The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Inflammation-induced interstitial migration of effector CD4+ T cells is dependent on integrin αV
Open accessAbstract
Leukocytes must traverse inflamed tissues to effectively control local infection. Although motility in dense tissues seems to be integrin independent and based on actomyosin-mediated protrusion and contraction, during inflammation, changes to the extracellular matrix (ECM) may necessitate distinct motility requirements. Indeed, we found that the interstitial motility of T cells was critically dependent on Arg-Gly-Asp (RGD)-binding integrins in the inflamed dermis. Inflammation-induced deposition of fibronectin was functionally linked to higher expression of integrin αV on effector CD4+ T cells. By intravital multiphoton imaging, we found that the motility of CD4+ T cells was dependent on αV expression. Selective blockade or knockdown of αV arrested T helper type 1 (TH1) cells in the inflamed tissue and attenuated local effector function. Our data demonstrate context-dependent specificity of lymphocyte movement in inflamed tissues that is essential for protective immunity.
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Cites
Adhesion receptors of the immune system
Springer, T. A. (1990) · Nature · doi:10.1038/346425a0 · Cited by 6,477
RGD AND OTHER RECOGNITION SEQUENCES FOR INTEGRINS
Ruoslahti, E. (1996) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.12.1.697 · Cited by 3,191 · cited 1×
“Fibronectin is a primary substrate for α v integrins 28 .”
Rapid leukocyte migration by integrin-independent flowing and squeezing
Lämmermann, T., Bader, B. L., Monkley, S. J., Worbs, T., Wedlich-Söldner, R., Hirsch, K., Keller, M., Förster, R., Critchley, D. R., Fässler, R., et al. (2008) · Nature · doi:10.1038/nature06887 · Cited by 1,397
Sojka, D. K., & Fowell, D. J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1110566108 · Cited by 93
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Tissue-Resident Memory T Cells
Schenkel, J. M., & Masopust, D. (2014) · Immunity · doi:10.1016/j.immuni.2014.12.007 · Cited by 1,059
“Blocking integrin av results in increased parasite burden during local Leishmania major infection, suggesting that increased T cell motility is in important for pathogen control (Overstreet et al., 2013).”
BackgroundT cell migration, search strategies and mechanisms
Krummel, M. F., Bartumeus, F., & Gérard, A. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2015.16 · Cited by 423
The lymphatic system: integral roles in immunity
Randolph, G. J., Ivanov, S., Zinselmeyer, B. H., & Scallan, J. P. (2017) · Annual Review of Immunology · doi:10.1146/annurev-immunol-041015-055354 · Cited by 338
The Dynamics of Apoptotic Cell Clearance
Elliott, M. R., & Ravichandran, K. S. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.06.029 · Cited by 319
Leukocyte trafficking to the lungs and beyond: lessons from influenza for COVID-19
Alon, R., Sportiello, M., Kozlovski, S., Kumar, A., Reilly, E. C., Zarbock, A., Garbi, N., & Topham, D. J. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-020-00470-2 · Cited by 197
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Metadata
- Authors
- Overstreet, M. G., Gaylo, A., Angermann, B. R., Hughson, A., Hyun, Y.-M., Lambert, K., Acharya, M., Billroth-MacLurg, A. C., Rosenberg, A. F., Topham, D. J., Yagita, H., Kim, M., Lacy-Hulbert, A., Meier-Schellersheim, M., & Fowell, D. J.
- Venue
- Nature Immunology
- Published
- 2013-08-11
- Volume
- 14
- Issue
- 9
- Pages
- 949-958
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2048175444
- Cited by
- 161
- References
- 4
- FWCI
- 12.80
- Type
- journal article
- Language
- en
- Open access
- green
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- Overstreet, M. G., Gaylo, A., Angermann, B. R., Hughson, A., Hyun, Y.-M., Lambert, K., Acharya, M., Billroth-MacLurg, A. C., Rosenberg, A. F., Topham, D. J., Yagita, H., Kim, M., Lacy-Hulbert, A., Meier-Schellersheim, M., & Fowell, D. J. (2013). Inflammation-induced interstitial migration of effector CD4+ T cells is dependent on integrin αV. Nature Immunology. https://doi.org/10.1038/ni.2682
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
