Cited by 482vaccines and immunoinformatics approachesPeptidase Inhibition and AnalysisImmunotherapy and Immune Responses

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Concerted peptide trimming by human ERAP1 and ERAP2 aminopeptidase complexes in the endoplasmic reticulum

Saveanu, Loredana, Carroll, Oliver, Lindo, Vivian, Del Val, Margarita, Lopez, Daniel, Lepelletier, Yves, Greer, Fiona, Schomburg, Lutz, Fruci, Doriana, Niedermann, Gabriele, van Endert, Peter M·2005·Nature Immunology

DOI 10.1038/ni1208

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Abstract

The generation of many HLA class I peptides entails a final trimming step in the endoplasmic reticulum that, in humans, is accomplished by two 'candidate' aminopeptidases. We show here that one of these, ERAP1, was unable to remove several N-terminal amino acids that were trimmed efficiently by the second enzyme, ERAP2. This trimming of a longer peptide required the concerted action of both ERAP1 and ERAP2, both for in vitro digestion and in vivo for cellular antigen presentation. ERAP1 and ERAP2 localized together in vivo and associated physically in complexes that were most likely heterodimeric. Thus, the human endoplasmic reticulum is equipped with a pair of trimming aminopeptidases that have complementary functions in HLA class I peptide presentation.

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Authors: Saveanu, L., Carroll, O., Lindo, V., Del Val, M., Lopez, D., Lepelletier, Y., Greer, F., Schomburg, L., Fruci, D., Niedermann, G., & van Endert, P. M.
Affiliations: Inserm (FR)
Centre National de la Recherche Scientifique (FR)
Charité – Universitätsmedizin Berlin (DE)
Max Planck Society (DE)
ORCID: Saveanu, Loredana
Lepelletier, Yves
Schomburg, Lutz
Fruci, Doriana
Niedermann, Gabriele
Venue: Nature Immunology
Publisher: Springer Science and Business Media LLC
Published: 2005-05-22
Volume: 6
Issue: 7
Pages: 689-697
ISSN: 1529-2908 (ISSN-L)
1529-2916
DOI: 10.1038/ni1208
OpenAlex: W1981338942
Cited by: 481
References: 35
Citations by year: 2026: 8 · 2025: 18 · 2024: 18 · 2023: 31 · 2022: 20 · 2021: 23 · 2020: 28 · 2019: 30 · 2018: 25 · 2017: 25 · 2016: 15 · 2015: 26 · 2014: 25 · 2013: 31 · 2012: 27
FWCI: 7.65
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature Immunology (publishedVersion)
PubMed (publishedVersion)
FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
Funders: Comunidad de Madrid
European Commission
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › vaccines and immunoinformatics approaches
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Peptidase Inhibition and Analysis
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords: ERAP1, ERAP2, aminopeptidase, peptide trimming, HLA class I, endoplasmic reticulum, antigen presentation
MeSH terms: Aminopeptidases, Epitopes, Endoplasmic Reticulum, HeLa Cells, Humans, Microsomes, Peptide Fragments, RNA, Immunoblotting, Histocompatibility Antigens Class I, Minor Histocompatibility Antigens, Antigen Presentation, Reverse Transcriptase Polymerase Chain Reaction, RNA Interference

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Concerted peptide trimming by human ERAP1 and ERAP2 aminopeptidase complexes in the endoplasmic reticulum

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