Bradfield, Christopher A.

Mop3 is an essential component of the master circadian pacemaker in mammals.

Bunger, M. K., Wilsbacher, L. D., Moran, S. M., Clendenin, C., Radcliffe, L. A., Hogenesch, J. B., Simon, M. C., Takahashi, J. S., & Bradfield, C. A. (2000) · Cell

Circadian rhythm and melatoninSleep and Wakefulness Research

Cited by 1,621

Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes

Marcheva, B., Ramsey, K. M., Buhr, E. D., Kobayashi, Y., Su, H., Ko, C. H., Ivanova, G., Omura, C., Mo, S., Vitaterna, M. H., et al. (2010) · Nature

Pancreatic function and diabetesCircadian rhythm and melatonin

Cited by 1,525

AH RECEPTOR SIGNALING PATHWAYS

Schmidt, J. V., & Bradfield, C. A. (1996) · Annual Review of Cell and Developmental Biology

Toxic Organic Pollutants ImpactPharmacogenetics and Drug Metabolism

Cited by 899

Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor.

Burbach, K. M., Poland, A., & Bradfield, C. A. (1992) · Proceedings of the National Academy of Sciences

Toxic Organic Pollutants ImpactPharmacogenetics and Drug Metabolism

Cited by 831

Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT

Maltepe, E., Schmidt, J. V., Baunoch, D., Bradfield, C. A., & Simon, M. C. (1997) · Nature

Angiogenesis and VEGF in CancerCancer, Hypoxia, and Metabolism

Cited by 781

AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch

Lee, J. S., Cella, M., McDonald, K. G., Garlanda, C., Kennedy, G. D., Nukaya, M., Mantovani, A., Kopan, R., Bradfield, C. A., Newberry, R. D., et al. (2012) · Nature Immunology

IL-33, ST2, and ILC PathwaysT-cell and B-cell Immunology

Cited by 777

Obesity in mice with adipocyte-specific deletion of clock component Arntl

Paschos, G. K., Ibrahim, S., Song, W.-L., Kunieda, T., Grant, G., Reyes, T. M., Bradfield, C. A., Vaughan, C. H., Eiden, M., Masoodi, M., et al. (2012) · Nature Medicine

Circadian rhythm and melatoninRegulation of Appetite and Obesity

Cited by 465

Portosystemic shunting and persistent fetal vascular structures in aryl hydrocarbon receptor-deficient mice

Lahvis, G. P., Lindell, S. L., Thomas, R. S., McCuskey, R. S., Murphy, C., Glover, E., Bentz, M., Southard, J., & Bradfield, C. A. (2000) · Proceedings of the National Academy of Sciences

Liver physiology and pathologyCardiovascular Conditions and Treatments

Cited by 377

Mammalian Per-Arnt-Sim Proteins in Environmental Adaptation

McIntosh, B. E., Hogenesch, J. B., & Bradfield, C. A. (2010) · Annual Review of Physiology

Circadian rhythm and melatoninNuclear Receptors and Signaling

Cited by 352

Cloning and expression of a human Ah receptor cDNA.

Dolwick, K. M., Schmidt, J. V., Carver, L. A., Swanson, H. I., & Bradfield, C. A. (1993) · Molecular Pharmacology

Toxic Organic Pollutants ImpactPharmacogenetics and Drug Metabolism

Cited by 348

Expression of ARNT, ARNT2, HIF1α, HIF2α and Ah receptor mRNAs in the developing mouse

Jain, S., Maltepe, E., Lu, M. M., Simon, C., & Bradfield, C. A. (1998) · Mechanisms of Development

Developmental Biology and Gene RegulationToxic Organic Pollutants Impact

Cited by 333

In vitro analysis of Ah receptor domains involved in ligand-activated DNA recognition.

Dolwick, K. M., Swanson, H. I., & Bradfield, C. A. (1993) · Proceedings of the National Academy of Sciences

Toxic Organic Pollutants ImpactPharmacogenetics and Drug Metabolism

Cited by 239

Aryl hydrocarbon receptor-dependent liver development and hepatotoxicity are mediated by different cell types

Walisser, J. A., Glover, E., Pande, K., Liss, A. L., & Bradfield, C. A. (2005) · Proceedings of the National Academy of Sciences

Toxic Organic Pollutants ImpactLiver physiology and pathology

Cited by 234

Cross-talk between the Aryl Hydrocarbon Receptor and Hypoxia Inducible Factor Signaling Pathways

Chan, W. K., Yao, G., Gu, Y.-Z., & Bradfield, C. A. (1999) · Journal of Biological Chemistry

Toxic Organic Pollutants ImpactPharmacogenetics and Drug Metabolism

Cited by 221

Resistance to 2,3,7,8-Tetrachlorodibenzo-p-dioxin Toxicity and Abnormal Liver Development in Mice Carrying a Mutation in the Nuclear Localization Sequence of the Aryl Hydrocarbon Receptor

Bunger, M. K., Moran, S. M., Glover, E., Thomae, T. L., Lahvis, G. P., Lin, B. C., & Bradfield, C. A. (2003) · Journal of Biological Chemistry

Toxic Organic Pollutants ImpactPharmacogenetics and Drug Metabolism

Cited by 215

The Aryl Hydrocarbon Receptor Is Required for Developmental Closure of the Ductus Venosus in the Neonatal Mouse

Lahvis, G. P., Pyzalski, R. W., Glover, E., Pitot, H. C., McElwee, M. K., & Bradfield, C. A. (2005) · Molecular Pharmacology

Cardiovascular Conditions and TreatmentsVascular anomalies and interventions

Cited by 168

Trace derivatives of kynurenine potently activate the aryl hydrocarbon receptor (AHR)

Seok, S.-H., Ma, Z.-X., Feltenberger, J. B., Chen, H., Chen, H., Scarlett, C., Lin, Z., Satyshur, K. A., Cortopassi, M., Jefcoate, C. R., et al. (2018) · Journal of Biological Chemistry

Tryptophan and brain disordersToxic Organic Pollutants Impact

Cited by 157

ahr null alleles: distinctive or different?

Lahvis, G. P., & Bradfield, C. A. (1998) · Biochemical Pharmacology

Pharmacogenetics and Drug MetabolismAnimal Genetics and Reproduction

Cited by 152

Abnormal Liver Development and Resistance to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Toxicity in Mice Carrying a Mutation in the DNA-Binding Domain of the Aryl Hydrocarbon Receptor

Bunger, M. K., Glover, E., Moran, S. M., Walisser, J. A., Lahvis, G. P., Hsu, E. L., & Bradfield, C. A. (2008) · Toxicological Sciences

Toxic Organic Pollutants ImpactEffects and risks of endocrine disrupting chemicals

Cited by 139

ARA9 Modifies Agonist Signaling through an Increase in Cytosolic Aryl Hydrocarbon Receptor

LaPres, J. J., Glover, E., Dunham, E. E., Bunger, M. K., & Bradfield, C. A. (2000) · Journal of Biological Chemistry

Heat shock proteins researchToxic Organic Pollutants Impact

Cited by 125

Polycyclic aromatic hydrocarbons (PAHs) present in ambient urban dust drive proinflammatory T cell and dendritic cell responses via the aryl hydrocarbon receptor (AHR) in vitro

O’Driscoll, C. A., Gallo, M. E., Hoffmann, E. J., Fechner, J. H., Schauer, J. J., Bradfield, C. A., & Mezrich, J. D. (2018) · PLOS ONE

Toxic Organic Pollutants ImpactImmunotoxicology and immune responses

Cited by 74

Identification of the Ah-Receptor Structural Determinants for Ligand Preferences

Xing, Y., Nukaya, M., Satyshur, K. A., Jiang, L., Stanevich, V., Korkmaz, E. N., Burdette, L., Kennedy, G. D., Cui, Q., & Bradfield, C. A. (2012) · Toxicological Sciences

Toxic Organic Pollutants ImpactProtein Structure and Dynamics

Cited by 67

Liver Deformation in Ahr-Null Mice: Evidence for Aberrant Hepatic Perfusion In Early Development

Harstad, E. B., Guite, C. A., Thomae, T. L., & Bradfield, C. A. (2006) · Molecular Pharmacology

Liver physiology and pathologyCardiovascular Conditions and Treatments

Cited by 67

Mapping the 90 kDa heat shock protein binding region of the Ah receptor

Perdew, G. H., & Bradfield, C. A. (1996) · IUBMB Life

Heat shock proteins researchToxic Organic Pollutants Impact

Cited by 63