The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Nucleation of platelets with blood-borne pathogens on Kupffer cells precedes other innate immunity and contributes to bacterial clearance
Open accessAbstract
Through the use of intravital imaging of the liver, we demonstrate a collaborative role for platelets with Kupffer cells (KCs) in eradicating blood-borne bacterial infection. Under basal conditions, platelets, via the platelet-adhesion receptor GPIb, formed transient 'touch-and-go' interactions with von Willebrand factor (vWF) constitutively expressed on KCs. Bacteria such as Bacillus cereus and methicillin-resistant Staphylococcus aureus (MRSA) were rapidly caught by KCs and triggered platelets to switch from 'touch-and-go' adhesion to sustained GPIIb-mediated adhesion on the KC surface to encase the bacterium. Infected GPIbα-deficient mice had more endothelial and KC damage than did their wild-type counterparts, which led to more fluid leakage, substantial polycythemia and rapid mortality. Our study identifies a previously unknown surveillance mechanism by which platelets survey macrophages that rapidly converts to a critical host response to blood-borne bacteria.
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Cites
Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood
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Self-citationPlatelets and the immune continuum
Semple, J. W., Italiano, J. E., & Freedman, J. (2011) · Nature Reviews Immunology · doi:10.1038/nri2956 · Cited by 1,692
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Intravascular Neutrophil Extracellular Traps Capture Bacteria from the Bloodstream during Sepsis
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Self-citationProfessional and non-professional phagocytes: an introduction
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The Clearance Mechanism of Chilled Blood Platelets
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Cited by
The immunopathology of sepsis and potential therapeutic targets
van der Poll, T., van de Veerdonk, F. L., Scicluna, B. P., & Netea, M. G. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.36 · Cited by 1,957
Liver Macrophages in Tissue Homeostasis and Disease
Krenkel, O., & Tacke, F. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.11 · Cited by 1,424
Immune surveillance by the liver
Jenne, C. N., & Kubes, P. (2013) · Nature Immunology · doi:10.1038/ni.2691 · Cited by 1,047
Self-citationWen, Y., Lambrecht, J., Ju, C., & Tacke, F. (2021) · Cellular & Molecular Immunology · doi:10.1038/s41423-020-00558-8 · Cited by 695
Liver — guardian, modifier and target of sepsis
Strnad, P., Tacke, F., Koch, A., & Trautwein, C. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.168 · Cited by 692
Metadata
- Authors
- Wong, C. H. Y., Jenne, C. N., Petri, B., Chrobok, N. L., & Kubes, P.
- Venue
- Nature Immunology
- Published
- 2013-06-16
- Volume
- 14
- Issue
- 8
- Pages
- 785-792
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W1996165201
- Cited by
- 386
- References
- 41
- FWCI
- 20.05
- Type
- journal article
- Language
- en
- Open access
- green
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- Wong, C. H. Y., Jenne, C. N., Petri, B., Chrobok, N. L., & Kubes, P. (2013). Nucleation of platelets with blood-borne pathogens on Kupffer cells precedes other innate immunity and contributes to bacterial clearance. Nature Immunology. https://doi.org/10.1038/ni.2631
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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