Environmental risk factors for type 1 diabetes
Open accessAbstract
The incidence of type 1 diabetes has risen considerably in the past 30 years due to changes in the environment that have been only partially identified. In this Series paper, we critically discuss candidate triggers of islet autoimmunity and factors thought to promote progression from autoimmunity to overt type 1 diabetes. We revisit previously proposed hypotheses to explain the growth in the incidence of type 1 diabetes in light of current data. Finally, we suggest a unified model in which immune tolerance to β cells can be broken by several environmental exposures that induce generation of hybrid peptides acting as neoautoantigens.
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Under the GBD's comparative risk assessment framework, we do not currently capture risk factors that have been reported in the literature for type 1 diabetes.
“Under the GBD's comparative risk assessment framework, we do not currently capture risk factors that have been reported in the literature for type 1 diabetes.93, 94”
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Cites
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
Arpaia, N., Campbell, C., Fan, X., Dikiy, S., van der Veeken, J., deRoos, P., Liu, H., Cross, J. R., Pfeffer, K., Coffer, P. J., et al. (2013) · Nature · doi:10.1038/nature12726 · Cited by 4,838 · see citing works
The effect of infections on susceptibility to autoimmune and allergic diseases.
Bach, J. (2002) · New England Journal of Medicine · doi:10.1056/nejmra020100 · Cited by 2,714 · see citing works
Classification and Diagnosis of Diabetes
Fajans, S. S. (1990) · Medical Entomology and Zoology · Cited by 2,356 · see citing works
Innate immunity and intestinal microbiota in the development of Type 1 diabetes
Wen, L., Ley, R. E., Volchkov, P. Y., Stranges, P. B., Avanesyan, L., Stonebraker, A. C., Hu, C., Wong, F. S., Szot, G. L., Bluestone, J. A., et al. (2008) · Nature · doi:10.1038/nature07336 · Cited by 1,921 · see citing works
Patterson, C. C., Dahlquist, G. G., Gyürüs, E., Green, A., & Soltész, G. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60568-7 · Cited by 1,854 · see citing works
(2) Classification and diagnosis of diabetes
American Diabetes Association (2015) · Diabetes Care · doi:10.2337/dc15-s005 · Cited by 1,841 · see citing works
Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children
Ziegler, A. G., Rewers, M., Simell, O., Simell, T., Lempainen, J., Steck, A., Winkler, C., Ilonen, J., Veijola, R., Knip, M., et al. (2013) · JAMA · doi:10.1001/jama.2013.6285 · Cited by 1,312 · see citing works
Self-citationDiet, gut microbiota and immune responses
Maslowski, K. M., & Mackay, C. R. (2011) · Nature Immunology · doi:10.1038/ni0111-5 · Cited by 1,261 · see citing works
Insel, R. A., Dunne, J. L., Atkinson, M. A., Chiang, J. L., Dabelea, D., Gottlieb, P. A., Greenbaum, C. J., Herold, K. C., Krischer, J. P., Lernmark, Å., et al. (2015) · Diabetes Care · doi:10.2337/dc15-1419 · Cited by 1,216 · see citing works
Self-citationKostic, A. D., Gevers, D., Siljander, H., Vatanen, T., Hyötyläinen, T., Hämäläinen, A., Peet, A., Tillmann, V., Pöhö, P., Mattila, I. M., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.01.001 · Cited by 1,165 · see citing works
Virus-Induced Diabetes Mellitus
Yoon, J., Austin, M., Onodera, T., & Notkins, A. L. (1979) · New England Journal of Medicine · doi:10.1056/nejm197905243002102 · Cited by 1,017 · see citing works
Toward defining the autoimmune microbiome for type 1 diabetes
Giongo, A., Gano, K. A., Crabb, D. B., Mukherjee, N., Novelo, L. L., Casella, G., Drew, J. C., Ilonen, J., Knip, M., Hyöty, H., et al. (2011) · The ISME Journal · doi:10.1038/ismej.2010.92 · Cited by 806 · see citing works
Brown, C. T., Davis-Richardson, A. G., Giongo, A., Gano, K. A., Crabb, D. B., Mukherjee, N., Casella, G., Drew, J. C., Ilonen, J., Knip, M., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025792 · Cited by 778 · see citing works
Murri, M., Leiva, I., Gómez‐Zumaquero, J. M., Tinahones, F. J., Cardona, F., Soriguer, F., & Queipo‐Ortuño, M. I. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-46 · Cited by 767 · see citing works
Endoplasmic reticulum stress, obesity and diabetes
Cnop, M., Foufelle, F., & Velloso, L. A. (2011) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2011.07.010 · Cited by 683 · see citing works
Zipitis, C. S., & Akobeng, A. K. (2008) · Archives of Disease in Childhood · doi:10.1136/adc.2007.128579 · Cited by 661 · see citing works
The accelerator hypothesis: weight gain as the missing link between type I and type II diabetes
Wilkin, T. J. (2001) · Diabetologia · doi:10.1007/s001250100548 · Cited by 623 · see citing works
Early Infant Feeding and Risk of Developing Type 1 Diabetes–Associated Autoantibodies
Ziegler, A. (2003) · JAMA · doi:10.1001/jama.290.13.1721 · Cited by 562 · see citing works
Fecal Microbiota Composition Differs Between Children With β-Cell Autoimmunity and Those Without
de Goffau, M. C., Luopajärvi, K., Knip, M., Ilonen, J., Ruohtula, T., Härkönen, T., Orivuori, L., Hakala, S., Welling, G. W., Harmsen, H. J. M., et al. (2012) · Diabetes · doi:10.2337/db12-0526 · Cited by 562 · see citing works
Genetic risk factors for type 1 diabetes
Pociot, F., & Lernmark, Å. (2016) · The Lancet · doi:10.1016/s0140-6736(16)30582-7 · Cited by 553 · see citing works
[Classification and diagnosis of diabetes].
Boulin (1953) · PubMed · Cited by 516 · see citing works
Timing of initial cereal exposure in infancy and risk of islet autoimmunity
Norris, J. M. (2003) · JAMA · doi:10.1001/jama.290.13.1713 · Cited by 515 · see citing works
Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion
Delong, T., Wiles, T. A., Baker, R. L., Bradley, B., Barbour, G., Reisdorph, R. M., Armstrong, M., Powell, R. L., Reisdorph, N. A., Kumar, N., et al. (2016) · Science · doi:10.1126/science.aad2791 · Cited by 507 · see citing works
the TEDDY Study Group, Krischer, J. P., Lynch, K. F., Schatz, D. A., Ilonen, J., Lernmark, Å., Hagopian, W. A., Rewers, M. J., She, J.-X., Simell, O. G., et al. (2015) · Diabetologia · doi:10.1007/s00125-015-3514-y · Cited by 444 · see citing works
Self-citationHyöty, H., Hiltunen, M., Knip, M., Laakkonen, M., Vähäsalo, P., Karjalainen, J., Koskela, P. U., Roivainen, M., Leinikki, P., Hovi, T., et al. (1995) · Diabetes · doi:10.2337/diab.44.6.652 · Cited by 420 · see citing works
Viral Antibodies in Diabetes Mellitus
Gamble, D. R., Kinsley, M., Fitzgerald, M. G., Bolton, R., & Taylor, K. W. (1969) · BMJ · doi:10.1136/bmj.3.5671.627 · Cited by 412 · see citing works
Richardson, S. J., Willcox, A., Bone, A. J., Foulis, A. K., & Morgan, N. G. (2009) · Diabetologia · doi:10.1007/s00125-009-1276-0 · Cited by 384 · see citing works
Chromogranin A is an autoantigen in type 1 diabetes
Stadinski, B. D., Delong, T., Reisdorph, N. A., Reisdorph, R. M., Powell, R. L., Armstrong, M., Piganelli, J. D., Barbour, G., Bradley, B., Crawford, F., et al. (2010) · Nature Immunology · doi:10.1038/ni.1844 · Cited by 339 · see citing works
Leete, P., O’Connell, A., Krogvold, L., Dahl‐Jørgensen, K., Foulis, A. K., Richardson, S. J., & Morgan, N. G. (2016) · Diabetes · doi:10.2337/db15-1615 · Cited by 330 · see citing works
Norris, J. M., Yin, X., Lamb, M. M., Barriga, K. J., Seifert, J. A., Hoffman, M., Orton, H. D., Barón, A. E., Clare-Salzler, M. J., Chase, H. P., et al. (2007) · JAMA · doi:10.1001/jama.298.12.1420 · Cited by 320 · see citing works
Self-citationKrogvold, L., Edwin, B., Buanes, T., Frisk, G., Skog, O., Anagandula, M., Korsgren, O., Undlien, D., Eike, M. C., Richardson, S. J., et al. (2015) · Diabetes · doi:10.2337/db14-1370 · Cited by 314 · see citing works
Self-citationDietary intervention in infancy and later signs of beta-cell autoimmunity
Knip, M., Virtanen, S. M., Seppä, K., Ilonen, J., Savilahti, E., Vaarala, O., Reunanen, A., Teramo, K., Hämäläinen, A.-M., Paronen, J., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1004809 · Cited by 281 · see citing works
Type 1 diabetes as a relapsing–remitting disease?
von Herrath, M., Sanda, S., & Herold, K. C. (2007) · Nature reviews. Immunology · doi:10.1038/nri2192 · Cited by 270 · see citing works
Age-related islet autoantibody incidence in offspring of patients with type 1 diabetes
the BABYDIAB-BABYDIET Study Group, Ziegler, A.-G., & Bonifacio, E. (2012) · Diabetologia · doi:10.1007/s00125-012-2472-x · Cited by 264 · see citing works
A missing link in the hygiene hypothesis?
Gale, E. (2002) · Diabetologia · doi:10.1007/s00125-002-0801-1 · Cited by 246 · see citing works
Blood and Islet Phenotypes Indicate Immunological Heterogeneity in Type 1 Diabetes
Arif, S., Leete, P., Nguyen, V., Marks, K., Nor, N. M., Estorninho, M., Kronenberg‐Versteeg, D., Bingley, P. J., Todd, J. A., Guy, C., et al. (2014) · Diabetes · doi:10.2337/db14-0365 · Cited by 240 · see citing works
Calvo, T. R., Ekwall, O., Amirian, N., Zapardiel‐Gonzalo, J., & von Herrath, M. G. (2014) · Diabetes · doi:10.2337/db14-0549 · Cited by 237 · see citing works
Dietary factors and the risk of developing insulin dependent diabetes in childhood.
Dahlquist, G. G., Blom, L., Persson, L. Å., Sandström, A. I., & Wall, S. (1990) · BMJ · doi:10.1136/bmj.300.6735.1302 · Cited by 226 · see citing works
Dahlquist, G. G., Ivarsson, S. A., Lindberg, B. A., & Forsgren, M. (1995) · Diabetes · doi:10.2337/diab.44.4.408 · Cited by 225 · see citing works
Enterovirus Infection and Progression From Islet Autoimmunity to Type 1 Diabetes
Stene, L. C., Oikarinen, S., Hyöty, H., Barriga, K. J., Norris, J. M., KLINGENSMITH, G. J., Hutton, J. C., Erlich, H. A., Eisenbarth, G. S., & Rewers, M. (2010) · Diabetes · doi:10.2337/db10-0866 · Cited by 223 · see citing works
Self-citationHarder, T., Roepke, K., Diller, N., Stechling, Y., Dudenhausen, J. W., & Plagemann, A. (2009) · American Journal of Epidemiology · doi:10.1093/aje/kwp065 · Cited by 220 · see citing works
Hummel, S., Pflüger, M., Hummel, M., Bonifacio, E. E., & Ziegler, A. (2011) · Diabetes Care · doi:10.2337/dc10-2456 · Cited by 217 · see citing works
SERREZE, D. V., Ottendorfer, E. W., Ellis, T. M., Gauntt, C. J., & Atkinson, M. A. (2000) · Diabetes · doi:10.2337/diabetes.49.5.708 · Cited by 217 · see citing works
Vitamin D Intake and Risk of Type 1 Diabetes: A Meta-Analysis of Observational Studies
Dong, J., Zhang, W., Chen, J., Zhang, Z., Han, S.-F., & Qin, L. (2013) · Nutrients · doi:10.3390/nu5093551 · Cited by 208 · see citing works
Patterns of β-Cell Autoantibody Appearance and Genetic Associations During the First Years of Life
Ilonen, J., Hammais, A., Laine, A., Lempainen, J., Vaarala, O., Veijola, R., Simell, O., & Knip, M. (2013) · Diabetes · doi:10.2337/db13-0300 · Cited by 206 · see citing works
Sørensen, I. M., Joner, G., Jenum, P. A., Eskild, A., Torjesen, P. A., & Stene, L. C. (2011) · Diabetes · doi:10.2337/db11-0875 · Cited by 189 · see citing works
Reduced Insulin Production Relieves Endoplasmic Reticulum Stress and Induces β Cell Proliferation
Szabat, M., Page, M. M., Panzhinskiy, E., Skovsø, S., Mojibian, M., Fernandez-Tajes, J. J., Bruin, J. E., Bround, M. J., Lee, J. T. C., Xu, E. E., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.10.016 · Cited by 183 · see citing works
A six‐fold gradient in the incidence of type 1 diabetes at the eastern border of Finland
Kondrashova, A., Reunanen, A., Romanov, A., Karvonen, A., Viskari, H., Vesikari, T., Ilonen, J., Knip, M., & Hyöty, H. (2005) · Annals of Medicine · doi:10.1080/07853890410018952 · Cited by 177 · see citing works
Compromised Gut Microbiota Networks in Children With Anti-Islet Cell Autoimmunity
Endesfelder, D., zu Castell, W., Ardissone, A. N., Davis‐Richardson, A. G., Achenbach, P., Hagen, M., Pflueger, M., Gano, K. A., Fagen, J. R., Drew, J. C., et al. (2014) · Diabetes · doi:10.2337/db13-1676 · Cited by 174 · see citing works
Hyppönen, E., Kenward, M. G., Virtanen, S. M., Piitulainen, A., Virta-Autio, P., Tuomilehto, J., Knip, M., & Åkerblom, H. K. (1999) · Diabetes Care · doi:10.2337/diacare.22.12.1961 · Cited by 168 · see citing works
The gut microbiota and Type 1 Diabetes
Gülden, E., Wong, F. S., & Li, W. (2015) · Clinical Immunology · doi:10.1016/j.clim.2015.05.013 · Cited by 165 · see citing works
Environmental Factors in Childhood IDDM: A population-based, case-control study
Verge, C. F., Howard, N. J., Irwig, L., Simpson, J. M., Mackerras, D., & Silink, M. (1994) · Diabetes Care · doi:10.2337/diacare.17.12.1381 · Cited by 161 · see citing works
Hydrolyzed Infant Formula and Early β-Cell Autoimmunity
Knip, M., Akerblom, H., Becker, D., Dosch, H., Dupré, J., Fraser, W., Howard, N., Ilonen, J., Krischer, J., Kordonouri, O., et al. (2014) · Journal of the American Medical Association (JAMA) · doi:10.1001/jama.2014.5610 · Cited by 160 · see citing works
No Protective Effect of Calcitriol on β-Cell Function in Recent-Onset Type 1 Diabetes
Bizzarri, C., Pitocco, D., Napoli, N., Stasio, E. D., Maggi, D., Manfrini, S., SURACI, C., Cavallo, M. G., Cappa, M., Ghirlanda, G., et al. (2010) · Diabetes Care · doi:10.2337/dc10-0814 · Cited by 158 · see citing works
Simpson, M. D., Brady, H. L., Yin, X., Seifert, J. A., Barriga, K. J., Hoffman, M., Bugawan, T. L., Barón, A. E., Sokol, R. J., Eisenbarth, G. S., et al. (2011) · Diabetologia · doi:10.1007/s00125-011-2278-2 · Cited by 156 · see citing works
Self-citationIs Diabetes of Infectious Origin?
Gundersen, E. (1927) · The Journal of Infectious Diseases · doi:10.1093/infdis/41.3.197 · Cited by 156 · see citing works
Walter, M., Kaupper, T., Adler, K., Foersch, J., Bonifacio, E. E., & Ziegler, A. (2010) · Diabetes Care · doi:10.2337/dc09-2297 · Cited by 152 · see citing works
Johansson, C., Samuelsson, U., & Ludvigsson, J. (1994) · Diabetologia · doi:10.1007/bf00428783 · Cited by 151 · see citing works
Self-citationRosenbauer, J., Herzig, P., & Giani, G. (2007) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.791 · Cited by 143 · see citing works
Recognition of Posttranslationally Modified GAD65 Epitopes in Subjects With Type 1 Diabetes
McGinty, J. W., Chow, I.-T., Greenbaum, C., Odegard, J., Kwok, W., & James, E. (2014) · Diabetes · doi:10.2337/db13-1952 · Cited by 143 · see citing works
Infant Exposures and Development of Type 1 Diabetes Mellitus
Frederiksen, B. N., Kroehl, M., Lamb, M. M., Seifert, J. A., Barriga, K. J., Eisenbarth, G. S., Rewers, M., & Norris, J. M. (2013) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2013.317 · Cited by 140 · see citing works
Self-citationCouper, J., Steele, C., Beresford, S., Powell, T. L., McCaul, K. A., Pollard, A. C., Gellert, S. A., Tait, B. D., Harrison, L. C., & Colman, P. G. (1999) · Diabetes · doi:10.2337/diabetes.48.11.2145 · Cited by 140 · see citing works
Richardson, S. J., Leete, P., Bone, A. J., Foulis, A. K., & Morgan, N. G. (2012) · Diabetologia · doi:10.1007/s00125-012-2745-4 · Cited by 137 · see citing works
Drescher, K. M., Kono, K., Bopegamage, S., Carson, S. D., & Tracy, S. (2004) · Virology · doi:10.1016/j.virol.2004.06.049 · Cited by 137 · see citing works
Pugliese, A., Yang, M., Kusmartseva, I., Heiple, T., Vendrame, F., Wasserfall, C. H., Rowe, P. A., Moraski, J., Ball, S., Jebson, L., et al. (2013) · Pediatric Diabetes · doi:10.1111/pedi.12097 · Cited by 136 · see citing works
Viskari, H., Ludvigsson, J., Uibo, R., Salur, L., Marčiulionytė, D., Hermann, R., Soltész, G., Füchtenbusch, M., Ziegler, A., Kondrashova, A., et al. (2005) · Diabetologia · doi:10.1007/s00125-005-1780-9 · Cited by 136 · see citing works
Self-citationVirtanen, S. M., Läärä, E., Hyppönen, E., Reijonen, H., Räsänen, L., Aro, A., Knip, M., Ilonen, J., & Åkerblom, H. K. (2000) · Diabetes · doi:10.2337/diabetes.49.6.912 · Cited by 134 · see citing works
Hummel, M., Füchtenbusch, M., Schenker, M., & Ziegler, A. (2000) · Diabetes Care · doi:10.2337/diacare.23.7.969 · Cited by 133 · see citing works
Cardwell, C. R., Stene, L. C., Joner, G., Davis, E. A., Cinek, O., Rosenbauer, J., Ludvigsson, J., Castell, C., Svensson, J., Goldacre, M. J., et al. (2010) · Diabetologia · doi:10.1007/s00125-009-1648-5 · Cited by 126 · see citing works
Self-citationAllen, H. F., Klingensmith, G. J., Jensen, P., Simões, E. A. F., Hayward, A. R., & Chase, H. P. (1999) · Diabetes Care · doi:10.2337/diacare.22.10.1703 · Cited by 122 · see citing works
A viral epitope that mimics a self antigen can accelerate but not initiate autoimmune diabetes
Christen, U., Edelmann, K. H., McGavern, D. B., Wolfe, T., Coon, B., Teague, M. K., Miller, S. D., Oldstone, M. B. A., & von Herrath, M. G. (2004) · Journal of Clinical Investigation · doi:10.1172/jci22557 · Cited by 121 · see citing works
Why Diabetes Incidence Increases—A Unifying Theory
Ludvigsson, J. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1375.058 · Cited by 117 · see citing works
Self-citationβ cell ER stress and the implications for immunogenicity in type 1 diabetes
Marré, M. L., James, E. A., & Piganelli, J. D. (2015) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2015.00067 · Cited by 112 · see citing works
Psychological Stress May Induce Diabetes-Related Autoimmunity in Infancy
Sepa, A., Wahlberg, J., Vaarala, O., FRODI, A. M., & Ludvigsson, J. (2005) · Diabetes Care · doi:10.2337/diacare.28.2.290 · Cited by 112 · see citing works
Self-citationAddressing Parents’ Concerns: Do Vaccines Cause Allergic or Autoimmune Diseases?
Offit, P. A., & Hackett, C. J. (2003) · PEDIATRICS · doi:10.1542/peds.111.3.653 · Cited by 108 · see citing works
Jarosz-Chobot, P. A., Polańska, J., Szadkowska, A., Kretowski, A. J., Bandurska-Stankiewicz, E. M., Ciechanowska, M., Deja, G., Myśliwiec, M., Peczyńska, J., Rutkowska, J., et al. (2010) · Diabetologia · doi:10.1007/s00125-010-1993-4 · Cited by 106 · see citing works
Self-citation5′ terminal deletions in the genome of a coxsackievirus B2 strain occurred naturally in human heart
Chapman, N. M., Kim, K., Drescher, K. M., Oka, K., & Tracy, S. (2008) · Virology · doi:10.1016/j.virol.2008.02.030 · Cited by 106 · see citing works
Nygren, M., Carstensen, J., Koch, F.-S., Ludvigsson, J., & Frostell, A. (2015) · Diabetologia · doi:10.1007/s00125-015-3555-2 · Cited by 104 · see citing works
Self-citationLamb, M. M., Miller, M. R., Seifert, J. A., Frederiksen, B. N., Kroehl, M., Rewers, M., & Norris, J. M. (2014) · Pediatric Diabetes · doi:10.1111/pedi.12115 · Cited by 98 · see citing works
Self-citationVirtanen, S., Nevalainen, J., Kronberg-Kippilä, C., Ahonen, S., Tapanainen, H., Uusitalo, L., Takkinen, H., Niinistö, S., Ovaskainen, M., Kenward, M., et al. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.018879 · Cited by 98 · see citing works
Metabolic stress, <scp>IAPP</scp> and islet amyloid
Montane, J., Klimek‐Abercrombie, A., Potter, K. J., Westwell‐Roper, C., & Bruce Verchere, C. (2012) · Diabetes, Obesity and Metabolism · doi:10.1111/j.1463-1326.2012.01657.x · Cited by 98 · see citing works
Stene, L. C., & Rewers, M. (2011) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2011.04555.x · Cited by 90 · see citing works
Self-citationSöderström, U., Åman, J., & Hjern, A. (2012) · Acta Paediatrica · doi:10.1111/j.1651-2227.2011.02410.x · Cited by 88 · see citing works
Increasing incidence of IDDM a consequence of improved hygiene?
Kolb, H., & Elliott, R. B. (1994) · Diabetologia · doi:10.1007/bf00417700 · Cited by 84 · see citing works
Wahlberg, J., Vaarala, O., Ludvigsson, J., & the ABIS-study group (2006) · British Journal Of Nutrition · doi:10.1079/bjn20051676 · Cited by 84 · see citing works
Self-citationHolmberg, H., Wahlberg, J., Vaarala, O., Ludvigsson, J., & for the ABIS study group (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507210189 · Cited by 84 · see citing works
Self-citationSerum 25-hydroxyvitamin D level during early pregnancy and type 1 diabetes risk in the offspring
Miettinen, M. E., Reinert‐Hartwall, L., Kinnunen, L., Harjutsalo, V., Koskela, P. U., Surcel, H., Lamberg-Allardt, C. J. E., & Tuomilehto, J. O. (2012) · Diabetologia · doi:10.1007/s00125-012-2458-8 · Cited by 80 · see citing works
Chromogranin A is a T cell antigen in human type 1 diabetes
Gottlieb, P. A., Delong, T., Baker, R. L., Fitzgerald-Miller, L., Wagner, R., Cook, G., Rewers, M., Michels, A. W., & HASKINS, K. M. (2013) · Journal of Autoimmunity · doi:10.1016/j.jaut.2013.10.003 · Cited by 77 · see citing works
Self-citationLack of association between early childhood immunizations and beta-cell autoimmunity.
Graves, P. M., Barriga, K. J., Norris, J. M., Hoffman, M., Yu, L., Eisenbarth, G. S., & Rewers, M. (1999) · Diabetes Care · doi:10.2337/diacare.22.10.1694 · Cited by 76 · see citing works
Self-citationSepa, A., FRODI, A. M., & Ludvigsson, J. (2005) · Diabetes Care · doi:10.2337/diacare.28.10.2394 · Cited by 75 · see citing works
Self-citationNeonatal Bacille Calmette-Guerin Vaccination and Type 1 Diabetes
Huppmann, M., Baumgarten, A., Ziegler, A., & Bonifacio, E. E. (2005) · Diabetes Care · doi:10.2337/diacare.28.5.1204 · Cited by 72 · see citing works
Hummel, M., Bonifacio, E. E., Naserke, H. E., & Ziegler, A. G. (2002) · Diabetes Care · doi:10.2337/diacare.25.7.1111 · Cited by 69 · see citing works
Enteroviruses as causative agents in type 1 diabetes: loose ends or lost cause?
Morgan, N. G., & Richardson, S. J. (2014) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2014.08.002 · Cited by 63 · see citing works
Beyerlein, A., Chmiel, R., Hummel, S., Winkler, C., Bonifacio, E. E., & Ziegler, A. (2014) · Diabetes Care · doi:10.2337/dc14-1208 · Cited by 63 · see citing works
Larsson, H. E., Vehik, K., Haller, M. J., Liu, X., Akolkar, B., Hagopian, W., Krischer, J. P., Lernmark, Å., She, J., Simell, O., et al. (2016) · Diabetes · doi:10.2337/db15-1180 · Cited by 60 · see citing works
Self-citationBacille Calmette-Guérin Vaccination and Incidence of IDDM in Montreal, Canada
Parent, M., Siemiatycki, J., Menzies, R., Fritschi, L., & Colle, E. (1997) · Diabetes Care · doi:10.2337/diacare.20.5.767 · Cited by 60 · see citing works
Sané, F., Caloone, D., Gmyr, V., Engelmann, I., Belaich, S., Kerr-Conte, J. A., Pattou, F. N., Desailloud, R., & Hober, D. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1383-4 · Cited by 59 · see citing works
Elliott, J. F., Marlin, K. L., & Couch, R. (1998) · Diabetes Care · doi:10.2337/diacare.21.10.1691 · Cited by 59 · see citing works
Coppieters, K. T., Wiberg, A. O. J., Tracy, S., & von Herrath, M. G. (2011) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2011.04554.x · Cited by 57 · see citing works
Early infant feeding and risk of developing islet autoimmunity and type 1 diabetes
Chmiel, R., Beyerlein, A., Knopff, A., Hummel, S., Ziegler, A., & Winkler, C. (2014) · Acta Diabetologica · doi:10.1007/s00592-014-0628-5 · Cited by 56 · see citing works
Jin, N., Wang, Y., Crawford, F., White, J., Marrack, P., Dai, S., & Kappler, J. W. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1517862112 · Cited by 56 · see citing works
Requirements for Viral-mediated Autoimmune Diabetes: β-Cell Damage and Immune Infiltration
Horwitz, M. S., Fine, C., Ilic, A., & Sarvetnick, N. (2001) · Journal of Autoimmunity · doi:10.1006/jaut.2000.0486 · Cited by 54 · see citing works
Rasmussen, T., Witsø, E., Tapia, G., Stene, L. C., & Rønningen, K. S. (2011) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.1258 · Cited by 54 · see citing works
Zhao, H., Mold, M. D., Stenhouse, E., Bird, S. C., Wright, D., Demaine, A. G., & Millward, B. A. (2001) · Diabetic Medicine · doi:10.1046/j.1464-5491.2001.00554.x · Cited by 53 · see citing works
Maternal Enterovirus Infection as a Risk Factor for Type 1 Diabetes in the Exposed Offspring
Viskari, H., Knip, M., Tauriainen, S., Huhtala, H., Veijola, R., Ilonen, J., Simell, O., Surcel, H., & Hyöty, H. (2012) · Diabetes Care · doi:10.2337/dc11-2389 · Cited by 53 · see citing works
The cumulative incidence of childhood diabetes mellitus in Sweden unaffected by BCG-vaccination
Dahlquist, G., & Gothefors, L. (1995) · Diabetologia · doi:10.1007/bf03035306 · Cited by 52 · see citing works
Vaccinations and childhood type 1 diabetes mellitus: a meta-analysis of observational studies.
Morgan, E., Halliday, S. R., Campbell, G. R., Cardwell, C. R., & Patterson, C. C. (2016) · Diabetologia · doi:10.1007/s00125-015-3800-8 · Cited by 52 · see citing works
Oilinki, T., Otonkoski, T., Ilonen, J., Knip, M., & Miettinen, P. J. (2011) · Pediatric Diabetes · doi:10.1111/j.1399-5448.2011.00783.x · Cited by 51 · see citing works
Virtanen, S. M., Takkinen, H. ‐., Nevalainen, J., Kronberg‐Kippilä, C., Salmenhaara, M., Uusitalo, L., Kenward, M. G., Erkkola, M., Veijola, R., Simell, O., et al. (2011) · Diabetic Medicine · doi:10.1111/j.1464-5491.2011.03294.x · Cited by 50 · see citing works
Cardwell, C. R., Carson, D. J., & Patterson, C. C. (2008) · Diabetic Medicine · doi:10.1111/j.1464-5491.2007.02351.x · Cited by 47 · see citing works
Lamb, M. M., Yin, X., Barriga, K. J., Hoffman, M., Barón, A. E., Eisenbarth, G. S., Rewers, M., & Norris, J. M. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0886 · Cited by 46 · see citing works
Self-citationThe Belgian Diabetes Registry, Weets, I., Kaufman, L., der Auwera, B. J. R. V., Crenier, L., Rooman, R., Block, C. E. M. D., Casteels, K., Weber, E., Coeckelberghs, M., et al. (2004) · Diabetologia · doi:10.1007/s00125-004-1369-8 · Cited by 46 · see citing works
Enteroviruses and type 1 diabetes
Tracy, S., Drescher, K. M., & Chapman, N. M. (2011) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.1255 · Cited by 46 · see citing works
Virtanen, S. M., Niinistö, S., Nevalainen, J., Salminen, I., Takkinen, H. ‐., Kääriä, S.-M., Uusitalo, L., Alfthan, G., Kenward, M. G., Veijola, R., et al. (2010) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2010.75 · Cited by 45 · see citing works
Low zinc in drinking water is associated with the risk of type 1 diabetes in children
Samuelsson, U., Oikarinen, S., Hyöty, H., & Ludvigsson, J. (2010) · Pediatric Diabetes · doi:10.1111/j.1399-5448.2010.00678.x · Cited by 44 · see citing works
Self-citationZinc and nitrate in the ground water and the incidence of Type 1 diabetes in Finland
Moltchanova, E. V., Rytkönen, M., Kousa, A., Taskinen, O., Tuomilehto, J., & M. Karvonen for the Spat Study Group (2004) · Diabetic Medicine · doi:10.1111/j.1464-5491.2004.01125.x · Cited by 41 · see citing works
Discovery of a Selective Islet Peptidome Presented by the Highest-Risk HLA-DQ8trans Molecule
van Lummel, M., van Veelen, P. A., de Ru, A. H., Pool, J., Nikolić, T., Laban, S., Joosten, A. M., Drijfhout, J. W., Gomez-Touriño, I. M., Arif, S., et al. (2015) · Diabetes · doi:10.2337/db15-1031 · Cited by 41 · see citing works
Magnus, M. C., Olsen, S. F., Granström, C., Joner, G., Skrivarhaug, T., Svensson, J., Johannesen, J., Njølstad, P. R., Magnus, P. M., Størdal, K., et al. (2015) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2015.3759 · Cited by 39 · see citing works
Autoantigens: Novel forms and presentation to the immune system
Doyle, H. A., Yang, M., Raycroft, M. T., Gee, R. J., & Mamula, M. J. (2013) · Autoimmunity · doi:10.3109/08916934.2013.850495 · Cited by 37 · see citing works
Larsson, P. G., Lakshmikanth, T., Svedin, E., King, C. M., & Flodström‐Tullberg, M. (2013) · Diabetologia · doi:10.1007/s00125-013-2834-z · Cited by 33 · see citing works
Benson, V. S., VanLeeuwen, J. A., Taylor, J. P., Somers, G. S., McKinney, P. A., & Til, L. V. (2010) · Journal of the American College of Nutrition · doi:10.1080/07315724.2010.10719900 · Cited by 33 · see citing works
High Plasma Levels of Islet Amyloid Polypeptide in Young with New-Onset of Type 1 Diabetes Mellitus
Paulsson, J., Ludvigsson, J., Carlsson, A., Casas, R., Forsander, G., Ivarsson, S., Kockum, I., Lernmark, Å., Marcus, C., Lindblad, B., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093053 · Cited by 32 · see citing works
Self-citationNo evidence that vaccines cause insulin dependent diabetes mellitus.
Jefferson, T., & Demicheli, V. (1998) · Journal of Epidemiology & Community Health · doi:10.1136/jech.52.10.674 · Cited by 31 · see citing works
Frederiksen, B. N., Steck, A. K., Kroehl, M., Lamb, M. M., Wong, R., Rewers, M., & Norris, J. M. (2013) · Clinical and Developmental Immunology · doi:10.1155/2013/417657 · Cited by 30 · see citing works
Self-citationSørensen, I. M., Joner, G., Jenum, P. A., Eskild, A., & Stene, L. C. (2012) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2293 · Cited by 28 · see citing works
Seroconversion to Islet Autoantibodies After Enterovirus Infection in Early Pregnancy
Lindehammer, S. R., Honkanen, H., Nix, W. A., Oikarinen, M., Lynch, K. F., Jönsson, I., Maršál, K., Oberste, S. M., Hyöty, H., & Lernmark, Å. (2012) · Viral Immunology · doi:10.1089/vim.2012.0022 · Cited by 25 · see citing works
Winkler, C., Mollenhauer, U., Hummel, S., Bonifacio, E. E., & Ziegler, A. (2008) · Hormone and Metabolic Research · doi:10.1055/s-2008-1073165 · Cited by 25 · see citing works
Bacillus Calmette‐Guérin ( BCG ) Vaccination in Infancy and Risk of Childhood Diabetes
Rousseau, M., El‐Zein, M., Conus, F., Legault, L., & Parent, M. (2015) · Paediatric and Perinatal Epidemiology · doi:10.1111/ppe.12263 · Cited by 22 · see citing works
Brekke, H. K., & Ludvigsson, J. (2009) · Pediatric Diabetes · doi:10.1111/j.1399-5448.2009.00563.x · Cited by 21 · see citing works
Self-citationNitrate in Community Water Supplies and Risk of Childhood Type 1 Diabetes in Sardinia, Italy
Muntoni, S., Cocco, P., Muntoni, S., & Aru, G. (2006) · European Journal of Epidemiology · doi:10.1007/s10654-006-0014-x · Cited by 21 · see citing works
Smithee, S., Tracy, S., & Chapman, N. M. (2015) · Journal of Virology · doi:10.1128/jvi.01308-15 · Cited by 21 · see citing works
The beta‐cell in type 1 diabetes: What have we learned from proteomic studies?
Crèvecoeur, I., Rondas, D., Mathieu, C., & Overbergh, L. (2015) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201400135 · Cited by 20 · see citing works
Rewers, M. (2011) · Pediatric Diabetes · doi:10.1111/j.1399-5448.2011.00832.x · Cited by 10 · see citing works
Self-citationAssessing Age-Related Etiologic Heterogeneity in the Onset of Islet Autoimmunity
Frederiksen, B. N., Kroehl, M., Barón, A. E., Lamb, M. M., Crume, T., Sontag, M. K., Rewers, M., & Norris, J. M. (2015) · BioMed Research International · doi:10.1155/2015/708289 · Cited by 7 · see citing works
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Ong, K. L., Stafford, L. K., McLaughlin, S. A., Boyko, E. J., Vollset, S. E., Smith, A. E., Dalton, B. E., Duprey, J., Cruz, J. A., Hagins, H., et al. (2023) · The Lancet · doi:10.1016/s0140-6736(23)01301-6 · Cited by 4,681 · see citing works
DiMeglio, L. A., Evans-Molina, C., & Oram, R. A. (2018) · The Lancet · doi:10.1016/s0140-6736(18)31320-5 · Cited by 1,561 · see citing works
The human gut microbiome in early-onset type 1 diabetes from the TEDDY study
Vatanen, T., Franzosa, E. A., Schwager, R., Tripathi, S. M., Arthur, T. D., Vehik, K., Lernmark, Å., Hagopian, W., Rewers, M., She, J., et al. (2018) · Nature · doi:10.1038/s41586-018-0620-2 · Cited by 897 · see citing works
Self-citationMolecular mechanisms of ROS production and oxidative stress in diabetes
Newsholme, P., Cruzat, V. F., Keane, K. N., Carlessi, R., & de Bittencourt, P. I. H. (2016) · Biochemical Journal · doi:10.1042/bcj20160503c · Cited by 878 · see citing works
Xu, G., Liu, B., Sun, Y., Du, Y., Snetselaar, L., Hu, F. B., & Bao, W. (2018) · BMJ · doi:10.1136/bmj.k1497 · Cited by 549 · see citing works
The heterogeneous pathogenesis of type 1 diabetes mellitus
Ilonen, J., Lempainen, J., & Veijola, R. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0254-y · Cited by 497 · see citing works
Navegantes, K. C., Gomes, R. D. S., Pereira, P. A., Czaikoski, P. G., Azevedo, C., & Monteiro, M. (2017) · Journal of Translational Medicine · doi:10.1186/s12967-017-1141-8 · Cited by 340 · see citing works
Gut Microbiota Regulation of T Cells During Inflammation and Autoimmunity
Brown, E., Kenny, D. J., & Xavier, R. J. (2019) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042718-041841 · Cited by 310 · see citing works
Robertson, C. C., Inshaw, J. R. J., Onengut-Gumuscu, S., Chen, W.-M., Santa Cruz, D. F., Yang, H., Cutler, A. J., Crouch, D. J. M., Farber, E., Bridges, S. L., et al. (2021) · Nature Genetics · doi:10.1038/s41588-021-00880-5 · Cited by 302 · see citing works
Self-citationInfluence of Vitamin D on Islet Autoimmunity and Beta-Cell Function in Type 1 Diabetes
Infante, M., Ricordi, C., Sanchez, J. E., Clare-Salzler, M. J., Padilla, N., Fuenmayor, V., Chavez, C., Alvarez, A., Baidal, D. A., Alejandro, R., et al. (2019) · Nutrients · doi:10.3390/nu11092185 · Cited by 275 · see citing works
Experimental animal models for diabetes and its related complications—a review
Kottaisamy, C. P. D., Raj, D. S., Kumar, V., & Umamaheswari, S. (2021) · Laboratory Animal Research · doi:10.1186/s42826-021-00101-4 · Cited by 265 · see citing works
Gea, I. L., Sánchez‐Alcoholado, L., Tejedor, B. M., Castellano‐Castillo, D., Moreno‐Indias, I., Urda-Cardona, A., Tinahones, F. J., Fernández‐García, J. C., & Queipo‐Ortuño, M. I. (2018) · Diabetes Care · doi:10.2337/dc18-0253 · Cited by 253 · see citing works
Treatment strategies against diabetes: Success so far and challenges ahead.
Khursheed, R., Singh, S. K., Wadhwa, S., Kapoor, B., Gulati, M., Kumar, R., Ramanunny, A. K., Awasthi, A., & Dua, K. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.172625 · Cited by 239 · see citing works
Vatanen, T., Plichta, D. R., Somani, J., Münch, P. C., Arthur, T. D., Hall, A. B., Rudolf, S., Oakeley, E. J., Ke, X., Young, R. A., et al. (2018) · Nature Microbiology · doi:10.1038/s41564-018-0321-5 · Cited by 216 · see citing works
Kobayashi, N., Takahashi, D., Takano, S., Kimura, S., & Hase, K. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02345 · Cited by 224 · see citing works
NOD1 and NOD2 in inflammatory and infectious diseases
Trindade, B. C., & Chen, G. (2020) · Immunological Reviews · doi:10.1111/imr.12902 · Cited by 214 · see citing works
Gut Microbiota and Type 1 Diabetes
Han, H., Li, Y., Fang, J., Liu, G., Yin, J., Li, T., & Yin, Y. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19040995 · Cited by 206 · see citing works
Chung, W. K., Erion, K., Florez, J. C., Hattersley, A. T., Hivert, M.-F., Lee, C. G., McCarthy, M. I., Nolan, J. J., Norris, J. M., Pearson, E. R., et al. (2020) · Diabetologia · doi:10.1007/s00125-020-05181-w · Cited by 203 · see citing works
Genetic risk for autoimmunity is associated with distinct changes in the human gut microbiome
Russell, J. T., Roesch, L. F. W., Ördberg, M., Ilonen, J., Atkinson, M. A., Schatz, D., Triplett, E. W., & Ludvigsson, J. (2019) · Nature Communications · doi:10.1038/s41467-019-11460-x · Cited by 203 · see citing works
Self-citationEarly prediction of autoimmune (type 1) diabetes.
Regnell, S. E., & Lernmark, Å. (2017) · Diabetologia · doi:10.1007/s00125-017-4308-1 · Cited by 195 · see citing works
The clinical consequences of heterogeneity within and between different diabetes types
REDONDO, M. J., Hagopian, W., Oram, R. A., Steck, A. K., Vehik, K., Weedon, M. N., Balasubramanyam, A., & Dabelea, D. (2020) · Diabetologia · doi:10.1007/s00125-020-05211-7 · Cited by 195 · see citing works
Gut microbiota and diabetes: From correlation to causality and mechanism
Li, W., Stirling, K., Yang, J., & Zhang, L. (2020) · World Journal of Diabetes · doi:10.4239/wjd.v11.i7.293 · Cited by 187 · see citing works
Intestinal Microbiota Influences Non-intestinal Related Autoimmune Diseases
Opazo, M. C., Ortega-Rocha, E. M., Coronado-Arrázola, I., Bonifaz, L. C., Boudin, H., Neunlist, M., Bueno, S. M., Kalergis, A. M., & Riedel, C. A. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00432 · Cited by 179 · see citing works
The Role of the Gut Microbiota in the Pathogenesis of Diabetes
Bielka, W., Przezak, A., & Pawlik, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23010480 · Cited by 184 · see citing works
Ma, Q., Li, Y., Wang, J., Li, P., Duan, Y., Dai, H., An, Y., Cheng, L., Wang, T., Wang, C., et al. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.109873 · Cited by 174 · see citing works
Zhang, C., Han, X., Yang, L., Fu, J., Sun, C., Huang, S., Xiao, W., Gao, Y., Liang, Q., Wang, X., et al. (2020) · Theranostics · doi:10.7150/thno.48264 · Cited by 171 · see citing works
Diagnosis and treatment of type 1 diabetes at the dawn of the personalized medicine era
Akil, A. A., Yassin, E., Al-Maraghi, A., ALIYEV, E. E., Al-Malki, K., & Fakhro, K. A. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-02778-6 · Cited by 184 · see citing works
The Role of Gut Microbiota and Environmental Factors in Type 1 Diabetes Pathogenesis
Dedrick, S., Sundaresh, B., Huang, Q., Brady, C., Yoo, T., Cronin, C. T., Rudnicki, C., Flood, M., Momeni, B., Ludvigsson, J., et al. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00078 · Cited by 164 · see citing works
Self-citationCannas, D., Loi, E., Serra, M., Firinu, D., Valera, P., & Zavattari, P. (2020) · Nutrients · doi:10.3390/nu12072074 · Cited by 169 · see citing works
Rahmati, M., Keshvari, M., Mirnasuri, S., Yon, D. K., Lee, S. W., Shin, J. I., & Smith, L. (2022) · Journal of Medical Virology · doi:10.1002/jmv.27996 · Cited by 164 · see citing works
Zhang, B., Zhai, M., Li, B., Liu, Z., Li, K., Jiang, L., Zhang, M., Yi, W., Yang, J. Z., Yi, D., et al. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/3159801 · Cited by 158 · see citing works
Gavin, P. G., Mullaney, J. A., Loo, D., Cao, K. L., Gottlieb, P. A., Hill, M. M. C., Zipris, D., & Hamilton‐Williams, E. E. (2018) · Diabetes Care · doi:10.2337/dc18-0777 · Cited by 148 · see citing works
A combined risk score enhances prediction of type 1 diabetes among susceptible children
Ferrat, L. A., Vehik, K., Sharp, S. A., Lernmark, Å., Rewers, M. J., She, J.-X., Ziegler, A.-G., Toppari, J., Akolkar, B., Krischer, J. P., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0930-4 · Cited by 148 · see citing works
Self-citationCouper, J., Haller, M. J., Greenbaum, C. J., Ziegler, A., Wherrett, D. K., Knip, M., & Craig, M. E. (2018) · Pediatric Diabetes · doi:10.1111/pedi.12734 · Cited by 146 · see citing works
Persistent coxsackievirus B infection and pathogenesis of type 1 diabetes mellitus
Nekoua, M. P., Alidjinou, E. K., & Hober, D. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00688-1 · Cited by 141 · see citing works
Evidence-based update on rosacea comorbidities and their common physiologic pathways
Holmes, A. D., Spoendlin, J., Chien, A. L.-L., Baldwin, H. E., & Chang, A. L. S. (2017) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2017.07.055 · Cited by 142 · see citing works
Current understandings of the pathogenesis of type 1 diabetes: genetics to environment
Giwa, A. M., Ahmed, R., Omidian, Z., Majety, N., Karakus, K. E., Omer, S. M., Donner, T., & Hamad, A. R. A. (2020) · World Journal of Diabetes · doi:10.4239/wjd.v11.i1.13 · Cited by 137 · see citing works
The Environmental Determinants of Diabetes in the Young (TEDDY) Study: 2018 Update
the TEDDY Study Group, Rewers, M., Hyöty, H., Lernmark, Å., Hagopian, W., She, J., Schatz, D., Ziegler, A., Toppari, J., Akolkar, B., et al. (2018) · Current Diabetes Reports · doi:10.1007/s11892-018-1113-2 · Cited by 136 · see citing works
Self-citationAtkinson, M. A., & Mirmira, R. G. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.06.018 · Cited by 135 · see citing works
Probiotics and prebiotics for the amelioration of type 1 diabetes: Present and future perspectives
Mishra, S., Wang, S., Nagpal, R., Miller, B., Singh, R., Taraphder, S., & Yadav, H. (2019) · Microorganisms · doi:10.3390/microorganisms7030067 · Cited by 131 · see citing works
Incidence of Diabetes in Children and Adolescents During the COVID-19 Pandemic
D'Souza, D. M., Empringham, J., Pechlivanoglou, P., Uleryk, E. M., Cohen, E., & Shulman, R. M. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.21281 · Cited by 131 · see citing works
Frazzei, G., van Vollenhoven, R., de Jong, B. A., Siegelaar, S. E., & van Schaardenburg, D. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.899372 · Cited by 125 · see citing works
Marine Organisms with Anti-Diabetes Properties
Lauritano, C., & Ianora, A. (2016) · Marine Drugs · doi:10.3390/md14120220 · Cited by 122 · see citing works
Pathophysiology of Type 1 Diabetes and Gut Microbiota Role
CHIERICO, F. D., Rapini, N., Deodati, A., Matteoli, M. C., Cianfarani, S., & Putignani, L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232314650 · Cited by 123 · see citing works
Runthala, A., Mbye, M., Ayyash, M. M., Xu, Y., & Kamal‐Eldin, A. (2023) · Molecules · doi:10.3390/molecules28052023 · Cited by 119 · see citing works
Etiology and Pathogenesis of Latent Autoimmune Diabetes in Adults (LADA) Compared to Type 2 Diabetes
Carlsson, S. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00320 · Cited by 115 · see citing works
Partners in Crime: Beta-Cells and Autoimmune Responses Complicit in Type 1 Diabetes Pathogenesis
Toren, E., Burnette, K., Banerjee, R. R., Hunter, C. S., & Tse, H. M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.756548 · Cited by 110 · see citing works
Yu, L., Di, W., Dong, X., Li, Z., Zhang, Y., Xue, X., Xu, Y., Zhang, J., Xiao, X., Han, J., et al. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.11.023 · Cited by 109 · see citing works
Rak, K., & Bronkowska, M. (2018) · Molecules · doi:10.3390/molecules24010053 · Cited by 106 · see citing works
Wang, C., Yen, H., Lu, W., Ho, H.-H., Lin, W., Kuo, Y., Huang, Y.-Y., Tsai, S., & Lin, H. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.754401 · Cited by 108 · see citing works
Mazur, A., Frączek, P., & Tabarkiewicz, J. (2022) · Nutrients · doi:10.3390/nu14204286 · Cited by 106 · see citing works
T cell receptor β-chains display abnormal shortening and repertoire sharing in type 1 diabetes
Gomez-Touriño, I. M., Kamra, Y., Baptista, R., Lorenc, A., & Peakman, M. (2017) · Nature Communications · doi:10.1038/s41467-017-01925-2 · Cited by 99 · see citing works
Zhu, M., Xu, K., Chen, Y., Gu, Y., Zhang, M., Luo, F., Liu, Y., Gu, W., Hu, J., Xu, H., et al. (2019) · Diabetes Care · doi:10.2337/dc18-2023 · Cited by 100 · see citing works
Große, J., Hornstein, H., Manuwald, U., Kügler, J., Glauche, I., & Rothe, U. (2018) · Hormone and Metabolic Research · doi:10.1055/s-0044-102090 · Cited by 99 · see citing works
A1 beta-casein milk protein and other environmental pre-disposing factors for type 1 diabetes
Chia, J. S., McRae, J. L., Kukuljan, S., Woodford, K. B., Elliott, R. B., Swinburn, B. A., & Dwyer, K. M. (2017) · Nutrition and Diabetes · doi:10.1038/nutd.2017.16 · Cited by 100 · see citing works
Type 1 diabetes genome‐wide association studies: not to be lost in translation
Pociot, F. (2017) · Clinical & Translational Immunology · doi:10.1038/cti.2017.51 · Cited by 95 · see citing works
Changing the landscape for type 1 diabetes: the first step to prevention
Dayan, C. M., Korah, M., Tatovic, D., Bundy, B. N., & Herold, K. C. (2019) · The Lancet · doi:10.1016/s0140-6736(19)32127-0 · Cited by 96 · see citing works
Bełtowski, J., Wójcicka, G., & Jamróz-Wiśniewska, A. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.01.004 · Cited by 95 · see citing works
An Insight Into the Intestinal Web of Mucosal Immunity, Microbiota, and Diet in Inflammation
Yap, Y. A., & Mariño, E. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02617 · Cited by 97 · see citing works
McKeigue, P., McGurnaghan, S. J., Blackbourn, L. A. K., Bath, L., McAllister, D., Caparrotta, T. M., Wild, S. H., Wood, S. N., Stockton, D., & Colhoun, H. M. (2022) · Diabetes Care · doi:10.2337/dc22-0385 · Cited by 94 · see citing works
Role of Vitamin D in Preventing and Treating Selected Extraskeletal Diseases—An Umbrella Review
Maretzke, F., Bechthold, A., Egert, S., Ernst, J. B., van Lent, D. M., Pilz, S., Reichrath, J., Stangl, G. I., Stehle, P., Volkert, D., et al. (2020) · Nutrients · doi:10.3390/nu12040969 · Cited by 91 · see citing works
Blotsky, A., Rahme, E., Dahhou, M., Nakhla, M. M., & Dasgupta, K. (2019) · Canadian Medical Association Journal · doi:10.1503/cmaj.181001 · Cited by 89 · see citing works
The Role of Epigenetics in Type 1 Diabetes
Jerram, S. T., Dang, M. N., & Leslie, R. D. (2017) · Current Diabetes Reports · doi:10.1007/s11892-017-0916-x · Cited by 85 · see citing works
Beneficial Effects of Milk Having A2 β-Casein Protein: Myth or Reality?
Kay, S.-I. S., Delgado, S., Mittal, J., Eshraghi, R. S., Mittal, R., & Eshraghi, A. A. (2020) · Journal of Nutrition · doi:10.1093/jn/nxaa454 · Cited by 83 · see citing works
Stem-cell based organ-on-a-chip models for diabetes research
Rogal, J., Zbinden, A., Schenke‐Layland, K., & Loskill, P. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.10.010 · Cited by 83 · see citing works
Environmental Determinants of Type 1 Diabetes: From Association to Proving Causality
Quinn, L. M., Wong, F. S., & Narendran, P. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.737964 · Cited by 84 · see citing works
Tetz, G. V., Brown, S. M., Hao, Y., & Tetz, V. (2019) · Scientific Reports · doi:10.1038/s41598-019-46087-x · Cited by 77 · see citing works
BCG turns 100: its nontraditional uses against viruses, cancer, and immunologic diseases
Singh, A. K., Netea, M. G., & Bishai, W. R. (2021) · Journal of Clinical Investigation · doi:10.1172/jci148291 · Cited by 76 · see citing works
Stress and Diabetes Mellitus: Pathogenetic Mechanisms and Clinical Outcome
Ingrosso, D. M. F., Primavera, M., Samvelyan, S., Tagi, V. M., & Chiarelli, F. (2022) · Hormone Research in Paediatrics · doi:10.1159/000522431 · Cited by 86 · see citing works
Vitamin-D concentrations, cardiovascular risk and events - a review of epidemiological evidence
Grübler, M. R., März, W., Pilz, S., Grammer, T. B., Trummer, C., Müllner, C., Theiler‐Schwetz, V., Pandis, M., Verheyen, N., Tomaschitz, A., et al. (2017) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-017-9417-0 · Cited by 75 · see citing works
Robertson, C. C., & Rich, S. S. (2018) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2018.01.006 · Cited by 72 · see citing works
Psychological stress and type 1 diabetes mellitus: what is the link?
Sharif, Κ., Watad, ., Coplan, L., Amital, H., Shoenfeld, Y., & Afek, A. B. (2018) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2018.1538787 · Cited by 71 · see citing works
Gastrointestinal Microbiota and Type 1 Diabetes Mellitus: The State of Art
Durazzo, M., Ferro, A., & Gruden, G. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8111843 · Cited by 72 · see citing works
Environmental Factors and the Risk of Developing Type 1 Diabetes—Old Disease and New Data
Zorena, K., Michalska, M., Kurpas, M., Jaskulak, M., Murawska, A., & Rostami, S. (2022) · Biology · doi:10.3390/biology11040608 · Cited by 80 · see citing works
The oral microbiome in autoimmune diseases: friend or foe?
Huang, X., Huang, X., Huang, Y., Zheng, J., Ye, L., Mai, Z., Zhao, X., Cui, L., & Huang, S. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-03995-x · Cited by 74 · see citing works
Rotavirus-related systemic diseases: clinical manifestation, evidence and pathogenesis
Dian, Z., Sun, Y., Zhang, G., Xu, Y. J., Fan, X., Yang, X., Pan, Q., Peppelenbosch, M. P., & Miao, Z. (2021) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2021.1907738 · Cited by 69 · see citing works
Kunath, B. J., Hickl, O., Queirós, P., Martin‐Gallausiaux, C., Lebrun, L., Halder, R., Laczny, C. C., Schmidt, T., Hayward, M. R., Becher, D., et al. (2022) · Microbiome · doi:10.1186/s40168-022-01435-4 · Cited by 69 · see citing works
The Genetic Contribution to Type 1 Diabetes
Bakay, M. A., Pandey, R., Grant, S. F. A., & Hakonarson, H. H. (2019) · Current Diabetes Reports · doi:10.1007/s11892-019-1235-1 · Cited by 67 · see citing works
Epigenetic Regulation in Etiology of Type 1 Diabetes Mellitus
Černá, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms21010036 · Cited by 66 · see citing works
Developmental Exposure to Endocrine Disrupting Chemicals and Type 1 Diabetes Mellitus
Howard, S. G. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00513 · Cited by 64 · see citing works
Javid, A. Z., Aminzadeh, M., Haghighizadeh, M. H., & Jamalvandi, M. (2020) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s238867 · Cited by 65 · see citing works
LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus
Cobo‐Vuilleumier, N., Lorenzo, P. I., Rodríguez, N. G., Herrera-Gómez, I. D. G., Fuente-Martín, E., López–Noriega, L., Mellado‐Gil, J. M., Romero‐Zerbo, S., Baquié, M., Lachaud, C. C., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03943-0 · Cited by 65 · see citing works
Kinin receptors: Key regulators of autoimmunity
Dutra, R. C. (2016) · Autoimmunity Reviews · doi:10.1016/j.autrev.2016.12.011 · Cited by 63 · see citing works
Gomber, A., Ward, Z. J., Ross, C., Owais, M., Mita, C., Yeh, J. M., Reddy, C. L., & Atun, R. A. (2022) · PLOS Global Public Health · doi:10.1371/journal.pgph.0001099 · Cited by 62 · see citing works
Knobler, R., Arenberger, P., Arun, A., Assaf, C., Bagot, M., Berlin, G., Bohbot, A., Calzavara‐Pinton, P., Child, F. J., Cho, A., et al. (2020) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.16889 · Cited by 63 · see citing works
Self-citationMustonen, N., Siljander, H., Peet, A., Tillmann, V., Härkönen, T., Ilonen, J., Hyöty, H., Knip, M., & The DIABIMMUNE Study Group (2017) · Pediatric Diabetes · doi:10.1111/pedi.12547 · Cited by 61 · see citing works
Stone, V. M., Hankaniemi, M. M., Svedin, E., Sioofy‐Khojine, A., Oikarinen, S., Hyöty, H., Laitinen, O. H., Hytönen, V. P., & Flodström‐Tullberg, M. (2017) · Diabetologia · doi:10.1007/s00125-017-4492-z · Cited by 61 · see citing works
Lampousi, A., Carlsson, S., & Löfvenborg, J. E. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103633 · Cited by 61 · see citing works
Longitudinal DNA methylation differences precede type 1 diabetes
Johnson, R. K., Vanderlinden, L., Dong, F., Carry, P., Seifert, J., Waugh, K., Shorrosh, H., Fingerlin, T., Frohnert, B., Yang, I. V., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-60758-0 · Cited by 50 · see citing works
Self-citationGut Microbiota and Type 1 Diabetes Mellitus: The Effect of Mediterranean Diet
Calabrese, C. M., Valentini, A., & Calabrese, G. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2020.612773 · Cited by 58 · see citing works
Promising role of medicinal plants in the regulation and management of male erectile dysfunction
Masuku, N. P., Unuofin, J. O., & Lebelo, S. L. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110555 · Cited by 57 · see citing works
Mahlknecht, J., Torres-Martínez, J. A., Kumar, M., Mora, A., Kaown, D., & Loge, F. J. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.166863 · Cited by 55 · see citing works
Type 1 diabetes in Sardinia: facts and hypotheses in the context of worldwide epidemiological data
Songini, M., Mannu, C., Targhetta, C., & Bruno, G. (2016) · Acta Diabetologica · doi:10.1007/s00592-016-0909-2 · Cited by 55 · see citing works
Anti-diabetics and antimicrobials: Harmony of mutual interplay
Hegazy, W. A. H., Rajab, A. A. H., Lila, A. S. A., & Abbas, H. A. (2021) · World Journal of Diabetes · doi:10.4239/wjd.v12.i11.1832 · Cited by 54 · see citing works
Goldacre, R. (2017) · Diabetologia · doi:10.1007/s00125-017-4493-y · Cited by 53 · see citing works
Blanter, M., Sork, H., Tuomela, S., & Flodström‐Tullberg, M. (2019) · Current Diabetes Reports · doi:10.1007/s11892-019-1192-8 · Cited by 50 · see citing works
Targeting the receptor for advanced glycation end products (RAGE) in type 1 diabetes
Bagge, S. L., Fotheringham, A. K., Leung, S. S., & Forbes, J. M. (2020) · Medicinal Research Reviews · doi:10.1002/med.21654 · Cited by 51 · see citing works
Impact of obesity on the increasing incidence of type 1 diabetes
Buzzetti, R., Zampetti, S., & Pozzilli, P. (2020) · Diabetes Obesity and Metabolism · doi:10.1111/dom.14022 · Cited by 52 · see citing works
Past, present and future of latent autoimmune diabetes in adults
Liu, B., Xiang, Y., Liu, Z., & Zhou, Z. (2020) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3205 · Cited by 50 · see citing works
Dietary Cows’ Milk Protein A1 Beta-Casein Increases the Incidence of T1D in NOD Mice
Chia, J. S., McRae, J. L., Enjapoori, A. K., Lefèvre, C. M., Kukuljan, S., & Dwyer, K. M. (2018) · Nutrients · doi:10.3390/nu10091291 · Cited by 52 · see citing works
- Authors
- Rewers, M., & Ludvigsson, J.
- Affiliations
- University of Colorado Anschutz (US)
- Linköping University (SE)
- Corresponding author
- Ludvigsson, Johnny
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2016-06
- Volume
- 387
- Issue
- 10035
- Pages
- 2340-2348
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- PMC
- PMC5571740
- OpenAlex
- W2416473596
- Semantic Scholar
- cfb08c15990c940ca28c917c4b6cd3743c3d269c
- Cited by
- 676
- References
- 136
- Citations by year
- 2026: 29 · 2025: 49 · 2024: 75 · 2023: 83 · 2022: 94 · 2021: 84 · 2020: 88 · 2019: 53 · 2018: 69 · 2017: 45 · 2016: 7
- FWCI
- 7.81
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 32493, R01DK032493, R37DK032493)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- type 1 diabetes, environmental risk factors, islet autoimmunity, disease incidence, hybrid peptides, environmental exposure
- MeSH terms
- Animals, Autoantigens, Birth Weight, Breast Feeding, Diabetes Mellitus, Type 1, Diet, Environment, Fatty Acids, Unsaturated, Growth, Humans, Hygiene, Infant, Infant Food, Milk, Risk Factors, RNA, Toxins, Biological, Vaccines, Vitamin D, Autoimmunity, Insulin-Secreting Cells
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