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Bidirectional regulation of neutrophil migration by mitogen-activated protein kinases
Open accessAbstract
To kill invading bacteria, neutrophils must interpret spatial cues, migrate and reach target sites. Although the initiation of chemotactic migration has been extensively studied, little is known about its termination. Here we found that two mitogen-activated protein kinases (MAPKs) had opposing roles in neutrophil trafficking. The extracellular signal–regulated kinase Erk potentiated activity of the G protein–coupled receptor kinase GRK2 and inhibited neutrophil migration, whereas the MAPK p38 acted as a noncanonical GRK that phosphorylated the formyl peptide receptor FPR1 and facilitated neutrophil migration by blocking GRK2 function. Therefore, the dynamic balance between Erk and p38 controlled neutrophil 'stop' and 'go' activity, which ensured that neutrophils reached their final destination as the first line of host defense.
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Citations
Cited by
Neutrophil recruitment and function in health and inflammation
Kolaczkowska, E., & Kubes, P. (2013) · Nature Reviews Immunology · doi:10.1038/nri3399 · Cited by 5,472
Neutrophil cell surface receptors and their intracellular signal transduction pathways
Futosi, K., Fodor, S., & Mócsai, A. (2013) · International Immunopharmacology · doi:10.1016/j.intimp.2013.06.034 · Cited by 642
Sun, D., Zhang, M., Liu, G., Wu, H., Zhu, X., Zhou, H., & Shi, M. (2016) · Infection and Immunity · doi:10.1128/iai.01197-15 · Cited by 39
Chen, Y., Liu, Z., Gong, P., Zhang, H., Chen, Y., Yao, S., Li, W., Zhang, Y., & Yu, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169041 · Cited by 25
Metadata
- Authors
- Liu, X., Ma, B., Malik, A. B., Tang, H., Yang, T., Sun, B., Wang, G., Minshall, R. D., Li, Y., Zhao, Y., Ye, R. D., & Xu, J.
- Venue
- Nature Immunology
- Published
- 2012-03-25
- Volume
- 13
- Issue
- 5
- Pages
- 457-464
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2143158290
- Cited by
- 204
- References
- 0
- FWCI
- 8.66
- Type
- journal article
- Language
- en
- Open access
- green
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- Liu, X., Ma, B., Malik, A. B., Tang, H., Yang, T., Sun, B., Wang, G., Minshall, R. D., Li, Y., Zhao, Y., Ye, R. D., & Xu, J. (2012). Bidirectional regulation of neutrophil migration by mitogen-activated protein kinases. Nature Immunology. https://doi.org/10.1038/ni.2258
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