TBK1, a central kinase in innate immune sensing of nucleic acids and beyond

Pattern Recognition Receptors and Inflammation

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Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

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Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

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STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

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Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3

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STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

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IKKε and TBK1 are essential components of the IRF3 signaling pathway

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Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

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IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

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Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

Chen, Q., Sun, L., & Chen, Z. J. (2016) · Nature Immunology · doi:10.1038/ni.3558 · Cited by 2,333 · see citing works

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

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Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

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VISA Is an Adapter Protein Required for Virus-Triggered IFN-β Signaling

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cGAS surveillance of micronuclei links genome instability to innate immunity

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CGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING.

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Triggering the Interferon Antiviral Response Through an IKK-Related Pathway

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Chromosomal instability drives metastasis through a cytosolic DNA response

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Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity

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The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation

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DNA sensing by the cGAS–STING pathway in health and disease

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Cytoplasmic chromatin triggers inflammation in senescence and cancer

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STING Specifies IRF3 Phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway

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Phosphorylation of the Autophagy Receptor Optineurin Restricts <i>Salmonella</i> Growth

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MAVS Forms Functional Prion-like Aggregates to Activate and Propagate Antiviral Innate Immune Response

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Autophagy induction via STING trafficking is a primordial function of the cGAS pathway

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Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence

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Glaucoma

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Cyclic [G(2′,5′)pA(3′,5′)p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase.

Gao, P., Ascano, M., Wu, Y., Barchet, W., Gaffney, B. L., Zillinger, T., Serganov, A. A., Liu, Y., Jones, R. A., Hartmann, G., et al. (2013) · Cell · doi:10.1016/j.cell.2013.04.046 · Cited by 1,101 · see citing works

Structural basis of STING binding with and phosphorylation by TBK1

Zhang, C., Shang, G., Gui, X., Zhang, X., Bai, X.-C., & Chen, Z. J. (2019) · Nature · doi:10.1038/s41586-019-1000-2 · Cited by 1,095 · see citing works

Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING

Zhang, X., Shi, H., Wu, J., Zhang, X., Sun, L., Chen, C., & Chen, Z. J. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.05.022 · Cited by 1,086 · see citing works

TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation

Everts, B., Amiel, E., Huang, S. C.-C., Smith, A. M., Chang, C.-H., Lam, W. Y., Redmann, V., Freitas, T. C., Blagih, J., van der Windt, G. J. W., et al. (2014) · Nature Immunology · doi:10.1038/ni.2833 · Cited by 1,064 · see citing works

cGAS is essential for cellular senescence

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Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways

Cirulli, E. T., Lasseigne, B. N., Petrovski, S., Sapp, P. C., Dion, P. A., Leblond, C. S., Couthouis, J., Lu, Y.-F., Wang, Q., Krueger, B. J., et al. (2015) · Science · doi:10.1126/science.aaa3650 · Cited by 966 · see citing works

The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy

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ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization

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Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response

Saitoh, T., Fujita, N., Hayashi, T., Takahara, K., Satoh, T., Lee, H., Matsunaga, K., Kageyama, S., Omori, H., Noda, T., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911267106 · Cited by 854 · see citing works

Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia

Freischmidt, A., Wieland, T., Richter, B., Ruf, W., Schaeffer, V., Müller, K., Marroquin, N., Nordin, F., Hübers, A., Weydt, P., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4000 · Cited by 786 · see citing works

The innate immune DNA Sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING.

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STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade

Fu, J., Kanne, D. B., Leong, M., Glickman, L. H., McWhirter, S. M., Lemmens, E., Mechette, K., Leong, J. J., Lauer, P., Liu, W., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa4306 · Cited by 720 · see citing works

Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases

Gao, D., Li, T., Li, X.-D., Chen, X., Li, Q., Wight‐Carter, M., & Chen, Z. J. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1516465112 · Cited by 685 · see citing works

TBK-1 Promotes Autophagy-Mediated Antimicrobial Defense by Controlling Autophagosome Maturation

Pilli, M., Arko-Mensah, J., Ponpuak, M., Roberts, E., Master, S., Mandell, M. A., Dupont, N., Ornatowski, W., Jiang, S., Bradfute, S. B., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.04.015 · Cited by 655 · see citing works

STING Activation by Translocation from the ER Is Associated with Infection and Autoinflammatory Disease

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Post-Translational Modification Control of Innate Immunity

Liu, J., Qian, C., & Cao, X. (2016) · Immunity · doi:10.1016/j.immuni.2016.06.020 · Cited by 632 · see citing works

NF‐κB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK‐related kinase

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STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity

Demaria, O., Gassart, A. D., Coso, S., Gestermann, N., Domizio, J. D., Flatz, L., Gaide, O., Michielin, O. A., Hwu, P., Petrova, T. V., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1512832112 · Cited by 574 · see citing works

Recognition of Endogenous Nucleic Acids by the Innate Immune System

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IFN-regulatory factor 3-dependent gene expression is defective in Tbk1 -deficient mouse embryonic fibroblasts

McWhirter, S. M., Fitzgerald, K. A., Rosains, J., Rowe, D. C., Golenbock, D. T., & Maniatis, T. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2237236100 · Cited by 540 · see citing works

TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging

Xu, D., Jin, T., Zhu, H., Chen, H., Ofengeim, D., Zou, C., Mifflin, L., Pan, L., Amin, P., Li, W., et al. (2018) · Cell · doi:10.1016/j.cell.2018.07.041 · Cited by 461 · see citing works

STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease

Petrasek, J., Iracheta‐Vellve, A., Csák, T., Satishchandran, A., Kodys, K., Kurt‐Jones, E. A., Fitzgerald, K. A., & Szabó, G. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1308331110 · Cited by 452 · see citing works

A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1

Zhao, B., Du, F., Xu, P., Shu, C., Sankaran, B., Bell, S. L., Liu, M., Lei, Y., Gao, X., Fu, X., et al. (2019) · Nature · doi:10.1038/s41586-019-1228-x · Cited by 447 · see citing works

An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice

Reilly, S. M., Chiang, S.-H., Decker, S. J., Chang, L. C., Uhm, M., Larsen, M. J., Rubin, J. R., Mowers, J. C., White, N. M. A., Hochberg, I., et al. (2013) · Nature Medicine · doi:10.1038/nm.3082 · Cited by 434 · see citing works

Use of the Pharmacological Inhibitor BX795 to Study the Regulation and Physiological Roles of TBK1 and IκB Kinase ϵ

Clark, K., Plater, L., Peggie, M. W., & Cohen, P. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.000414 · Cited by 389 · see citing works

Deficiency of T2K leads to apoptotic liver degeneration and impaired NF‐κB‐dependent gene transcription

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Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKε‐mediated IRF activation

Schröder, M., Baran, M., & Bowie, A. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.143 · Cited by 374 · see citing works

Activation of STAT6 by STING Is Critical for Antiviral Innate Immunity

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RalB GTPase-Mediated Activation of the IκB Family Kinase TBK1 Couples Innate Immune Signaling to Tumor Cell Survival

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Dynamic recruitment and activation of ALS-associated TBK1 with its target optineurin are required for efficient mitophagy

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The tumour suppressor CYLD is a negative regulator of RIG‐I‐mediated antiviral response

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Mapping a Dynamic Innate Immunity Protein Interaction Network Regulating Type I Interferon Production

Li, S., Wang, L., Berman, M. A., Kong, Y., & Dorf, M. E. (2011) · Immunity · doi:10.1016/j.immuni.2011.06.014 · Cited by 334 · see citing works

STING Senses Microbial Viability to Orchestrate Stress-Mediated Autophagy of the Endoplasmic Reticulum

Moretti, J., Roy, S., Bozec, D., Martinez, J., Chapman, J. R., Ueberheide, B. M., Lamming, D. W., Chen, Z. J., Horng, T., Yeretssian, G., et al. (2017) · Cell · doi:10.1016/j.cell.2017.09.034 · Cited by 329 · see citing works

Novel cross-talk within the IKK family controls innate immunity

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Agonist-Mediated Activation of STING Induces Apoptosis in Malignant B Cells

Tang, C.-H. A., Zundell, J. A., Ranatunga, S., Lin, C., Nefedova, Y., Valle, J. R. D., & Hu, C. A. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-1885 · Cited by 318 · see citing works

The E3 ubiquitin ligase Nrdp1 'preferentially' promotes TLR-mediated production of type I interferon

Wang, C., Chen, T., Zhang, J., Yang, M., Li, N., Xu, X., & Cao, X. (2009) · Nature Immunology · doi:10.1038/ni.1742 · Cited by 317 · see citing works

Whole-genome sequencing reveals important role for TBK1 and OPTN mutations in frontotemporal lobar degeneration without motor neuron disease

Pottier, C., Bieniek, K. F., Finch, N., van de Vorst, M., Baker, M., Perkersen, R., Brown, P., Ravenscroft, T., van Blitterswijk, M., Nicholson, A. M., et al. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1436-x · Cited by 312 · see citing works

Molecular and cellular pathways of neurodegeneration in motor neurone disease

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NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4

Cui, J., Li, Y., Zhu, L., Liu, D., Songyang, Z., Wang, H. Y., & Wang, R. (2012) · Nature Immunology · doi:10.1038/ni.2239 · Cited by 306 · see citing works

Intrinsic antiproliferative activity of the innate sensor STING in T lymphocytes

Cerboni, S., Jeremiah, N., Gentili, M., Gehrmann, U., Conrad, C., Stolzenberg, M., Pïcard, C., Neven, B., Fischer, A., Amigorena, S., et al. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20161674 · Cited by 303 · see citing works

Immune-mediated Mechanisms in the Pathoprogression of Amyotrophic Lateral Sclerosis

Zhao, W., Beers, D. R., & Appel, S. H. (2013) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-013-9489-x · Cited by 298 · see citing works

Zika Virus Disrupts Phospho-TBK1 Localization and Mitosis in Human Neuroepithelial Stem Cells and Radial Glia

Onorati, M., Li, Z., Liu, F., Sousa, A. M. M., Nakagawa, N., Li, M., Dell’Anno, M. T., Gulden, F. O., Pochareddy, S., Tebbenkamp, A. T. N., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.08.038 · Cited by 292 · see citing works

Heterozygous TBK1 mutations impair TLR3 immunity and underlie herpes simplex encephalitis of childhood

Casadio, M., Ciancanelli, M. J., Ou, Y.-H., Lorenzo, L., Klaudel‐Dreszler, M., Pauwels, E., Sancho‐Shimizu, V., de Diego, R. P., Abhyankar, A., Israelsson, E., et al. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20111316 · Cited by 279 · see citing works

HER2 recruits AKT1 to disrupt STING signalling and suppress antiviral defence and antitumour immunity

Wu, S., Zhang, Q., Zhang, F., Meng, F., Liu, S., Zhou, R., Wu, Q., Li, X., Shen, L., Huang, J., et al. (2019) · Nature Cell Biology · doi:10.1038/s41556-019-0352-z · Cited by 274 · see citing works

Severe Acute Respiratory Syndrome Coronavirus M Protein Inhibits Type I Interferon Production by Impeding the Formation of TRAF3·TANK·TBK1/IKKϵ Complex

Siu, K., Kok, K., Ng, M.-H. J., Poon, V. K., Yuen, K., Zheng, B.-J., & Jin, D. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.008227 · Cited by 273 · see citing works

The critical role of toll-like receptors — From microbial recognition to autoimmunity: A comprehensive review

Jimenez-Dalmaroni, M. J., Gerswhin, M. E., & Adamopoulos, I. E. (2015) · Autoimmunity Reviews · doi:10.1016/j.autrev.2015.08.009 · Cited by 259 · see citing works

TBK1 at the Crossroads of Inflammation and Energy Homeostasis in Adipose Tissue

Zhao, P., Wong, K. I., Sun, X., Reilly, S. M., Uhm, M., Liao, Z., Skorobogatko, Y. V., & Saltiel, A. R. (2018) · Cell · doi:10.1016/j.cell.2018.01.007 · Cited by 252 · see citing works

Crystal Structure and Mechanism of Activation of TANK-Binding Kinase 1

Larabi, A., Devos, J. M., Ng, S., Nanao, M., Round, A. R., Maniatis, T., & Panne, D. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.01.034 · Cited by 251 · see citing works

iRhom2 is essential for innate immunity to DNA viruses by mediating trafficking and stability of the adaptor STING

Luo, W., Li, S., Li, C., Lian, H., Yang, Q., Zhong, B., & Shu, H. (2016) · Nature Immunology · doi:10.1038/ni.3510 · Cited by 248 · see citing works

SHP-2 Phosphatase Negatively Regulates the TRIF Adaptor Protein-Dependent Type I Interferon and Proinflammatory Cytokine Production

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Molecular basis of Tank-binding kinase 1 activation by transautophosphorylation

Ma, X., Helgason, E., Phung, Q. T., Quan, C. L., Iyer, R. S., Lee, M. W., Bowman, K. K., Starovasnik, M. A., & Dueber, E. C. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1121552109 · Cited by 240 · see citing works

TBK1 Directly Engages Akt/PKB Survival Signaling to Support Oncogenic Transformation

Ou, Y.-H., Torres, M. J., Ram, R. R., Formstecher, É., Roland, C. L., Cheng, T., Brekken, R. A., Wurz, R. P., Tasker, A. S., Polverino, T., et al. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.01.019 · Cited by 229 · see citing works

Dengue Virus NS Proteins Inhibit RIG-I/MAVS Signaling by Blocking TBK1/IRF3 Phosphorylation: Dengue Virus Serotype 1 NS4A Is a Unique Interferon-Regulating Virulence Determinant

Dalrymple, N. A., Cimica, V., & Mackow, E. R. (2015) · mBio · doi:10.1128/mbio.00553-15 · Cited by 228 · see citing works

IκB kinase ε and TANK-binding kinase 1 activate AKT by direct phosphorylation

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Copy number variations on chromosome 12q14 in patients with normal tension glaucoma

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PAMPs and DAMPs in Sepsis: A Review of Their Molecular Features and Potential Clinical Implications

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The A137R Protein of African Swine Fever Virus Inhibits Type I Interferon Production via the Autophagy-Mediated Lysosomal Degradation of TBK1

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AMPK directly phosphorylates TBK1 to integrate glucose sensing into innate immunity

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Von Hippel–Lindau protein signalling in clear cell renal cell carcinoma

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TBK1 (TANK-binding kinase 1)-mediated regulation of autophagy in health and disease

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USP19 (ubiquitin specific peptidase 19) promotes TBK1 (TANK-binding kinase 1) degradation via chaperone-mediated autophagy

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Targeting TANK-binding kinase 1 (TBK1) in cancer

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TBK1-medicated DRP1 phosphorylation orchestrates mitochondrial dynamics and autophagy activation in osteoarthritis

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The Inflammatory Puzzle: Piecing together the Links between Neuroinflammation and Amyotrophic Lateral Sclerosis

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Targeting STING: From antiviral immunity to treat osteoporosis

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Rabies virus P protein binds to TBK1 and interferes with the formation of innate immunity-related liquid condensates

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The protein phosphatase PPM1A dephosphorylates and activates YAP to govern mammalian intestinal and liver regeneration

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DIA-Based Proteome Profiling of Nasopharyngeal Swabs from COVID-19 Patients

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Small molecule approaches to treat autoimmune and inflammatory diseases (Part I): Kinase inhibitors

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The innate immune kinase TBK1 directly increases mTORC2 activity and downstream signaling to Akt

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Manganese enhances DNA- or RNA-mediated innate immune response by inducing phosphorylation of TANK-binding kinase 1

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Prospects for gene replacement therapies in amyotrophic lateral sclerosis

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Antagonisms of ASFV towards Host Defense Mechanisms: Knowledge Gaps in Viral Immune Evasion and Pathogenesis

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Molecular Mechanisms of the Toll-Like Receptor, STING, MAVS, Inflammasome, and Interferon Pathways

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Emerging roles of TBK1 in cancer immunobiology

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RNA virus infections and their effect on host alternative splicing

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GSNOR facilitates antiviral innate immunity by restricting TBK1 cysteine S-nitrosation

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TBK1 promotes thyroid cancer progress by activating the PI3K/Akt/mTOR signaling pathway

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Application of deep generative model for design of Pyrrolo[2,3-d] pyrimidine derivatives as new selective TANK binding kinase 1 (TBK1) inhibitors

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Radix Isatidis polysaccharide (RIP) resists the infection of QX-type infectious bronchitis virus via the MDA5/TLR3/IRF7 signaling pathway

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β-Glucan Induces Training Immunity to Promote Antiviral Activity by Activating TBK1

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TBK1 pharmacological inhibition mitigates osteoarthritis through attenuating inflammation and cellular senescence in chondrocytes

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LncRNA NEAT1 Potentiates SREBP2 Activity to Promote Inflammatory Macrophage Activation and Limit Hantaan Virus Propagation

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Zebrafish MARCH7 negatively regulates IFN antiviral response by degrading TBK1

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Lumpy skin disease virus ORF127 protein suppresses type I interferon responses by inhibiting K63‐linked ubiquitination of tank binding kinase 1

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TANK-Binding Kinase 1 in the Pathogenesis and Treatment of Inflammation-Related Diseases

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Analysis of structure–activity relationship of indol-3-yl-N-phenylcarbamic amides as potent STING inhibitors

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Fine-tuning AMPK in physiology and disease using point-mutant mouse models

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Abscopal Effect and Drug-Induced Xenogenization: A Strategic Alliance in Cancer Treatment?

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Zika virus NS4B protein targets TANK-binding kinase 1 and inhibits type I interferon production

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Role of alternative splicing in fish immunity

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Mechanism of TBK1 activation in cancer cells

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TBK1 Mediates Innate Antiviral Immune Response against Duck Enteritis Virus

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Identification of 1 H -pyrazolo[3,4-b]pyridine derivatives as novel and potent TBK1 inhibitors: design, synthesis, biological evaluation, and molecular docking study

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TBK1-Zyxin signaling controls tumor-associated macrophage recruitment to mitigate antitumor immunity

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Factor inhibiting HIF negatively regulates antiviral innate immunity via hydroxylation of IKKϵ

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CDK9 inhibition activates innate immune response through viral mimicry

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Manganese Mediates Its Antiviral Functions in a cGAS-STING Pathway Independent Manner

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Liraglutide versus pramlintide in protecting against cognitive function impairment through affecting PI3K/AKT/GSK-3β/TTBK1 pathway and decreasing Tau hyperphosphorylation in high-fat diet- streptozocin rat model

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Kinome-wide siRNA screen identifies a DCLK2-TBK1 oncogenic signaling axis in clear cell renal cell carcinoma

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Separable Cell Cycle Arrest and Immune Response Elicited through Pharmacological CDK4/6 and MEK Inhibition in RASmut Disease Models

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Molecular insights into the immune response of Ruditapes philippinarum under Vibrio anguillarum infection at high temperature

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Mitochondrial Reactive Oxygen Species in TRIF-Dependent Toll-like Receptor 3 Signaling in Bronchial Epithelial Cells against Viral Infection

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Mutant p53R211* ameliorates inflammatory arthritis in AIA rats via inhibition of TBK1-IRF3 innate immune response

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Immune response of Rhinogobio ventralis to Ichthyophthirius multifiliis infection: Insights from histopathological and real-time gene expression analyses

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Impact of modeled microgravity stress on innate immunity in a beneficial animal-microbe symbiosis

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In Silico Insights: QSAR Modeling of TBK1 Kinase Inhibitors for Enhanced Drug Discovery

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HSV-1 Triggers an Antiviral Transcriptional Response during Viral Replication That Is Completely Abrogated in PKR−/− Cells

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Human RNase H2 upregulation counteracts oncogene- and chemotherapy-induced replication stress

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Molecular characterization, expression, and functional identification of TANK-binding kinase 1 (TBK1) of the cow (Bos taurus) and goat (Capra hircus)

Yang, X. Y., Ren, S., Rehman, Z. U., Wang, X., Yin, X., Sun, Y., Wan, X., & Chen, H.-T. (2022) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2022.104444 · Cited by 5 · see citing works

Crosstalk and Prospects of TBK1 in Inflammation

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Functional Involvement of TANK‐Binding Kinase 1 in the MyD88‐Dependent NF‐ κ B Pathway Through Syk

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Identification of multifunctionality of grass carp (Ctenopharyngodon idella) TBK1 during bacterial infection

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Pigeon TBK1 is involved in antiviral innate immunity by mediating IFN activation

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Type I IFN in Glomerular Disease: Scarring beyond the STING

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Pseudorabies virus DNA polymerase processivity factor pUL42 inhibits type I IFN production by negatively regulating cGAS-STING signaling pathway

Ye, G., Gao, J., Cao, H., Liu, X., Liu, H., Wang, S., Liu, Y., Han, L., Zhou, Q., Tang, Y.-D., et al. (2025) · Journal of Virology · doi:10.1128/jvi.01218-25 · Cited by 2 · see citing works

Exploring TANK-Binding Kinase 1 in Amyotrophic Lateral Sclerosis: From Structural Mechanisms to Machine Learning-Guided Therapeutics

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The Mitigating Effect and Mechanism of Polydeoxyribonucleotide Against Zoledronic Acid-Induced Growth Suppression of Human Gingival Fibroblasts

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TBK1 associates with TRIF and TRAF3 related IRF3, IRF7, and type I IFN signaling in large yellow croaker Larimichthys crocea

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Role of TBK1 Inhibition in Targeted Therapy of Cancer

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Activation of cellular responses by cyclic dinucleotides and Porphyromonas gingivalis lipopolysaccharide: a proteomic study on gingival fibroblasts

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Molecular cloning, identification and expression analysis of MDA5/MAVS/TRAF3/TANK/TBK1, five pivotal molecules of RLR signalling pathway in turbot ( Scophthalmus maximus )

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Dual Role of Host Toll-Like Receptor 3 in Parasitic Diseases

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Tissue‐Resident Macrophage‐Derived E3 Ligase SMURF2 Restricts Autoimmune Inflammation by Mediating the Degradation of p‐TBK1

An, X., Li, J., Wang, L., Li, C., Jin, Z. L., Yao, Y., Jiang, M., Lin, W., & Wang, X. (2025) · Advanced Science · doi:10.1002/advs.202504930 · Cited by 1 · see citing works

Tank-binding kinase 1 regulates inflammation and autophagy in glaucoma

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Targeting VPS4 elicits STING-driven anti-tumor immunity to suppress rhabdomyosarcoma growth

Zhang, R., Chen, L., Liang, X., Zhang, J., Hamamoto, K., Hattori, T., Vangala, V., Schell, T. D., Sholler, G. S., Takahashi, Y., et al. (2026) · Oncogene · doi:10.1038/s41388-026-03800-1 · Cited by 1 · see citing works

MELK inhibition disrupts actin cytoskeleton and broadly restricts human coronavirus infections

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Disruption of macrophage cell volume drives inflammatory responses and type I interferon signaling

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Tumoral IL-10-activated SHP2 in macrophages promotes mammary carcinoma progression

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A novel role of ETV6 as a pro-viral factor in host response by inhibiting TBK1 phosphorylation

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A special issue on the 10-year anniversary of Life Sciences Institute, Zhejiang University

Feng, X. H. (2020) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmaa062

Separable cell cycle arrest and immune response elicited through pharmacological CDK4/6 and MEK inhibition in RASmut disease modelsPreprint

Knudsen, E. S., Wu, J., Wang, J., O’Connor, T., Tzetzo, S. L., Gurova, K. V., & Witkiewicz, A. K. (2024) · Research Square · doi:10.21203/rs.3.rs-4138843/v1

Role of pattern recognition receptors in cardiac remodeling

Duttaroy, A. K., & Mallick, R. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-99570-2.00003-5

TANK-binding kinase 1 inhibitor GSK8612 suppresses platelet function and thrombosis via the ERK/P38 signaling pathway

Gu, C., Wang, L., Tian, R., Qian, H., Wu, M., Zhu, X., Li, S., Zuo, W., Liu, Z., & Zhang, S. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2025.168101

TBK1 associated with TRIF and TRAF3 related IRF3, IRF7, and type I IFN signaling in large yellow croaker Larimichthys croceaPreprint

Zha, W. Q., Cui, W. F., Li, M. J., Chen, Y. M. N., Huang, Q. Y., Yang, Q. Y., Shen, Y. J., Wang, Y., Jiang, Y. H., Li, Y., et al. (2026) · SSRN Electronic Journal · doi:10.2139/ssrn.6179571

The Role of Protein Kinases in the Management of Oncological Diseases by Acting on Ferroptotic Pathways

Folgiero, V., & Caforio, M. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27062673

HSPA2 modulates antiviral immunity by inhibiting TBK1 activation

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Infections virales, stress mitochondrial, et cytidines désaminases APOBEC3

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