The Chemerin/CMKLR1 Axis Is Involved in the Recruitment of Microglia to Aβ Deposition through p38 MAPK Pathway
Open accessAbstract
The accumulation of microglia around senile plaques is one of the pathological features of Alzheimer’s disease (AD). Chemerin is an adipokine with immune-modulating properties. Our previous study showed that chemokine-like receptor 1 (CMKLR1), the receptor for chemerin, is also a functional receptor of Aβ. However, it remains unclear whether and how the chemerin/CMKLR1 axis affects the migration of microglia. The impact of CMKLR1 on microglial activation and recruitment toward Aβ deposits was examined in APP/PS1 mice mated with CMKLR1 knockout (CMKLR1−/−) mice. CMKLR1 deficiency reduced the number of microglia around Aβ deposits in aged APP/PS1-CMKLR1−/− mice compared with APP/PS1 mice. Chemerin expression was significantly decreased in the hippocampus and cortex of aged APP/PS1 mice compared with WT mice. In vitro assays demonstrated that activation of the chemerin/CMKLR1 axis promoted the migration of primary cultures of microglia and murine microglial N9 cells. Mechanistic studies found that chemerin/CMKLR1 induced polarization and protrusion formation of microglia by promoting the remodeling of actin filaments and microtubules, and Golgi apparatus reorientation. The inhibition of p38 MAPK attenuated the promotion of the chemerin/CMKLR1 axis on microglial migration and polarization. In addition, chemerin inhibited Aβ-induced microglial clustering. The inhibition of p38 MAPK alleviated the suppressive effect of chemerin on Aβ-induced microglial aggregation. Our data indicate that the chemerin/CMKLR1 axis is involved in the migration and recruitment of microglia to senile plaques via the p38 MAPK pathway. Modulation of the chemerin/CMKLR1 axis is a potential new strategy for AD therapy.
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CMKLR1 and its ligand chemerin regulate the migration and recruitment of microglia to Aβ plaques in vivo and in vitro.
“Further studies found that CMKLR1 and its ligand chemerin regulate the migration and recruitment of microglia to Aβ plaques in vivo and in vitro [155].”
From Tau and neuroinflammation in Alzheimer’s disease: interplay mechanisms and clinical translation (2023) · cites this paper as [155]
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Zhang, Y., Xu, N., Ding, Y. P., Doycheva, D. M., Zhang, Y., Li, Q., Flores, J. J., Haghighiabyaneh, M., Tang, J., & Zhang, J. H. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1374-y · Cited by 69 · see citing works
Self-citationRetractedNeuroinflammation in Alzheimer's disease
Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)70016-5 · Cited by 6,226 · see citing works
Cell Migration: Integrating Signals from Front to Back
Ridley, A. J., Schwartz, M. A., Burridge, K., Firtel, R., Ginsberg, M. H., Borisy, G. G., Parsons, J. T., & Horwitz, A. R. (2003) · Science · doi:10.1126/science.1092053 · Cited by 4,929 · see citing works
In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro
Liang, C.-C., Park, A. Y., & Guan, J.-L. (2007) · Nature Protocols · doi:10.1038/nprot.2007.30 · Cited by 4,696 · see citing works
The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes
Benilova, I., Karran, E., & De Strooper, B. (2012) · Nature Neuroscience · doi:10.1038/nn.3028 · Cited by 1,962 · see citing works
Microglia emerge as central players in brain disease
Salter, M. W., & Stevens, B. (2017) · Nature Medicine · doi:10.1038/nm.4397 · Cited by 1,767 · see citing works
Microglia in neurodegeneration
Hickman, S., Izzy, S., Sen, P., Morsett, L., & El Khoury, J. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0242-x · Cited by 1,710 · see citing works
Clinical diagnosis of Alzheimer’s disease: Recommendations of the International Working Group
Dubois, B., Villain, N., Frisoni, G. B., Rabinovici, G. D., Sabbagh, M., Cappa, S., Bejanin, A., Bombois, S., Epelbaum, S., Teichmann, M., et al. (2021) · The Lancet Neurology · doi:10.1016/s1474-4422(21)00066-1 · Cited by 1,051 · cited 1× · see citing works
“Alzheimer’s disease (AD) is a chronic neurodegenerative disorder characterized by progressive memory loss and cognitive impairment [1].”
BackgroundIntegrin-Mediated Activation of Cdc42 Controls Cell Polarity in Migrating Astrocytes through PKCζ
Etienne‐Manneville, S., & Hall, A. K. (2001) · Cell · doi:10.1016/s0092-8674(01)00471-8 · Cited by 1,025 · see citing works
Wittamer, V., Franssen, J.-D., Vulcano, M., Mirjolet, J.-F., Le Poul, E., Migeotte, I., Brézillon, S., Tyldesley, R., Blanpain, C., Detheux, M., et al. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030382 · Cited by 888 · see citing works
Chemerin, a Novel Adipokine That Regulates Adipogenesis and Adipocyte Metabolism
Goralski, K. B., McCarthy, T. C., Hanniman, E. A., Zabel, B. A., Butcher, E. C., Parlee, S. D., Muruganandan, S., & Sinal, C. J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700793200 · Cited by 851 · see citing works
The genetic design of signaling cascades to record receptor activation
Barnea, G., Strapps, W. R., Herrada, G., Berman, Y. L., Ong, J., Kloss, B., Axel, R., & Lee, K. J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710487105 · Cited by 673 · see citing works
Mechanoreciprocity in cell migration
van Helvert, S., Storm, C., & Friedl, P. (2018) · Nature Cell Biology · doi:10.1038/s41556-017-0012-0 · Cited by 587 · see citing works
The role of chemerin in the colocalization of NK and dendritic cell subsets into inflamed tissues
Parolini, S., Santoro, A., Marcenaro, E., Luini, W., Massardi, L., Facchetti, F., Communi, D., Parmentier, M., Majorana, A., Sironi, M., et al. (2007) · Blood · doi:10.1182/blood-2006-08-038844 · Cited by 377 · see citing works
p38 Kinase Is Activated in the Alzheimer's Disease Brain
Hensley, K., Floyd, R. A., Zheng, N., Nael, R., Robinson, K. A., Nguyen, X., Pye, Q. N., Stewart, C. A., Geddes, J., Markesbery, W. R., et al. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0722053.x · Cited by 373 · see citing works
Synthetic chemerin-derived peptides suppress inflammation through ChemR23
Cash, J. L., Hart, R., Russ, A., Dixon, J. P. C., Colledge, W. H., Doran, J., Hendrick, A. G., Carlton, M. B. L., & Greaves, D. R. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20071601 · Cited by 372 · see citing works
Mairet-Coello, G., Courchet, J., Pieraut, S., Courchet, V., Maximov, A., & Polleux, F. (2013) · Neuron · doi:10.1016/j.neuron.2013.02.003 · Cited by 351 · see citing works
Kaur, J., Adya, R., Tan, B. K., Chen, J., & Randeva, H. S. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.12.150 · Cited by 349 · see citing works
Chemerin: a multifaceted adipokine involved in metabolic disorders
Helfer, G., & Wu, Q. (2018) · Journal of Endocrinology · doi:10.1530/joe-18-0174 · Cited by 317 · see citing works
Zabel, B. A., Nakae, S., Zuniga, L. A., Kim, J., Ohyama, T., Alt, C., Pan, J., Suto, H., Soler, D. F., Allen, S. J., et al. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080300 · Cited by 298 · see citing works
Vermi, W., Riboldi, E., Wittamer, V., Gentili, F., Luini, W., Marrelli, S., Vecchi, A., Franssen, J., Communi, D., Massardi, L., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041310 · Cited by 289 · see citing works
Zabel, B. A., Silverio, A. M., & Butcher, E. C. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.1.244 · Cited by 265 · see citing works
Site-specific phosphorylation of tau inhibits amyloid-β toxicity in Alzheimer’s mice
Ittner, A., Chua, S. W., Bertz, J., Volkerling, A., van der Hoven, J., Gladbach, A., Przybyla, M., Bi, M., van Hummel, A., Stevens, C. H., et al. (2016) · Science · doi:10.1126/science.aah6205 · Cited by 263 · see citing works
Luangsay, S., Wittamer, V., Bondue, B., Henau, O. D., Rouger, L., Brait, M., Franssen, J.-D., de Nadaı̈, P., Huaux, F., & Parmentier, M. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901037 · Cited by 256 · see citing works
Microglial Aβ Receptors in Alzheimer’s Disease
Yu, Y., & Ye, R. D. (2015) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-014-0101-6 · Cited by 247 · see citing works
Self-citationOsmani, N., Vitale, N., Borg, J.-P., & Etienne-Manneville, S. (2006) · Current Biology · doi:10.1016/j.cub.2006.10.026 · Cited by 239 · see citing works
Chemerin, a Novel Adipokine in the Regulation of Angiogenesis
Bozaoglu, K., Curran, J. E., Stocker, C. J., Zaibi, M. S., Segal, D., Konstantopoulos, N., Morrison, S., Carless, M. A., Dyer, T. D., Cole, S. A., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0042 · Cited by 226 · see citing works
Wittamer, V., Grégoire, F., Robberecht, P., Vassart, G., Communi, D., & Parmentier, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313016200 · Cited by 206 · see citing works
Characterization of human circulating TIG2 as a ligand for the orphan receptor ChemR23
Meder, W., Wendland, M., Busmann, A., Kutzleb, C., Spodsberg, N., John, H., Richter, R., Schleuder, D., Meyer, M., & Forssmann, W. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)01312-7 · Cited by 205 · see citing works
Bidirectional regulation of neutrophil migration by mitogen-activated protein kinases
Liu, X., Ma, B., Malik, A. B., Tang, H., Yang, T., Sun, B., Wang, G., Minshall, R. D., Li, Y., Zhao, Y. X., et al. (2012) · Nature Immunology · doi:10.1038/ni.2258 · Cited by 203 · see citing works
Kennedy, A. J., & Davenport, A. P. (2017) · Pharmacological Reviews · doi:10.1124/pr.116.013177 · Cited by 175 · see citing works
Pachynski, R. K., Zabel, B. A., Kohrt, H. E. K., Tejeda, N., Monnier, J., Swanson, C., Holzer, A. K., Gentles, A. J., Sperinde, G. V., Edalati, A., et al. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20112124 · Cited by 151 · see citing works
Phagocytosis of full-length Tau oligomers by Actin-remodeling of activated microglia
Das, R. R., Balmik, A. A., & Chinnathambi, S. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1694-y · Cited by 129 · see citing works
Xie, Y., Huang, Y., Ling, X., Qin, H., Wang, M., & Luo, B. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00381 · Cited by 107 · see citing works
Chemerin is highly expressed in hepatocytes and is induced in non-alcoholic steatohepatitis liver
Krautbauer, S., Wanninger, J., Eisinger, K., Hader, Y., Beck, M., Kopp, A., Schmid, A., Weiß, T. S., Dorn, C., & Buechler, C. (2013) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2013.07.009 · Cited by 95 · see citing works
Zhang, Y., Xu, N., Ding, Y. P., Zhang, Y., Li, Q., Flores, J. J., Haghighiabyaneh, M., Doycheva, D. M., Tang, J., & Zhang, J. H. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.02.015 · Cited by 84 · see citing works
Self-citationChemerin Peptides Promote Phagocytosis in a ChemR23- and Syk-Dependent Manner
Cash, J. L., Christian, A., & Greaves, D. R. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903378 · Cited by 81 · see citing works
Kunimoto, H., Kazama, K., Takai, M., Oda, M., Okada, M., & Yamawaki, H. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00820.2014 · Cited by 79 · see citing works
Huang, W.-C., Yen, F.-C., Shie, F., Pan, C., Shiao, Y.-J., Yang, C.-N., Huang, F.-L., Sung, Y. J., & Tsay, H. J. (2010) · Journal of Neuroinflammation · doi:10.1186/1742-2094-7-28 · Cited by 64 · see citing works
Adipokine Chemerin Bridges Metabolic Dyslipidemia and Alveolar Bone Loss in Mice
Ramos‐Junior, E. S., Leite, G. A., Carmo-Silva, C. C., Taira, T. M., Neves, K. B., Colón, D. F., da Silva, L. A. B., Salvador, S. L. D. S., Tostes, R. C., Cunha, F. Q., et al. (2016) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3072 · Cited by 64 · see citing works
The Chemerin Receptor CMKLR1 is a Functional Receptor for Amyloid-β Peptide
Lei, P., Yu, Y., Liu, J., Li, S., He, H., Cheng, N., & Ye, R. D. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-141227 · Cited by 59 · see citing works
Self-citationSuppression of LPS-induced tau hyperphosphorylation by serum amyloid A
Liu, J., Wang, D., Li, S.-Q., Yu, Y., & Ye, R. D. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0493-y · Cited by 58 · see citing works
Self-citationLi, S.-Q., Su, N., Gong, P., Zhang, H.-B., Liu, J., Wang, D., Sun, Y.-P., Zhang, Y., Qian, F., Zhao, B., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-06368-9 · Cited by 54 · see citing works
Self-citationKumar, J. D., Aolymat, I., Tiszlavicz, L., Reisz, Z., Garalla, H. M., Beynon, R. J., Simpson, D. M., Dockray, G. J., & Varró, A. (2019) · Oncotarget · doi:10.18632/oncotarget.26414 · Cited by 42 · see citing works
p38 MAPK Is a Major Regulator of Amyloid Beta-Induced IL-6 Expression in Human Microglia
Lin, H., Dixon, S. G., Hu, W., Hamlett, E. D., Jin, J., Ergul, A., & Wang, G. Y. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02909-0 · Cited by 41 · see citing works
Chamberland, J. P., Berman, R., Aronis, K. N., & Mantzoros, C. S. (2013) · European Journal of Endocrinology · doi:10.1530/eje-13-0098 · Cited by 39 · see citing works
Serum Amyloid A Differentially Activates Microglia and Astrocytes via the PI3K Pathway
Yu, Y., Liu, J., Li, S.-Q., Lei, P., & Ye, R. D. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130818 · Cited by 35 · see citing works
Self-citationExpression of chemerin correlates with a poor prognosis in female breast cancer patients
Sagheer, G. E., Gayyed, M. F., Ahmad, A., El-Fattah, A. A., & Mohamed, M. M. (2018) · Breast Cancer Targets and Therapy · doi:10.2147/bctt.s178181 · Cited by 35 · see citing works
Wen, J., Wang, J., Guo, L. P., Cai, W., Wu, Y., Chen, W., & Tang, X. (2019) · Europe PMC (PubMed Central) · Cited by 31 · see citing works
Serum amyloid A inhibits astrocyte migration via activating p38 MAPK
Lin, A., Liu, J., Gong, P., Chen, Y., Zhang, H., Zhang, Y., & Yu, Y. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01924-z · Cited by 29 · see citing works
Self-citationZhang, H., Lin, A., Gong, P., Chen, Y., Ye, R. D., Qian, F., Zhang, Y., & Yu, Y. (2020) · The Journal of Neuroscience · doi:10.1523/jneurosci.0455-20.2020 · Cited by 24 · see citing works
Self-citationPeng, L., Chen, Y., Li, Y., Feng, P., Zheng, Y., Dong, Y., Yang, Y., Wang, R., Li, A., Yan, J., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.767705 · Cited by 19 · see citing works
Self-citationSuzuki, T., Tatsuno, K., Ito, T., Sakabe, J., Funakoshi, A., & TOKURA, Y. (2016) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2016.06.003 · Cited by 14 · see citing works
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- Authors
- Chen, Y., Liu, Z., Gong, P., Zhang, H., Chen, Y., Yao, S., Li, W., Zhang, Y., & Yu, Y.
- Affiliations
- Shanghai Jiao Tong University (CN)
- Corresponding author
- Yu, Yang
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2022-08-12
- Volume
- 23
- Issue
- 16
- Pages
- 9041
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC9409288
- OpenAlex
- W4291885337
- Cited by
- 25
- References
- 53
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 5 · 2023: 5 · 2022: 1
- FWCI
- 1.85
- Type
- journal article
- Language
- en
- Update notices
- correction (2022-08-12)
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (81870835, 22ZR1434700)
- Natural Science Foundation of Shanghai (81870835, 22ZR1434700)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Keywords
- chemerin, CMKLR1, microglial migration, amyloid-beta, Alzheimer's disease, p38 MAPK, microglial polarization, amyloid plaques, APP/PS1 mice
- MeSH terms
- Alzheimer Disease, Animals, Disease Models, Animal, Mice, Transgenic, Amyloid beta-Peptides, Microglia, Chemokines, Receptors, Chemokine, Intercellular Signaling Peptides and Proteins, p38 Mitogen-Activated Protein Kinases, Mice, Plaque, Amyloid
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