The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
An efficient and versatile system for acute and chronic modulation of renal tubular function in transgenic mice
Open accessAbstract
We describe a transgenic mouse line, Pax8-rtTA, which, under control of the mouse Pax8 promoter, directs high levels of expression of the reverse tetracycline–dependent transactivator (rtTA) to all proximal and distal tubules and the entire collecting duct system of both embryonic and adult kidneys. Using crosses of Pax8-rtTA mice with tetracycline-responsive c-MYC mice, we established a new, inducible model of polycystic kidney disease that can mimic adult onset and that shows progression to renal malignant disease. When targeting the expression of transforming growth factor-β1 to the kidney, we avoided early lethality by discontinuous treatment and successfully established an inducible model of renal fibrosis. Finally, a conditional knockout of the gene encoding tuberous sclerosis complex-1 was achieved, which resulted in the early outgrowth of giant polycystic kidneys reminiscent of autosomal recessive polycystic kidney disease. These experiments establish Pax8-rtTA mice as a powerful tool for modeling renal diseases in transgenic mice.
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Cites
Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.
Gossen, M., & Bujard, H. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.12.5547 · Cited by 4,943 · cited 1×
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Self-citationTranscriptional Activation by Tetracyclines in Mammalian Cells
Gossen, M., Freundlieb, S., Bender, G., Müller, G., Hillen, W., & Bujard, H. (1995) · Science · doi:10.1126/science.7792603 · Cited by 2,488 · cited 1×
“1865" language="eng" relation="no"> Conditional gene expression systems, such as the tetracycline-dependent (Tet) syste”
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Koesters, R., Kaissling, B., LeHir, M., Picard, N., Theilig, F., Gebhardt, R., Glick, A. B., Hähnel, B., Hosser, H., Gröne, H.-J., et al. (2010) · The American Journal of Pathology · doi:10.2353/ajpath.2010.091012 · Cited by 271
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mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress
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Inducible kidney-specific Sgk1 knockout mice show a salt-losing phenotype
Faresse, N., Lagnaz, D., Debonneville, A., Ismailji, A., Maillard, M., Fejes-Toth, G., Náray-Fejes-Tóth, A., & Staub, O. (2012) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00535.2011 · Cited by 93
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Resident mesenchymal cells and fibrosis
Hutchison, N., Fligny, C., & Duffield, J. S. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.11.015 · Cited by 51
Metadata
- Authors
- Traykova-Brauch, M., Schönig, K., Greiner, O., Miloud, T., Jauch, A., Bode, M., Felsher, D. W., Glick, A. B., Kwiatkowski, D. J., Bujard, H., Horst, J., von Knebel Doeberitz, M., Niggli, F. K., Kriz, W., Gröne, H.-J., & Koesters, R.
- Venue
- Nature Medicine
- Published
- 2008-08-24
- Volume
- 14
- Issue
- 9
- Pages
- 979-984
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2050475853
- Cited by
- 304
- References
- 2
- FWCI
- 3.52
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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