The DOI matches its Crossref record; 52 of the 53 references it cites were found in a registry or an index.
Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells
Abstract
Interleukin 22 (IL-22) is a cytokine produced by the T(H)-17 lineage of helper T cells and NK-22 subset of natural killer cells that acts on epithelial cells and keratinocytes and has been linked to skin homeostasis and inflammation. Here we characterize a population of human skin-homing memory CD4(+) T cells that expressed the chemokine receptors CCR10, CCR6 and CCR4 and produced IL-22 but neither IL-17 nor interferon-gamma (IFN-gamma). Clones isolated from this population produced IL-22 only and had low or undetectable expression of the T(H)-17 and T helper type 1 (T(H)1) transcription factors RORgammat and T-bet. The differentiation of T cells producing only IL-22 was efficiently induced in naive T cells by plasmacytoid dendritic cells in an IL-6- and tumor necrosis factor-dependent way. Our findings delineate a previously unknown subset of human CD4(+) effector T cells dedicated to skin pathophysiology.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Th17 and Th22 subsets are pivotal to tackle extracellular pathogens, such as extracellular bacteria and fungi, and they both lack CXCR3 and express CCR6 and CCR4 [152-154].”
From Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) (2021) · cites this paper as [154]
In the citing paper
“However, Th17 can be distinguished by the expression of the killer-cell lectin-like receptor CD161 (KLRB1) [155,156], while Th22 expresses the skin-homing receptor CCR10 [154].”
From Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) (2021) · cites this paper as [154]
Citations
Cites
Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L., & Kuchroo, V. K. (2006) · Nature · doi:10.1038/nature04753 · Cited by 6,992
Ivanov, I. I., McKenzie, B. S., Zhou, L., Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J., & Littman, D. R. (2006) · Cell · doi:10.1016/j.cell.2006.07.035 · Cited by 5,145
Harrington, L. E., Hatton, R. D., Mangan, P. R., Turner, H., Murphy, T. L., Murphy, K. M., & Weaver, C. T. (2005) · Nature Immunology · doi:10.1038/ni1254 · Cited by 4,742
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
Park, H., Li, Z., Yang, X. O., Chang, S. H., Nurieva, R., Wang, Y.-H., Wang, Y., Hood, L., Zhu, Z., Tian, Q., et al. (2005) · Nature Immunology · doi:10.1038/ni1261 · Cited by 4,265
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
Langrish, C. L., Chen, Y., Blumenschein, W. M., Mattson, J., Basham, B., Sedgwick, J. D., McClanahan, T., Kastelein, R. A., & Cua, D. J. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041257 · Cited by 4,099
Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M., & Stockinger, B. (2006) · Immunity · doi:10.1016/j.immuni.2006.01.001 · Cited by 3,605
A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment
Szabo, S. J., Kim, S. T., Costa, G. L., Zhang, X., Fathman, C. G., & Glimcher, L. H. (2000) · Cell · doi:10.1016/s0092-8674(00)80702-3 · Cited by 3,589
Transforming growth factor-β induces development of the TH17 lineage
Mangan, P. R., Harrington, L. E., O'Quinn, D. B., Helms, W. S., Bullard, D. C., Elson, C. O., Hatton, R. D., Wahl, S. M., Schoeb, T. R., & Weaver, C. T. (2006) · Nature · doi:10.1038/nature04754 · Cited by 3,087
Lymphocyte Homing and Homeostasis
Butcher, E. C., & Picker, L. J. (1996) · Science · doi:10.1126/science.272.5258.60 · Cited by 2,846
Zheng, W.-P., & Flavell, R. A. (1997) · Cell · doi:10.1016/s0092-8674(00)80240-8 · Cited by 2,384
Liang, S. C., Tan, X.-Y., Luxenberg, D. P., Karim, R., Dunussi-Joannopoulos, K., Collins, M., & Fouser, L. A. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061308 · Cited by 2,330
Development, cytokine profile and function of human interleukin 17-producing helper T cells
Wilson, N. J., Boniface, K., Chan, J. R., McKenzie, B. S., Blumenschein, W. M., Mattson, J. D., Basham, B., Smith, K., Chen, T., Morel, F., et al. (2007) · Nature Immunology · doi:10.1038/ni1497 · Cited by 2,035
TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function
Zhou, L., Lopes, J. E., Chong, M. M. W., Ivanov, I. I., Min, R., Victora, G. D., Shen, Y., Du, J., Rubtsov, Y. P., Rudensky, A. Y., et al. (2008) · Nature · doi:10.1038/nature06878 · Cited by 1,928
Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide
Lande, R., Gregorio, J., Facchinetti, V., Chatterjee, B., Wang, Y.-H., Homey, B., Cao, W., Wang, Y.-H., Su, B., Nestle, F. O., et al. (2007) · Nature · doi:10.1038/nature06116 · Cited by 1,910
IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells
Korn, T., Bettelli, E., Gao, W., Awasthi, A., Jäger, A., Strom, T. B., Oukka, M., & Kuchroo, V. K. (2007) · Nature · doi:10.1038/nature05970 · Cited by 1,896
Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
Zheng, Y., Danilenko, D. M., Valdez, P. A., Kasman, I. M., Eastham‐Anderson, J., Wu, J., & Ouyang, W. (2006) · Nature · doi:10.1038/nature05505 · Cited by 1,888
Phenotypic and functional features of human Th17 cells
Annunziato, F., Cosmi, L., Santarlasci, V., Maggi, L., Liotta, F., Mazzinghi, B., Parente, E., Filì, L., Ferri, S., Frosali, F., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070663 · Cited by 1,861
Acosta-Rodriguez, E. V., Napolitani, G., Lanzavecchia, A., & Sallusto, F. (2007) · Nature Immunology · doi:10.1038/ni1496 · Cited by 1,857
Self-citationSurface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cells
Acosta-Rodriguez, E. V., Rivino, L., Geginat, J., Jarrossay, D., Gattorno, M., Lanzavecchia, A., Sallusto, F., & Napolitani, G. (2007) · Nature Immunology · doi:10.1038/ni1467 · Cited by 1,828
Self-citationThe aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins
Veldhoen, M., Hirota, K., Westendorf, A. M., Buer, J., Dumoutier, L., Renauld, J.-C., & Stockinger, B. (2008) · Nature · doi:10.1038/nature06881 · Cited by 1,634
T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ
Yang, X. O., Pappu, B. P., Nurieva, R., Akimzhanov, A., Kang, H. S., Chung, Y., Ma, L., Shah, B., Panopoulos, A. D., Schluns, K. S., et al. (2008) · Immunity · doi:10.1016/j.immuni.2007.11.016 · Cited by 1,605
T-cell quality in memory and protection: implications for vaccine design
Seder, R. A., Darrah, P. A., & Roederer, M. (2008) · Nature reviews. Immunology · doi:10.1038/nri2274 · Cited by 1,565
Retinoic acid imprints gut-homing specificity on T cells
Iwata, M., Hirakiyama, A., Eshima, Y., Kagechika, H., Kato, C., & Song, S.-Y. (2004) · Immunity · doi:10.1016/j.immuni.2004.08.011 · Cited by 1,541
Flexible Programs of Chemokine Receptor Expression on Human Polarized T Helper 1 and 2 Lymphocytes
Sallusto, F., Lenig, D., Mackay, C. R., & Lanzavecchia, A. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.6.875 · Cited by 1,535
Self-citationMcGeachy, M. J., Bak-Jensen, K. S., Chen, Y., Tato, C. M., Blumenschein, W., McClanahan, T., & Cua, D. J. (2007) · Nature Immunology · doi:10.1038/ni1539 · Cited by 1,520
IL-22 Increases the Innate Immunity of Tissues
Wolk, K., Kunz, S., Witte, E., Friedrich, M., Asadullah, K., & Sabat, R. (2004) · Immunity · doi:10.1016/j.immuni.2004.07.007 · Cited by 1,406
A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity
Cella, M., Fuchs, A. G., Vermi, W., Facchetti, F., Otero, K., Lennerz, J. K., Doherty, J. M., Mills, J. C., & Colonna, M. (2008) · Nature · doi:10.1038/nature07537 · Cited by 1,298
Reboldi, A., Coisne, C., Baumjohann, D., Benvenuto, F., Bottinelli, D., Lira, S., Uccelli, A., Lanzavecchia, A., Engelhardt, B., & Sallusto, F. (2009) · Nature Immunology · doi:10.1038/ni.1716 · Cited by 1,206
Self-citationPlasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases
Gilliet, M., Cao, W., & Liu, Y.-J. (2008) · Nature Reviews Immunology · doi:10.1038/nri2358 · Cited by 1,190
IL-21 and TGF-β are required for differentiation of human TH17 cells
Yang, L., Anderson, D. E., Baecher‐Allan, C., Hastings, W. D., Bettelli, E., Oukka, M., Kuchroo, V. K., & Hafler, D. A. (2008) · Nature · doi:10.1038/nature07021 · Cited by 951
Wolk, K., Witte, E., Wallace, E., Döcke, W., Kunz, S., Asadullah, K., Volk, H., Sterry, W., & Sabat, R. (2006) · European Journal of Immunology · doi:10.1002/eji.200535503 · Cited by 911
Innate and Adaptive Interleukin-22 Protects Mice from Inflammatory Bowel Disease
Zenewicz, L. A., Yancopoulos, G. D., Valenzuela, D. M., Murphy, A. J., Stevens, S. G., & Flavell, R. A. (2008) · Immunity · doi:10.1016/j.immuni.2008.11.003 · Cited by 833
Immune surveillance in the skin: mechanisms and clinical consequences
Kupper, T. S., & Fuhlbrigge, R. C. (2004) · Nature reviews. Immunology · doi:10.1038/nri1310 · Cited by 822
CCL27–CCR10 interactions regulate T cell–mediated skin inflammation
Homey, B., Alenius, H. T., Müller, A., Soto, H., Bowman, E. P., Yuan, W., McEvoy, L. M., Lauerma, A., Assmann, T., Bünemann, E., et al. (2002) · Nature Medicine · doi:10.1038/nm0202-157 · Cited by 807
Sigmundsdóttir, H., Pan, J., Debes, G. F., Alt, C., Habtezion, A., Soler, D. F., & Butcher, E. C. (2007) · Nature Immunology · doi:10.1038/ni1433 · Cited by 630
Nograles, K. E., Zaba, L. C., Shemer, A., Fuentes-Duculan, J., Cardinale, I., Kikuchi, T., Ramon, M., Bergman, R., Krueger, J. G., & Guttman-Yassky, E. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.03.041 · Cited by 627
Orchestrating the orchestrators: chemokines in control of T cell traffic
Bromley, S. K., Mempel, T. R., & Luster, A. D. (2008) · Nature Immunology · doi:10.1038/ni.f.213 · Cited by 617
Ma, H., Liang, S. C., Li, J., Napierata, L., Brown, T., Benoit, S., Senices, M., Gill, D. S., Dunussi‐Joannopoulos, K., Collins, M. A., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33263 · Cited by 555
Luci, C., Reynders, A., Ivanov, I. I., Cognet, C., Chiche, L., Chasson, L., Hardwigsen, J., Anguiano, E., Banchereau, J., Chaussabel, D., et al. (2008) · Nature Immunology · doi:10.1038/ni.1681 · Cited by 551
Reiss, Y., Proudfoot, A. E. I., Power, C., Campbell, J. J., & Butcher, E. C. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.10.1541 · Cited by 516
Human T Cells That Are Able to Produce IL-17 Express the Chemokine Receptor CCR6
SINGH, S. P., Zhang, H. H., Foley, J. F., Hedrick, M. N., & Farber, J. M. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.1.214 · Cited by 391
Messi, M., Giacchetto, I., Nagata, K., Lanzavecchia, A., Natoli, G., & Sallusto, F. (2002) · Nature Immunology · doi:10.1038/ni872 · Cited by 347
Self-citationEnvironmental cues, dendritic cells and the programming of tissue-selective lymphocyte trafficking
Sigmundsdóttir, H., & Butcher, E. C. (2008) · Nature Immunology · doi:10.1038/ni.f.208 · Cited by 330
Albanesi, C., Scarponi, C., Pallotta, S., Daniele, R., Bosisio, D., Madonna, S., Fortugno, P., Gonzalvo-Feo, S., Franssen, J., Parmentier, M., et al. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080129 · Cited by 328
Interleukin-22: A novel T- and NK-cell derived cytokine that regulates the biology of tissue cells
Wolk, K., & Sabat, R. (2006) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2006.09.001 · Cited by 303
Rivino, L., Messi, M., Jarrossay, D., Lanzavecchia, A., Sallusto, F., & Geginat, J. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040774 · Cited by 298
Self-citationA role for T cell-derived interleukin 22 in psoriatic skin inflammation
Boniface, K., Guignouard, E., Pedretti, N., Garcia, M., Delwail, A., Bernard, F.-X., Nau, F., Guillet, G., Dagrégorio, G., Yssel, H., et al. (2007) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2007.03511.x · Cited by 295
T-bet is required for optimal proinflammatory CD4+ T-cell trafficking
Lord, G. M. (2005) · Blood · doi:10.1182/blood-2005-04-1393 · Cited by 270
Hughes, T. L., Becknell, B., McClory, S., Briercheck, E. L., Freud, A. G., Zhang, X., Mao, H. C., Nuovo, G. J., Yu, J., & Caligiuri, M. A. (2009) · Blood · doi:10.1182/blood-2008-12-192443 · Cited by 130
Lymphocyte homing to the gut: attraction, adhesion, and commitment
Salmi, M., & Jalkanen, S. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00285.x · Cited by 118
Chemoattractants and their receptors in homeostasis and inflammation
Sallusto, F., & Mackay, C. R. (2004) · Current Opinion in Immunology · doi:10.1016/j.coi.2004.09.012 · Cited by 114
Self-citationOR.41. IL-21 and TGF-β are Required for Differentiation of Human Th17 Cells
Anderson, D., Yang, L., Baecher‐Allan, C., Bettelli, E., Oukka, M., Kuchroo, V. K., & Hafler, D. A. (2008) · Clinical Immunology · doi:10.1016/j.clim.2008.03.047 · Cited by 83
Flagged first, then by citations
1 of the 53 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Trifari, S., Kaplan, C.D., Tran, E.H., Crellin, N.K. & Spitz, H. Identification of a human helper T cell population that produces abundant IL-22 and is distinct from TH-17, TH1 and TH2 cells. Nat. Immunol. advance online publication, doi:10.1038/ni1770 (5 July 2009). · DOI
Cited by
Sorted by citations
Chemokines and Chemokine Receptors: Positioning Cells for Host Defense and Immunity
Griffith, J. W., Sokol, C. L., & Luster, A. D. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120145 · Cited by 2,119
Regulation and Functions of the IL-10 Family of Cytokines in Inflammation and Disease
Ouyang, W., Rutz, S., Crellin, N. K., Valdez, P. A., & Hymowitz, S. G. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101312 · Cited by 2,011
Skin immune sentinels in health and disease
Nestle, F. O., Meglio, P. D., Qin, J., & Nickoloff, B. J. (2009) · Nature reviews. Immunology · doi:10.1038/nri2622 · Cited by 1,529
Mechanisms Underlying Lineage Commitment and Plasticity of Helper CD4 + T Cells
O’Shea, J. J., & Paul, W. E. (2010) · Science · doi:10.1126/science.1178334 · Cited by 1,401
T cell subsets and their signature cytokines in autoimmune and inflammatory diseases
Raphael, I., Nalawade, S. A., Eagar, T. N., & Forsthuber, T. G. (2014) · Cytokine · doi:10.1016/j.cyto.2014.09.011 · Cited by 1,240
Metadata
- Authors
- Duhen, T., Geiger, R., Jarrossay, D., Lanzavecchia, A., & Sallusto, F.
- Affiliations
- Institute for Research in Biomedicine (CH)
- Corresponding author
- Sallusto, Federica
- Venue
- Nature Immunology
- Published
- 2009-07-05
- Volume
- 10
- Issue
- 8
- Pages
- 857-863
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2082450021
- Cited by
- 1,079
- References
- 53
- Citations by year
- 2026: 14 · 2025: 18 · 2024: 29 · 2023: 48 · 2022: 38 · 2021: 53 · 2020: 64 · 2019: 45 · 2018: 66 · 2017: 68 · 2016: 76 · 2015: 79 · 2014: 111 · 2013: 96 · 2012: 95
- FWCI
- 39.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute for Health and Care Research
- European Commission
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- National Institutes of Health
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- IL-22, IL-17, CD4+ T cells, CCR10, CCR6, CCR4, RORγ, T-bet, plasmacytoid dendritic cells, interleukin-6, TNF-α, T cell differentiation, skin inflammation, keratinocytes
- MeSH terms
- Interleukin-22, T-bet Transcription Factor, Cell Differentiation, T-Lymphocytes, Helper-Inducer, Humans, Immunologic Memory, Interleukins, Receptors, Thyroid Hormone, Skin, CD4-Positive T-Lymphocytes, T-Lymphocyte Subsets, Receptors, Retinoic Acid, Interleukin-17, T-Box Domain Proteins, Receptors, CCR4, Receptors, CCR6, Receptors, CCR10, Nuclear Receptor Subfamily 1, Group F, Member 3, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
