CCR7 and its ligands: balancing immunity and tolerance
Abstract
A key feature of the immune system is its ability to induce protective immunity against pathogens while maintaining tolerance towards self and innocuous environmental antigens. Recent evidence suggests that by guiding cells to and within lymphoid organs, CC-chemokine receptor 7 (CCR7) essentially contributes to both immunity and tolerance. This receptor is involved in organizing thymic architecture and function, lymph-node homing of naive and regulatory T cells via high endothelial venules, as well as steady state and inflammation-induced lymph-node-bound migration of dendritic cells via afferent lymphatics. Here, we focus on the cellular and molecular mechanisms that enable CCR7 and its two ligands, CCL19 and CCL21, to balance immunity and tolerance.
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Organ-specific non-peripheral cells with tissue-homing markers can transiently appear in blood cell preparations.
“In these blood cell preparations, organ-specific non-peripheral cells with tissue-homing markers can also transiently appear. 16-20”
From Revealing viral and cellular dynamics of HIV-1 at the single-cell level during early treatment periods (2023) · cites this paper as [19]
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“In order to specifically interrogate the role of transiently appearing non-peripheral cells, this study aimed at separating and characterizing leukocytes with external homing properties using characteristic homingmarkers such as integrin a4b7 for gut homing(16,17) andcutaneous leukocyte antigen (CLA) for skin homing,(…”
Method
- Authors
- Förster, R., Davalos-Misslitz, A. C., & Rot, A.
- Affiliations
- Medizinische Hochschule Hannover (DE)
- Novartis (Austria) (AT)
- Corresponding author
- Förster, Reinhold
- Venue
- Nature Reviews Immunology
- Published
- 2008-05
- Volume
- 8
- Issue
- 5
- Pages
- 362-371
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2003566453
- Cited by
- 1,410
- References
- 1
- Citations by year
- 2026: 67 · 2025: 97 · 2024: 80 · 2023: 84 · 2022: 79 · 2021: 110 · 2020: 70 · 2019: 84 · 2018: 60 · 2017: 88 · 2016: 82 · 2015: 74 · 2014: 65 · 2013: 72 · 2012: 84
- FWCI
- 6.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- CCR7, CCL19, CCL21, chemokines, chemokine receptors, immune tolerance, thymic architecture, regulatory T cells, high endothelial venules, dendritic cell migration, afferent lymphatics, lymph nodes, inflammation, self-tolerance
- MeSH terms
- Animals, Cell Differentiation, Cell Movement, Dendritic Cells, Humans, Immune Tolerance, Immunity, Cellular, Lymph Nodes, T-Lymphocytes, Thymus Gland, Autoimmunity, Receptors, CCR7, Chemokine CCL19, Chemokine CCL21
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