The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
The sphingosine 1-phosphate receptor S1P2 maintains the homeostasis of germinal center B cells and promotes niche confinement
Open accessAbstract
Mice deficient in sphingosine 1-phosphate receptor type 2 (S1P2) develop diffuse large B cell lymphoma. However, the role of S1P2 in normal germinal center (GC) physiology is unknown. Here we show that S1P2-deficient GC B cells outgrew their wild-type counterparts in chronically established GCs. We found that antagonism of the kinase Akt mediated by S1P2 and its downstream mediators Gα12, Gα13 and p115RhoGEF regulated cell viability and was required for growth control in chronically proliferating GCs. Moreover, S1P2 inhibited GC B cell responses to follicular chemoattractants and helped confine cells to the GC. In addition, S1P2 overexpression promoted the centering of activated B cells in the follicle. We suggest that by inhibiting Akt activation and migration, S1P2 helps restrict GC B cell survival and localization to an S1P-low niche at the follicle center.
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Cites
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Self-citationPromotion of Lymphocyte Egress into Blood and Lymph by Distinct Sources of Sphingosine-1-Phosphate
Pappu, R., Schwab, S. R., Cornelissen, I., Pereira, J. P., Regard, J. B., Xu, Y., Camerer, E., Zheng, Y.-W., Huang, Y., Cyster, J. G., et al. (2007) · Science · doi:10.1126/science.1139221 · Cited by 877
Self-citationGerminal center dark and light zone organization is mediated by CXCR4 and CXCR5
Allen, C. D. C., Ansel, K. M., Low, C., Lesley, R., Tamamura, H., Fujii, N., & Cyster, J. G. (2004) · Nature Immunology · doi:10.1038/ni1100 · Cited by 802
Self-citationLymphocyte Sequestration Through S1P Lyase Inhibition and Disruption of S1P Gradients
Schwab, S. R., Pereira, J. P., Matloubian, M., Xu, Y., Huang, Y., & Cyster, J. G. (2005) · Science · doi:10.1126/science.1113640 · Cited by 787
Self-citationImaging of Germinal Center Selection Events During Affinity Maturation
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Self-citationLysophospholipid Receptors: Signaling and Biology
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Cyster, J. G., & Schwab, S. R. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075011 · Cited by 815
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Metadata
- Authors
- Green, J. A., Suzuki, K., Cho, B., Willison, L. D., Palmer, D., Allen, C. D. C., Schmidt, T. H., Xu, Y., Proia, R. L., Coughlin, S. R., & Cyster, J. G.
- Venue
- Nature Immunology
- Published
- 2011-06-05
- Volume
- 12
- Issue
- 7
- Pages
- 672-680
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2013262178
- Cited by
- 280
- References
- 49
- FWCI
- 6.70
- Type
- journal article
- Language
- en
- Open access
- green
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- Green, J. A., Suzuki, K., Cho, B., Willison, L. D., Palmer, D., Allen, C. D. C., Schmidt, T. H., Xu, Y., Proia, R. L., Coughlin, S. R., & Cyster, J. G. (2011). The sphingosine 1-phosphate receptor S1P2 maintains the homeostasis of germinal center B cells and promotes niche confinement. Nature Immunology. https://doi.org/10.1038/ni.2047
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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