The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy
Open accessAbstract
Sustained glucose and glutamine transport are essential for activated T lymphocytes to support ATP and macromolecule biosynthesis. We found that glutamine and glucose also fuel an indispensable dynamic regulation of intracellular protein O-GlcNAcylation at key stages of T cell development, transformation and differentiation. Glucose and glutamine are precursors of uridine diphosphate N-acetylglucosamine (UDP-GlcNAc), a substrate for cellular glycosyltransferases. Immune-activated T cells contained higher concentrations of UDP-GlcNAc and increased intracellular protein O-GlcNAcylation controlled by the enzyme O-linked-β-N-acetylglucosamine (O-GlcNAc) glycosyltransferase as compared with naive cells. We identified Notch, the T cell antigen receptor and c-Myc as key controllers of T cell protein O-GlcNAcylation via regulation of glucose and glutamine transport. Loss of O-GlcNAc transferase blocked T cell progenitor renewal, malignant transformation and peripheral T cell clonal expansion. Nutrient-dependent signaling pathways regulated by O-GlcNAc glycosyltransferase are thus fundamental for T cell biology.
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Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression
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Metadata
- Authors
- Swamy, M., Pathak, S., Grzes, K. M., Damerow, S., Sinclair, L. V., van Aalten, D. M. F., & Cantrell, D. A.
- Venue
- Nature Immunology
- Published
- 2016-04-25
- Volume
- 17
- Issue
- 6
- Pages
- 712-720
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2343796589
- Cited by
- 350
- References
- 10
- FWCI
- 16.10
- Type
- journal article
- Language
- en
- Open access
- green
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- Swamy, M., Pathak, S., Grzes, K. M., Damerow, S., Sinclair, L. V., van Aalten, D. M. F., & Cantrell, D. A. (2016). Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy. Nature Immunology. https://doi.org/10.1038/ni.3439
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