The AIM2 inflammasome is critical for innate immunity to Francisella tularensis

Pathogen Recognition and Innate Immunity

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Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

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Cryopyrin activates the inflammasome in response to toxins and ATP

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Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

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AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

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The NALP3 inflammasome is involved in the innate immune response to amyloid-β

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The Inflammasomes: Guardians of the Body

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Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

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AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

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Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1β in salmonella-infected macrophages

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ASC Controls IFN-γ Levels in an IL-18–Dependent Manner in Caspase-1–Deficient Mice Infected with Francisella novicida

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Chemotherapeutic Agent Paclitaxel Mediates Priming of NLRP3 Inflammasome Activation

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Bacterial secretion systems and regulation of inflammasome activation

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New insights into nucleic acid sensor AIM2: The potential benefit in targeted therapy for cancer

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Aim2 Deficiency in Mice Suppresses the Expression of the Inhibitory Fcγ Receptor (FcγRIIB) through the Induction of the IFN-Inducible p202, a Lupus Susceptibility Protein

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The expression and activation of the AIM2 inflammasome correlates with inflammation and disease severity in patients with acute pancreatitis

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Francisella Recognition by Inflammasomes: Differences between Mice and Men

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Inflammasome-Independent NLRP3 Restriction of a Protective Early Neutrophil Response to Pulmonary Tularemia

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Cytosolic Nucleic Acid Sensors in Inflammatory and Autoimmune Disorders

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Correlation of AIM2 expression in peripheral blood mononuclear cells from humans with acute and chronic hepatitis B

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Gene silencing of non-obese diabetic receptor family (NLRP3) protects against the sepsis-induced hyper-bile acidaemia in a rat model

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A tug-of-war between the host and the pathogen generates strategic hotspots for the development of novel therapeutic interventions against infectious diseases

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Manipulation of the host cell death pathway byShigella

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The inflammasome regulatory pathway and infections: Role in pathophysiology and clinical implications

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Artemisia Extract Suppresses NLRP3 and AIM2 Inflammasome Activation by Inhibition of ASC Phosphorylation

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Updates on autoinflammatory diseases

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STING1 in sepsis: Mechanisms, functions, and implications

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USP21 Deubiquitinase Regulates AIM2 Inflammasome Activation

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Neutrophils Facilitate Prolonged Inflammasome Response in the DAMP-Rich Inflammatory Milieu

Son, S., Yoon, S.-H., Chae, B. J., Hwang, I., Shim, D.-W., Choe, Y. H., Hyun, Y., & Yu, J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.746032 · Cited by 34

The Role of Nucleic Acid Sensing in Controlling Microbial and Autoimmune Disorders

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Regulation and Sensing of Inflammasomes and Their Impact on Intestinal Health

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Technical Advance: caspase-1 activation and IL-1β release correlate with the degree of lysosome damage, as illustrated by a novel imaging method to quantify phagolysosome damage

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Zinc Acquisition Mechanisms Differ between Environmental and Virulent Francisella Species

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Absent in melanoma 2 inflammasome is required for host defence against Streptococcus pneumoniae infection

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The Goldilocks Conundrum: NLR Inflammasome Modulation of Gastrointestinal Inflammation during Inflammatory Bowel Disease

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The Inflammasome: Regulation of Nitric Oxide and Antimicrobial Host Defence

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Discordant Results Obtained with Francisella tularensis during In Vitro and In Vivo Immunological Studies Are Attributable to Compromised Bacterial Structural Integrity

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Strategies Used by Bacteria to Grow in Macrophages

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Mucosal co-immunization with AIM2 enhances protective SIgA response and increases prophylactic efficacy of chitosan-DNA vaccine against coxsackievirus B3-induced myocarditis

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A galU mutant of francisella tularensisis attenuated for virulence in a murine pulmonary model of tularemia

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Host inflammatory responses to intracellular invaders: Review study

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Anti-inflammatory effect of Impatiens textori Miq. extract via inhibition of NLRP3 inflammasome activation in in vitro and in vivo experimental models

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Inflammasomes in Myeloid Cells: Warriors Within

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Inflammasome biology taught by Legionella pneumophila

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Beneficial properties of mucus in coral adaptations and ecological interactions

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Detection of cytosolic bacteria by inflammatory caspases

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Progress in understanding the role of cGAS-STING pathway associated with programmed cell death in intervertebral disc degeneration

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Inflammasome gene expression is associated with immunopathology in human localized cutaneous leishmaniasis

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Francisella Subverts Innate Immune Signaling: Focus On PI3K/Akt

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Intracellular sensing of viral DNA by the innate immune system

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Importance of PdpC, IglC, IglI, and IglG for Modulation of a Host Cell Death Pathway Induced by Francisella tularensis

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Genome-Wide RNAi Screen in IFN-γ-Treated Human Macrophages Identifies Genes Mediating Resistance to the Intracellular Pathogen Francisella tularensis

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Protection induced by a Francisella tularensis subunit vaccine delivered by glucan particles

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Mycobacterium tuberculosis stimulates IL-1β production by macrophages in an ESAT-6 dependent manner with the involvement of serum amyloid A3

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Distinct axial and lateral interactions within homologous filaments dictate the signaling specificity and order of the AIM2-ASC inflammasome

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Antimicrobial drimane sesquiterpenes and their effect on endophyte communities in the medical tree Warburgia ugandensis

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Epigallocatechin-3-gallate attenuates the AIM2-induced secretion of IL-1β in human epidermal keratinocytes

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Bacterial Secretant from Pseudomonas aeruginosa Dampens Inflammasome Activation in a Quorum Sensing-Dependent Manner

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From fat to fire: The lipid–inflammasome connection

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The Interplay between Salmonella enterica Serovar Typhimurium and the Intestinal Mucosa during Oral Infection

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Atypical Inflammasomes

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Structural mechanism of DNA recognition by the p202 HINa domain: insights into the inhibition of Aim2-mediated inflammatory signalling

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General Strategies in Inflammasome Biology

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Inflammasome and Cognitive Symptoms in Human Diseases: Biological Evidence from Experimental Research

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Innate DNA Sensing Moves to the Nucleus

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Protective and detrimental roles of inflammasomes in disease

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An optimized whole blood assay measuring expression and activity of NLRP3, NLRC4 and AIM2 inflammasomes

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Fas/CD95 Signaling Pathway in Damage-Associated Molecular Pattern (DAMP)-Sensing Receptors

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Identification of AIM2 as a downstream target of JAK2V617F

Liew, E. L., Araki, M., Hironaka, Y., Mori, S., Tan, T. Z., Morishita, S., Edahiro, Y., Ohsaka, A., & Komatsu, N. (2015) · Experimental Hematology and Oncology · doi:10.1186/s40164-016-0032-7 · Cited by 22

Francisella Inflammasomes: Integrated Responses to a Cytosolic Stealth Bacterium

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AIMing 2 defend against intracellular pathogens

Krieg, A. Μ. (2010) · Nature Immunology · doi:10.1038/ni0510-367 · Cited by 22

Host-pathogen protein-nucleic acid interactions: A comprehensive review

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Discovery of Bakuchiol as Aim2 Inflammasome Activator and Cause Hepatotoxicity

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Filament assembly underpins the double-stranded DNA specificity of AIM2-like receptors

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Potential roles of inflammasomes in the pathophysiology of Psoriasis: A comprehensive review

Shahi, A., Afzali, S., Amirzargar, A., Mohaghegh, P., Salehi, S., & Mansoori, Y. (2023) · Molecular Immunology · doi:10.1016/j.molimm.2023.06.007 · Cited by 21

Pyrin Domain (PYD)-containing Inflammasome in Innate Immunity

Hong, S., Park, S., & Yu, J. (2011) · Journal of Bacteriology and Virology · doi:10.4167/jbv.2011.41.3.133 · Cited by 25

Comparative Phosphoproteomics Reveals Components of Host Cell Invasion and Post-transcriptional Regulation During Francisella Infection

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Juniperus rigida Sieb. extract inhibits inflammatory responses via attenuation of TRIF-dependent signaling and inflammasome activation

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Pyrin-only protein 2 limits inflammation but improves protection against bacteria

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Ubiquitination-Mediated Inflammasome Activation during Bacterial Infection

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Innate immune sensing of nucleic acids from mycobacteria

Yamashiro, L. H., Oliveira, S. C., & Báfica, A. L. B. (2014) · Microbes and Infection · doi:10.1016/j.micinf.2014.09.006 · Cited by 21

Immune System of Dental Pulp in Inflamed and Normal Tissue

Sarfi, S., Azaryan, E., & Naseri, M. (2024) · DNA and Cell Biology · doi:10.1089/dna.2024.0044 · Cited by 21

FcγR mediates TLR2- and Syk-dependent NLRP3 inflammasome activation by inactivated Francisella tularensis LVS immune complexes

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The absent in melanoma 2 (AIM2) inflammasome in microbial infection

Zhu, W., Zu, X., Liu, S., & Zhang, H. (2019) · Clinica Chimica Acta · doi:10.1016/j.cca.2019.04.052 · Cited by 20

Structural mechanism of DNA recognition by the p204 HIN domain

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Pyroptosis: A Caspase-1-Dependent Programmed Cell Death and a Barrier to Infection

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Overview of pyroptosis mechanism and in-depth analysis of cardiomyocyte pyroptosis mediated by NF-κB pathway in heart failure

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Caspase-1 activity affects AIM2 speck formation/stability through a negative feedback loop

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Measuring Inflammasome Activation in Response to Bacterial Infection

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Cellular Exit Strategies of Intracellular Bacteria

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Inflammasome Priming Is Similar for Francisella Species That Differentially Induce Inflammasome Activation

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The NLRP3 inflammasome in age-related eye disease: Evidence-based connexin hemichannel therapeutics

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Calycosin represses AIM2 inflammasome‐mediated inflammation and pyroptosis to attenuate monosodium urate‐induced gouty arthritis through NF‐κB and p62‐Keap1 pathways

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Absent in Melanoma 2 (AIM2) limits pro-inflammatory cytokine transcription in cardiomyocytes by inhibiting STAT1 phosphorylation

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Summary

(2016)

Sensing Cytoplasmic Danger Signals by the Inflammasome

Alnemri, E. S. (2010) · Journal of Clinical Immunology · doi:10.1007/s10875-010-9419-0 · Cited by 64

Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis

Jones, J. W. M., Kayagaki, N., Brož, P., Henry, T., Newton, K., O’Rourke, K. M., Chan, S. B., Dong, J. J., Qu, Y., Roose-Girma, M., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003738107 · Cited by 487

Characterization of the Role of Francisella‐Sensing Inflammasomes in the Development of Innate and Vaccine‐ Induced Immunity

Alqahtani, M. (2020) · Touro Scholar (Touro College)

The role of AIM2 and NLRP12 in the innate immune response to Francisella tularensis

Ulland, T. K. (2014) · doi:10.17077/etd.680pwptd