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Chromogranin A is an autoantigen in type 1 diabetes
Open accessAbstract
Autoreactive CD4+ T cells are involved in the pathogenesis of many autoimmune diseases, but the antigens that stimulate their responses have been difficult to identify and in most cases are not well defined. In the nonobese diabetic (NOD) mouse model of type 1 diabetes, we have identified the peptide WE14 from chromogranin A (ChgA) as the antigen for highly diabetogenic CD4+ T cell clones. Peptide truncation and extension analysis shows that WE14 bound to the NOD mouse major histocompatibility complex class II molecule I-Ag7 in an atypical manner, occupying only the carboxy-terminal half of the I-Ag7 peptide-binding groove. This finding extends the list of T cell antigens in type 1 diabetes and supports the idea that autoreactive T cells respond to unusually presented self peptides.
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Citations
Cited by
Environmental risk factors for type 1 diabetes
Rewers, M., & Ludvigsson, J. (2016) · The Lancet · doi:10.1016/s0140-6736(16)30507-4 · Cited by 676
Todd, J. A. (2010) · Immunity · doi:10.1016/j.immuni.2010.04.001 · Cited by 560
Maruhashi, T., Okazaki, I.-M., Sugiura, D., Takahashi, S., Maeda, T. K., Shimizu, K., & Okazaki, T. (2018) · Nature Immunology · doi:10.1038/s41590-018-0217-9 · Cited by 275
How Does Type 1 Diabetes Develop?
Atkinson, M. A., Bluestone, J. A., Eisenbarth, G. S., Hebrok, M., Herold, K. C., Accili, D., Pietropaolo, M., Arvan, P. R., Von Herrath, M., Markel, D. S., et al. (2011) · Diabetes · doi:10.2337/db10-1797 · Cited by 232
Ferris, S. T., Carrero, J. A., Mohan, J. F., Calderon, B., Murphy, K. M., & Unanue, E. R. (2014) · Immunity · doi:10.1016/j.immuni.2014.09.012 · Cited by 164
Metadata
- Authors
- Stadinski, B. D., Delong, T., Reisdorph, N., Reisdorph, R., Powell, R. L., Armstrong, M., Piganelli, J. D., Barbour, G., Bradley, B., Crawford, F., Marrack, P., Mahata, S. K., Kappler, J. W., & Haskins, K.
- Venue
- Nature Immunology
- Published
- 2010-02-07
- Volume
- 11
- Issue
- 3
- Pages
- 225-231
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2100950956
- Cited by
- 338
- References
- 0
- FWCI
- 21.29
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Chromogranin A is an autoantigen in type 1 diabetes. https://app.cochat.ai/papers/10.1038/ni.1844
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- Stadinski, B. D., Delong, T., Reisdorph, N., Reisdorph, R., Powell, R. L., Armstrong, M., Piganelli, J. D., Barbour, G., Bradley, B., Crawford, F., Marrack, P., Mahata, S. K., Kappler, J. W., & Haskins, K. (2010). Chromogranin A is an autoantigen in type 1 diabetes. Nature Immunology. https://doi.org/10.1038/ni.1844
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
