bloodadvances.2017012781 · Cited by 17
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de Oliveira, C. C. F., Busquets, S., Fuster, G., Ametller, E., Figueras, M., Oliván, M., Toledo, M., López-Soriano, F. J., Qu, X. A., DeMuth, J. P., et al. (2013) · Muscle & Nerve · doi:10.1002/mus.23893 · Cited by 16
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Zhang, L., Zhang, L.-J., Zhang, L.-J., Xia, T., Xia, R., Xia, T., Zhang, W., Zhang, W., Zhang, W., Wu, R., et al. (2025) · Cellular and Molecular Immunology · doi:10.1038/s41423-025-01296-5 · Cited by 15
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Son, B., Eto, M., Oura, M., Ishida, Y., Taniguchi, S., Ito, K., Umeda‐Kameyama, Y., Kojima, T., & Akishita, M. (2019) · Gerontology · doi:10.1159/000499826 · Cited by 15
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Calton, C. M. (2014) · doi:10.6083/m4jq0z12
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Couture, O. P. (2011) · doi:10.31274/etd-180810-2557
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Kielland, A., & Carlsen, H. (2010)
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Additional file 6 of Propofol improves survival in a murine model of sepsis via inhibiting Rab5a-mediated intracellular trafficking of TLR4
Zhou, B.-W., Zhang, W.-J., Zhang, F.-L., Yang, X., Ding, Y.-Q., Yao, Z.-W., Yan, Z.-Z., Zhao, B.-C., Chen, X.-D., Li, C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26699021
Additional file 7 of Propofol improves survival in a murine model of sepsis via inhibiting Rab5a-mediated intracellular trafficking of TLR4
Zhou, B.-W., Zhang, W.-J., Zhang, F.-L., Yang, X., Ding, Y.-Q., Yao, Z.-W., Yan, Z.-Z., Zhao, B.-C., Chen, X.-D., Li, C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26699024
Additional file 3 of Propofol improves survival in a murine model of sepsis via inhibiting Rab5a-mediated intracellular trafficking of TLR4
Zhou, B.-W., Zhang, W.-J., Zhang, F.-L., Yang, X., Ding, Y.-Q., Yao, Z.-W., Yan, Z.-Z., Zhao, B.-C., Chen, X.-D., Li, C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26699012
Additional file 2 of Propofol improves survival in a murine model of sepsis via inhibiting Rab5a-mediated intracellular trafficking of TLR4
Zhou, B.-W., Zhang, W.-J., Zhang, F.-L., Yang, X., Ding, Y.-Q., Yao, Z.-W., Yan, Z.-Z., Zhao, B.-C., Chen, X.-D., Li, C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.25506652
Additional file 6 of The linkage of NF-κB signaling pathway-associated long non-coding RNAs with tumor microenvironment and prognosis in cervical cancer
Feng, X., Shan, R., & Hu, X. (2023) · Figshare · doi:10.6084/m9.figshare.23700464
Additional file 4 of The linkage of NF-κB signaling pathway-associated long non-coding RNAs with tumor microenvironment and prognosis in cervical cancer
Feng, X., Shan, R., & Hu, X. (2023) · Figshare · doi:10.6084/m9.figshare.23700458
Additional file 4 of Propofol improves survival in a murine model of sepsis via inhibiting Rab5a-mediated intracellular trafficking of TLR4
Zhou, B.-W., Zhang, W.-J., Zhang, F.-L., Yang, X., Ding, Y.-Q., Yao, Z.-W., Yan, Z.-Z., Zhao, B.-C., Chen, X.-D., Li, C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26699015
Additional file 3 of The linkage of NF-κB signaling pathway-associated long non-coding RNAs with tumor microenvironment and prognosis in cervical cancer
Feng, X., Shan, R., & Hu, X. (2023) · Figshare · doi:10.6084/m9.figshare.23700455
Additional file 2 of The linkage of NF-κB signaling pathway-associated long non-coding RNAs with tumor microenvironment and prognosis in cervical cancer
Feng, X., Shan, R., & Hu, X. (2023) · Figshare · doi:10.6084/m9.figshare.23700452
Additional file 1 of Propofol improves survival in a murine model of sepsis via inhibiting Rab5a-mediated intracellular trafficking of TLR4
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Additional file 5 of Propofol improves survival in a murine model of sepsis via inhibiting Rab5a-mediated intracellular trafficking of TLR4
Zhou, B.-W., Zhang, W.-J., Zhang, F.-L., Yang, X., Ding, Y.-Q., Yao, Z.-W., Yan, Z.-Z., Zhao, B.-C., Chen, X.-D., Li, C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26699018
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Liu, J., Liu, H., Wan, Y., Wu, A., Qiu, J., Gong, X., Zhao, Y., Li, Y., Zhou, B., Zheng, Y., et al. (2026) · Advanced Science · doi:10.1002/advs.77422
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Rebl, A., Collet, B., Kyslík, J., & Korytář, T. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1938274
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Toll-Like Receptor 2 and Partner Receptors in Alzheimers Disease
Shirong, L. (2011) · Publications of the UdS (Saarland University) · doi:10.22028/d291-21508

Authors: Litvak, V., Ramsey, S. A., Rust, A. G., Zak, D. E., Kennedy, K. A., Lampano, A. E., Nykter, M., Shmulevich, I., & Aderem, A.
Affiliations: Institute for Systems Biology (US)
Corresponding author: Aderem, Alan
ORCID: Ramsey, Stephen A
Rust, Alistair G
Zak, Daniel E
Lampano, Aaron E
Nykter, Matti
Aderem, Alan
Venue: Nature Immunology
Publisher: Springer Science and Business Media LLC
Published: 2009-03-08
Volume: 10
Issue: 4
Pages: 437-443
ISSN: 1529-2908 (ISSN-L)
1529-2916
DOI: 10.1038/ni.1721
PMC: PMC2780024
OpenAlex: W2036584139
Cited by: 295
References: 52
Citations by year: 2026: 8 · 2025: 12 · 2024: 13 · 2023: 11 · 2022: 11 · 2021: 13 · 2020: 3 · 2019: 9 · 2018: 18 · 2017: 12 · 2016: 15 · 2015: 16 · 2014: 21 · 2013: 28 · 2012: 27
FWCI: 15.10
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature Immunology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Allergy and Infectious Diseases (R01AI032972, R01AI025032)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
Keywords: C/EBPδ, TLR4, NF-κB, ATF3, transcriptional regulatory networks, gene regulatory networks, innate immunity, interleukin-6, inflammation
MeSH terms: Animals, Bone Marrow Cells, Cells, Cultured, Escherichia coli Infections, Immunity, Innate, Lipopolysaccharides, Macrophages, Mice, Inbred C57BL, Models, Genetic, Interleukin-6, NF-kappa B, Mice, Knockout, Systems Biology, Toll-Like Receptor 4, Mice, Activating Transcription Factor 3, CCAAT-Enhancer-Binding Protein-delta, Gene Regulatory Networks

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Function of C/EBPδ in a regulatory circuit that discriminates between transient and persistent TLR4-induced signals

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