The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch
Open accessAbstract
Innate lymphoid cells (ILCs) of the ILC22 type protect the intestinal mucosa from infection by secreting interleukin 22 (IL-22). ILC22 cells include NKp46(+) and lymphoid tissue-inducer (LTi)-like subsets that express the aryl hydrocarbon receptor (AHR). Here we found that Ahr(-/-) mice had a considerable deficit in ILC22 cells that resulted in less secretion of IL-22 and inadequate protection against intestinal bacterial infection. Ahr(-/-) mice also lacked postnatally 'imprinted' cryptopatches and isolated lymphoid follicles (ILFs), but not embryonically 'imprinted' Peyer's patches. AHR induced the transcription factor Notch, which was required for NKp46(+) ILCs, whereas LTi-like ILCs, cryptopatches and ILFs were partially dependent on Notch signaling. Thus, AHR was essential for ILC22 cells and postnatal intestinal lymphoid tissues. Moreover, ILC22 subsets were heterogeneous in their requirement for Notch and their effect on the generation of intestinal lymphoid tissues.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“This idea has been supported and expanded upon recently as additional evidence emerges detailing missing or impaired populations of resident immune cells in adult null mice at barrier tissues like the lung, intestine, and skin (Esser & Rannug, 2015; Kiss et al., 2011; Lee et al., 2012; Li et al., 2018; Qiu et al., 2012; Stockinger et al., 2014).”
From Rodent Genetic Models of Ah Receptor Signaling (2021) · cites this paper as Lee et al., 2012
In the citing paper
“Ahr−/− mice suffer from multiple immunological deficits, including reduced resistance to infection with the bacteria Listeria monocytogenes or Citrobacter rodentium, as well as the fungus Candida albicans; exacerbated DSS-induced colitis; and even altered susceptibility to experimental autoimmune encephalomyelitis (EAE)”
From Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System (2017) · cites this paper as Lee et al., 2011
In the citing paper
“the AhR is in fact required for postnatal maintenance of IL-22-producing ILC3s, as well as the formation of isolated lymphoid follicles (Kiss et al., 2011; Lee et al., 2011; Y. Li et al., 2011; J. Qiu et al., 2012).”
From Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System (2017) · cites this paper as Lee et al., 2011
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Korn, T., Bettelli, E., Oukka, M., & Kuchroo, V. K. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132710 · Cited by 4,873
Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens
Zheng, Y., Valdez, P. A., Danilenko, D. M., Hu, Y., Susan, M. L., Gong, Q., Abbas, A. R., Modrusan, Z. D., Ghilardi, N., de Sauvage, F. J., et al. (2008) · Nature Medicine · doi:10.1038/nm1720 · Cited by 1,972
An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor
Opitz, C. A., Litzenburger, U. M., Sahm, F., Ott, M., Tritschler, I., Trump, S., Schumacher, T., Jestaedt, L., Schrenk, D., Weller, M., et al. (2011) · Nature · doi:10.1038/nature10491 · Cited by 1,898
Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor
Quintana, F. J., Basso, A. S., Iglesias, A. H., Korn, T., Farez, M. F., Bettelli, E., Caccamo, M., Oukka, M., & Weiner, H. L. (2008) · Nature · doi:10.1038/nature06880 · Cited by 1,865
The Biological Functions of T Helper 17 Cell Effector Cytokines in Inflammation
Ouyang, W., Kolls, J. K., & Zheng, Y. (2008) · Immunity · doi:10.1016/j.immuni.2008.03.004 · Cited by 1,750
An Interaction between Kynurenine and the Aryl Hydrocarbon Receptor Can Generate Regulatory T Cells
Mezrich, J. D., Fechner, J. H., Zhang, X., Johnson, B. P., Burlingham, W. J., & Bradfield, C. A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903670 · Cited by 1,674
Self-citationThe aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins
Veldhoen, M., Hirota, K., Westendorf, A. M., Buer, J., Dumoutier, L., Renauld, J.-C., & Stockinger, B. (2008) · Nature · doi:10.1038/nature06881 · Cited by 1,634
Immune adaptations that maintain homeostasis with the intestinal microbiota
Hooper, L. V., & Macpherson, A. J. (2010) · Nature reviews. Immunology · doi:10.1038/nri2710 · Cited by 1,530
A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity
Cella, M., Fuchs, A. G., Vermi, W., Facchetti, F., Otero, K., Lennerz, J. K., Doherty, J. M., Mills, J. C., & Colonna, M. (2008) · Nature · doi:10.1038/nature07537 · Cited by 1,298
Self-citationSatoh‐Takayama, N., Vosshenrich, C. A. J., Lesjean‐Pottier, S., Sawa, S., Lochner, M., Rattis, F. M., Mention, J., Thiam, K., Cerf–Bensussan, N., Mandelboim, O., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.11.001 · Cited by 1,133
Cited by
Sorted by citations
Items 601–700 of 778
Mehrani, Y., Morovati, S., Keivan, F., Tajik, T., Forouzanpour, D., Shojaei, S., Bridle, B. W., & Karimi, K. (2025) · Pathogens · doi:10.3390/pathogens14080794 · Cited by 14
Altered fecal microbiome and metabolome profiles in rat models of short bowel syndrome
Huang, Y., Jiao, J., Yao, D., Guo, F., & Li, Y. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1185463 · Cited by 10
Nehmar, R., Fauconnier, L., Alves-Filho, J. C., Togbe, D., de Cauwer, A., Bahram, S., Bert, M. L., Ryffel, B., & Georgel, P. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16433 · Cited by 9
Jackson, C. M., Demmert, M., Mukherjee, S., Isaacs, T., Thompson, R., Chastain, C., Gray, J. K., Senthamaraikannan, P., Presicce, P., Chetal, K., et al. (2022) · Mucosal Immunology · doi:10.1038/s41385-022-00495-x · Cited by 10
Innate Lymphoid Cells: Emerging Players in Pancreatic Disease
Shi, S., Ye, L., Jin, K., Xiao, Z., Yu, X., & Wu, W. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073748 · Cited by 11
Gao, X., Shen, X., Liu, K., Lu, C., Fan, Y., Xu, Q., Meng, X., Hong, S., Huang, Z., Liu, X., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.939033 · Cited by 9
The Role of TOX in the Development of Innate Lymphoid Cells
Seehus, C. R., & Kaye, J. G. (2015) · Mediators of Inflammation · doi:10.1155/2015/243868 · Cited by 9
Liu, Y., Wei, Y., Zhang, S., Yan, X., Zhu, H., Xu, S. L., Zhao, B., Xie, H. Q., & Yan, B. (2019) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.9b00431 · Cited by 9
Hu, Y., Chen, L., Ye, Z., Li, L., Qian, H., Wu, M., Wang, J., Qin, K., & Ye, Q. (2024) · Pharmaceutical Biology · doi:10.1080/13880209.2024.2415652 · Cited by 9
Regulatory T cells: master orchestrators of immune tolerance and tissue homeostasis
Bluestone, J. A., Levings, M. K., Ramsdell, F. J., Rudensky, A. Y., Tang, Q., & Trzonkowski, P. (2026) · Frontiers in Science · doi:10.3389/fsci.2026.1792210 · Cited by 10
Tissue‐resident innate lymphoid cells in asthma
Wang, X., Kong, Y., Zheng, B., Zhao, X., Zhao, M., Wang, B., Liu, C., & Yan, P. (2023) · The Journal of Physiology · doi:10.1113/jp284686 · Cited by 10
Mudd, J. C., & Brenchley, J. M. (2019) · Current HIV/AIDS Reports · doi:10.1007/s11904-019-00439-4 · Cited by 8
Interleukin-22 and keratinocytes; pathogenic implications in skin inflammation
Furue, M., & Furue, M. (2021) · Exploration of Immunology · doi:10.37349/ei.2021.00005 · Cited by 10
The Aryl Hydrocarbon Receptor: A Sentinel Safeguarding the Survival of Immune Cells in the Gut
Spits, H., & Mjösberg, J. (2012) · Immunity · doi:10.1016/j.immuni.2012.01.004 · Cited by 8
Innate lymphoid cells—key immune integrators of overall body homeostasis
Karagiannis, F., & Wilhelm, C. (2018) · Seminars in Immunopathology · doi:10.1007/s00281-018-0684-y · Cited by 9
The Aryl Hydrocarbon Receptor and Immunity
Sulentic, C. E. W., Snyder, A. D., & Salisbury, R. L. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.64231-9 · Cited by 8
Effect of GVHD on the gut and intestinal microflora
Ji, H., Feng, S., Liu, Y., Cao, Y., Lou, H., & Li, Z. (2024) · Transplant Immunology · doi:10.1016/j.trim.2023.101977 · Cited by 11
Liu, M., Pang, Y., Xu, L., Ji, T., Yang, J., Huang, D., Cheng, M., Chen, M. H., Huang, B., Xu, S., et al. (2025) · Journal of Neurotrauma · doi:10.1177/08977151251367404 · Cited by 8
Zou, Q., Zhang, W., Xie, H., Ying, S., Zeng, X., Yao, Y., Zeng, D., Wang, J., Zhang, C., & Meng, F. (2026) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2026.1745929 · Cited by 7
Caballero‐Franco, C., Gumá, M., Choo, M., Sano, Y., Enzler, T., Karin, M., Mizoguchi, A., & Park, J. M. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1501724 · Cited by 7
Dynamic regulation of innate lymphoid cell development during ontogeny
Wu, T., Chen, S., Zhu, X., Ma, J., Luo, M., Wang, Y., Tian, Y., Sun, Q., Guo, X., Zhang, J., et al. (2024) · Mucosal Immunology · doi:10.1016/j.mucimm.2024.08.009 · Cited by 7
Zhang, M., Li, D., Sun, L., He, Y., Liu, Q., He, Y., & Li, F. (2024) · Mediators of Inflammation · doi:10.1155/mi/4965271 · Cited by 7
Aryl hydrocarbon receptor agonists trigger avoidance of novel food in rats
Mahiout, S., & Pohjanvirta, R. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.08.033 · Cited by 7
T cells regulate lymph node-resident ILC populations in a tissue and subset-specific way
Bresler, P., Tejerina, E., Jacob, J. M., Legrand, A., Quellec, V., Ezine, S., Peduto, L., & Cherrier, M. (2021) · iScience · doi:10.1016/j.isci.2021.102158 · Cited by 7
AHR and the issue of immunotoxicity
Esser, C., Haarmann‐Stemmann, T., Hochrath, K., Schikowski, T., & Krutmann, J. (2018) · Current Opinion in Toxicology · doi:10.1016/j.cotox.2018.03.001 · Cited by 8
Lymphoid Tissues Associated with Gastrointestinal (GI) Mucosa
Nagatake, T., Kunisawa, J., & Kiyono, H. (2019) · Springer eBooks · doi:10.1007/978-981-10-4699-5_5 · Cited by 7
Wu, C., Lin, Q., Ying, S., Luo, J., Hong, W., Lin, Z., & Jiang, Y. (2019) · Immunological Investigations · doi:10.1080/08820139.2019.1569677 · Cited by 7
Berberine augments hypertrophy of colonic patches in mice with intraperitoneal bacterial infection
Shu, J., Zhong, C.-S., Shi, Z., Zeng, B., Xu, L., Ye, J., Wang, Y., Yang, F., Zhong, M.-Y., Ouyang, D., et al. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.107242 · Cited by 7
Impact of environmental factors on alloimmunity and transplant fate
Riella, L. V., Bagley, J., Iacomini, J., & Alegre, M. (2017) · Journal of Clinical Investigation · doi:10.1172/jci90596 · Cited by 7
Wen, Y., Zhang, W., Yang, R., Jiang, L., Zhang, X., Wang, B., Hua, Y., Ji, P., Yuan, Z., Wei, Y., et al. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1039884 · Cited by 8
Local and systemic features of ILC immunometabolism
Surace, L., & Santo, J. P. D. (2022) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000722 · Cited by 6
Kim, K., Jinno, C. N., Li, X., Bravo, D., Cox, E., Ji, P., & Liu, Y. (2024) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-023-00956-8 · Cited by 6
Intestinal-region-specific functions of AHR in intrinsic enteric neurons during infections
Sun, Z., Wang, Y., Liu, S., Li, H., He, D., & Xu, H. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115524 · Cited by 5
Coordination of Mucosal Immunity by Innate Lymphoid Cells
Zhou, J., & Sonnenberg, G. F. (2022) · Advances in experimental medicine and biology · doi:10.1007/978-981-16-8387-9_8 · Cited by 5
Bhakta-Yadav, M. S., Burra, K., Alhamdan, N., Allex-Buckner, C., & Sulentic, C. E. W. (2024) · Toxicological Sciences · doi:10.1093/toxsci/kfae035 · Cited by 5
Villageliú, D. N., Cunningham, K. C., Smith, D. R., Knoell, D. L., Mandolfo, M., Wyatt, T. A., & Samuelson, D. R. (2024) · npj Biofilms and Microbiomes · doi:10.1038/s41522-024-00558-w · Cited by 5
Interplay Between Metabolic Sensors and Immune Cell Signaling
Chauhan, P. S., Sarkar, A., & Saha, B. (2018) · Experientia supplementum · doi:10.1007/978-3-319-74932-7_3 · Cited by 5
Non‐zero‐sum microbiome immune system interactions
Tuganbaev, T., & Honda, K. (2021) · European Journal of Immunology · doi:10.1002/eji.202049065 · Cited by 7
Identification and characterization of innate lymphoid cells generated from pluripotent stem cells
Xiong, J., Zhao, Y., Lin, Y., Chen, L., Weng, Q., Shi, C., Liu, X., Yang, G., Liu, L., Wang, J., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111569 · Cited by 5
Peng, Z., Dong, X., He, M., Zhao, Y., Liu, Y., Li, M., Li, G., Wang, X., Li, L., & Hu, Y. (2023) · Thoracic Cancer · doi:10.1111/1759-7714.15119 · Cited by 6
Cao, Y. Z., Xiao, S., He, B., Shi, X., Xiao, N., Liu, X., Liu, D., Zhou, Z., & Wang, P. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c02749 · Cited by 5
A vasculature-resident innate lymphoid cell population in mouse lungs
Shirley, S., Ichise, H., Natale, V. D., Jin, J., Wu, C. C., Zou, R., Zhang, W., Fang, Y., Zhang, Y., Chen, M., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-58982-1 · Cited by 6
Intestinal Microbes, Metabolites, and Hormones in Alcohol-Associated Liver Disease
Wang, R., Ma, F., Yin, D., Wang, H., & Wei, X. (2025) · Seminars in Liver Disease · doi:10.1055/a-2601-9480 · Cited by 4
The intestinal interferon system and specialized enterocytes as putative drivers of HIV latency
Creighton, R. L., Hughes, S. M., Hladik, F., & Gornalusse, G. G. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1589752 · Cited by 5
Mao, X., Cheng, L., Liu, Y., & Wu, Y. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1629012 · Cited by 4
Shen, J., Xiao, Y., Hui-juan, B., Guo, R., Qu, M., Ding, R., Zhang, X., Li, H., Han, M., & Huang, S. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114275 · Cited by 4
Factors regulating Th17 cells: a review
Seki, R., & Nishizawa, K. (2016) · Biomedical Research and Clinical Practice · doi:10.15761/brcp.1000122 · Cited by 4
Magrone, T., & Jirillo, E. (2018) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530319666181128160411 · Cited by 4
Chen, H., Huang, S., Zhao, Y., Sun, R., Wang, J., Yao, S., Huang, J., & Yu, Z. (2024) · Microbiology Spectrum · doi:10.1128/spectrum.03735-23 · Cited by 4
Neumann, S., Peyroux, E. M., Woodall, M. J., Shields, N. J., Young, S. L., & Pattison, S. T. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.88137 · Cited by 4
Jung, B., Ferrer, G., Chiu, P. Y., Aslam, R., Ng, A. K. Y., Palacios, F., Wysota, M., Cardillo, M., Kolitz, J. E., Allen, S. L., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.158243 · Cited by 4
Wagage, S., & Hunter, C. A. (2014) · Current Immunology Reviews · doi:10.2174/1573395510666141105234917 · Cited by 4
Lymphoid Hematopoiesis and Lymphocytes Differentiation and Maturation
Marti, L. C., Bacal, N. S., Bento, L. C., Correia, R. P., & Rocha, F. A. (2017) · InTech eBooks · doi:10.5772/intechopen.69058 · Cited by 4
Darabi, S., Keshavarzi, F., Ashtari, P., Motamedi-Sedeh, F., & Alirezapour, B. (2025) · Journal of Genetic Engineering and Biotechnology · doi:10.1016/j.jgeb.2025.100610 · Cited by 3
Bantavi, V., Gloeck, L., Leven, P., Zafeiropoulou, K., Welting, O., Sengül, H., Efferz, P., Schneiker, B., McCulloch, T. R., Wilhelm, C., et al. (2026) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2026.101756 · Cited by 3
Notch Signaling and Immune Regulation in Alloimmunity
Murakami, N., Maillard, I. P., & Riella, L. V. (2016) · Current Transplantation Reports · doi:10.1007/s40472-016-0126-5 · Cited by 3
Modeling the Effect of the Aryl Hydrocarbon Receptor on Transplant Immunity
Julliard, W. A., Fechner, J. H., Owens, L. A., O’Driscoll, C. A., Zhou, L., Sullivan, J. A., Frydrych, L. M., Mueller, A., & Mezrich, J. D. (2017) · Transplantation Direct · doi:10.1097/txd.0000000000000666 · Cited by 3
Controversial role of ILC3s in intestinal diseases: A novelty perspective on immunotherapy
Zhang, Y., Feng, X., Chen, J., Liu, J., Wu, J., Tan, H., Mi, Z., & Rong, P. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1134636 · Cited by 3
The Function of Tryptophan Metabolism in the Gut
Tang, X., Wan, L., Gao, J., Jiang, Q., Hu, S., Xiao, H., Wang, J., Qi, M., Wang, L., Huang, L., et al. (2024) · Springer eBooks · doi:10.1007/978-981-97-4719-1_2 · Cited by 3
Innate lymphoid cells in autoimmune diseases
Kumar, V. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822564-6.00007-0 · Cited by 3
Innate Lymphoid Cells in Mucosal Homeostasis, Infections, Autoimmune Disorders, and Tumors
Colonna, M., Fuchs, A. G., & Cella, M. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-415847-4.00052-5 · Cited by 3
Self-citationThe Aryl Hydrocarbon Receptor (AhR) as a Mediator of Adverse Immune Reactions
Esser, C. (2014) · Wiley eBooks · doi:10.1002/9783527676965.ch6 · Cited by 2
Vasoactive intestinal peptide confers anticipatory mucosal immunity by regulating ILC3 activityPreprint
Seillet, C., Luong, K., Tellier, J., Jacquelot, N., Shen, R. D., Hickey, P. F., Wimmer, V. C., Whitehead, L. W., Rogers, K. L., Smyth, G. K., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/729400 · Cited by 3
Shah, K., Maradana, M. R., Delàs, M. J., Metidji, A., Graelmann, F. J., Llorian, M., Chakravarty, P., Li, Y., Tolaini, M., Shapiro, M., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-827700/v1 · Cited by 3
Xie, A., Wang, T., Shi, W., He, F., Sun, X., & Li, P. (2024) · Discover Oncology · doi:10.1007/s12672-024-01480-5 · Cited by 2
Jin, T., Yi, Q., Wang, Y., Liu, W., Zheng, L., An, J., Mi, H., Zhou, L., Liu, F., & Wang, X. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1764082 · Cited by 2
Functional significance of the aryl hydrocarbon receptor in oncogenic signaling pathways
Arciga, B. M., Katepalli, A., Natesh, N. S., Teixeiro, E., Kaifi, J. T., & Rachagani, S. (2025) · Carcinogenesis · doi:10.1093/carcin/bgaf068 · Cited by 2
The Role of the Gut Microbiota in Allogeneic Hematopoietic Cell Transplantation
Hao, W., Stocker, N., Gaugler, B., Mohty, M., & Malard, F. (2026) · American Journal of Hematology · doi:10.1002/ajh.70360 · Cited by 2
Dupraz, L., Orianne, G., Costa, G. D., Gauthier, R., Blondeau, A., Boinet, M., Farfar, A., Creusot, L., Magniez, A., Dubois, L., et al. (2026) · Gut Microbes · doi:10.1080/19490976.2026.2690688 · Cited by 4
Hawash, M. B. F., Eldeeb, M. A., Gaber, R., & Morsy, K. (2022) · BioEssays · doi:10.1002/bies.202200080 · Cited by 2
Expansion of the Innate Lymphocyte Family: Discovery of IL-22–Producing ILC3s
Choi, H. S., & Kuchroo, V. K. (2023) · The Journal of Immunology · doi:10.4049/jimmunol.2300390 · Cited by 2
Agmatine ameliorates sepsis-related intestinal injury via the AhR-STAT3-IL-10 pathway
Pan, J., Gan, L., Chen, Y., Zhong, L., Deng, H., Huang, L., & Liang, H. (2025) · Molecular Immunology · doi:10.1016/j.molimm.2025.06.004 · Cited by 2
Profile of interleukin-22 in gut mucosal health and disease
Sousa, A. E., Foxall, R. B., & Fernandes, S. M. (2016) · International Journal of Interferon Cytokine and Mediator Research · doi:10.2147/ijicmr.s64856 · Cited by 2
Aryl Hydrocarbon Receptor: An Environmental Sensor in Control of Allergy Outcomes
Gargaro, M., Pirro, M., Manni, G., LUCA, A. D., Zelante, T., & Fallarino, F. (2017) · Birkhäuser advances in infectious diseases · doi:10.1007/978-3-319-69968-4_9 · Cited by 2
Innate Lymphoid Cells for the Control of Mucosal Immunity
Longman, R., Metz, M. L., & Artis, D. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-811924-2.00014-6 · Cited by 2
The Role of the Aryl Hydrocarbon Receptor (AhR) in the Immune Response against Microbial Infections
Huang, L., He, R., Zhang, Y., & Yan, Q. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.96526 · Cited by 3
Pohjanvirta, R., Karppinen, I., Galbán-Velázquez, S., Esteban, J., Håkansson, H., Sankari, S., & Lindén, J. (2021) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2021.108762 · Cited by 3
The gut way to health : In vitro studies on immunomodulatory food compounds
Koper, J. E. B. (2020) · doi:10.18174/505381 · Cited by 2
Inhibition of IL-22-producing cells by Sutterella sp. bacteriaPreprint
Dupraz, L., Orianne, G., da Costa, G., Gauthier, R., Blondeau, A., Boinet, M., Creusot, L., Magniez, A., Chollet, L., Rolhion, N., et al. (2025) · bioRxiv · doi:10.1101/2025.03.20.644103 · Cited by 2
Modern Techniques for Protein Assessment
Nunez, J. H., & Nomellini, V. (2025) · Success in academic surgery · doi:10.1007/978-3-031-83034-1_9 · Cited by 1
Microniche control of innate lymphocyte biology in the gut
Towers, B. E., & Sonnenberg, G. F. (2025) · International Immunology · doi:10.1093/intimm/dxaf071 · Cited by 1
Sun, N., Paul, R., Helm, E. Y., Chen, Z.-M. E., Bostick, J. W., & Zhou, L. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.116952 · Cited by 1
Bennstein, S. B., Reiß, J., Raba, K., Pham, T. X. U., Paulusch, S., Domenico, E. D., Niehues, T., Fischer, J., Kögler, G., Beyer, M. D., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117000 · Cited by 1
Dong, K., Guan, Z., Wang, D., Sun, J., Zhang, Y., You, C., & Xing, Y. (2026) · Biomaterials Research · doi:10.34133/bmr.0356 · Cited by 1
LINGO4 coordinates ILC3-intrinsic IL-22 production and microbiota-mediated ILC3 homeostasis
Fachi, J. L., Tršan, T., Sécca, C., de Oliveira, S., Rodovalho, V. R., Rodrigues, P. F., Beatty, W. L., Sudan, R., Wu, S., Bhattarai, B., et al. (2026) · The Journal of Experimental Medicine · doi:10.1084/jem.20252632 · Cited by 1
Self-citationPlasticity of the infant immune system during the perinatal period
Kierdorf, K., Sperandio, M., Hornef, M. W., & Henneke, P. (2026) · Nature reviews. Immunology · doi:10.1038/s41577-026-01354-7 · Cited by 2
Yao, L., Avella, T. G., Kulkarni, A. J., Waardenburg, M. D., Delgado-Dolset, M. I., Wypych, T., Walters, A., Nieves, K., Devotta, H., Kim, S., et al. (2026) · Mucosal Immunology · doi:10.1016/j.mucimm.2026.100405 · Cited by 2
Modern Techniques for Protein Assessment
Nomellini, V., & Kennedy, G. D. (2013) · Success in academic surgery · doi:10.1007/978-1-4471-4736-7_7 · Cited by 1
Self-citationLe récepteur d’aryl d’hydrocarbone, lien moléculaire entre alimentation et immunité
Vonarbourg, C. (2012) · médecine/sciences · doi:10.1051/medsci/2012283009 · Cited by 1
Lymphotoxin and the amazing technicolor circus of intestinal homeostasis
Browning, J. L. (2012) · Mucosal Immunology · doi:10.1038/mi.2012.3 · Cited by 1
NK cells – Versatile tools for viral defense and cancer treatment
Momburg, F., Watzl, C., & Cerwenka, A. (2013) · European Journal of Immunology · doi:10.1002/eji.201370044 · Cited by 1
Influence of diet on gastrointestinal immunology
Das, D., Biswas, N., & Mandal, L. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-821232-5.00002-1 · Cited by 1
Role of Gut Microbiome Composition in Shaping Host Immune System Development and Health
Phani, P., Kolla, H. B., Bramhachari, P. V., & Reddy, P. N. (2023) · Springer eBooks · doi:10.1007/978-981-99-5114-7_3 · Cited by 1
Tang, C., Su, L., Xue, F., Sun, Y., Zhang, F., He, C., Zuo, Z., & Liu, Z. (2025) · Environmental Pollution · doi:10.1016/j.envpol.2025.126684 · Cited by 1
The Aryl Hydrocarbon Receptor as a Regulator of Barrier Physiology
Díaz-Díaz, C. J., Wilson, R. H., Vazquez-Rivera, E., Mezrich, J. D., Lee, C. W., Kennedy, G. D., & Bradfield, C. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.64217-4 · Cited by 1
Self-citationNotch Signaling: A Pivot Regulator of Adaptive and Innate Immunity
Kumai, T., & Rodrı́guez, P. C. (2018) · Springer eBooks · doi:10.1007/978-1-4939-8859-4_5 · Cited by 1
Lindén, J. (2013) · Työväentutkimus Vuosikirja · Cited by 1
Development of Group 2 Innate Lymphoid Cells
Ghaedi, M., & Takei, F. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-374279-7.04003-0 · Cited by 1
A Non-redundant Role for T cell-derived IL-22 in Antibacterial Defense of Colonic CryptsPreprint
Zindl, C. L., Witte, S. J., Laufer, V. A., Gao, M., Yue, Z., Silberger, D. J., Harbour, S. N., Singer, J. R., Pham, D., Moseley, C. E., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.05.11.443677 · Cited by 1
Editorial: Role of the Aryl Hydrocarbon Receptor in Immune Modulation
Kaplan, B. L. F., Baglole, C. J., & Sulentic, C. E. W. (2022) · Frontiers in Toxicology · doi:10.3389/ftox.2022.941665 · Cited by 1
Metadata
- Authors
- Lee, J. S., Cella, M., McDonald, K. G., Garlanda, C., Kennedy, G. D., Nukaya, M., Mantovani, A., Kopan, R., Bradfield, C. A., Newberry, R. D., & Colonna, M.
- Affiliations
- Washington University in St. Louis (US)
- University of Wisconsin–Madison (US)
- University of Milan (IT)
- Corresponding author
- Colonna, Marco
- ORCID
- Venue
- Nature Immunology
- Published
- 2011-11-20
- Volume
- 13
- Issue
- 2
- Pages
- 144-151
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- PMC
- PMC3468413
- OpenAlex
- W2068162195
- Cited by
- 777
- References
- 50
- Citations by year
- 2026: 27 · 2025: 36 · 2024: 57 · 2023: 40 · 2022: 51 · 2021: 61 · 2020: 54 · 2019: 61 · 2018: 59 · 2017: 60 · 2016: 59 · 2015: 58 · 2014: 58 · 2013: 61 · 2012: 34
- FWCI
- 21.70
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Public Health Service (A1067854)
- National Institute of General Medical Sciences (R01GM055479)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK064798, P30DK020579, P30DK052574)
- National Institute of Environmental Health Sciences (K08ES017283, R01ES005703)
- National Institute of Dental and Craniofacial Research (R01DE021255)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Keywords
- aryl hydrocarbon receptor, innate lymphoid cells, IL-22, Notch signaling, isolated lymphoid follicles, Peyer's patches, intestinal mucosal immunity, bacterial intestinal infections
- MeSH terms
- Interleukin-22, Animals, Antigens, Ly, Female, Interleukins, Lymphoid Tissue, Male, Mice, Inbred C57BL, Mice, Transgenic, Signal Transduction, Receptors, Aryl Hydrocarbon, Gastrointestinal Tract, Mice, Receptor, Notch1, Receptor, Notch2, Natural Cytotoxicity Triggering Receptor 1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
