The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Tumor-induced stromal reprogramming drives lymph node transformation
Open accessAbstract
Lymph node (LN) stromal cells, particularly fibroblastic reticular cells (FRCs), provide critical structural support and regulate immunity, tolerance and the transport properties of LNs. For many tumors, metastasis to the LNs is predictive of poor prognosis. However, the stromal contribution to the evolving microenvironment of tumor-draining LNs (TDLNs) remains poorly understood. Here we found that FRCs specifically of TDLNs proliferated in response to tumor-derived cues and that the network they formed was remodeled. Comparative transcriptional analysis of FRCs from non-draining LNs and TDLNs demonstrated reprogramming of key pathways, including matrix remodeling, chemokine and/or cytokine signaling, and immunological functions such as the recruitment, migration and activation of leukocytes. In particular, downregulation of the expression of FRC-derived chemokine CCL21 and cytokine IL-7 were accompanied by altered composition and aberrant localization of immune-cell populations. Our data indicate that following exposure to tumor-derived factors, the stroma of TDLNs adapts on multiple levels to exhibit features typically associated with immunosuppression.
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TM4: a free, open-source system for microarray data management and analysis
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CCR7 and its ligands: balancing immunity and tolerance
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Suppression of Antitumor Immunity by Stromal Cells Expressing Fibroblast Activation Protein–α
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Regulation of Dendritic Cell Migration to the Draining Lymph Node
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Metadata
- Authors
- Riedel, A., Shorthouse, D., Haas, L., Hall, B. A., & Shields, J.
- Venue
- Nature Immunology
- Published
- 2016-07-11
- Volume
- 17
- Issue
- 9
- Pages
- 1118-1127
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2460036490
- Cited by
- 204
- References
- 8
- FWCI
- 6.80
- Type
- journal article
- Language
- en
- Open access
- green
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- Riedel, A., Shorthouse, D., Haas, L., Hall, B. A., & Shields, J. (2016). Tumor-induced stromal reprogramming drives lymph node transformation. Nature Immunology. https://doi.org/10.1038/ni.3492
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
