The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity
Open accessAbstract
Interleukin 4 (IL-4) and IL-13 are critical for responses to parasitic helminthes. We used genetically engineered reporter mice to assess the temporal and spatial production of these cytokines in vivo. In lymph nodes, IL-4, but not IL-13, was made by follicular helper T cells (TFH cells). In contrast, tissue type 2 helper T cells (TH2 cells) produced both cytokines. There was also divergent production of IL-4 and IL-13 among cells of the innate immune system, whereby basophils produced IL-4, whereas innate helper type 2 cells (Ih2 cells) produced IL-13. IL-13 production by TH2 and Ih2 cells was dependent on the transcription factor GATA-3, which was present in large amounts in these cells, and in contrast to the small amount of GATA-3 in TFH cells and basophils. The distinct localization and cellular expression of IL-4 and IL-13 explains their unique roles during allergic immunity.
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Cites
Bcl6 mediates the development of T follicular helper cells
Nurieva, R. I., Chung, Y., Martinez, G. J., Yang, X. O., Tanaka, S., Matskevitch, T. D., Wang, Y.-H., & Dong, C. (2009) · Science · doi:10.1126/science.1176676 · Cited by 1,506
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Self-citationT follicular helper cell differentiation, function, and roles in disease
Crotty, S. (2014) · Immunity · doi:10.1016/j.immuni.2014.10.004 · Cited by 1,847
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Crotty, S. (2019) · Immunity · doi:10.1016/j.immuni.2019.04.011 · Cited by 1,591
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von Moltke, J., Ji, M., Liang, H.-E., & Locksley, R. M. (2016) · Nature · doi:10.1038/nature16161 · Cited by 1,230
Self-citationSARS-CoV-2 infection: The role of cytokines in COVID-19 disease
Costela-Ruiz, V. J., Illescas-Montes, R., Puerta-Puerta, J. M., Ruiz, C., & Melguizo-Rodríguez, L. (2020) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2020.06.001 · Cited by 1,121
Metadata
- Authors
- Liang, H.-E., Reinhardt, R. L., Bando, J. K., Sullivan, B. M., Ho, I.-C., & Locksley, R. M.
- Venue
- Nature Immunology
- Published
- 2011-12-04
- Volume
- 13
- Issue
- 1
- Pages
- 58-66
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W1980690159
- Cited by
- 434
- References
- 1
- FWCI
- 13.99
- Type
- journal article
- Language
- en
- Open access
- green
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- Liang, H.-E., Reinhardt, R. L., Bando, J. K., Sullivan, B. M., Ho, I.-C., & Locksley, R. M. (2012). Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity. Nature Immunology. https://doi.org/10.1038/ni.2182
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