The immunopathology of sepsis and potential therapeutic targets

The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure: On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine (see contributors to the project in the appendix)

Vincent, J. L., Moreno, R., Takala, J., Willatts, S., De Mendonça, A., Bruining, H., Reinhart, C. K., Suter, P. M., & Thijs, L. G. (1996) · Intensive Care Medicine · doi:10.1007/bf01709751 · Cited by 11,674 · see citing works

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

Tannahill, G. M., Curtis, A. M., Adamik, J., Palsson-McDermott, E. M., McGettrick, A. F., Goel, G., Frezza, C., Bernard, N. J., Kelly, B., Foley, N. H., et al. (2013) · Nature · doi:10.1038/nature11986 · Cited by 4,176 · see citing works

Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy

Hotchkiss, R. S., Monneret, G., & Payen, D. (2013) · Nature Reviews Immunology · doi:10.1038/nri3552 · Cited by 2,772 · see citing works

Long-term cognitive impairment and functional disability among survivors of severe sepsis.

Iwashyna, T. J., Ely, E. W., Smith, D. M., & Langa, K. M. (2010) · JAMA · doi:10.1001/jama.2010.1553 · Cited by 2,582 · see citing works

Bone marrow stromal cells attenuate sepsis via prostaglandin E2–dependent reprogramming of host macrophages to increase their interleukin-10 production

Németh, K., Leelahavanichkul, A., Yuen, P. S. T., Mayer, B., Parmelee, A., Doi, K., Robey, P. G., Leelahavanichkul, K., Koller, B. H., Brown, J. M., et al. (2009) · Nature Medicine · doi:10.1038/nm.1905 · Cited by 2,364 · see citing works

Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity

Saeed, S., Quintin, J., Kerstens, H. H. D., Rao, N. A., Aghajanirefah, A., Matarese, F., Cheng, S.-C., Ratter, J., Berentsen, K., van der Ent, M. A., et al. (2014) · Science · doi:10.1126/science.1251086 · Cited by 1,761 · see citing works

Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial

Besselink, M. G., van Santvoort, H. C., Buskens, E., Boermeester, M. A., van Goor, H., Timmerman, H. M., Nieuwenhuijs, V. B., Bollen, T. L., van Ramshorst, B., Witteman, B. J., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60207-x · Cited by 1,367 · see citing works

The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing

De Santa, F., Totaro, M. G., Prosperini, E., Notarbartolo, S., Testa, G., & Natoli, G. (2007) · Cell · doi:10.1016/j.cell.2007.08.019 · Cited by 965 · see citing works

Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity

Arts, R. J. W., Novakovic, B., ter Horst, R., Carvalho, A., Bekkering, S., Lachmandas, E., Rodrigues, F., Silvestre, R., Cheng, S.-C., Wang, S.-Y., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.10.008 · Cited by 930 · see citing works

The Gut Microbiota Plays a Protective Role in the Host Defence Against Pneumococcal Pneumonia

Schuijt, T. J., Lankelma, J. M., Scicluna, B. P., de Sousa e Melo, F., Roelofs, J. J. T. H., de Boer, J. D., Hoogendijk, A. J., de Beer, R., de Vos, A., Belzer, C., et al. (2016) · Gut · doi:10.1136/gutjnl-2015-309728 · Cited by 832 · see citing works

Why have clinical trials in sepsis failed?

Marshall, J. C. (2014) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.01.007 · Cited by 805 · see citing works

Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis

Cheng, S.-C., Scicluna, B. P., Arts, R. J. W., Gresnigt, M. S., Lachmandas, E., Giamarellos-Bourboulis, E. J., Kox, M., Manjeri, G. R., Wagenaars, J. A. L., Cremer, O. L., et al. (2016) · Nature Immunology · doi:10.1038/ni.3398 · Cited by 637 · see citing works

A Central Role for Free Heme in the Pathogenesis of Severe Sepsis

Larsen, R., Gozzelino, R., Jeney, V., Tokaji, L., Bozza, F. A., Japiassú, A. M., Bonaparte, D., Cavalcante, M. M., Chora, Â., Ferreira, A., et al. (2010) · Science Translational Medicine · doi:10.1126/scitranslmed.3001118 · Cited by 483 · see citing works

Intestinal Microbiota of Mice Influences Resistance to Staphylococcus aureus Pneumonia

Gauguet, S., D'Ortona, S., Ahnger-Pier, K., Duan, B., Surana, N. K., Lu, R., Cywes-Bentley, C., Gadjeva, M., Shan, Q., Priebe, G. P., et al. (2015) · Infection and Immunity · doi:10.1128/iai.00037-15 · Cited by 208 · see citing works

Hospitalization type and subsequent severe sepsis

Prescott, H. C., Dickson, R. P., Rogers, M. A. M., Langa, K. M., & Iwashyna, T. J. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201503-0483oc · Cited by 181 · see citing works

Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages

Merad, M., & Martin, J. C. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-020-0331-4 · Cited by 2,472 · see citing works

Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans

Arunachalam, P. S., Wimmers, F., Mok, C. K. P., Perera, R. A. P. M., Scott, M., Hagan, T., Sigal, N., Feng, Y., Bristow, L., Tak-Yin Tsang, O., et al. (2020) · Science · doi:10.1126/science.abc6261 · Cited by 1,186 · see citing works

A guiding map for inflammation

Netea, M. G., Balkwill, F., Chonchol, M., Cominelli, F., Donath, M. Y., Giamarellos-Bourboulis, E. J., Golenbock, D., Gresnigt, M. S., Heneka, M. T., Hoffman, H. M., et al. (2017) · Nature Immunology · doi:10.1038/ni.3790 · Cited by 831 · see citing works

How COVID-19 induces cytokine storm with high mortality

Hojyo, S., Uchida, M., Tanaka, K., Hasebe, R., Tanaka, Y., Murakami, M., & Hirano, T. (2020) · Inflammation and Regeneration · doi:10.1186/s41232-020-00146-3 · Cited by 663 · see citing works

GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance

Luan, H. H., Wang, A., Hilliard, B. K., Carvalho, F., Rosen, C. E., Ahasic, A. M., Herzog, E. L., Kang, I., Pisani, M. A., Yu, S., et al. (2019) · Cell · doi:10.1016/j.cell.2019.07.033 · Cited by 527 · see citing works

Epidemiology and Immune Pathogenesis of Viral Sepsis

Lin, G.-L., McGinley, J. P., Drysdale, S. B., & Pollard, A. J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02147 · Cited by 351 · see citing works

The role of lipopolysaccharide-induced cell signalling in chronic inflammation

Page, M. J., Kell, D. B., & Pretorius, E. (2022) · Chronic Stress · doi:10.1177/24705470221076390 · Cited by 315 · see citing works

Disruption of a self-amplifying catecholamine loop reduces cytokine release syndrome

Staedtke, V., Bai, R.-Y., Kim, K., Darvas, M., Davila, M. L., Riggins, G. J., Rothman, P. B., Papadopoulos, N., Kinzler, K. W., Vogelstein, B., et al. (2018) · Nature · doi:10.1038/s41586-018-0774-y · Cited by 277 · see citing works

Bioresponsive Nanoparticles Targeted to Infectious Microenvironments for Sepsis Management

Zhang, C. Y., Gao, J., & Wang, Z. (2018) · Advanced Materials · doi:10.1002/adma.201803618 · Cited by 222 · see citing works

Biomarkers in Sepsis.

van Engelen, T. S. R., Wiersinga, W. J., Scicluna, B. P., & van der Poll, T. (2018) · Critical Care Clinics · doi:10.1016/j.ccc.2017.08.010 · Cited by 178 · see citing works

Towards precision medicine in sepsis: a position paper from the European Society of Clinical Microbiology and Infectious Diseases

Rello, J., van Engelen, T. S. R., Alp, E., Calandra, T., Cattoir, V., Kern, W. V., Netea, M. G., Nseir, S., Opal, S. M., van de Veerdonk, F. L., et al. (2018) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2018.03.011 · Cited by 143 · see citing works

Point-of-care sensors for the management of sepsis

Reddy, B., Hassan, U., Seymour, C., Angus, D. C., Isbell, T. S., White, K., Weir, W., Yeh, L., Vincent, A., & Bashir, R. (2018) · Nature Biomedical Engineering · doi:10.1038/s41551-018-0288-9 · Cited by 142 · see citing works

Integrated pathogen load and dual transcriptome analysis of systemic host-pathogen interactions in severe malaria

Lee, H. J., Georgiadou, A., Walther, M., Nwakanma, D., Stewart, L. B., Levin, M., Otto, T. D., Conway, D. J., Coin, L. J., & Cunnington, A. J. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aar3619 · Cited by 141 · see citing works

Nutrition in Sepsis: A Bench-to-Bedside Review.

De Waele, E., Malbrain, M. L. N. G., & Spapen, H. (2020) · Nutrients · doi:10.3390/nu12020395 · Cited by 140 · see citing works

Iron and innate antimicrobial immunity-depriving the pathogen, defending the host

Nairz, M., Dichtl, S., Schroll, A., Haschka, D., Tymoszuk, P., Theurl, I., & Weiss, G. (2018) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2018.03.007 · Cited by 123 · see citing works

Inflammasome-mediated GSDMD activation facilitates escape of Candida albicans from macrophages

Ding, X., Kambara, H., Guo, R., Kanneganti, A., Acosta-Zaldívar, M., Li, J., Liu, F., Bei, T., Qi, W., Xie, X., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-27034-9 · Cited by 115 · see citing works

Leukotriene B4-Mediated Neutrophil Recruitment Causes Pulmonary Capillaritis during Lethal Fungal Sepsis

Lee, E. K. S., Gillrie, M. R., Li, L., Arnason, J. W., Kim, J. H., Babes, L., Lou, Y., Sanati-Nezhad, A., Kyei, S. K., Kelly, M. M., et al. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2017.11.009 · Cited by 89 · see citing works

Multiscale PHATE identifies multimodal signatures of COVID-19

Kuchroo, M., Huang, J., Wong, P., Grenier, J.-C., Shung, D., Tong, A., Lucas, C., Klein, J., Burkhardt, D. B., Gigante, S., et al. (2022) · Nature Biotechnology · doi:10.1038/s41587-021-01186-x · Cited by 72 · see citing works

C5a anaphylatoxin and its role in critical illness-induced organ dysfunction

Wood, A. J. T., Vassallo, A., Summers, C., Chilvers, E. R., & Conway‐Morris, A. (2018) · European Journal of Clinical Investigation · doi:10.1111/eci.13028 · Cited by 45 · see citing works

Mast cell activation mediates blood–brain barrier impairment and cognitive dysfunction in septic mice in a histamine-dependent pathway

Yue, J., Tan, Y., Huan, R., Guo, J., Yang, S., Deng, M., Xiong, Y., Han, G., Liu, L., Liu, J., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1090288 · Cited by 46 · see citing works

PD-L1 promotes GSDMD-mediated NET release by maintaining the transcriptional activity of Stat3 in sepsis-associated encephalopathy

Zhu, C.-L., Xie, J., Liu, Q., Wang, Y., Li, H.-R., Yu, C.-M., Li, P., Deng, X.-M., Bian, J.-J., & Wang, J.-F. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.79913 · Cited by 42 · see citing works

Enhanced meningeal lymphatic drainage ameliorates lipopolysaccharide-induced brain injury in aged mice

Dong, H., Dai, X., Zhou, Y., Shi, C., Bhuiyan, P., Sun, Z., Li, N., & Jin, W. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03028-4 · Cited by 27 · see citing works

Protective effect of gut microbiota restored by fecal microbiota transplantation in a sepsis model in juvenile mice

Han, Y. J., Kim, S., Shin, H., Kim, H. W., & Park, J. D. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1451356 · Cited by 17 · see citing works

Cell wall N-glycan of Candida albicans ameliorates early hyper- and late hypo-immunoreactivity in sepsis

Kawakita, M., Oyama, T., Shirai, I., Tanaka, S., Akaki, K., Abe, S., Asahi, T., Cui, G., Itoh, F., Sasaki, M., et al. (2021) · Communications Biology · doi:10.1038/s42003-021-01870-3 · Cited by 14 · see citing works