The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Regulation of inflammasome signaling
Open accessAbstract
Innate immune responses have the ability to both combat infectious microbes and drive pathological inflammation. Inflammasome complexes are a central component of these processes through their regulation of interleukin 1β (IL-1β), IL-18 and pyroptosis. Inflammasomes recognize microbial products or endogenous molecules released from damaged or dying cells both through direct binding of ligands and indirect mechanisms. The potential of the IL-1 family of cytokines to cause tissue damage and chronic inflammation emphasizes the importance of regulating inflammasomes. Many regulatory mechanisms have been identified that act as checkpoints for attenuating inflammasome signaling at multiple steps. Here we discuss the various regulatory mechanisms that have evolved to keep inflammasome signaling in check to maintain immunological balance.
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Cites
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A role for mitochondria in nlrp3 inflammasome activation
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Autophagy in immunity and inflammation
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Cryopyrin activates the inflammasome in response to toxins and ATP
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Self-citationNakahira, K., Haspel, J. A., Rathinam, V. A. K., Lee, S.-J., Dolinay, T., Lam, H. C., Englert, J. A., Rabinovitch, M., Cernadas, M., Kim, H. P., et al. (2011) · Nature Immunology · doi:10.1038/ni.1980 · Cited by 3,049
Self-citationAIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
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Self-citationNon-canonical inflammasome activation targets caspase-11
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The NALP3 inflammasome is involved in the innate immune response to amyloid-β
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Self-citationThe AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses
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Cited by
Inflammasomes: mechanism of action, role in disease, and therapeutics
Guo, H., Callaway, J. B., & Ting, J. P.-Y. (2015) · Nature Medicine · doi:10.1038/nm.3893 · Cited by 3,340
Control of adaptive immunity by the innate immune system
Iwasaki, A., & Medzhitov, R. (2015) · Nature Immunology · doi:10.1038/ni.3123 · Cited by 2,160
“When CD22 is engaged by its sialic acid ligand, it activates the lipid phosphatase SHIP, which converts phosphatidylinositol-(3,4,5)trisphosphate (generated by PI(3)K) into phosphatidylinositol-(3,4)-bisphosphate and thus inhibits downstream steps in the PI(3)K signaling pathway96.”
BackgroundAutophagy in infection, inflammation and immunity
Deretic, V., Saitoh, T., & Akira, S. (2013) · Nature Reviews Immunology · doi:10.1038/nri3532 · Cited by 1,919
Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes
Lu, A., Magupalli, V. G., Ruan, J., Yin, Q., Atianand, M. K., Vos, M. R., Schröder, G. F., Fitzgerald, K. A., Wu, H., & Egelman, E. H. (2014) · Cell · doi:10.1016/j.cell.2014.02.008 · Cited by 1,353
Self-citationNEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux
He, Y., Zeng, M. Y., Yang, D., Motro, B., & Núñez, G. (2016) · Nature · doi:10.1038/nature16959 · Cited by 1,295
Metadata
- Authors
- Rathinam, V. A. K., Vanaja, S. K., & Fitzgerald, K. A.
- Venue
- Nature Immunology
- Published
- 2012-03-19
- Volume
- 13
- Issue
- 4
- Pages
- 333-342
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2009523990
- Cited by
- 927
- References
- 18
- FWCI
- 35.32
- Type
- journal article
- Language
- en
- Open access
- bronze
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