The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Mcl-1 is essential for the survival of plasma cells
Open accessAbstract
The long-term survival of plasma cells is entirely dependent on signals derived from their environment. These extrinsic factors presumably induce and sustain the expression of antiapoptotic proteins of the Bcl-2 family. It is uncertain whether there is specificity among Bcl-2 family members in the survival of plasma cells and whether their expression is linked to specific extrinsic factors. We found here that deletion of the gene encoding the antiapoptotic protein Mcl-1 in plasma cells resulted in rapid depletion of this population in vivo. Furthermore, we found that the receptor BCMA was needed to establish high expression of Mcl-1 in bone marrow but not spleen plasma cells and that establishing this survival pathway preceded the component of plasma cell differentiation that depends on the transcriptional repressor Blimp-1. Our results identify a critical role for Mcl-1 in the maintenance of plasma cells.
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BCMA Is Essential for the Survival of Long-lived Bone Marrow Plasma Cells
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Cited by
Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy
Czabotar, P. E., Lessene, G., Strasser, A., & Adams, J. M. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3722 · Cited by 3,219
Self-citationThe generation of antibody-secreting plasma cells
Nutt, S. L., Hodgkin, P. D., Tarlinton, D. M., & Corcoran, L. M. (2015) · Nature Reviews Immunology · doi:10.1038/nri3795 · Cited by 1,454
Self-citationThirty years of BCL-2: translating cell death discoveries into novel cancer therapies
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γ-secretase directly sheds the survival receptor BCMA from plasma cells
Laurent, S. A., Hoffmann, F. S., Kuhn, P.-H., Cheng, Q., Chu, Y., Schmidt-Supprian, M., Hauck, S. M., Schuh, E., Krumbholz, M., Rübsamen, H., et al. (2015) · Nature Communications · doi:10.1038/ncomms8333 · Cited by 377
Metadata
- Authors
- Peperzak, V., Vikström, I., Walker, J., Glaser, S. P., LePage, M., Coquery, C. M., Erickson, L. D., Fairfax, K., Mackay, F., Strasser, A., Nutt, S. L., & Tarlinton, D. M.
- Venue
- Nature Immunology
- Published
- 2013-02-03
- Volume
- 14
- Issue
- 3
- Pages
- 290-297
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2064759291
- Cited by
- 320
- References
- 49
- FWCI
- 12.10
- Type
- journal article
- Language
- en
- Open access
- green
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- Peperzak, V., Vikström, I., Walker, J., Glaser, S. P., LePage, M., Coquery, C. M., Erickson, L. D., Fairfax, K., Mackay, F., Strasser, A., Nutt, S. L., & Tarlinton, D. M. (2013). Mcl-1 is essential for the survival of plasma cells. Nature Immunology. https://doi.org/10.1038/ni.2527
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