The DOI matches its Crossref record; 264 of the 264 references it cites were found in a registry or an index.
Current understanding of periodontal disease pathogenesis and targets for host‐modulation therapy
Open accessAbstract
Recent advances indicate that periodontitis is driven by reciprocally reinforced interactions between a dysbiotic microbiome and dysregulated inflammation. Inflammation is not only a consequence of dysbiosis but, via mediating tissue dysfunction and damage, fuels further growth of selectively dysbiotic communities of bacteria (inflammophiles), thereby generating a self‐sustained feed‐forward loop that perpetuates the disease. These considerations provide a strong rationale for developing adjunctive host‐modulation therapies for the treatment of periodontitis. Such host‐modulation approaches aim to inhibit harmful inflammation and promote its resolution or to interfere directly with downstream effectors of connective tissue and bone destruction. This paper reviews diverse strategies targeted to modulate the host periodontal response and discusses their mechanisms of action, perceived safety, and potential for clinical application.
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Citations
Cites
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Self-citationPro-resolving lipid mediators are leads for resolution physiology
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Cited by
Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities
Hajishengallis, G., & Chavakis, T. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-020-00488-6 · Cited by 1,871
Self-citationCurrent concepts in the pathogenesis of periodontitis: from symbiosis to dysbiosis
Abdulkareem, A. A., Al-Taweel, F. B., Al-Sharqi, A. J. B., Gul, S. S., Sha, A., & Chapple, I. L. C. (2023) · Journal of Oral Microbiology · doi:10.1080/20002297.2023.2197779 · Cited by 367
Polarized Macrophages in Periodontitis: Characteristics, Function, and Molecular Signaling
Sun, X., Gao, J., Meng, X., Lu, X., Zhang, L., & Chen, R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.763334 · Cited by 291
A Roadmap towards Precision Periodontics
Rakic, M., Pejcic, N., Perunovic, N., & Vojvodic, D. (2021) · Medicina · doi:10.3390/medicina57030233 · Cited by 36
Afacan, B., Öztürk, V. Ö., Emingil, G., Köse, T., Mitsakakis, K., & Bostanci, N. (2022) · Scientific Reports · doi:10.1038/s41598-022-24295-2 · Cited by 10
Metadata
- Authors
- Hajishengallis, G., Chavakis, T., & Lambris, J. D.
- Venue
- Periodontology 2000
- Publisher
- Wiley
- Published
- 2020-08-25
- Volume
- 84
- Issue
- 1
- Pages
- 14-34
- ISSN
- 0906-6713 (ISSN-L)
- 1600-0757
- OpenAlex
- W3080228553
- Cited by
- 502
- References
- 264
- FWCI
- 40.14
- Type
- journal article
- Language
- en
- Open access
- green
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