The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Novel mechanisms and functions of complement
Open accessAbstract
Progress at the beginning of the 21st century transformed the perception of complement from that of a blood-based antimicrobial system to that of a global regulator of immunity and tissue homeostasis. More recent years have witnessed remarkable advances in structure–function insights and understanding of the mechanisms and locations of complement activation, which have added new layers of complexity to the biology of complement. This complexity is readily reflected by the multifaceted and contextual involvement of complement-driven networks in a wide range of inflammatory and neurodegenerative disorders and cancer. This Review provides an updated view of new and previously unanticipated functions of complement and how these affect immunity and disease pathogenesis.
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1 retracted
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Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner
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Self-citationComplement and microglia mediate early synapse loss in Alzheimer mouse models
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Self-citationComplement factor H variant increases the risk of age-related macular degeneration
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Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities
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Self-citationUltra-High-Throughput Clinical Proteomics Reveals Classifiers of COVID-19 Infection
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Current understanding of periodontal disease pathogenesis and targets for host‐modulation therapy
Hajishengallis, G., Chavakis, T., & Lambris, J. D. (2020) · Periodontology 2000 · doi:10.1111/prd.12331 · Cited by 502
Self-citationNew insights into the immune functions of complement
Reis, E. S., Mastellos, D. C., Hajishengallis, G., & Lambris, J. D. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-019-0168-x · Cited by 470
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Metadata
- Authors
- Hajishengallis, G., Reis, E. S., Mastellos, D. C., Ricklin, D., & Lambris, J. D.
- Venue
- Nature Immunology
- Published
- 2017-11-16
- Volume
- 18
- Issue
- 12
- Pages
- 1288-1298
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2770722600
- Cited by
- 488
- References
- 24
- FWCI
- 16.54
- Type
- journal article
- Language
- en
- Open access
- green
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