Cited by 2,899Peroxisome Proliferator-Activated ReceptorsInflammatory mediators and NSAID effectsAdipokines, Inflammation, and Metabolic Diseases

PPAR-γ agonists inhibit production of monocyte inflammatory cytokines

Jiang, Chengyu, Ting, Adrian T., Seed, Brian·1998·Nature

Abstract

The peroxisome proliferator-activated receptor-gamma (PPAR-gamma) is a member of the nuclear receptor family of transcription factors, a large and diverse group of proteins that mediate ligand-dependent transcriptional activation and repression. Expression of PPAR-gamma is an early and pivotal event in the differentiation of adipocytes. Several agents that promote differentiation of fibroblast lines into adipocytes have been shown to be PPAR-gamma agonists, including several prostanoids, of which 15-deoxy-delta-prostaglandin J2 is the most potent, as well as members of a new class of oral antidiabetic agents, the thiazolidinediones, and a variety of non-steroidal anti-inflammatory drugs (NSAIDs). Here we show that PPAR-gamma agonists suppress monocyte elaboration of inflammatory cytokines at agonist concentrations similar to those found to be effective for the promotion of adipogenesis. Inhibition of cytokine production may help to explain the incremental therapeutic benefit of NSAIDs observed in the treatment of rheumatoid arthritis at plasma drug concentrations substantially higher than are required to inhibit prostaglandin G/H synthase (cyclooxygenase).

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Crossref · 10.1038/34184

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3 of 3 references verified0 citation errors · 0 not checkable

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Authors
Jiang, C., Ting, A. T., & Seed, B.
Affiliations
Massachusetts General Hospital (US)
Corresponding author
Seed, Brian
Venue
Nature
Published
1998-01
Volume
391
Issue
6662
Pages
82-86
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
OpenAlex
W1639924204
Cited by
2,899
References
3
Citations by year
2026: 20 · 2025: 25 · 2024: 36 · 2023: 31 · 2022: 51 · 2021: 68 · 2020: 62 · 2019: 56 · 2018: 55 · 2017: 73 · 2016: 74 · 2015: 81 · 2014: 100 · 2013: 82 · 2012: 98
FWCI
46.75
Type
journal article
Language
en
Open access
closed
Locations
  • Nature (publishedVersion)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
  • Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
PPARγ agonists, monocytes, inflammatory cytokines, cytokine production inhibition, adipogenesis, thiazolidinediones, nonsteroidal anti-inflammatory drugs, prostanoids, rheumatoid arthritis, cyclooxygenase, nuclear receptors
MeSH terms
Troglitazone, Anti-Inflammatory Agents, Non-Steroidal, Cell Line, Chromans, Humans, Leukocytes, Mononuclear, Promoter Regions, Genetic, Thiazoles, Transcription Factors, Tumor Necrosis Factor-alpha, Prostaglandin D2, Cytokines, Receptors, Cytoplasmic and Nuclear, Inflammation Mediators, Thiazolidinediones

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