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MHC Class I Expression in Mice Lacking the Proteasome Subunit LMP-7
Abstract
Proteasomes degrade endogenous proteins. Two subunits, LMP-2 and LMP-7, are encoded in a region of the major histocompatibility complex (MHC) that is critical for class I-restricted antigen presentation. Mice with a targeted deletion of the gene encoding LMP-7 have reduced levels of MHC class I cell-surface expression and present the endogenous antigen HY inefficiently; addition of peptides to splenocytes deficient in LMP-7 restores wild-type class I expression levels. This demonstrates the involvement of LMP-7 in the MHC class I presentation pathway and suggests that LMP-7 functions as an integral part of the peptide supply machinery.
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Cited by
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TANAKA, K. (2009) · Proceedings of the Japan Academy, Series B · doi:10.2183/pjab.85.12 · Cited by 862
Ubiquitin, proteasomes, and the regulation of intracellular protein degradation
Hochstrasser, M. (1995) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(95)80031-x · Cited by 874
Regulation of CD8 + T Cell Development by Thymus-Specific Proteasomes
Murata, S., Sasaki, K., Kishimoto, T., Niwa, S.-I., Hayashi, H., Takahama, Y., & Tanaka, K. (2007) · Science · doi:10.1126/science.1141915 · Cited by 580
Development and Selection of T Cells: Facts and Puzzles
Kisielow, P., & Von Boehmer, H. (1995) · Advances in Immunology · doi:10.1016/s0065-2776(08)60620-3 · Cited by 444
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Metadata
- Authors
- Fehling, H. J., Swat, W., Laplace, C., Kühn, R., Rajewsky, K., Müller, U., & von Boehmer, H.
- Venue
- Science
- Published
- 1994-08-26
- Volume
- 265
- Issue
- 5176
- Pages
- 1234-1237
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2077147012
- Cited by
- 525
- References
- 0
- FWCI
- 12.99
- Type
- journal article
- Language
- en
- Open access
- closed
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- Fehling, H. J., Swat, W., Laplace, C., Kühn, R., Rajewsky, K., Müller, U., & von Boehmer, H. (1994). MHC Class I Expression in Mice Lacking the Proteasome Subunit LMP-7. Science. https://doi.org/10.1126/science.8066463
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
