The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Mycobacterium tuberculosis induces the miR-33 locus to reprogram autophagy and host lipid metabolism
Open accessAbstract
Mycobacterium tuberculosis (Mtb) survives in macrophages by evading delivery to the lysosome and promoting the accumulation of lipid bodies, which serve as a bacterial source of nutrients. We found that by inducing the microRNA (miRNA) miR-33 and its passenger strand miR-33*, Mtb inhibited integrated pathways involved in autophagy, lysosomal function and fatty acid oxidation to support bacterial replication. Silencing of miR-33 and miR-33* by genetic or pharmacological means promoted autophagy flux through derepression of key autophagy effectors (such as ATG5, ATG12, LC3B and LAMP1) and AMPK-dependent activation of the transcription factors FOXO3 and TFEB, which enhanced lipid catabolism and Mtb xenophagy. These data define a mammalian miRNA circuit used by Mtb to coordinately inhibit autophagy and reprogram host lipid metabolism to enable intracellular survival and persistence in the host.
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Mizushima, N., Yoshimori, T., & Levine, B. (2010) · Cell · doi:10.1016/j.cell.2010.01.028 · Cited by 4,497
Autophagy regulates lipid metabolism
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Regulation mechanisms and signaling pathways of autophagy
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Antimicrobial Autophagy: A Conserved Innate Immune Response in Drosophila
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TFEB Links Autophagy to Lysosomal Biogenesis
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A Gene Network Regulating Lysosomal Biogenesis and Function
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Autophagy in infection, inflammation and immunity
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MiR-33 Contributes to the Regulation of Cholesterol Homeostasis
Rayner, K. J., Suárez, Y., Dávalos, A., Parathath, S., Fitzgerald, M. L., Tamehiro, N., Fisher, E. A., Moore, K. J., & Fernández-Hernando, C. (2010) · Science · doi:10.1126/science.1189862 · Cited by 1,260
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Cited by
Regulation of macrophage immunometabolism in atherosclerosis
Koelwyn, G. J., Corr, E. M., Erbay, E., & Moore, K. J. (2018) · Nature Immunology · doi:10.1038/s41590-018-0113-3 · Cited by 555
Self-citationMetabolism of tissue macrophages in homeostasis and pathology
Wculek, S. K., Dunphy, G., Heras-Murillo, I., Mastrangelo, A., & Sancho, D. (2022) · Cellular & Molecular Immunology · doi:10.1038/s41423-021-00791-9 · Cited by 501
microRNA-33 regulates macrophage autophagy in atherosclerosis
Ouimet, M., Ediriweera, H., Afonso, M. S., Ramkhelawon, B., Singaravelu, R., Liao, X., Bandler, R. C., Rahman, K., Fisher, E. A., Rayner, K. J., et al. (2017) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.116.308916 · Cited by 221
Self-citationKöster, S., Upadhyay, S., Chandra, P., Papavinasasundaram, K., Yang, G., Hassan, A., Grigsby, S. J., Mittal, E., Park, H. S., Jones, V., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1707792114 · Cited by 208
Self-citationMicroRNAs and lipid metabolism
Aryal, B., Singh, A. K., Rotllan, N., Price, N., & Fernández-Hernando, C. (2017) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000420 · Cited by 191
Metadata
- Authors
- Ouimet, M., Koster, S., Sakowski, E., Ramkhelawon, B., van Solingen, C., Oldebeken, S., Karunakaran, D., Portal-Celhay, C., Sheedy, F. J., Ray, T. D., Cecchini, K., Zamore, P. D., Rayner, K. J., Marcel, Y. L., Philips, J. A., & Moore, K. J.
- Venue
- Nature Immunology
- Published
- 2016-04-18
- Volume
- 17
- Issue
- 6
- Pages
- 677-686
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2340680032
- Cited by
- 361
- References
- 56
- FWCI
- 30.24
- Type
- journal article
- Language
- en
- Open access
- green
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- Ouimet, M., Koster, S., Sakowski, E., Ramkhelawon, B., van Solingen, C., Oldebeken, S., Karunakaran, D., Portal-Celhay, C., Sheedy, F. J., Ray, T. D., Cecchini, K., Zamore, P. D., Rayner, K. J., Marcel, Y. L., Philips, J. A., & Moore, K. J. (2016). Mycobacterium tuberculosis induces the miR-33 locus to reprogram autophagy and host lipid metabolism. Nature Immunology. https://doi.org/10.1038/ni.3434
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