Resident mesenchymal cells and fibrosis
Open accessAbstract
Fibrosis is a major clinical problem associated with as many as 45% of all natural deaths in developed nations. It can affect all organs and accumulating evidence indicates that fibrogenesis is not merely a bystander product of injury, but is a central pathological problem directly contributing to loss of organ function. In the majority of clinical cases, fibrogenesis is strongly associated with the recruitment of leukocytes, even in the absence of infection. Although chronic infections are a significant cause of fibrogenesis, in most cases fibrotic disease occurs in the context of sterile injury, such as microvascular disease, toxic epithelial injury or diabetes mellitus. Fibrogenesis is a direct consequence of the activation of extensive, and previously poorly appreciated, populations of mesenchymal cells in our organs which are either wrapped around capillaries and known as 'pericytes', or embedded in interstitial spaces between cell structures and known as resident 'fibroblasts'. Recent fate-mapping and complementary studies in several organs indicate that these cells are the precursors of the scar-forming myofibroblasts that appear in our organs in response to injury. Here we will review the literature supporting a central role for these cells in fibrogenesis, and highlight some of the critical cell to cell interactions that are necessary for the initiation and continuation of the fibrogenic process. This article is part of a Special Issue entitled: Fibrosis: Translation of basic research to human disease.
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In rodent models of parenchymal injury, it is predominantly HSCs that activate and differentiate into myofibroblasts.
“In rodent models of parenchymal injury, it is predominantly HSCs that activate and differentiate into myofibroblasts.112,113”
From Understanding the cellular interactome of non-alcoholic fatty liver disease (2022) · cites this paper as [112]
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Pericytes, Microvasular Dysfunction, and Chronic Rejection
Kloc, M., Kubiak, J. Z., Li, X. C., & Ghobrial, R. M. (2015) · Transplantation · doi:10.1097/tp.0000000000000648 · Cited by 34 · see citing works
- Authors
- Hutchison, N., Fligny, C., & Duffield, J. S.
- Affiliations
- University of Washington (US)
- Corresponding author
- Duffield, Jeremy S.
- ORCID
- Duffield, Jeremy S.
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Publisher
- Elsevier BV
- Published
- 2013-07
- Volume
- 1832
- Issue
- 7
- Pages
- 962-971
- ISSN
- 0925-4439 (ISSN-L)
- PMC
- PMC3672235
- OpenAlex
- W2059118406
- Cited by
- 51
- References
- 91
- Citations by year
- 2026: 1 · 2024: 2 · 2022: 4 · 2021: 2 · 2020: 2 · 2019: 7 · 2018: 3 · 2017: 5 · 2016: 5 · 2015: 6 · 2014: 7 · 2013: 7
- FWCI
- 4.06
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (DK93493, DK84077, DK87389)
- University of Washington
- Genzyme
- Nephcure Foundation
- Regulus Therapeutics
- Diabetes UK
- Sanofi Renal Fellowship Award
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Keywords
- fibrosis, fibrogenesis, pericytes, fibroblasts, myofibroblasts, sterile injury, leukocyte recruitment, fate mapping, cell-cell interactions
- MeSH terms
- Fibroblasts, Fibrosis, Humans, Pericytes, Myofibroblasts, Mesenchymal Stem Cells
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