Cognate CD4+ T cell licensing of dendritic cells in CD8+ T cell immunity
Abstract
Several studies have indicated that CD8(+) T cells require CD4(+) T cell help for memory formation. Evidence suggests that such help can be antigen independent, challenging whether the 'licensing' of dendritic cells (DCs) by CD4(+) T cells is ever required for cytotoxic T lymphocyte (CTL) responses. We show here that help is essential for the generation of CTL immunity to herpes simplex virus 1 and that CD4(+) T cells mediate help in a cognate, antigen-specific way. We provide direct in vivo evidence for DC licensing by helper T cells and show that licensing is rapid and essential for the formation of effector and memory CTLs. In situations in which DCs are poorly licensed by pathogen-derived signals, our findings suggest that CTL immunity may be heavily dependent on cognate DC licensing.
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Differentiated dendritic cells support antigen presentation and play a pivotal role in initiating adaptive immune response.
“whereas differentiated dendritic cells support antigen presentation and play a pivotal role in initiating the adaptive immune response [44].”
From The Immune Landscape and Immunotherapeutic Strategies in Platinum-Refractory Testicular Germ Cell Tumors (2024) · cites this paper as [44]
MDSCs and Tregs are characterized by immune inhibitory potential.
“MDSCs and Tregs are characterized by an immune inhibitory potential”
From The Immune Landscape and Immunotherapeutic Strategies in Platinum-Refractory Testicular Germ Cell Tumors (2024) · cites this paper as [44]
Cites
Kaech, S. M., Tan, J. T., Wherry, E. J., Konieczny, B. T., Surh, C. D., & Ahmed, R. (2003) · Nature Immunology · doi:10.1038/ni1009 · Cited by 1,830 · cited 1× · see citing works
“These parameters showed that CD8 + DCs from T H cell–deficient (MHC class II–deficient) mice were marginally compromised in their ability to stimulate CD8 + T cell proliferation over the course of this short-term assay and notably deficient at inducing upregulation of Bcl-2, IL-2 receptor and IL-7 receptor; the latter…”
BackgroundCD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes
Janssen, E. M., Lemmens, E. E., Wolfe, T., Christen, U., von Herrath, M. G., & Schoenberger, S. P. (2003) · Nature · doi:10.1038/nature01441 · Cited by 1,635 · see citing works
Defective CD8 T Cell Memory Following Acute Infection Without CD4 T Cell Help
Sun, J. C., & Bevan, M. J. (2003) · Science · doi:10.1126/science.1083317 · Cited by 1,213 · see citing works
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Merad, M., Sathe, P., Helft, J., Miller, J., & Mortha, A. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-074950 · Cited by 2,309 · see citing works
cDC1 prime and are licensed by CD4(+) T cells to induce anti-tumour immunity
Ferris, S. T., Durai, V., Wu, R., Theisen, D. J., Ward, J. P., Bern, M. D., Davidson, J. T., Bagadia, P., Liu, T., Briseño, C. G., et al. (2020) · Nature · doi:10.1038/s41586-020-2611-3 · Cited by 611 · see citing works
Evmorfopoulos, K., Marsitopoulos, K., Karachalios, R., Karathanasis, A., Dimitropoulos, K., Tzortzis, V., Zachos, I., & Vlachostergios, P. J. (2024) · Cancers · doi:10.3390/cancers16020428 · Cited by 11 · see citing works
“MDSCs and Tregs are characterized by an immune inhibitory potential, whereas differentiated dendritic cells support antigen presentation and play a pivotal role in initiating the adaptive immune response [44].”
Background
- Authors
- Smith, C. M., Wilson, N. S., Waithman, J., Villadangos, J. A., Carbone, F. R., Heath, W. R., & Belz, G. T.
- Affiliations
- Walter and Eliza Hall Institute of Medical Research (AU)
- The University of Melbourne (AU)
- Corresponding author
- Heath, William R
- Belz, Gabrielle T
- Venue
- Nature Immunology
- Published
- 2004-10-10
- Volume
- 5
- Issue
- 11
- Pages
- 1143-1148
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W1994453856
- Cited by
- 448
- References
- 3
- Citations by year
- 2026: 11 · 2025: 11 · 2024: 14 · 2023: 12 · 2022: 13 · 2021: 16 · 2020: 16 · 2019: 9 · 2018: 17 · 2017: 13 · 2016: 18 · 2015: 13 · 2014: 21 · 2013: 20 · 2012: 29
- FWCI
- 9.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- Minerva Access (University of Melbourne) (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- CD4+ T cell help, CD8+ T cell immunity, cytotoxic T lymphocytes, herpes simplex virus type 1, T cell help
- MeSH terms
- Animals, Histocompatibility Antigens Class II, Dendritic Cells, Immunologic Memory, Models, Biological, T-Lymphocytes, Cytotoxic, CD4-Positive T-Lymphocytes, Herpesvirus 1, Human, CD8-Positive T-Lymphocytes, Mice
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