The kinase TBK1 controls IgA class switching by negatively regulating noncanonical NF-κB signaling

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

Kawai, T., & Akira, S. (2010) · Nature Immunology · doi:10.1038/ni.1863 · Cited by 9,304

Shared Principles in NF-κB Signaling

Hayden, M. S., & Ghosh, S. (2008) · Cell · doi:10.1016/j.cell.2008.01.020 · Cited by 4,954

Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme

Muramatsu, M., Kinoshita, K., Fagarasan, S., Yamada, S., Shinkai, Y., & Honjo, T. (2000) · Cell · doi:10.1016/s0092-8674(00)00078-7 · Cited by 3,475

IKKε and TBK1 are essential components of the IRF3 signaling pathway

Fitzgerald, K. A., McWhirter, S. M., Faia, K. L., Rowe, D. C., Latz, E., Golenbock, D. T., Coyle, A. J., Liao, S.-M., & Maniatis, T. (2003) · Nature Immunology · doi:10.1038/ni921 · Cited by 2,680

Regulation and Function of NF-κB Transcription Factors in the Immune System

Vallabhapurapu, S., & Karin, M. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132641 · Cited by 2,635

Triggering the Interferon Antiviral Response Through an IKK-Related Pathway

Sharma, S., tenOever, B. R., Grandvaux, N., Zhou, G., Lin, R., & Hiscott, J. B. (2003) · Science · doi:10.1126/science.1081315 · Cited by 1,685

The immune geography of IgA induction and function

Macpherson, A. J., McCoy, K. D., Johansen, F.-E., & Brandtzaeg, P. (2007) · Mucosal Immunology · doi:10.1038/mi.2007.6 · Cited by 1,047

The regulation of IgA class switching

Cerutti, A. (2008) · Nature reviews. Immunology · doi:10.1038/nri2322 · Cited by 777

The noncanonical NF‐κB pathway

Sun, S. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01088.x · Cited by 752

Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study

Yu, H., Lin, L., Zhang, Z., Zhang, H., & Hu, H. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00312-6 · Cited by 2,329

The non-canonical NF-κB pathway in immunity and inflammation

Sun, S. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2017.52 · Cited by 1,959

NF‐κB signaling in inflammation and cancer

Zhang, T., Ma, C., Zhang, Z., Zhang, H., & Hu, H. (2021) · MedComm · doi:10.1002/mco2.104 · Cited by 639

NF-κB in inflammation and cancer

Mao, H., Zhao, X., & Sun, S. (2025) · Cellular and Molecular Immunology · doi:10.1038/s41423-025-01310-w · Cited by 601

NF-κB in inflammation and renal diseases

Zhang, H., & Sun, S.-C. (2015) · Cell & Bioscience · doi:10.1186/s13578-015-0056-4 · Cited by 383

Regulation of nuclear factor-κB in autoimmunity

Sun, S., Chang, J., & Jin, J. (2013) · Trends in Immunology · doi:10.1016/j.it.2013.01.004 · Cited by 324

Mucosal Profiling of Pediatric-Onset Colitis and IBD Reveals Common Pathogenics and Therapeutic Pathways

Huang, B., Chen, Z., Geng, L., Wang, J., Liang, H., Cao, Y., Chen, H., Huang, W., Su, M., Wang, H., et al. (2019) · Cell · doi:10.1016/j.cell.2019.10.027 · Cited by 309

Noncanonical NF-κB Signaling in Health and Disease

Cildir, G., Low, K. C., & Tergaonkar, V. (2016) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2016.03.002 · Cited by 301

Non-canonical NF-κB Antagonizes STING Sensor-Mediated DNA Sensing in Radiotherapy

Hou, Y., Liang, H. L., Rao, E., Zheng, W., Huang, X., Deng, L., Zhang, Y., Yu, X., Xu, M. M., Mauceri, H. J., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.07.008 · Cited by 278

Inducing Mucosal IgA: A Challenge for Vaccine Adjuvants and Delivery Systems

Boyaka, P. N. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601775 · Cited by 258

TBK1 at the Crossroads of Inflammation and Energy Homeostasis in Adipose Tissue

Zhao, P., Wong, K. I., Sun, X., Reilly, S. M., Uhm, M., Liao, Z., Skorobogatko, Y., & Saltiel, A. R. (2018) · Cell · doi:10.1016/j.cell.2018.01.007 · Cited by 250

Recent insights into the complexity of Tank‐binding kinase 1 signaling networks: The emerging role of cellular localization in the activation and substrate specificity of TBK1

Helgason, E., Phung, Q. T., & Dueber, E. C. (2013) · FEBS Letters · doi:10.1016/j.febslet.2013.01.059 · Cited by 184

Targeting TBK1 to overcome resistance to cancer immunotherapy

Sun, Y., Revach, O.-Y., Anderson, S., Kessler, E. A., Wolfe, C. H., Jenney, A., Mills, C. E., Robitschek, E. J., Davis, T. G. R., Kim, S., et al. (2023) · Nature · doi:10.1038/s41586-023-05704-6 · Cited by 174

Emerging Roles for Noncanonical NF-κB Signaling in the Modulation of Inflammatory Bowel Disease Pathobiology

McDaniel, D. K., Eden, K. B., Ringel-Scaia, V. M., & Allen, I. C. (2016) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000858 · Cited by 167

Targeting NF-κB-Inducing Kinase (NIK) in Immunity, Inflammation, and Cancer

Pflug, K. M., & Sitcheran, R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228470 · Cited by 163

The role of TBK1 in cancer pathogenesis and anticancer immunity

Runde, A. P., Mack, R. M., Breslin, P., & Zhang, J. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-022-02352-y · Cited by 159

Negative regulation of TBK1‐mediated antiviral immunity

Zhao, W. (2013) · FEBS Letters · doi:10.1016/j.febslet.2013.01.052 · Cited by 151

Biallelic loss-of-function mutation in NIK causes a primary immunodeficiency with multifaceted aberrant lymphoid immunity

Willmann, K. L., Klaver, S., Doğu, F., Santos-Valente, E., Garncarz, W., Bilić, I., Mace, E. M., Salzer, E., Conde, C. D., Sic, H., et al. (2014) · Nature Communications · doi:10.1038/ncomms6360 · Cited by 157

Regulation of IRF3 activation in human antiviral signaling pathways

Hamrashdi, M. A., & Brady, G. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115026 · Cited by 137

TBKBP1 and TBK1 form a growth factor signalling axis mediating immunosuppression and tumourigenesis

Zhu, L., Li, Y., Xie, X., Zhou, X., Gu, M., Jie, Z., Ko, C.-J., Gao, T., Hernandez, B. E., Cheng, X., et al. (2019) · Nature Cell Biology · doi:10.1038/s41556-019-0429-8 · Cited by 109

Nuclear Factor-κB Activation as a Pathological Mechanism of Lipid Metabolism and Atherosclerosis

Yu, X., Zheng, X., & Tang, C. (2015) · Advances in clinical chemistry · doi:10.1016/bs.acc.2015.03.004 · Cited by 132

NF-κB inducing kinase is a therapeutic target for systemic lupus erythematosus

Brightbill, H. D., Suto, E., Blaquière, N., Ramamoorthi, N., Sujatha-Bhaskar, S., Gogol, E. B., Castanedo, G. M., Jackson, B. T., Kwon, Y. C., Haller, S., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02672-0 · Cited by 132

NFκB and Kidney Injury

Song, N., Thaiss, F., & Guo, L. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00815 · Cited by 127

Biochemistry, Cell Biology, and Pathophysiology of the Innate Immune cGAS–cGAMP–STING Pathway

Ritchie, C., Carozza, J. A., & Li, L. (2022) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-040320-101629 · Cited by 123

Regulation of T-cell activation and migration by the kinase TBK1 during neuroinflammation

Yu, J., Zhou, X., Chang, M., Nakaya, M., Chang, J.-H., Xiao, Y., William Lindsey, J., Dorta-Estremera, S., Cao, W., Zal, A., et al. (2015) · Nature Communications · doi:10.1038/ncomms7074 · Cited by 118

Molecular control of the NEMO family of ubiquitin-binding proteins

Clark, K., Nanda, S. K., & Cohen, P. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3644 · Cited by 123

Roles of NF-κB Signaling in the Regulation of miRNAs Impacting on Inflammation in Cancer

Markopoulos, G. S., Roupakia, E., Tokamani, M., Alabasi, G., Sandaltzopoulos, R., Marcu, K. B., & Kolettas, E. (2018) · Biomedicines · doi:10.3390/biomedicines6020040 · Cited by 116

TBK1 Is a Synthetic Lethal Target in Cancer with VHL Loss

Hu, L., Xie, H., Liu, X., Potjewyd, F., James, L. I., Wilkerson, E., Herring, L. E., Xie, L., Chen, X., Cabrera, J. C., et al. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-0837 · Cited by 109

TBK1, a central kinase in innate immune sensing of nucleic acids and beyond

Zhou, R., Zhang, Q., & Xu, P. (2020) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmaa051 · Cited by 104

Expanding the View of IKK: New Substrates and New Biology

Antonia, R. J., Hagan, R. S., & Baldwin, A. S. (2021) · Trends in Cell Biology · doi:10.1016/j.tcb.2020.12.003 · Cited by 106

Discovery of GSK8612, a Highly Selective and Potent TBK1 Inhibitor

Thomson, D. W., Poeckel, D., Zinn, N., Rau, C., Strohmer, K., Wagner, A. J., Graves, A. P., Perrin, J., Bantscheff, M., Duempelfeld, B., et al. (2019) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.9b00027 · Cited by 103

IκB kinase ɛ (IKKɛ): A therapeutic target in inflammation and cancer

Verhelst, K., Verstrepen, L., Carpentier, I., & Beyaert, R. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.01.007 · Cited by 100

The kinase TBK1 functions in dendritic cells to regulate T cell homeostasis, autoimmunity, and antitumor immunity

Xiao, Y., Zou, Q., Xie, X., Liu, T., Li, H. S., Jie, Z., Jin, J., Hu, H., Manyam, G., Zhang, L., et al. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20161524 · Cited by 87

Heterozygous Tbk1 loss has opposing effects in early and late stages of ALS in mice

Brenner, D., Sieverding, K., Bruno, C., Lüningschrör, P., Buck, E., Mungwa, S., Fischer, L., Brockmann, S. J., Ulmer, J., Bliederhäuser, C., et al. (2019) · Journal of Experimental Medicine · doi:10.1084/jem.20180729 · Cited by 83

CD40-Mediated Activation of the NF-κB2 Pathway

Hostager, B. S., & Bishop, G. A. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00376 · Cited by 90

Roles for the IKK-Related Kinases TBK1 and IKKε in Cancer

Durand, J. K., Zhang, Q. H., & Baldwin, A. S. (2018) · Cells · doi:10.3390/cells7090139 · Cited by 73

A TRAF-like motif of the inducible costimulator ICOS controls development of germinal center TFH cells via the kinase TBK1

Pedros, C., Zhang, Y., Hu, J. K., Choi, Y. S., Canonigo-Balancio, A. J., Yates, J. R., Altman, A., Crotty, S., & Kong, K. (2016) · Nature Immunology · doi:10.1038/ni.3463 · Cited by 76

Peli1 negatively regulates noncanonical NF-κB signaling to restrain systemic lupus erythematosus

Liu, J., Huang, X., Hao, S., Wang, Y., Liu, M., Xu, J., Zhang, X., Yu, T., Gan, S., Dai, D., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03530-3 · Cited by 69

TANK-Binding Kinase 1-Dependent Responses in Health and Autoimmunity

Louis, C., Burns, C. J., & Wicks, I. P. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00434 · Cited by 64

Conditional Deletion of NF-κB–Inducing Kinase (NIK) in Adult Mice Disrupts Mature B Cell Survival and Activation

Brightbill, H. D., Jackman, J. K., Suto, E., Kennedy, H., Jones, C., Chalasani, S., Lin, Z., Tam, L., Roose-Girma, M., Balázs, M., et al. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1401514 · Cited by 65

Noncanonical NF-κB Signaling Is Limited by Classical NF-κB Activity

Gray, C. M., Remouchamps, C., McCorkell, K. A., Solt, L. A., Dejardin, E., Orange, J. S., & May, M. J. (2014) · Science Signaling · doi:10.1126/scisignal.2004557 · Cited by 62

TRIM14 Promotes Noncanonical NF‐κB Activation by Modulating p100/p52 Stability via Selective Autophagy

Chen, M., Zhao, Z., Meng, Q., Liang, P., Su, Z., Wu, Y., Huang, J., & Cui, J. (2019) · Advanced Science · doi:10.1002/advs.201901261 · Cited by 55

Activation of Melanocortin 1 Receptor Attenuates Early Brain Injury in a Rat Model of Subarachnoid Hemorrhage viathe Suppression of Neuroinflammation through AMPK/TBK1/NF-κB Pathway in Rats

Xu, W., Mo, J., Ocak, U., Travis, Z. D., Enkhjargal, B., Zhang, T., Wu, P., Peng, J., Li, T., Zuo, Y., et al. (2019) · Neurotherapeutics · doi:10.1007/s13311-019-00772-x · Cited by 48

Fasting-Mimicking Diet Drives Antitumor Immunity against Colorectal Cancer by Reducing IgA-Producing Cells

Zhong, Z., Zhang, H., Nan, K., Zhong, J., Wu, Q., Lu, L., Yue, Y., Zhang, Z., Guo, M., Wang, Z., et al. (2023) · Cancer Research · doi:10.1158/0008-5472.can-23-0323 · Cited by 50

Deletion of Tbk1 disrupts autophagy and reproduces behavioral and locomotor symptoms of FTD-ALS in mice

Duan, W., Guo, M., Yi, L., Zhang, J., Bi, Y., Liu, Y., Li, Y., Li, Z., Ma, Y., Zhang, G., et al. (2019) · Aging · doi:10.18632/aging.101936 · Cited by 51

Transcriptome analysis of response mechanism to ammonia stress in Asian clam (Corbicula fluminea)

Zhang, T., Yan, Z., Zheng, X., Fan, J., Wang, S., Wei, Y., Yang, L., Wang, P., & Guo, S. (2019) · Aquatic Toxicology · doi:10.1016/j.aquatox.2019.105235 · Cited by 45

CRL4DCAF2 negatively regulates IL-23 production in dendritic cells and limits the development of psoriasis

Huang, T., Gao, Z., Zhang, Y., Fan, K.-Q., Wang, F., Li, Y., Zhong, J.-Y., Fan, H., Cao, Q., Zhou, J., et al. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20180210 · Cited by 41

A TRAF3-NIK module differentially regulates DNA vs RNA pathways in innate immune signaling

Parvatiyar, K., Pindado, J., Dev, A., Aliyari, S. R., Zaver, S. A., Gerami, H., Chapon, M., Ghaffari, A. A., Dhingra, A., & Cheng, G. (2018) · Nature Communications · doi:10.1038/s41467-018-05168-7 · Cited by 43

NIK as a Druggable Mediator of Tissue Injury

Rivas, L. V., Vaquero, J. J., Sucunza, D., Gutiérrez, S., Sanz, A. B., Fresno, M., Ortíz, A., & Sánchez-Niño, M. D. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.02.005 · Cited by 42

A review on the role of TANK-binding kinase 1 signaling in cancer

Alam, M., Hasan, G. M., & Hassan, M. I. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.06.022 · Cited by 43

Signaling mechanisms regulating B-lymphocyte activation and tolerance

Hobeika, E., Nielsen, P. J., & Medgyesi, D. (2015) · Journal of Molecular Medicine · doi:10.1007/s00109-015-1252-8 · Cited by 42

METTL23 mutation alters histone H3R17 methylation in normal-tension glaucoma

Pan, Y., Suga, A., Kimura, I., Kimura, C., Minegishi, Y., Nakayama, M., Yoshitake, K., Iejima, D., Minematsu, N., Yamamoto, M., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci153589 · Cited by 39

NF-κB Inducing Kinase Regulates Intestinal Immunity and Homeostasis

Wang, B., & Shen, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.895636 · Cited by 42

Targeting TBK1 Attenuates LPS-Induced NLRP3 Inflammasome Activation by Regulating of mTORC1 Pathways in Trophoblasts

Lee, S., Shin, J., Kim, J.-S., Shin, J., Lee, S. K., & Park, H. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.743700 · Cited by 38

IFN Regulatory Factor 3 Balances Th1 and T Follicular Helper Immunity during Nonlethal Blood-Stage Plasmodium Infection

James, K. R., Soon, M. S. F., Sebina, I., Fernandez‐Ruiz, D., Davey, G. M., Liligeto, U. N., Nair, A. S., Fogg, L. G., Edwards, C. L., Best, S. E., et al. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1700782 · Cited by 32

Myeloid cell TBK1 restricts inflammatory responses

Gao, T., Liu, T., Ko, C., Zhang, L., Joo, D., Xie, X., Zhu, L., Li, Y., Cheng, X., & Sun, S. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2107742119 · Cited by 35

A Complex Relationship between TRAF3 and Non-Canonical NF-κB2 Activation in B Lymphocytes

Lin, W., Hildebrand, J. M., & Bishop, G. A. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00477 · Cited by 34

NF-kappaB-inducing kinase in cancer

Maubach, G., Feige, M. H., Lim, M. C. C., & Naumann, M. (2018) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2018.10.002 · Cited by 33

NIK regulates MT1-MMP activity and promotes glioma cell invasion independently of the canonical NF-κB pathway

Duran, C. L., Lee, D. W., Jung, J.-U., Ravi, S., Pogue, C. B., Toussaint, L. G., Bayless, K. J., & Sitcheran, R. (2016) · Oncogenesis · doi:10.1038/oncsis.2016.39 · Cited by 32

Intestinal Epithelial TBK1 Prevents Differentiation of T-helper 17 Cells and Tumorigenesis in Mice

Yang, J., Jie, Z., Mathews, A., Zhou, X., Li, Y., Gu, M., Xie, X., Ko, C., Cheng, X., Qi, Y., et al. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.07.047 · Cited by 32

Neutrophils negatively regulate induction of mucosal IgA responses after sublingual immunization

Jee, J., Bonnegarde-Bernard, A., Duverger, A. E., Iwakura, Y., Cormet‐Boyaka, E., Martin, T. L., Steiner, H. E., Bachman, R. C., & Boyaka, P. N. (2015) · Mucosal Immunology · doi:10.1038/mi.2014.105 · Cited by 30

Noncanonical NF-κB Signaling Pathway in Liver Diseases

Chen, Q., Lu, X., & Zhang, X. (2020) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2020.00063 · Cited by 30

N4BP1 coordinates ubiquitin-dependent crosstalk within the IκB kinase family to limit Toll-like receptor signaling and inflammation

Gitlin, A. D., Maltzman, A., Kanno, Y., Heger, K., Reja, R., Schubert, A. F., Wierciszewski, L. J., Pantua, H., Kapadia, S. B., Harris, S. F., et al. (2024) · Immunity · doi:10.1016/j.immuni.2024.04.004 · Cited by 28

Hemizygous deletion of Tbk1 worsens neuromuscular junction pathology in TDP-43 transgenic mice

Sieverding, K., Ulmer, J., Bruno, C., Satoh, T., Tsao, W., Freischmidt, A., Akira, S., Wong, P. C., Ludolph, A. C., Danzer, K. M., et al. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113496 · Cited by 30

TCR signaling to NF-κB and mTORC1: Expanding roles of the CARMA1 complex

Shi, J., & Sun, S. (2015) · Molecular Immunology · doi:10.1016/j.molimm.2015.07.024 · Cited by 31

The canonical and non-canonical NF-κB pathways and their crosstalk: A comparative study based on Petri nets

Trares, K., Ackermann, J., & Koch, I. (2021) · Biosystems · doi:10.1016/j.biosystems.2021.104564 · Cited by 29

Regulation of pyroptosis by NF-κB signaling

Yang, L., Zhang, Y., Chai, Z., Zhou, Y., Li, Z., & Wei, Y. (2025) · Frontiers in Cell Death · doi:10.3389/fceld.2024.1503799 · Cited by 28

Signaling control of antibody isotype switching

Chen, Z., & Wang, J. H. (2019) · Advances in immunology · doi:10.1016/bs.ai.2019.01.001 · Cited by 28

The chemical biology of IL-12 production via the non-canonical NFkB pathway

Koch, P. D., Pittet, M. J., & Weissleder, R. (2020) · RSC Chemical Biology · doi:10.1039/d0cb00022a · Cited by 25

Acute TBK1/IKK-ε Inhibition Enhances the Generation of Disease-Associated Microglia-Like Phenotype Upon Cortical Stab-Wound Injury

Rehman, R., Tar, L., Olamide, A. J., Li, Z., Kassubek, J., Böckers, T. M., Weishaupt, J. H., Ludolph, A. C., Wiesner, D., & Roselli, F. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.684171 · Cited by 24

Prospects for gene replacement therapies in amyotrophic lateral sclerosis

Giovannelli, I., Higginbottom, A., Kirby, J., Azzouz, M., & Shaw, P. J. (2022) · Nature Reviews Neurology · doi:10.1038/s41582-022-00751-5 · Cited by 23

Myeloid TBK1 Signaling Contributes to the Immune Response to Influenza

Hagan, R. S., Torres-Castillo, J. L., & Doerschuk, C. M. (2018) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2018-0122oc · Cited by 23

B cell–intrinsic TBK1 is essential for germinal center formation during infection and vaccination in mice

Lee, M. S. J., Inoue, T., Ise, W., Matsuo-Dapaah, J., Wing, J. B., Temizoz, B., Kobiyama, K., Hayashi, T., Patil, A., Sakaguchi, S., et al. (2022) · Journal of Experimental Medicine · doi:10.1084/jem.20211336 · Cited by 21

Protein kinase networks that limit TLR signalling

Clark, K. (2014) · Biochemical Society Transactions · doi:10.1042/bst20130124 · Cited by 21

All roads lead to IgA : Mapping the many pathways of IgA induction in the gut

Siniscalco, E. R., Williams, A., & Eisenbarth, S. C. (2024) · Immunological Reviews · doi:10.1111/imr.13369 · Cited by 20

Novel T Follicular Helper-like T-Cell Lymphoma Therapies: From Preclinical Evaluation to Clinical Reality

Krug, A., Tari, G., Saidane, A., Gaulard, P., Ricci, J., Lemonnier, F., & Verhoeyen, E. (2022) · Cancers · doi:10.3390/cancers14102392 · Cited by 22

Constitutive renal Rel/nuclear factor-κB expression in Lewis polycystic kidney disease rats

Ta, M. H. T., Schwensen, K. G., Liuwantara, D., Huso, D. L., Watnick, T. J., & Rangan, G. K. (2016) · World Journal of Nephrology · doi:10.5527/wjn.v5.i4.339 · Cited by 21

TBK1 as a regulator of autoimmunity and antitumor immunity

Shi, J., Xie, X., & Sun, S. (2018) · Cellular and Molecular Immunology · doi:10.1038/cmi.2017.165 · Cited by 19

Therapeutic targeting of TANK-binding kinase signaling towards anticancer drug development: Challenges and opportunities

Alam, M., Ansari, M. M., Noor, S., Mohammad, T., Hasan, G. M., Kazim, S. N., & Hassan, M. I. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.03.157 · Cited by 21

Deleted in Breast Cancer 1 Suppresses B Cell Activation through RelB and Is Regulated by IKKα Phosphorylation

Kong, S., Dong, H., Song, J. J., Thiruppathi, M., Prabhakar, B. S., Qiu, Q., Lin, Z., Chini, E. N., Zhang, B., & Fang, D. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500713 · Cited by 19

LUBAC enables tumor-promoting LTβ receptor signaling by activating canonical NF-κB

Chen, Y., Rieser, E., Bhamra, A., Šurinová, S., Kreuzaler, P. A., Ho, M.-H., Tsai, W., Peltzer, N., de Miguel, D., & Walczak, H. (2024) · Cell Death and Differentiation · doi:10.1038/s41418-024-01355-w · Cited by 18

The Therapeutic Potential of Targeting NIK in B Cell Malignancies

Haselager, M. V., & Eldering, E. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.930986 · Cited by 21

IKKε and TBK1 prevent RIPK1 dependent and independent inflammation

Eren, R. O., Kaya, G. G., Schwarzer, R., & Pasparakis, M. (2024) · Nature Communications · doi:10.1038/s41467-023-44372-y · Cited by 18

Cytosolic DNA sensors in neurodegenerative diseases: from physiological defenders to pathological culprits

Xie, J., Cheng, J., Ko, H., & Tang, Y. (2024) · EMBO Molecular Medicine · doi:10.1038/s44321-024-00046-w · Cited by 17

Poxviral Targeting of Interferon Regulatory Factor Activation

Lawler, C., & Brady, G. (2020) · Viruses · doi:10.3390/v12101191 · Cited by 18

Recent progress in small molecule TBK1 inhibitors: a patent review (2015– 2020)

Thomson, D. W., & Bergamini, G. (2021) · Expert Opinion on Therapeutic Patents · doi:10.1080/13543776.2021.1904893 · Cited by 16

Inhibition of TANK‐binding kinase1 attenuates the astrocyte‐mediated neuroinflammatory response through YAP signaling after spinal cord injury

Zhang, W., Jia, M., Lian, J., Lu, S., Zhou, J., Fan, Z., Zhu, Z., He, Y., Huang, C., Zhu, M., et al. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14170 · Cited by 16

TRIM55 promotes noncanonical NF-κB signaling and B cell–mediated immune responses by coordinating p100 ubiquitination and processing

Lin, L., Yu, H., Li, L., Yang, W., Chen, X., Gong, Y., Lei, Q., Li, Z., Zhou, Z., Dai, L., et al. (2023) · Science Signaling · doi:10.1126/scisignal.abn5410 · Cited by 16

DBC1 Is a Suppressor of B Cell Activation by Negatively Regulating Alternative NF-κB Transcriptional Activity

Kong, S., Thiruppathi, M., Qiu, Q., Lin, Z., Dong, H., Chini, E. N., Prabhakar, B. S., & Fang, D. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1401798 · Cited by 16

A recombinant trans-membrane protein hMnSOD–R9 inhibits the proliferation of cervical cancer cells in vitro

Zhang, Z., Huang, L., Wu, Q., Yang, E., Zhang, G., Sun, H., & Wang, F. (2013) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-013-1816-2 · Cited by 16

TANK-Binding Kinase 1 in the Pathogenesis and Treatment of Inflammation-Related Diseases

Lü, H., Chen, X., Huang, M., Jiang, Y., & Liu, T. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26051941 · Cited by 15

IKKe in osteoclast inhibits the progression of methylprednisolone-induced osteonecrosis

Liu, Y., Shan, H., Zong, Y., Lin, Y., Xia, W., Wang, N., Zhou, L., Gao, Y., Ma, X., Jiang, C., et al. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.57962 · Cited by 15

TLR4 agonist activity of Alcaligenes lipid a utilizes MyD88 and TRIF signaling pathways for efficient antigen presentation and T cell differentiation by dendritic cells

Sun, X., Hosomi, K., Shimoyama, A., Yoshii, K., Lan, H., Wang, Y., Yamaura, H., Nagatake, T., Ishii, K. J., Akira, S., et al. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.109852 · Cited by 15

CD11b regulates antibody class switching via induction of AID

Park, S., Sim, H., Kim, H., Jeong, D., Wu, G. J., Cho, S. Y., Lee, Y. S., Kwon, H., & Lee, K. (2017) · Molecular Immunology · doi:10.1016/j.molimm.2017.04.005 · Cited by 15

Haploinsufficiency of TANK-binding kinase 1 prepones age-associated neuroinflammatory changes without causing motor neuron degeneration in aged mice

Bruno, C., Sieverding, K., Freischmidt, A., Satoh, T., Walther, P., Mayer, B., Ludolph, A. C., Akira, S., Yilmazer‐Hanke, D., Danzer, K. M., et al. (2020) · Brain Communications · doi:10.1093/braincomms/fcaa133 · Cited by 14

Negative feedback regulation of NF-κB-inducing kinase is proteasome-dependent but does not require cellular inhibitors of apoptosis

Gray, C. M., McCorkell, K. A., Chunduru, S. K., McKinlay, M. A., & May, M. J. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.05.122 · Cited by 13

The path less traveled: the non-canonical NF-κB pathway in systemic lupus erythematosus

Montano, H., Allen, I. C., & Reilly, C. M. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1588486 · Cited by 12

miR-200bc/429 cluster alleviates inflammation in IgA nephropathy by targeting TWEAK/Fn14

Guo, Y., & Liao, Y. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2017.09.002 · Cited by 12

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Chandrasekar, A. P., Maynes, M. A., & Badley, A. D. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1354502 · Cited by 11

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Wang, Y., Yuan, J., Dai, D., Liu, J., Xu, J., Miao, X., Wang, H., Mao, C., & Xiao, Y. (2018) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmy082 · Cited by 11

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Jin, J., Xiao, Y., Chang, J.-H., Yu, J., Hu, H., Starr, R., George, C., Chang, M., Cheng, X., & Sun, S.-C. (2012)

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Carney, E. F. (2012) · Nature Reviews Nephrology · doi:10.1038/nrneph.2012.226

TBK1 suppression of IgA in the NIK of time

Bram, R. J. (2012) · Nature Immunology · doi:10.1038/ni.2451 · Cited by 10

TBK1 as a regulator of autoimmunity and antitumor immunity

Shi, J., Xie, X., & Sun, S. (2018) · Cellular and Molecular Immunology · doi:10.1038/cmi.2017.165 · Cited by 19

T-bet regulates IgG class switching and pathogenic autoantibody production

Peng, S. L., Szabo, S. J., & Glimcher, L. H. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.082114899 · Cited by 498