Dendritic epidermal T cells regulate skin homeostasis through local production of insulin-like growth factor 1
Abstract
A fine balance between rates of proliferation and apoptosis in the skin provides a defensive barrier and a mechanism for tissue repair after damage. Vgamma3(+) dendritic epidermal T cells (DETCs) are primary modulators of skin immune responses. Here we show that DETCs both produce and respond to insulin-like growth factor 1 (IGF-1) after T cell receptor stimulation. Mice deficient in DETCs had a notable increase in epidermal apoptosis that was abrogated by the addition of DETCs or IGF-1. Furthermore, DETC-deficient mice had reduced IGF-1 receptor activation at wound sites. These findings indicate critical functions for DETC-mediated IGF-1 production in regulating skin homeostasis and repair.
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The lack of DETCs in Tcrγ-/- mice results in increased keratinocyte apoptosis due to a deficiency of insulin-like growth factor 1 (IGF1).
“Wendy and colleagues have found that the lack of DETCs in Tcrγ-/- (which means the mice lack all γδ T cell subsets) mice also results in increased keratinocyte apoptosis due to a deficiency of insulin-like growth factor 1 (IGF1) (34).”
From Comparing Mouse and Human Tissue-Resident γδ T Cells (2022) · cites this paper as [34]
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“Similar to DETCs, human epidermal T cells produce keratinocyte growth factor (KGF) and insulin-like growth factor 1 (IGF1) and promote wound healing upon activation.”
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- Authors
- Sharp, L. L., Jameson, J. M., Cauvi, G., & Havran, W. L.
- Affiliations
- Scripps Research Institute (US)
- Corresponding author
- Havran, Wendy L
- Venue
- Nature Immunology
- Published
- 2004-12-12
- Volume
- 6
- Issue
- 1
- Pages
- 73-79
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2022221965
- Cited by
- 273
- References
- 0
- Citations by year
- 2026: 9 · 2025: 21 · 2024: 13 · 2023: 13 · 2022: 13 · 2021: 17 · 2020: 17 · 2019: 11 · 2018: 14 · 2017: 12 · 2016: 21 · 2015: 11 · 2014: 10 · 2013: 15 · 2012: 6
- FWCI
- 3.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (T32AI07244, T32AI007244, T32AI36964)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- dendritic epidermal T cells, insulin-like growth factor I, skin homeostasis, wound healing, IGF-1 receptor, T cell receptor stimulation, tissue repair
- MeSH terms
- Epidermal Cells, Animals, Dendritic Cells, Epidermis, Homeostasis, Insulin-Like Growth Factor I, Mice, Inbred C57BL, Skin, Wound Healing, T-Lymphocyte Subsets, Receptor, IGF Type 1, Mice, Knockout, Mice
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