The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15
Open accessAbstract
Interleukin 15 (IL-15) and IL-2 have distinct immunological functions even though both signal through the receptor subunit IL-2Rβ and the common γ-chain (γc). Here we found that in the structure of the IL-15–IL-15Rα–IL-2Rβ–γc quaternary complex, IL-15 binds to IL-2Rβ and γc in a heterodimer nearly indistinguishable from that of the IL-2–IL-2Rα–IL-2Rβ–γc complex, despite their different receptor-binding chemistries. IL-15Rα substantially increased the affinity of IL-15 for IL-2Rβ, and this allostery was required for IL-15 trans signaling. Consistent with their identical IL-2Rβ–γc dimer geometries, IL-2 and IL-15 showed similar signaling properties in lymphocytes, with any differences resulting from disparate receptor affinities. Thus, IL-15 and IL-2 induced similar signals, and the cytokine specificity of IL-2Rα versus IL-15Rα determined cellular responsiveness. Our results provide new insights for the development of specific immunotherapeutics based on IL-15 or IL-2.
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Cites
Coot : model-building tools for molecular graphics
Emsley, P., & Cowtan, K. (2004) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444904019158 · Cited by 30,571
PHENIX : building new software for automated crystallographic structure determination
Adams, P. D., Grosse-Kunstleve, R. W., Hung, L.-W., Ioerger, T. R., McCoy, A. J., Moriarty, N. W., Read, R. J., Sacchettini, J. C., Sauter, N. K., & Terwilliger, T. C. (2002) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444902016657 · Cited by 4,361
Bowman, G. R., Beauchamp, K. A., Boxer, G., & Pande, V. S. (2009) · The Journal of Chemical Physics · doi:10.1063/1.3216567 · Cited by 396 · cited 1×
“For crystallization, human IL-15 (1-114)-6xH in pET22b and human IL-15Rα (1-67)-6xH in pET26b were co-expressed in the periplasm of BL21(DE3) cells by induction with IPTG for 20 hours at 22°C.”
MethodSelf-citation
Cited by
Interleukin-2 at the Crossroads of Effector Responses, Tolerance, and Immunotherapy
Liao, W., Lin, J.-X., & Leonard, W. J. (2013) · Immunity · doi:10.1016/j.immuni.2013.01.004 · Cited by 1,075
Self-citationBiology and regulation of IL-2: from molecular mechanisms to human therapy
Spolski, R., Li, P., & Leonard, W. J. (2018) · Nature Reviews Immunology · doi:10.1038/s41577-018-0046-y · Cited by 637
Self-citationDe novo design of potent and selective mimics of IL-2 and IL-15
Silva, D.-A., Yu, S., Ulge, U. Y., Spangler, J. B., Jude, K. M., Labão-Almeida, C., Ali, L. R., Quijano-Rubio, A., Ruterbusch, M., Leung, I., et al. (2019) · Nature · doi:10.1038/s41586-018-0830-7 · Cited by 531
mRNA therapeutics in cancer immunotherapy
Beck, J. D., Reidenbach, D., Salomon, N., Sahin, U., Türeci, Ö., Vormehr, M., & Kranz, L. M. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01348-0 · Cited by 385
IL-15 functions as a danger signal to regulate tissue-resident T cells and tissue destruction
Jabri, B., & Abadie, V. (2015) · Nature Reviews Immunology · doi:10.1038/nri3919 · Cited by 315
Metadata
- Authors
- Ring, A. M., Lin, J.-X., Feng, D., Mitra, S., Rickert, M., Bowman, G. R., Pande, V. S., Li, P., Moraga, I., Spolski, R., Özkan, E., Leonard, W. J., & Garcia, K. C.
- Venue
- Nature Immunology
- Published
- 2012-10-28
- Volume
- 13
- Issue
- 12
- Pages
- 1187-1195
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2015848791
- Cited by
- 248
- References
- 3
- FWCI
- 9.23
- Type
- journal article
- Language
- en
- Open access
- green
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- Ring, A. M., Lin, J.-X., Feng, D., Mitra, S., Rickert, M., Bowman, G. R., Pande, V. S., Li, P., Moraga, I., Spolski, R., Özkan, E., Leonard, W. J., & Garcia, K. C. (2012). Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15. Nature Immunology. https://doi.org/10.1038/ni.2449
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
