‘PPAR’ting ways with inflammation

Bailey, Shannon T; Ghosh, Sankar

doi:10.1038/ni1005-966

Cited by 49Peroxisome Proliferator-Activated ReceptorsNF-κB Signaling PathwaysNuclear Receptors and Signaling

‘PPAR’ting ways with inflammation

Bailey, Shannon T, Ghosh, Sankar·2005·Nature Immunology

DOI 10.1038/ni1005-966

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Bailey and Ghosh proposed that in unstimulated macrophages, NF-κB together with a corepressor complex actively suppresses pro-inflammatory genes, and this complex contains nuclear receptor corepressor, HDAC3, and other proteins.
“Bailey and Ghosh [58] suggested that NF-κB in association with a corepressor complex actively represses pro-inflammatory gene expression in unstimulated macrophages and the corepressor complex is composed of nuclear receptor corepressor, HDAC3 and others.”
From Edible blue-green algae reduce the production of pro-inflammatory cytokines by inhibiting NF-κB pathway in macrophages and splenocytes (2013) · cites this paper as [58]

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Authors: Bailey, S. T., & Ghosh, S.
Affiliations: Yale University (US)
ORCID: Ghosh, Sankar
Venue: Nature Immunology
Publisher: Springer Science and Business Media LLC
Published: 2005-10
Volume: 6
Issue: 10
Pages: 966-967
ISSN: 1529-2908 (ISSN-L)
1529-2916
DOI: 10.1038/ni1005-966
OpenAlex: W1990383249
Cited by: 49
References: 11
Citations by year: 2024: 1 · 2022: 2 · 2021: 1 · 2019: 1 · 2018: 1 · 2016: 1 · 2015: 4 · 2014: 1 · 2013: 3 · 2012: 3
FWCI: 1.87
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
Keywords: PPARγ, SUMOylation, NF-κB, transrepression, inflammation, nuclear receptors, transcriptional repression, repressor complex
MeSH terms: Rosiglitazone, Animals, Inflammation, Promoter Regions, Genetic, Transcriptional Activation, Cytokines, NF-kappa B, Small Ubiquitin-Related Modifier Proteins, Thiazolidinediones, PPAR gamma

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