Bcl6 mediates the development of T follicular helper cells
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T Follicular Helper Cell Differentiation: When B cells respond to an infection, they often require help from CD4 + T cells to mount a proper response. It is thought that a subset of CD4 + effector T cells, called T follicular helper cells (T FH ), performs this function. Several subsets of effector CD4 + T cells arise, depending on the type of infection, which have distinct transcriptional programs driving their differentiation. Whether this is also the case for T FH cells has not been clear (see the Perspective by Awasthi and Kuchroo ). Nurieva et al. (p. 1001 , published online 23 July) and Johnston et al. (p. 1006 ; published online 16 July) now demonstrate that the transcription factor Bcl6 is both necessary and sufficient for T FH differentiation and subsequent B cell–mediated immunity, suggesting that it is a master regulator of this lineage. Johnston et al. also show that expression of Bcl6 and the transcription factor, Blimp-1, are reciprocally regulated in T FH cells and that, when ectopically expressed, Blimp-1 inhibits T FH development.
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TFH cells are distinct from conventional CD4 cells.
“TFH cells are thought to be distinct from conventional CD4 cells (Nurieva et al., 2008; Nurieva et al., 2009)”
From Distinct characteristics of hippocampal pathogenic th17 cells in a mouse model of depression (2018) · cites this paper as Nurieva et al., 2009
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- Authors
- Nurieva, R. I., Chung, Y., Martinez, G. J., Yang, X. O., Tanaka, S., Matskevitch, T. D., Wang, Y.-H., & Dong, C.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- Department of Immunology, M. D. Anderson Cancer Center, Houston, TX 77030, USA.
- Corresponding author
- Nurieva, Roza I.
- Dong, Chen
- Venue
- Science
- Published
- 2009-08-21
- Volume
- 325
- Issue
- 5943
- Pages
- 1001-1005
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC2857334
- OpenAlex
- W2038976543
- Cited by
- 1,506
- References
- 1
- Citations by year
- 2026: 43 · 2025: 65 · 2024: 68 · 2023: 90 · 2022: 87 · 2021: 101 · 2020: 92 · 2019: 103 · 2018: 102 · 2017: 103 · 2016: 107 · 2015: 101 · 2014: 114 · 2013: 91 · 2012: 93
- FWCI
- 34.23
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (R01AI050761, R01AI083761, R01AI050746)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR050772)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- BCL6, T follicular helper cells, CD4+ T helper cells, interleukin-6, germinal center, humoral immunity, transcription factors, T cell differentiation, B cell help
- MeSH terms
- Interleukin-21, Animals, Antibody Formation, B-Lymphocytes, Cell Differentiation, DNA-Binding Proteins, T-Lymphocytes, Helper-Inducer, Immunoglobulins, Interleukins, Lymphocyte Activation, Mice, Inbred C57BL, Mice, Transgenic, Mutation, RNA, Messenger, Transcription Factors, Interleukin-6, T-Lymphocyte Subsets, Cytokines, Germinal Center, Cell Lineage, Mice, Proto-Oncogene Proteins c-bcl-6
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