Revival of the autoantibody model in rheumatoid arthritis
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Interactions between immune cells and non-immune tissues play critical roles in chronic inflammatory diseases and autoimmune diseases.
“Consistently, evidence has indicated that interactions between immune cells and non-immune tissues play critical roles in chronic inflammatory diseases and autoimmune diseases (3, 41, 49–51).”
From IL-6 in inflammation, autoimmunity and cancer (2021) · cites this paper as [51]
Cites
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Self-citationFrom Systemic T Cell Self-Reactivity to Organ-Specific Autoimmune Disease via Immunoglobulins
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IL-6 in inflammation, autoimmunity and cancer
Hirano, T. (2021) · International Immunology · doi:10.1093/intimm/dxaa078 · Cited by 1,453 · see citing works
“This view highlights the importance of local initiators in the target tissue as a trigger of auto-immunity (49, 51, 52, 57, 232).”
BackgroundSelf-citationSuzuki, A., Yamada, R., Chang, X., Tokuhiro, S., Sawada, T., Suzuki, M., Nagasaki, M., Nakayama-Hamada, M., Kawaida, R., Ono, M., et al. (2003) · Nature Genetics · doi:10.1038/ng1206 · Cited by 1,168 · see citing works
“PADI4 is therefore expressed in hematological tissues and cell types, which are known to be intimately involved in the pathogenesis of rheumatoid arthriti”
BackgroundIL-6 in autoimmune disease and chronic inflammatory proliferative disease
Ishihara, K., & Hirano, T. (2002) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(02)00027-8 · Cited by 807 · see citing works
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“digits of the forelimb; (2) swelling of the footpad; (3) swelling of”
BackgroundInfluentialSelf-citationSawa, S.-I., Kamimura, D., Jin, G.-H., Morikawa, H., Kamon, H., Nishihara, M., Ishihara, K., Murakami, M., & Hirano, T. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20052187 · Cited by 176 · see citing works
“Therefore, it is also possible that some cytokines, alone and in the absence of autoreactive lymphocytes, can induce tissuespecifi c autoimmune-like diseases (5, 6).”
BackgroundSelf-citationInterleukin 6 in autoimmune and inflammatory diseases: a personal memoir
HIRANO, T. (2010) · Proceedings of the Japan Academy, Series B · doi:10.2183/pjab.86.717 · Cited by 172 · see citing works
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“It is now clear that, dependent on the property of the target tissue, the alternative complement pathway also plays a crucial role (1), and that late complement components, C5a and C5aR, are essential effectors in the majority of complement-mediated inflammatory reactions (2– 4).”
BackgroundTsuboi, N., Ernandez, T., Li, X., Nishi, H., Culleré, X., Mekala, D. J., Hazen, M. M., Köhl, J., Lee, D. M., & Mayadas, T. N. (2010) · Arthritis & Rheumatism · doi:10.1002/art.30141 · Cited by 78 · see citing works
Antoniv, T. T., & Ivashkiv, L. B. (2006) · Arthritis & Rheumatism · doi:10.1002/art.22055 · Cited by 77 · see citing works
Inhibition of Interleukin 10 Signaling after Fc Receptor Ligation and during Rheumatoid Arthritis
Ji, J.-D., Tassiulas, I. O., Park‐Min, K., Aydin, A., Mecklenbräuker, I., Tarakhovsky, A., Pricop, L., Salmon, J. E., & Ivashkiv, L. B. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021820 · Cited by 77 · see citing works
“We report that IL-10 signal transduction was blocked in IFN- –activated macrophages when Fc Rs were ligated, and in RA macrophages that exhibit an IFN- –activated phenotype and are exposed to ICs in synovial fluid and tissue (24, 62).”
BackgroundCD69‐null mice protected from arthritis induced with anti‐type II collagen antibodies
Murata, K., Inami, M., Hasegawa, A., Kubo, S., Kimura, M. Y., Yamashita, M., Hosokawa, H., Nagao, T., Suzuki, K., Hashimoto, K., et al. (2003) · International Immunology · doi:10.1093/intimm/dxg102 · Cited by 69 · see citing works
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Murakami, M., & Hirano, T. (2011) · Frontiers in Immunology · doi:10.3389/fimmu.2011.00022 · Cited by 53 · see citing works
“…triggered by certain genetic and/or environmental factors (Hirano, 1998, 2010; Matsumoto et al., 1999; Marrack et al., 2001; Sawa et al., 2006) such that the specificity of an autoimmune disease could be determined by the non-immune target tissue itself (Brennan et al., 2002; Hirano, 2002).”
InfluentialSelf-citationWong, M.-X., Hayball, J. D., Hogarth, P. M., & Jackson, D. E. (2005) · Journal of Clinical Immunology · doi:10.1007/s10875-005-0354-7 · Cited by 47 · see citing works
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Polymorphisms in the IL4 and IL4RA genes in Colombian patients with rheumatoid arthritis.
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“The pathogenesis of RA is multifactorial, including genetic influences on susceptibility, environmental factors, immune mechanisms, and amplifying cytokine networks that perpetuate inflammation 1,2,3,4 .”
BackgroundEffect of locally administered Syk siRNA on allergen-induced arthritis and asthma
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“A key pathogenic hallmark of rheumatoid arthritis (RA) is the expansion of both autoreactive CD4 þ CD28 þ helper T cell type 1 (Th1) cells and autoantibody-producing B cells resulting from aberrant or impaired T cell control mechanisms of both regulatory CD4 þ CD25 þ T (Tr) cells and suppressor CD8 þ CD28 (cid:2) T (T…”
InfluentialJouen, F., Vittecoq, O., Guillou, F. L., TABTI-TITON, I., Ménard, J.-F., Mejjad, O., Pouplin, S., BOUMIER, P., Fardellone, P., Gayet, A., et al. (2004) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2004.02552.x · Cited by 18 · see citing works
Targeting B-cells in Inflammatory Disease
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(2008) · The Internet Journal of Rheumatology · doi:10.5580/1ddb · Cited by 2 · see citing works
“In addition to producing auto-antibodies, B cells function as highly efficient APCs and, like APCs, express co-stimulatory molecules (53) and secrete chemokines and cytokines (54,55,56,57).”
Pathogenese der Rheumatoiden Arthritis: Die pathologische Basis
Burkhardt, H., & Möller, B. (2003) · Pharmazie in unserer Zeit · doi:10.1002/pauz.200300035
- Authors
- Hirano, T.
- Affiliations
- RIKEN (JP)
- Corresponding author
- Hirano, Toshio
- Venue
- Nature Immunology
- Published
- 2002-04
- Volume
- 3
- Issue
- 4
- Pages
- 342-344
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2076269825
- Cited by
- 29
- References
- 13
- Citations by year
- 2020: 1 · 2012: 1
- FWCI
- 2.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- rheumatoid arthritis, autoantibodies, B cells, autoantigens, synovial joints, autoimmunity
- MeSH terms
- Animals, Arthritis, Rheumatoid, Autoantibodies, Autoantigens, Disease Models, Animal, Glucose-6-Phosphate Isomerase, Models, Immunological, Mice
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