The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Mice completely lacking immunoproteasomes show major changes in antigen presentation
Open accessAbstract
The importance of immunoproteasomes to antigen presentation has been unclear because animals totally lacking immunoproteasomes had not been available. Having now developed mice lacking the three immunoproteasome catalytic subunits, we found that the dendritic cells of these mice had defects in presenting several major histocompatibility complex (MHC) class I epitopes. During viral infection in vivo, the presentation of a majority of MHC class I epitopes was markedly reduced in immunoproteasome-deficient animals compared with wild-type animals, whereas presentation of MHC class II peptides was unaffected. According to mass spectrometry, the repertoire of MHC class I–presented peptides was ∼50% different from that in wild-type mice, and these differences were sufficient to stimulate robust transplant rejection of wild-type cells in mutant mice. These results indicated that immunoproteasomes were more important in antigen presentation than previously thought.
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Self-citationSTRUCTURE AND FUNCTIONS OF THE 20S AND 26S PROTEASOMES
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Self-citationMHC Class I Expression in Mice Lacking the Proteasome Subunit LMP-7
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Cancer Immune Evasion Through Loss of MHC Class I Antigen Presentation
Dhatchinamoorthy, K., Colbert, J. D., & Rock, K. L. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.636568 · Cited by 1,077
Self-citationA guide to antigen processing and presentation
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Major Histocompatibility Complex Genomics and Human Disease
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Targeting the ubiquitin-proteasome pathway to overcome anti-cancer drug resistance
Narayanan, S., Cai, C.-Y., Assaraf, Y. G., Guo, H.-Q., Cui, Q., Wei, L., Huang, J.-J., Ashby, C. R., & Chen, Z.-S. (2020) · Drug Resistance Updates · doi:10.1016/j.drup.2019.100663 · Cited by 332
Metadata
- Authors
- Kincaid, E. Z., Che, J. W., York, I., Escobar, H., Reyes-Vargas, E., Delgado, J. C., Welsh, R. M., Karow, M. L., Murphy, A. J., Valenzuela, D. M., Yancopoulos, G. D., & Rock, K. L.
- Venue
- Nature Immunology
- Published
- 2011-12-25
- Volume
- 13
- Issue
- 2
- Pages
- 129-135
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2058156851
- Cited by
- 289
- References
- 36
- FWCI
- 7.36
- Type
- journal article
- Language
- en
- Open access
- green
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- Kincaid, E. Z., Che, J. W., York, I., Escobar, H., Reyes-Vargas, E., Delgado, J. C., Welsh, R. M., Karow, M. L., Murphy, A. J., Valenzuela, D. M., Yancopoulos, G. D., & Rock, K. L. (2012). Mice completely lacking immunoproteasomes show major changes in antigen presentation. Nature Immunology. https://doi.org/10.1038/ni.2203
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