Concerted peptide trimming by human ERAP1 and ERAP2 aminopeptidase complexes in the endoplasmic reticulum

Saveanu, Loredana, Carroll, Oliver, Lindo, Vivian, Del Val, Margarita, Lopez, Daniel, Lepelletier, Yves, Greer, Fiona, Schomburg, Lutz, Fruci, Doriana, Niedermann, Gabriele, van Endert, Peter M·2005·Nature Immunology

DOI 10.1038/ni1208

Cited by (482)

Items 201–300 of 482

Antigen presentation in SARS-CoV-2 infection: the role of class I HLA and ERAP polymorphisms
Irma Saulle, Chiara Vicentini, Mario Clerici, Mara Biasin · 2021 · Human Immunology
The association between seven ERAP1 polymorphisms and ankylosing spondylitis susceptibility: a meta-analysis involving 8,530 cases and 12,449 controls
Rui Chen, Lei Yao, Tong Meng, Weidong Xu · 2011 · Rheumatology International
Production of spliced peptides by the proteasome
Nathalie Vigneron, Vincent Stroobant, Violette Ferrari, Joanna Abi Habib, Benoit J. Van den Eynde · 2018 · Molecular Immunology
The Intracellular Antigen Transport Machinery TAP in Adaptive Immunity and Virus Escape Mechanisms
Christian Wilfried Scholz, Robert Tampé · 2005 · Journal of Bioenergetics and Biomembranes
Discovery of potent and selective inhibitors of human aminopeptidases ERAP1 and ERAP2 by screening libraries of phosphorus-containing amino acid and dipeptide analogues
Ewelina Węglarz‐Tomczak, Stamatia Vassiliou, Artur Mucha · 2016 · Bioorganic & Medicinal Chemistry Letters
Redundancy and Complementarity between ERAP1 and ERAP2 Revealed by their Effects on the Behcet's Disease-associated HLA-B*51 Peptidome*[S]
Pablo Guasp, Elena Lorente, Adrian Martín‐Esteban, Eilon Barnea, Paolo Romania, Doriana Fruci, JonasJ.W. Kuiper, Arie Admon, José A. Łópez de Castro · 2019 · Molecular & Cellular Proteomics
EPIPOX: Immunoinformatic Characterization of the Shared T-Cell Epitome between Variola Virus and Related Pathogenic Orthopoxviruses
Magdalena Molero-Abraham, John-Paul Glutting, Darren R. Flower, Esther M. Lafuente, Pedro Antonio Reche · 2015 · Journal of Immunology Research
Novel selective inhibitors of aminopeptidases that generate antigenic peptides
Athanasios Papakyriakou, Efthalia Zervoudi, Emmanuel A. Theodorakis, Loredana Saveanu, Efstratios Stratikos, Dionisios Vourloumis · 2013 · Bioorganic & Medicinal Chemistry Letters
The partial dissociation of MHC class I–bound peptides exposes their N terminus to trimming by endoplasmic reticulum aminopeptidase 1
Athanasios Papakyriakou, Emma Reeves, Mary E. Beton, Halina Mikolajek, Leon R. Douglas, Grace E. Cooper, Tim J Elliott, Jörn M. Werner, Edward James · 2018 · Journal of Biological Chemistry
ERAP2 Increases the Abundance of a Peptide Submotif Highly Selective for the Birdshot Uveitis-Associated HLA-A29
Wouter J. Venema, Sanne Hiddingh, Joke Helena de Boer, Frans H.J. Claas, Arend Mulder, Anneke I. den Hollander, Efstratios Stratikos, Siranush Sarkizova, Lars T. van der Veken, George M. C. Janssen et al. · 2021 · Frontiers in Immunology
Genetics, Epigenetics, and Gender Impact in Axial-Spondyloarthritis Susceptibility: An Update on Genetic Polymorphisms and Their Sex Related Associations
Maria Sole Chimenti, Carlo Perricone, Arianna D’Antonio, Mario Ferraioli, Paola Conigliaro, Paola Triggianese, Cinzia Ciccacci, Paola Borgiani, Roberto Perricone · 2021 · Frontiers in Genetics
Running the gauntlet: from peptide generation to antigen presentation by MHC class I
Philippa M. Saunders, Peter Van Endert · 2011 · Tissue Antigens
Genetic risk factors for death with SARS-CoV-2 from the UK Biobank
Chang Lu, Rihab Gam, Arun Prasad Pandurangan, Julian Gough · 2020 · medRxiv
ERAP, KIR, and HLA-C Profile in Recurrent Implantation Failure
Karolina Piekarska, Paweł Radwan, Agnieszka Tarnowska, Andrzej Wiśniewski, Michał Radwan, Jacek R. Wilczyński, Andrzej Malinowski, Izabela Nowak · 2021 · Frontiers in Immunology
Endoplasmic reticulum aminopeptidase 2 haplotypes play a role in modulating susceptibility to HIV infection
Mara Biasin, Manuela Sironi, Irma Saulle, Mariacristina De Luca, Francesca La Rosa, Rachele Cagliani, Diego Forni, Cristina Agliardi, Sergio Lo Caputo, Francesco Mazzotta et al. · 2013 · AIDS
Identification of immune-inflammation targets for intracranial aneurysms: a multiomics and epigenome-wide study integrating summary-data-based Mendelian randomization, single-cell-type expression analysis, and DNA methylation regulation
Peng-Wei Lin, Zhen-Rong Lin, Weiwei Wang, Ai-Shun Guo, Yu-Xiang Chen · 2024 · International Journal of Surgery
Immunoproteasome Activation Expands the MHC Class I Immunopeptidome, Unmasks Neoantigens, and Enhances T-cell Anti-Myeloma Activity
Priyanka Shailendra Rana, James John Ignatz-Hoover, Chunna Guo, Amber L. Mosley, Ehsan Malek, Yuriy Federov, Drew Adams, James Joseph Driscoll · 2024 · Molecular Cancer Therapeutics
ERAP1 and HLA-C interaction in inflammatory bowel disease in the Spanish population
Patricia Garrido Castro, Marco Antonio Moro‐García, Raquel Marcos-Fernández, Rebeca Alonso‐Arias, Roberto Díaz‐Peña · 2017 · Innate Immunity
ERAP1 and ERAP2 Enzymes: A Protective Shield for RAS against COVID-19?
Silvia D’Amico, Patrizia Tempora, Valeria Lucarini, Ombretta Melaiu, Stefania Gaspari, Mattia Algeri, Doriana Fruci · 2021 · International Journal of Molecular Sciences
Discovery of the First Selective Nanomolar Inhibitors of ERAP2 by Kinetic Target‐Guided Synthesis
Virgyl Camberlein, Charlotte Fléau, Pierre Sierocki, Lenong Li, Ronan Gealageas, Damien Bosc, Valentin Guillaume, Sandrine Warenghem, Florence Leroux, Melissa Rosell et al. · 2022 · Angewandte Chemie International Edition
Monitoring peptide processing for MHC class I molecules in the endoplasmic reticulum
Nilabh Shastri, Niranjana A. Nagarajan, Kristin Camfield Lind, Takayuki Kanaseki · 2013 · Current Opinion in Immunology
Differential Recognition of Influenza A Viruses by M158–66Epitope-Specific CD8+T Cells Is Determined by Extraepitopic Amino Acid Residues
Carolien E. van de Sandt, Joost H. C. M. Kreijtz, Martina M. Geelhoed-Mieras, Nella J. Nieuwkoop, Monique I. J. Spronken, David A. M. C. van de Vijver, Ron A. M. Fouchier, Albert D. M. E. Osterhaus, Guus F. Rimmelzwaan · 2015 · Journal of Virology
ERAP1 reduces accumulation of aberrant and disulfide-linked forms of HLA-B27 on the cell surface
Tri Minh Tran, So‐Hee Hong, Jehad H. Edwan, Robert Allen Colbert · 2016 · Molecular Immunology
The biogenesis of the immunopeptidome
Arie Admon · 2023 · Seminars in Immunology
Integrated analysis of fine-needle-aspiration cystic fluid proteome, cancer cell secretome, and public transcriptome datasets for papillary thyroid cancer biomarker discovery
Chia‐Chun Wu, Jen‐Der Lin, Jeng-Ting Chen, Chih‐Min Chang, Hsiao‐Fen Weng, Chuen Hsueh, Hui‐Ping Chien, Jau‐Song Yu · 2018 · Oncotarget
Endoplasmic reticulum aminopeptidase 1 and rheumatic disease
Tri Minh Tran, Robert Allen Colbert · 2015 · Current Opinion in Rheumatology
Evolutionary immuno-genetics of endoplasmic reticulum aminopeptidase II (ERAP2)
Aroosha Raja, Jonas J. W. Kuiper · 2023 · Genes and Immunity
Rare inborn errors associated with chronic hepatitis B virus infection
Qiang Zhao, Liang Peng, Weijun Huang, Qibin Li, Yuanyuan Pei, Ping Yuan, Lingyan Zheng, Yongling Zhang, Jia Deng, Cheng Zhong et al. · 2012 · Hepatology
Dynamic Changes in Gene Expression that Occur during the Period of Spontaneous Functional Regression in the Rhesus Macaque Corpus Luteum
Randy L. Bogan, Melinda J. Murphy, Jon D. Hennebold · 2008 · Endocrinology
Cytosolic Processing Governs TAP-Independent Presentation of a Critical Melanoma Antigen
Nathalie Vigneron, Violette Ferrari, Benoit J. Van den Eynde, Peter Cresswell, Ralf M. Leonhardt · 2018 · The Journal of Immunology
Substrate-dependent nitric oxide synthesis by secreted endoplasmic reticulum aminopeptidase 1 in macrophages
Yoshikuni Goto, Kenji Ogawa, Takahiro J. Nakamura, Akira Hattori, Masafumi Tsujimoto · 2015 · The Journal of Biochemistry
Proteasome-independent HLA-B27 Ligands Arise Mainly from Small Basic Proteins
Miguel Marcilla, Juan José Cragnolini, José A. Łópez de Castro · 2007 · Molecular & Cellular Proteomics
Update on the genetics of spondyloarthritis – ankylosing spondylitis and psoriatic arthritis
Vinod Chandran, Proton Rahman · 2010 · Best Practice & Research Clinical Rheumatology
Fxna, a novel gene differentially expressed in the rat ovary at the time of folliculogenesis, is required for normal ovarian histogenesis
Cecilia Garcia‐Rudaz, Félix Luna, Veronica M. Tapia, Bredford Kerr, Lois M. A. Colgin, Francesco Galimi, Gregory A. Dissen, Neil David Rawlings, Sergio R. Ojeda · 2007 · Development
ERAP Inhibitors in Autoimmunity and Immuno-Oncology: Medicinal Chemistry Insights
Vasileios Fougiaxis, Ben He, Tuhina Khan, Rodolphe Vatinel, Nikoletta-Maria Koutroumpa, Antreas Afantitis, Laëtitia Lesire, Pierre Sierocki, Benoit P. Deprez, Rebecca F. Deprez-Poulain · 2024 · Journal of Medicinal Chemistry
Different Antigen-Processing Activities in Dendritic Cells, Macrophages, and Monocytes Lead to Uneven Production of HIV Epitopes and Affect CTL Recognition
Jens Dinter, Pauline Gourdain, Nicole Y. Lai, Ellen Duong, Edith Bracho-Sanchez, Marijana Ručević, Paul H Liebesny, Yang Xu, Mariko Shimada, Musie S Ghebremichael et al. · 2014 · The Journal of Immunology
Ranking the Contribution of Ankylosing Spondylitis-associated Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) Polymorphisms to Shaping the HLA-B*27 Peptidome
Alejandro Sanz‐Bravo, Carlos Alvarez‐Navarro, Adrian Martín‐Esteban, Eilon Barnea, Arie Admon, José A. Łópez de Castro · 2018 · Molecular & Cellular Proteomics
Concerted In Vitro Trimming of Viral HLA-B27-Restricted Ligands by Human ERAP1 and ERAP2 Aminopeptidases
Elena Lorente, Alejandro Barriga, Carolina Johnstone, Carmen Mir, Mercedes Jiménez, Daniel López · 2013 · PLoS ONE
What is the role of alternate splicing in antigen presentation by major histocompatibility complex class I molecules?
Alan Belicha‐Villanueva, Jennifer Blickwedehl, Sarah M. McEvoy, Michelle Golding, Sandra Oppel Gollnick, Naveen Bangia · 2009 · Immunologic Research
The Efficiency of Human Cytomegalovirus pp65495–503 CD8+ T Cell Epitope Generation Is Determined by the Balanced Activities of Cytosolic and Endoplasmic Reticulum-Resident Peptidases
Sabrina Urban, Kathrin Textoris‐Taube, Barbara Reimann, Katharina Janek, Tanja Dannenberg, Frédéric Ebstein, Christin Seifert, Fang Zhao, Jan H. Kessler, Anne Halenius et al. · 2012 · The Journal of Immunology
ERAP1/ERAP2 and RUNX3 polymorphisms are not associated with ankylosing spondylitis susceptibility in Chinese Han
Wencheng Su, Liping Du, S Liu, Jing Deng, Qingfeng Cao, Gangxiang Yuan, Aize Kijlstra, Peizeng Yang · 2018 · Clinical & Experimental Immunology
Molecular pathways for antigenic peptide generation by ER aminopeptidase 1
Anastasia Mpakali, Zachary Maben, Lawrence J. Stern, Efstratios Stratikos · 2018 · Molecular Immunology
Allele-specific Alterations in the Peptidome Underlie the Joint Association of HLA-A*29:02 and Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) with Birdshot Chorioretinopathy
Alejandro Sanz‐Bravo, Adrian Martín‐Esteban, Jonas J. W. Kuiper, Marina García-Peydró, Eilon Barnea, Arie Admon, José A. Łópez de Castro · 2018 · Molecular & Cellular Proteomics
The Role of Insulin Regulated Aminopeptidase in Endocytic Trafficking and Receptor Signaling in Immune Cells
Delphyne Descamps, Irini Evnouchidou, Vivien Caillens, Carole Drajac, Sabine Riffault, Peter Van Endert, Loredana Saveanu · 2020 · Frontiers in Molecular Biosciences
Traffic of Proteins and Peptides across Membranes for Immunosurveillance by CD8+ T Lymphocytes: A Topological Challenge
Carolina Johnstone, Margarita Del Val · 2007 · Traffic
Crystal Structures of ERAP2 Complexed with Inhibitors Reveal Pharmacophore Requirements for Optimizing Inhibitor Potency
Anastasia Mpakali, Petros Giastas, Rebecca F. Deprez-Poulain, Athanasios Papakyriakou, Despoina Koumantou, Ronan Gealageas, Sofia Tsoukalidou, Dionisios Vourloumis, Irene M. Mavridis, Efstratios Stratikos et al. · 2017 · ACS Medicinal Chemistry Letters
HLA class I is most tightly linked to levels of tapasin compared with other antigen-processing proteins in glioblastoma
Camilla Thuring, Elna Follin, Linda Geironson, Eva Freyhult, Victoria Junghans, Mikkel Nors Harndahl, Søren Buus, Kajsa M. Paulsson · 2015 · British Journal of Cancer
ERAP2 is a novel target involved in autophagy and activation of pancreatic stellate cells via UPR signaling pathway
Weiyu Guan, Kohei Nakata, Akiko Sagara, Chika Iwamoto, Sho Endo, Ryota Matsuda, Sokichi Matsumoto, Naoki Ikenaga, Koji Shindo, Taiki Moriyama et al. · 2021 · Pancreatology
Disparate folding and stability of the ankylosing spondylitis–associated HLA–B*1403 and B*2705 proteins
Elena Merino, Begoña Galocha, Miriam Vázquez, José A. Łópez de Castro · 2008 · Arthritis & Rheumatism
EpCAM associates with endoplasmic reticulum aminopeptidase 2 (ERAP2) in breast cancer cells
Salah-Eldin Gadalla, Karin Öjemalm, Patricia Lara Vasquez, IngMarie Nilsson, Christer Ericsson, Jian Zhao, Monica Nistér · 2013 · Biochemical and Biophysical Research Communications
A Naturally Variable Residue in the S1 Subsite of M1 Family Aminopeptidases Modulates Catalytic Properties and Promotes Functional Specialization
Seema R. Dalal, Daniel R.T. Ragheb, Florian David Schubot, Michael Klemba · 2013 · Journal of Biological Chemistry
Modulation of Natural HLA-B*27:05 Ligandome by Ankylosing Spondylitis-associated Endoplasmic Reticulum Aminopeptidase 2 (ERAP2)
Elena Lorente, Miguel Gomez Fontela, Eilon Barnea, Antonio J. Martín-Galiano, Carmen Mir, Begoña Galocha, Arie Admon, Pilar Lauzurica, Daniel López · 2020 · Molecular & Cellular Proteomics
Metallophilic marginal zone macrophages cross-prime CD8+ T cell-mediated protective immunity against blood-borne tumors
François‐Xavier Mauvais, Yamina Hamel, Aymeric Silvin, Kevin Mulder, Kai Hildner, Ramazan Akyol, Marc Dalod, Despoina Koumantou, Loredana Saveanu, Meriem Garfa‐Traoré et al. · 2025 · Immunity
The emerging multifunctional roles of ERAP1, ERAP2 and IRAP between antigen processing and renin-angiotensin system modulation
Benedetta Mattorre, Valentina Tedeschi, Giorgia Paldino, Maria Teresa Fiorillo, Fabiana Paladini, Rosa Sorrentino · 2022 · Frontiers in Immunology
Axial Spondyloarthritis: an overview of the disease
Mariana G. Ivanova, Olena Zimba, Ivan Dimitrov, Alexander Krasimirov Angelov, Tsvetoslav Georgiev · 2024 · Rheumatology International
Generation of SARS-CoV‑2 S1 Spike Glycoprotein Putative Antigenic Epitopes in Vitro by Intracellular Aminopeptidases
George M. Stamatakis, Martina K. Samiotaki, Anastasia Mpakali, George Panayotou, Efstratios Stratikos · 2020 · Journal of Proteome Research
Minor histocompatibility antigens: presentation principles, recognition logic and the potential for a healing hand
Charles T. Spencer, Pavlo Gilchuk, Srdan M. Dragovic, Sebastian Joyce · 2010 · Current Opinion in Organ Transplantation
The genetic backbone of ankylosing spondylitis: how knowledge of genetic susceptibility informs our understanding and management of disease
Marcus Kenyon, Sinead Maguire, Anna Rueda Pujol, Finbar D. O'Shea, Ross McManus · 2022 · Rheumatology International
The TAP translocation machinery in adaptive immunity and viral escape mechanisms
Rupert Abele, Robert Tampé · 2011 · Essays in Biochemistry
Human Respiratory Syncytial Virus Infection
Bernhard Resch · 2011 · InTech eBooks
The ERAP gene is associated with HCV chronic infection in a Chinese Han population
Shuyuan Liu, Danfeng Cao, Yunsong Shen, Yalin Li, Ying Li, Li Shi, Jiankun Yu, Chuanyin Li, Xinwen Zhang, Mingbo Sun et al. · 2017 · Human Immunology
Identification of an Unconventional Subpeptidome Bound to the Behçet's Disease-associated HLA-B*51:01 that is Regulated by Endoplasmic Reticulum Aminopeptidase 1 (ERAP1)
Liye Chen, Hui Shi, Danai Koftori, Takuya Sekine, Annalisa Nicastri, Nicola Ternette, Paul Bowness · 2020 · Molecular & Cellular Proteomics
Immunogenetic Study in Chinese Population with Ankylosing Spondylitis: Are There Specific Genes Recently Disclosed?
Jiayu Zhai, Ju Rong, Qiuxia Li, Jieruo Gu · 2013 · Clinical and Developmental Immunology
Structural aspects of chemical modifications in the MHC-restricted immunopeptidome; Implications for immune recognition
Tatyana Sandalova, Benedetta Maria Sala, Adnane Achour · 2022 · Frontiers in Chemistry
Identification of potential HLA class I and class II epitope precursors associated with heat shock protein 70 (HSPA)
Paweł Stocki, Nicholas J. Morris, Christian Preisinger, Xiao Nong Wang, Walter Kölch, Gabriele Multhoff, Anne Mary Dickinson · 2010 · Cell Stress and Chaperones
Crystal structure of a polypeptide’s C-terminus in complex with the regulatory domain of ER aminopeptidase 1
Lufei Sui, Amit K. Gandhi, Hwai‐Chen Guo · 2016 · Molecular Immunology
Endoplasmic reticulum aminopeptidase 2 involvement in metastasis of oral cavity squamous cell carcinoma discovered by proteome profiling of primary cancer cells
I‐Chun Kuo, Huang‐Kai Kao, Yenlin Huang, Chun‐I Wang, Jui‐Shan Yi, Ying Jie Liang, Chun‐Ta Liao, Tzu‐Chen Yen, Chih‐Ching Wu, Kai‐Ping Chang · 2017 · Oncotarget
Evaluation of ERAP1 gene single nucleotide polymorphisms in immunomodulation of pro-inflammatory and anti-inflammatory cytokines profile in ankylosing spondylitis
Farhad Babaie, Hamed Mohammadi, Maryam Hemmatzadeh, Mehrdad Ebrazeh, Shahram Torkamandi, Mehdi Yousefi, Mehrzad Hajaliloo, Alireza Rezaiemanesh, Sorayya Salimi, Reza Salimi et al. · 2019 · Immunology Letters
Polymorphisms in endoplasmic reticulum aminopeptidase genes are associated with cervical cancer risk in a Chinese Han population
Chuanyin Li, Yaheng Li, Zhiling Yan, Shuying Dai, Shuyuan Liu, Xia Wang, Jun Wang, Xinwen Zhang, Li Shi, Yufeng Yao · 2020 · BMC Cancer
Modulators of hERAP2 discovered by high-throughput screening
Laura Medve, Ronan Gealageas, Bao Vy Lam, Valentin Guillaume, Omar Castillo‐Aguilera, Virgyl Camberlein, Catherine Piveteau, Melissa Rosell, Charlotte Fléau, Sandrine Warenghem et al. · 2020 · European Journal of Medicinal Chemistry
ERAPs Reduce In Vitro HIV Infection by Activating Innate Immune Response
Irma Saulle, Ivana Marventano, Marina Saresella, Claudia Vanetti, Micaela Garziano, Claudio Fenizia, Daria Trabattoni, Mario Clerici, Mara Biasin · 2021 · The Journal of Immunology
Cutting Edge: H-2Ld Class I Molecule Protects an HIV N-Extended Epitope from In Vitro Trimming by Endoplasmic Reticulum Aminopeptidase Associated with Antigen Processing
Susana Infantes, Yolanda Samino, Elena Lorente, Mercedes Jiménez, Ruth García, Margarita Del Val, Daniel López · 2010 · The Journal of Immunology
ERAP2 Is Associated With Immune Infiltration and Predicts Favorable Prognosis in SqCLC
Zhenlin Yang, He Tian, Fenglong Bie, Jiachen Xu, Zheng Zhou, Junhui Yang, Renda Li, Yue Peng, Guangyu Bai, Yanhua Tian et al. · 2021 · Frontiers in Immunology
The Lack of STING Impairs the MHC-I Dependent Antigen Presentation and JAK/STAT Signaling in Murine Macrophages
Carmen Caiazza, Teresa Brusco, Federica D’Alessio, Massimo D’Agostino, Angelica Avagliano, Alessandro Arcucci, Concetta Ambrosino, Giuseppe Fiume, Massimo Mallardo · 2022 · International Journal of Molecular Sciences
ERAP1 in ankylosing spondylitis
Carlos Alvarez‐Navarro, José A. Łópez de Castro · 2013 · Current Opinion in Rheumatology
The putative role of proteolytic pathways in the pathogenesis of Type 1 diabetes mellitus: The ‘autophagy’ hypothesis
Alessandra Fierabracci · 2014 · Medical Hypotheses
Chaperone function in antigen presentation by MHC class I molecules—tapasin in the PLC and TAPBPR beyond
David H. Margulies, Jiansheng Jiang, Javeed Ahmad, Lisa F. Boyd, Kannan Natarajan · 2023 · Frontiers in Immunology
A common functional variant of endoplasmic reticulum aminopeptidase 2 (ERAP2) that reduces major histocompatibility complex class I expression is not associated with ankylosing spondylitis
D. Harvey, Jennifer J. Pointon, Tugce Karaderi, Louise Appleton, C. Farrar, B P Wordsworth · 2011 · Rheumatology
Endoplasmic Reticulum Aminopeptidase Associated with Antigen Processing Regulates Quality of Processed Peptides Presented by MHC Class I Molecules
Takayuki Kanaseki, Nilabh Shastri · 2008 · The Journal of Immunology
Role of genetic variations on MHC class I antigen-processing genes in human cancer and viral-mediated diseases
Valerio D’Alicandro, Paolo Romania, Ombretta Melaiu, Doriana Fruci · 2018 · Molecular Immunology
Role of Metalloproteases in Vaccinia Virus Epitope Processing for Transporter Associated with Antigen Processing (TAP)-independent Human Leukocyte Antigen (HLA)-B7 Class I Antigen Presentation
Elena Lorente, Ruth García, Carmen Mir, Alejandro Barriga, François A. Lemonnier, Manuel Ramos, Daniel López · 2012 · Journal of Biological Chemistry
Endoplasmic Reticulum Aminopeptidase 2, a common immunological link to adverse pregnancy outcomes and cancer clearance?
Eun D. Lee · 2017 · Placenta
Sex-specific differences in endoplasmic reticulum aminopeptidase 1 modulation influence blood pressure and renin-angiotensin system responses
Sanjay Ranjit, Jian Yao Wong, Jia Wei Tan, Chee Sin Tay, Jessica M. Lee, Kelly Yin Han Wong, Luminita H. Pojoga, Danielle L. Peacock Brooks, Amanda Garza, Stephen A. Maris et al. · 2019 · JCI Insight
The Effect of Interferons on Presentation of Defective Ribosomal Products as HLA Peptides
Liran Komov, Dganit Melamed Kadosh, Eilon Barnea, Arie Admon · 2021 · Molecular & Cellular Proteomics
Allele-dependent Processing Pathways Generate the Endogenous Human Leukocyte Antigen (HLA) Class I Peptide Repertoire in Transporters Associated with Antigen Processing (TAP)-deficient Cells
Elena Lorente, Ruth García, Daniel López · 2011 · Journal of Biological Chemistry
Tripeptidyl peptidase II is dispensable for the generation of both proteasome‐dependent and proteasome‐independent ligands of HLA‐B27 and other class I molecules
Miguel Marcilla, Eugenia M. Villasevil, José A. Łópez de Castro · 2008 · European Journal of Immunology
How Has Molecular Biology Enhanced Our Undertaking of axSpA and Its Management
Mauro Fatica, Arianna D’Antonio, Lucia Novelli, Paola Triggianese, Paola Conigliaro, Elisabetta Greco, Alberto Bergamini, Carlo Perricone, Maria Sole Chimenti · 2022 · Current Rheumatology Reports
Exploring the Pathogenesis of Spondylarthritis beyond HLA-B27: A Descriptive Review
Ruxandra-Elena Nagit, Elena Rezuş, Petru Cianga · 2024 · International Journal of Molecular Sciences
Gene expression profiling of high altitude polycythemia in Han Chinese migrating to the Qinghai-Tibetan plateau
Yuqi Gao · 2011 · Molecular Medicine Reports
Association between ERAP1 gene polymorphisms and ankylosing spondylitis susceptibility in Han population.
Jianan Wang, Hang Li, Jianwei Wang, Xiang Gao · 2015 · PubMed Central
The role of endoplasmic reticulum aminopeptidase 2 in modulating immune detection of choriocarcinoma†
Michelle D. Warthan, Sonya L. Washington, Samone Franzese, Ronald M. Ramus, Kyu-Rae Kim, Timothy P. York, Efstratios Stratikos, Jerome F. Strauss, Eun D. Lee · 2018 · Biology of Reproduction
General Principles of Tumor Immunotherapy
Howard L. Kaufman, Jedd D. Wolchok · 2007 · Springer eBooks
Proteasomes, TAP, and Endoplasmic Reticulum-Associated Aminopeptidase Associated with Antigen Processing Control CD4+ Th Cell Responses by Regulating Indirect Presentation of MHC Class II-Restricted Cytoplasmic Antigens
Srdan M. Dragovic, Timothy M. Hill, Gregory J. Christianson, Sungjune Kim, Tim J Elliott, Diane M. Scott, Derry C. Roopenian, Luc Van Kaer, Sebastian Joyce · 2011 · The Journal of Immunology
Unconventional modes of peptide–HLA-I presentation change the rules of TCR engagement
Jade R. Hopkins, Bruce J. MacLachlan, Stephen J Harper, Andrew Kelvin Sewell, David K. Cole · 2022 · Discovery Immunology
Perpetual complexity: predicting human CD8+ T‐cell responses to pathogenic peptides
Anthony R. Di Carluccio, Cristina F. Triffon, Weisan Chen · 2018 · Immunology and Cell Biology
Associations between ERAP1 polymorphisms and ankylosing spondylitis susceptibility: An updated meta-analysis
Guoqi Cai, Lihong Xin, Li Wang, Dazhi Fan, Li Liu, Yanting Hu, Ning Ding, Shengqian Xu, Guo Xia, Xingzhong Jin et al. · 2014 · Modern Rheumatology
A cis-regulatory element regulates ERAP2 expression through autoimmune disease risk SNPs
Wouter J. Venema, Sanne Hiddingh, Jorg van Loosdregt, John Bowes, Brunilda Balliu, Joke Helena de Boer, Jeannette Ossewaarde‐van Norel, Susan D. Thompson, Carl D. Langefeld, Aafke de Ligt et al. · 2023 · Cell Genomics
The use of proteomics to understand antiviral immunity
Amanda P. Woon, Anthony Wayne Purcell · 2018 · Seminars in Cell and Developmental Biology
Distinct modulation of cellular immunopeptidome by the allosteric regulatory site of ER aminopeptidase 1
Ioannis Temponeras, Martina K. Samiotaki, Despoina Koumantou, Martha Nikopaschou, Jonas J. W. Kuiper, George Panayotou, Efstratios Stratikos · 2023 · European Journal of Immunology
Targeted Delivery of an Antigenic Peptide to the Endoplasmic Reticulum: Application for Development of a Peptide Therapy for Ankylosing Spondylitis
Hui-Chun Yu, Ming‐Chi Lu, Chin Li, Hsien-Lu Huang, Kuang‐Yung Huang, Su-Qin Liu, Ning‐Sheng Lai, Hsien-Bin Huang · 2013 · PLoS ONE