The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Expression profiling of constitutive mast cells reveals a unique identity within the immune system
Open accessAbstract
Mast cells are evolutionarily ancient sentinel cells. Like basophils, mast cells express the high-affinity receptor for immunoglobulin E (IgE) and have been linked to host defense and diverse immune-system-mediated diseases. To better characterize the function of these cells, we assessed the transcriptional profiles of mast cells isolated from peripheral connective tissues and basophils isolated from spleen and blood. We found that mast cells were transcriptionally distinct, clustering independently from all other profiled cells, and that mast cells demonstrated considerably greater heterogeneity across tissues than previously appreciated. We observed minimal homology between mast cells and basophils, which shared more overlap with other circulating granulocytes than with mast cells. The derivation of mast-cell and basophil transcriptional signatures underscores their differential capacities to detect environmental signals and influence the inflammatory milieu.
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Depuydt, M. A. C., Prange, K. H. M., Slenders, L., Örd, T., Elbersen, D., Boltjes, A., de Jager, S. C. A., Asselbergs, F. W., de Borst, G. J., Aavik, E., et al. (2020) · Circulation Research · doi:10.1161/circresaha.120.316770 · Cited by 594
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Mast Cells in Inflammation and Disease: Recent Progress and Ongoing Concerns
Galli, S. J., Gaudenzio, N., & Tsai, M. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-071719-094903 · Cited by 367
Understanding the tumor microenvironment for effective immunotherapy
Sadeghi Rad, H., Monkman, J., Warkiani, M. E., Ladwa, R., O'Byrne, K., Rezaei, N., & Kulasinghe, A. (2021) · Medicinal Research Reviews · doi:10.1002/med.21765 · Cited by 334
Metadata
- Authors
- The Immunological Genome Project Consortium, Dwyer, D. F., Barrett, N. A., & Austen, K. F.
- Venue
- Nature Immunology
- Published
- 2016-05-02
- Volume
- 17
- Issue
- 7
- Pages
- 878-887
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2347163170
- Cited by
- 365
- References
- 50
- FWCI
- 16.99
- Type
- journal article
- Language
- en
- Open access
- green
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- The Immunological Genome Project Consortium, Dwyer, D. F., Barrett, N. A., & Austen, K. F. (2016). Expression profiling of constitutive mast cells reveals a unique identity within the immune system. Nature Immunology. https://doi.org/10.1038/ni.3445
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