The DOI matches its Crossref record; 115 of the 115 references it cites were found in a registry or an index.
Regulation of macrophage immunometabolism in atherosclerosis
Open accessAbstract
After activation, cells of the myeloid lineage undergo robust metabolic transitions, as well as discrete epigenetic changes, that can dictate both ongoing and future inflammatory responses. In atherosclerosis, in which macrophages play central roles in the initiation, growth, and ultimately rupture of arterial plaques, altered metabolism is a key feature that dictates macrophage function and subsequent disease progression. This Review explores how factors central to the plaque microenvironment (for example, altered cholesterol metabolism, oxidative stress, hypoxia, apoptotic and necrotic cells, and hyperglycemia) shape the metabolic rewiring of macrophages in atherosclerosis as well as how these metabolic shifts in turn alter macrophage immune-effector and tissue-reparative functions. Finally, this overview offers insight into the challenges and opportunities of harnessing metabolism to modulate aberrant macrophage responses in disease. In this Review, Moore and colleagues discuss regulation of macrophage immunometabolism in atherosclerosis.
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Cites
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
Ridker, P. M., Everett, B. M., Thuren, T., MacFadyen, J. G., Chang, W. H., Ballantyne, C., Fonseca, F., Nicolau, J., Koenig, W., Anker, S. D., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1707914 · Cited by 9,482
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Succinate is an inflammatory signal that induces IL-1β through HIF-1α
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NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
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Self-citationProgress and challenges in translating the biology of atherosclerosis
Libby, P., Ridker, P. M., & Hansson, G. K. (2011) · Nature · doi:10.1038/nature10146 · Cited by 4,010
Inflammasomes: mechanism of action, role in disease, and therapeutics
Guo, H., Callaway, J. B., & Ting, J. P.-Y. (2015) · Nature Medicine · doi:10.1038/nm.3893 · Cited by 3,340
A guide to immunometabolism for immunologists
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The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
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Macrophages in atherosclerosis: a dynamic balance
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Self-citationOxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis
Shimada, K., Crother, T. R., Karlin, J., Dagvadorj, J., Chiba, N., Chen, S., Ramanujan, V. K., Wolf, A. J., Vergnes, L., Ojcius, D. M., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.01.009 · Cited by 2,282
Cited by
Crosstalk between Hypoxia and ER Stress Response: a Key Regulator of Macrophage Polarization
Díaz-Bulnes, P., Saiz, M. L., López-Larrea, C., & Rodríguez, R. M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02951 · Cited by 175
Triglyceride-rich lipoproteins and cardiovascular diseases
Xu, D., Xie, L., Cheng, C., Xue, F., & Sun, C. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1409653 · Cited by 73
“While this immune response initially serves a protective function, excessive lipoprotein accumulation surpassing macrophage clearance capacity results in cholesterol-rich foam cell accumulation, fostering plaque formation (48, 49).”
BackgroundO'Rourke, S. A., Neto, N. G. B., Devilly, E., Shanley, L. C., Fitzgerald, H. K., Monaghan, M. G., & Dunne, A. (2022) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2022.05.015 · Cited by 62
Small Heterodimer Partner Regulates Dichotomous T Cell Expansion by Macrophages
Shahoei, S. H., Kim, Y.-C., Cler, S. J., Ma, L., Anakk, S., Kemper, J. K., & Nelson, E. R. (2019) · Endocrinology · doi:10.1210/en.2019-00025 · Cited by 16
Mu, F., Wang, Y., Wu, H., You, Q., & Zhang, D. (2022) · Bioengineered · doi:10.1080/21655979.2021.2005932 · Cited by 6
Retracted
Metadata
- Authors
- Koelwyn, G. J., Corr, E. M., Erbay, E., & Moore, K. J.
- Venue
- Nature Immunology
- Published
- 2018-05-18
- Volume
- 19
- Issue
- 6
- Pages
- 526-537
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2804609215
- Cited by
- 555
- References
- 115
- FWCI
- 14.48
- Type
- journal article
- Language
- en
- Open access
- bronze
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